The acceptability, safety, and performance of primary cervical screening through self-collected vaginal samples in an urban teaching hospital antenatal clinic setting.

This study evaluated the feasibility, safety, and acceptability of self-collected vaginal samples for human papillomavirus (HPV) testing among pregnant women in an urban teaching hospital in Malaysia. This cross-sectional study recruited pregnant women aged 30 years and above who attended antenatal care at the University of Malaya Medical Centre. Participants self-collected vaginal samples using FLOQSwabs and completed pre- and post-sampling questionnaires assessing acceptability.

E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin-dependent receptor-interacting protein kinase 3 (RIP3) degradation.

Background And Purpose: Severe acute pancreatitis (SAP) is a critical abdominal condition with high mortality rates. The activation of necroptosis in acinar cells is an critical mechanism for SAP. Pellino1 (PELI1), as an E3 ubiquitin ligase, is involved in pathogenic mechanisms in various diseases.

Routine Vaginal Examination Scheduled At 8 vs 4 Hours In Multiparous Women In Early Spontaneous Labour: A Randomised Controlled Trial.

Background: Vaginal examination can cause pain and embarrassment, but it is recommended to be performed at least every 4 hours to monitor progress in labor. Trial data is sparse on its ideal intensity. Haste to diagnose labor dystocia, especially in low-risk multiparous women and to resort to oxytocin augmentation and operative delivery may be counterproductive.

Activity Modulation of an Enzyme in a Confined Space.

Enzyme immobilization in metal-organic frameworks (MOFs) features improved catalytic efficiency, enhanced stability, and good recyclability. However, remote modulation of enzymatic activity in a confined space has never been reported, despite its great significance in biochemical systems. Here we develop a photoresponsive system with remote controllability in terms of the activity of an enzyme in a confined space.

Wound Healing Effects of Aqueous Extract on Feline Gingivitis.

Periodontal disease is the most common health problem in domestic cats. The goal of periodontal disease treatment is to decrease bacterial accumulation and control inflammation, thereby decreasing periodontal tissue attachment loss. (Haruan) is known for its antibacterial and anti-inflammatory properties.

A Novel Polymorphic Form of Sodium Benzoate (Ω-NaBen): Improved Solubility, Stability, Central Nervous System Effects, and Antipsychotic Activities via D-Amino Acid Regulation.

Introduction: Sodium benzoate (NaBen), a D-amino acid oxidase inhibitor, has been demonstrated to possess antipsychotic and cognition-enhancing effects in animal models. However, the clinical findings in patients with schizophrenia and dementia are mixed and inconclusive.

Objectives: To further improve its therapeutic potential, a novel crystalline polymorph of NaBen (abbreviated as Ω-NaBen) was developed.

Hepatic Stellate Cell TM4SF1 Accelerates Hepatic Fibrosis Progression via Interacting With the Tyrosine Kinase c-Src.

Background & Aims: Identifying genes involved in hepatic stellate cell (HSC) activation is essential for understanding hepatic fibrosis (HF). The role of Transmembrane 4 L six family member 1 (TM4SF1) in HF is not well understood, despite recent investigations into its involvement in various malignant tumors.

Methods: Bioinformatics analysis identified key genes involved in HSC activation.

Ti-diffused KTN waveguide enabling intensity modulation based on the quadratic electro-optic effect.

Optical waveguides are fundamental components in integrated optics, enabling the confinement of light beams at micron and nanometer scales. The performance of electro-optic materials is the key to realizing waveguide-based modulation devices. Potassium tantalate niobate (KTN) crystals exhibit exceptional quadratic electro-optic effects, making them highly promising for applications in optical waveguides and electro-optic modulators.

Antenatal dexamethasone vs betamethasone on glycemic control in mild gestational diabetes: a randomized clinical trial.

Background: Preterm birth and gestational diabetes mellitus are common complications of pregnancy. A widely known side effect of antenatal corticosteroids on fetal maturity in preterm births is maternal hyperglycemia. The choice of antenatal corticosteroid regimens between dexamethasone and betamethasone highly depends on local availability and cost, as current but inconclusive evidence shows similar neonatal outcomes for both regimes.

Mesostructured Dodecagonal Quasicrystal: the Interplay Between Temperature Regulation and Kinetic Structural Transition.

Quasicrystals, characterized by long-range order and the absence of translational symmetry, have attracted great attention due to their extraordinary physicochemical properties. Although quasicrystals have been discovered in various experimental systems, the formation mechanisms that yield quasicrystals at the mesostructural scale remain elusive. Herein, a unique formation pathway of dodecagonal quasicrystal in silica mesoporous crystals is reported, employing cationic surfactant as a soft template and organosilane as a co-structure directing agent.

Unified iontronic sensing for operando monitoring of physical-chemical events in lithium-ion batteries.

Operando measurement of expansion force has become an effective way of monitoring physical-chemical events in lithium-ion batteries, of which the conventional optical means is limited by material fragility, structural incompatibility and system complexity. The utilization of flexible sensors can potentially address these challenges; however, their functionality and stability are restricted within hours in corrosive environments. Here, an unified iontronic sensing mechanism, derived from the super-capacitive electrode/electrolyte interface, is developed for expansion-force measurement in highly corrosive electrolyte environments.

Crosstalk between Hepatic Stellate Cells and Hepatic Macrophages in Metabolic Dysfunction-Associated Steatohepatitis.

Metabolic dysfunction-associated steatotic liver disease is the most prevalent liver condition worldwide. Its more severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH), is accompanied by distinctive hepatocellular injury and inflammation with fibrosis. The involvement of chronic inflammation and accompanying immune cell activation in the maturation phases of MASH progression, mediated through hepatic stellate cells (HSCs), plays a central role.

Network pharmacology analysis reveals that coumestrol targets ZYX to inhibit ferroptosis and alleviate acute pancreatitis.

Aim: The therapeutic effect of CMS on acute pancreatitis (AP) and the mechanism of targeting Zyxin (ZYX) to regulate ferroptosis in acinar cells.

Methods: To assess the therapeutic effects of CMS in AP, we established caerulein-induced AP and caerulein plus LPS-induced SAP mouse models. Subsequently, weighted gene co-expression network analysis (WGCNA) and network pharmacology analysis were used to investigate the mechanism and target of CMS in the treatment of AP.

Guideline of Dynamic Tunnel Structural Evolution for Durable Sodium-Ion Oxide Cathodes.

Mn-based oxide cathodes hold great promise for sodium-ion batteries (SIBs) due to their cost-effectiveness and environmental compatibility. In this study, using tunnel-type NaMnO as a prototype, a systematic investigation is conducted to examine how different element substitutions affect structural evolution and found that these element substitutions alter the total energy of the pristine system, driving the structure to evolve gradually from a tunnel to a different crystal configuration. Notably, using advanced scanning transmission electron microscopy (STEM), the transition zone is captured from tunnel to layered structure for the first time, providing direct evidence of phase evolution.

Evaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [F]SynVesT-1 metabolism analysis in rats.

Purpose: Alterations in synaptic vesicle glycoprotein 2A (SV2A) are linked to various neurodegenerative and neuropsychiatric disorders. Positron emission tomography (PET) imaging with radiotracers targeting SV2A, such as [F]SynVesT-1, has proven effective for monitoring these changes. However, SV2A PET quantification using kinetic modeling requires radiometabolite analysis, which presents challenges, particularly in preclinical longitudinal studies due to the relatively large sample volume required by the standard radio-high-performance liquid chromatography (radio-HPLC) method.

Effects of Adding BCH0 to the Diet on Growth Performance, Tissue Structures, and Gut Microbiota in Broilers.

Studies demonstrated that () as a dietary additive enhanced broiler growth performance, yet its mechanisms of action modulation remained unclear. Therefore, this study investigated effects of dietary BCH0 (1 × 10 CFU/kg) on growth performance, intestinal morphology, gut microbiota, and ileal transcriptomics in Arbor Acres broilers using a completely randomized design. A total of 200 one-day-old broilers were allocated to control (Con, basal diet) and experimental (BCH0, basal diet + 1 × 10 CFU/kg BCH0) groups (10 replicates/group, 10 birds/replicate) over a 42-day trial.

Mannosylated MOF Encapsulated in Lactobacillus Biofilm for Dual-Targeting Intervention Against Mammalian Escherichia coli Infections.

Pathogenic bacterial infections pose a major concern, especially concerning mammalian enteritis and diarrhea. Compared to conventional antibiotic intervention, metal-organic frameworks (MOFs) exhibit superior antibacterial properties and lower cytotoxicity, demonstrating great promise in the treatment of pathogen-induced diarrhea. However, the achievement of their precise targeted delivery is still a significant challenge.

Capacity Enhancement in Quasi-Solid-State Lithium-Oxygen Batteries via Self-Constructing Li Transport Channels.

Lithium-oxygen batteries (LOBs) attract widespread attention due to their high energy density and safety. The morphology of the solid discharge product bears a close correlation with the battery capacity. In this work, the capacity of LOBs surprisingly increases from 790 mAh g under the liquid electrolyte to 2395 mAh g by using a quasi-solid-state electrolyte (QSSE).

A multi-task domain-adapted model to predict chemotherapy response from mutations in recurrently altered cancer genes.

Next-generation sequencing (NGS) is increasingly utilized in oncological practice; however, only a minority of patients benefit from targeted therapy. Developing drug response prediction (DRP) models is important for the "untargetable" majority. Prior DRP models typically use whole-transcriptome and whole-exome sequencing data, which are clinically unavailable.

Mechanisms and Potential of Antitumor Therapy With Natural Products Regulating Non-Coding RNAs.

Non-coding RNAs (ncRNAs) are a distinctive class of RNA transcripts that have received extensive attention from the global scientific community due to their intricate and important roles in tumor malignancy. The dysregulated expression of ncRNAs is closely associated with the progression of different types of cancer, suggesting that ncRNAs serve as key regulatory factors and modulate numerous cancer biomarkers. The complex interactions between regulatory ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), as well as their intricate interactions with mRNAs or RNA-binding proteins, orchestrate many biological processes in tumors.

Calcium single atom catalyst with unusual activity and stability for the synthesis of dimethyl carbonate.

Solid base catalysts with strong basicity are highly desirable for various reactions because of their minimal corrosion, ease of separation, and environmental sustainability. Nevertheless, their broader application is hindered by issues including mediocre activity and poor stability. Herein, aiming at enhancing the catalytic performance and stability of conventional solid bases, we designed and fabricated calcium (Ca) single-atom solid bases on zeolite imidazolate framework (ZIF-8) derived N-doped carbon (NPC) with Ca-N motifs as the active center for transesterification of methanol and ethylene carbonate.

Dynamic and asymmetric colloidal molecules.

"Colloidal molecules" represent artificial colloidal clusters replicating the geometries of molecules and exhibiting flexibility and fluctuations similar to macromolecules and proteins. Their dynamic and anisotropic characters make them unique and indispensable building blocks for creating hierarchically organized superstructures. Despite the progress in synthesizing and assembling colloidal molecules, unveiling their dynamic characters is challenging in experiments.

Hydrogen bubble evolution and its induced mass transfer on zinc electrodes in alkaline and neutral media.

The evolution of hydrogen bubbles plays a critical role in governing the performance of Zn-based batteries by influencing Zn deposition, electrode morphology, and mass transfer dynamics. This work consolidates recent progress in understanding the dual influence of hydrogen bubble evolution on Zn-based batteries, emphasizing its implications for mass transfer and electrochemical performance. While presenting challenges such as inhomogeneous Zn deposition, dendrite formation, and Zn passivation, hydrogen bubble evolution simultaneously facilitates mass transfer through its forced convective disturbance.