Explosive tumor growth in a patient with colon cancer is associated with reduced neoantigen levels and decreased interferon-gamma (IFN-γ) signaling.

Background: Explosive tumor growth is characterized by rapid tumor growth in a short time period. Currently, there is no precise scientific definition for the condition, which is often accompanied with a poor clinical prognosis. Herein, we presented a study of a young patient with colon cancer who experienced explosive tumor growth.

Cold sintering of ammonium phosphomolybdate ((NH)PMoO·xHO) as soild-state matrices for cesium immobilization.

Ammonium phosphomolybdate (APM) is often used for the adsorption of Cs. However, the decomposition temperature of cesium-containing ammonium phosphomolybdate waste is low and difficult to dispose of. This study introduces the first use of cold sintering to solidify ammonium phosphomolybdate monomers at low temperatures.

Prevalence, antimicrobial resistance and phylogenetic analysis of contamination and transmission in yellow-feathered broiler hatcheries in China.

is a significant avian pathogen causing infectious diseases in poultry, with hatching playing a crucial role in its transmission. Despite its importance, systematic research on transmission in hatcheries remains limited. This study evaluates the prevalence and antimicrobial resistance of throughout all production stages in yellow-feathered broiler hatcheries: laying, egg storage, incubating, hatching, and post-hatch.

Epidemiological and Molecular Investigation of Feline Panleukopenia Virus Infection in China.

The feline panleukopenia virus (FPV) is a highly contagious virus that affects cats worldwide, characterized by leukopenia, high temperature and diarrhea. Recently, the continuous prevalence and variation of FPV have attracted widespread concern. The aim of this study was to investigate the isolation, genetic evolution, molecular characterization and epidemiological analysis of FPV strains among cats and dogs in China from 2019 to 2024.

Chaos in Optomechanical Systems Coupled to a Non-Markovian Environment.

We study the chaotic motion of a semi-classical optomechanical system coupled to a non-Markovian environment with a finite correlation time. By studying the emergence of chaos using the Lyapunov exponent with the changing non-Markovian parameter, we show that the non-Markovian environment can significantly enhance chaos. It is observed that a non-Markovian environment characterized by the Ornstein-Uhlenbeck type noise can modify the generation of chaos with different environmental memory times.

possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein diet.

Introduction: Hyperuricemia is widespread in humans and birds which is a necessary physiological factor leading to gout. Studies have shown an inextricable relationship between gut microbiota and hyperuricemia. This study explored the association between intestinal flora and hyperuricemia in Goslings.

BolA affects the biofilm formation ability, outer membrane permeability and virulence, thus is required for the adaptability of Salmonella enterica serotype Typhimurium to the harsh survival environment.

Salmonella enterica serotype Typhimurium, an important foodborne pathogen with high adaptability to the host's internal and external survival environment, seriously threatens public health. Therefore, to understand the mechanism underlying the high adaptability, this study investigated the transcription factor BolA by constructing BolA deletion strain 269△BolA, complemented strain 269BolAR and overexpression strain 269BolA+ based on WT269. BolA significantly inhibited motility; at 6 h, the BolA overexpression strain (269BolA+) showed 91.

Total neoadjuvant treatment for MRI-stratified high-risk rectal cancer: a single-center, single-arm, prospective Phase II trial (PKUCH-R02).

Background: Induction chemotherapy combined with neoadjuvant chemoradiotherapy has been recommended for patients with high-risk, locally advanced rectal cancer. However, the benefit of more intensive total neoadjuvant treatment (TNT) is unknown. This study aimed to assess the safety and efficacy of induction chemotherapy combined with chemoradiotherapy and consolidation chemotherapy for magnetic resonance imaging-stratified high-risk rectal cancer.

Genetic characteristic of coexisting of and in isolates from lesion-bearing animal organs.

The coexistence of and in the plasmid of has been widely reported and such strains have been mainly isolated from animal and human feces. However, few reports have focused on the genetic diversity of -carrying chromosomes and -carrying plasmids in isolates from lesion-bearing animal organs. This study investigated the genetic characteristics of chromosome-mediated and plasmid-mediated in isolated from lesion-bearing animal organs.

The effect of O-antigen length determinant wzz on the immunogenicity of Salmonella Typhimurium for Escherichia coli O2 O-polysaccharides delivery.

Attenuated Salmonella Typhimurium is a promising antigen delivery system for live vaccines such as polysaccharides. The length of polysaccharides is a well-known key factor in modulating the immune response induced by glycoconjugates. However, the relationship between the length of Lipopolysaccharide (LPS) O-antigen (OAg) and the immunogenicity of S.

Survival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts.

Background: Approximately 10% of stage I colorectal cancer (CRC) patients experience unfavorable clinical outcomes after surgery. However, little is known about the subset of stage I patients who are predisposed to high risk of recurrence or death. Previous evidence was limited by small sample sizes and lack of validation.

MiR-143-3p targets ATG2B to inhibit autophagy and promote endothelial progenitor cells tube formation in deep vein thrombosis.

Deep vein thrombosis (DVT) is a common disease in vascular surgery. In recent study, microRNA (miRNA) plays a regulatory role in function of Endothelial progenitor cells (EPCs), which showed promising therapeutic choice for DVT. However, the function of miR-143-3p in EPCs remains incomplete.

Clinical Decision Support for High-Risk Stage II Colon Cancer: A Real-World Study of Treatment Concordance and Survival.

Background: Prognostic and pathologic risk factors typically guide clinicians and patients in their choice of surveillance or adjuvant chemotherapy when managing high-risk stage II colon cancer. However, variations in treatment and outcomes in patients with stage II colon cancer remain.

Objective: This study aimed to assess the survival benefits of treatments concordant with suggested therapeutic options from Watson for Oncology, a clinical decision support system.

Meta-replication, sampling bias, and multi-scale model selection: A case study on snow leopard () in western China.

Replicated multiple scale species distribution models (SDMs) have become increasingly important to identify the correct variables determining species distribution and their influences on ecological responses. This study explores multi-scale habitat relationships of the snow leopard () in two study areas on the Qinghai-Tibetan Plateau of western China. Our primary objectives were to evaluate the degree to which snow leopard habitat relationships, expressed by predictors, scales of response, and magnitude of effects, were consistent across study areas or locally landcape-specific.

Circular RNA circCTNNA1 promotes colorectal cancer progression by sponging miR-149-5p and regulating FOXM1 expression.

Circular RNAs (circRNAs) are an emerging class of non-coding RNAs, identified to participate in multiple malignancies. Nevertheless, the clinical significance, biological function, and regulatory mechanisms of circRNAs in colon cancer (CC) remain largely unclear. In this study, the circRNA expression profile in CC and matched normal tissues was analyzed using circRNA microarrays.

Prognostic value of nucleotyping, DNA ploidy and stroma in high-risk stage II colon cancer.

Background: Heterogeneity with respect to recurrence and survival in high-risk stage II colon cancer patients still exists, and further classification is urgently required. This study aimed to ascertain the prognostic value of DNA ploidy, stroma-tumour fraction and nucleotyping in the prognosis of high-risk stage II colon cancer.

Methods: A total of 188 high-risk stage II colon cancer patients received radical surgery in Peking University Cancer Hospital, from 2009 to 2015.

Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies.

Background: Malignant bowel obstruction (MBO) is a common event for end-stage gastrointestinal cancer patients. Previous studies had demonstrated manifestations and clinical management of MBO with mixed malignancies. There still lack reports of the surgical treatment of MBO.

WITHDRAWN: Circular RNA circUBA1 promotes gastric cancer proliferation and metastasis by acting as a competitive endogenous RNA through sponging miR-375 and regulating TEAD4.

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.

Quality evaluation based on color grading: quality discrimination of the Chinese medicine Corni Fructus by an E-eye.

'Quality evaluation based on color grading' is one of the features used in Chinese medicine discrimination. In order to assess the feasibility of electronic eye (E-eye) in implementing 'quality evaluation based on color grading', the present study applied an IRIS VA400 E-eye to test 58 batches of Corni Fructus samples. Their optical data were acquired and combined with their corresponding classes.

Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition).

The lungs are the second most common site of metastasis for colorectal cancer (CRC) after the liver. Rectal cancer is associated with a higher incidence of lung metastases compared to colon cancer. In China, the proportion of rectal cancer cases is around 50%, much higher than that in Western countries (nearly 30%).

The blocking effect of atmospheric particles by forest and wetland at different air quality grades in Beijing China.

To understand the effect of forests and wetlands on air quality, the PM and PM concentration and meteorological data were collected in the forest and wetland in the Beijing Olympic Forest Park in China from May 2106 to May 2017. The blocking rates of forest and wetland to PMs were calculated under different air quality grades which were divided into six levels base on a technical regulation. And we have got three main conclusions.

Assessment of habitat suitability of the snow leopard () in Qomolangma National Nature Reserve based on MaxEnt modeling.

Habitat evaluation constitutes an important and fundamental step in the management of wildlife populations and conservation policy planning. Geographic information system (GIS) and species presence data provide the means by which such evaluation can be done. Maximum Entropy (MaxEnt) is widely used in habitat suitability modeling due to its power of accuracy and additional descriptive properties.

[Effect of adjuvant chemotherapy on the prognosis of stage II( colon cancer patients with high risk factors].

Objective: To investigate the effect of adjuvant chemotherapy on the prognosis of stage II( colon cancer patients with high risk factors.

Methods: Clinicopathological and follow-up data of stage II( colon cancer patients undergoing radical surgery from January 2001 to March 2012 at Gastrointestinal Cancer Center of Peking University Cancer Hospital were retrospectively analyzed. The effect of adjuvant chemotherapy (within postoperative 2 month, fluorine uracil as main drugs) on the prognosis of high-risk patients was analyzed.