High-Temperature Superconductivity of Thermodynamically Stable Fluorite-Type Hydrides at Ambient Pressure.

Hydride superconductors have attracted significant attention, yet achieving superconductivity at ambient pressure remains a key challenge. Here, a family of high-T (superconducting critical temperature, T) hydrides based on the fluorite-type AXH structure, exhibiting thermodynamic and dynamic stability at low to atmospheric pressure, is proposed. Through comprehensive screening of 150 ternary systems, eight stable hydrides below 35 GPa are identified.

OTUB1 antagonizes TRIM21 to induce deubiquitination of SPHK1 and promote the progression of hepatocellular carcinoma.

SPHK1 is critical for maintaining cellular lipid balance. Aberrant expression of SPHK1 aggravates malignancy of tumor through multiple signaling pathways. Here, we report a novel regulatory mechanism in ubiquitination of SPHK1.

Physically Enhanced Antibacterial Performance in Nanostructures Inspired by Nature: A Route to Avoiding Antimicrobial Resistance.

The rise of antimicrobial resistance (AMR) and the challenge of developing safe and effective antibacterial strategies pose growing public health threats. Bioinspired nanostructured surfaces with mechano-bactericidal activity provide a purely physical antibacterial strategy without the risk of inducing AMR. However, their antibacterial performance is often limited, particularly regarding long-term effectiveness and varying bactericidal efficacy against different strains.

Unravelling the regulatory network underlying divergent expression of the key lipid metabolism transcription factor SREBP in two congeneric oyster species.

SREBP serves as the master transcriptional regulator of lipid metabolism, playing a crucial role in temperature adaptation. However, the regulatory mechanisms controlling SREBP expression remain poorly understood in marine organisms. The basic bHLH domain of single-copy SREBP was highly conserved in mollusks, confirming its fundamental role in lipid metabolic regulation.

Ctnnb1 and Keap1-Nrf2 mediating divergent heat resistance in two congeneric oysters.

Global warming has led to rising temperatures of sea, which in turn increases oxidative stress on marine organisms. The Nuclear factor erythroid 2-related factor 2 (Nrf2), as widely recognized antioxidative transcription factor, has been reported playing a significant role in the thermal stress response of marine organisms; however, its precise function and regulatory mechanisms remain unclear. In this study, we demonstrated regulatory mechanisms of Nrf2 in two congeneric oyster species with differential thermal tolerance Crassostrea gigas (C.

Oily Long-Term Anti-Icing Coating Based on Hydrophobic Cross-Linking Composite Resin.

In this paper, a new type of passive anti-icing coating, i.e., interfacial lubrication coating, is proposed and investigated.

Prediction of high- superconductivity in heavy rare earth metals compressed Be-H alloy backbone.

As the lightest element, hydrogen has the potential to become a room temperature superconductor upon metallization, though achieving this remains a significant challenge. Hydrogen-rich compounds leveraging the hydrogen pre-compression effect may offer promising alternatives for high-temperature superconductivity. In this study, we incorporated heavy rare earth elements into a fluorite-type Be-H alloy framework, resulting in the formation of XBeH (where X = Tm, Yb, Lu).

Recanalization is more important than procedure time on outcome of thrombectomy in acute vertebrobasilar artery occlusion.

Longer procedure time (PT) predicts worse prognosis after endovascular treatment (EVT) in acute vertebrobasilar artery occlusion (VBAO), but it remains unknown whether it is worth pursuing recanalization when the PT is obviously extended. Patients with acute VBAO who received EVT were retrospectively enrolled from 21 stroke centers in China from December 2015 to December 2018. Multivariable logistic analysis was performed to analyze the associations of PT with favorable outcome (defined as modified Rankin Scale score of 0 to 3) and mortality at 90 days.

Association Between Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Pneumonia After Endovascular Treatment of Vertebrobasilar Artery Occlusion.

Background: The uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel marker of inflammation and metabolism. We aimed to explore the association of UHR with pneumonia after endovascular thrombectomy (EVT) in patients with vertebrobasilar artery occlusion (VBAO).

Methods: We retrospectively enrolled participants diagnosed with acute VBAO treated with EVT within 24 hours of estimated occlusion time from the multicenter PERSIST study.

The Molecular Mechanism of in Thermal Adaptation of Two Congeneric Oyster Species.

Clock genes regulate physiological and metabolic processes by responding to changes in environmental light and temperature, and genetic variations in these genes may facilitate environmental adaptation, offering opportunities for resilience to climate change. However, the genetic and molecular mechanisms remain unclear in marine organisms. In this study, we investigated the role of a key clock gene, the circadian locomotor output cycles kaput (), in thermal adaptation using DNA affinity purification sequencing (DAP-Seq) and RNA interference (RNAi)-based transcriptome analysis.

Genotype-by-Environment Effects of Cis-Variations in the Atgl Promoter Mediate the Divergent Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species.

Phenotypic plasticity plays an essential role in adaptive evolution. However, the molecular mechanisms of how genotype-by-environment interaction (G × E) effects shape phenotypic plasticity in marine organisms remain poorly understood. The crucial temperature-responsive trait triacylglycerol (TAG) content and its major gene adipose triglyceride lipase (Atgl) expression have divergent plastic patterns in two congeneric oyster species (Crassostrea gigas and Crassostrea angulata) to adapt to relative-cold/northern and relative-warm/southern habitats, respectively.

Genome-Wide Identification of the GPAT Family in L. and Expression Profiling Under Abiotic Stress.

Glycerol-3-phosphate acyltransferase (GPAT), as a rate-limiting enzyme engaged in lipid synthesis pathways, exerts an important role in plant growth and development as well as environmental adaptation throughout diverse growth stages. Alfalfa ( L.) is one of the most significant leguminous forages globally; however, its growth process is frequently exposed to environmental stress, giving rise to issues such as impeded growth and decreased yield.

Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters.

Phosphorylation of Ser32 and Ser36 controls the degradation of IκBα is the conserved cascade mechanisms of immune core signaling pathway, NF-κB pathway in metazoans, but it's response to abiotic stress and the presence of novel phosphorylation mechanisms in other species remain unclear. Herein, we reported a novel heat-induced phosphorylation site (Ser74) at oysters' major IκBα, which independently regulated ubiquitination-proteasome degradation without the requirement of phosphorylation at S32 and S36. And this site was phosphorylated by ERK/MAPK pathway, which then promoted REL nuclear translocation to activate cell survival related genes to defend heat-stress.

PI3K-AKT-mediated phosphorylation of Thr260 in CgCaspase-3/6/7 regulates heat-induced activation in oysters.

Cysteine-aspartic proteases (caspases) are critical drivers of apoptosis, exhibiting expansion and domain shuffling in mollusks. However, the functions and regulatory mechanisms of these caspases remain unclear. In this study, we identified a group of Caspase-3/6/7 in Bivalvia and Gastropoda with a long inter-subunit linker (IL) that inhibits cleavage activation.

High-Temperature Superconductivity in Perovskite Hydride Below 10 GPa.

Hydrogen and hydride materials have long been considered promising materials for high-temperature superconductivity. However, the extreme pressures required for the metallization of hydrogen-based superconductors limit their applications. Here, a series of high-temperature perovskite hydrides is designed that can be stable within 10 GPa.

A perspective on reducing stabilizing pressure for high-temperature superconductivity in hydrides.

The theoretical predictions and experimental syntheses of hydrogen sulfide (HS) have ignited a surge of research interest in hydride superconductors. Over the past two decades, extensive investigations have been conducted on hydrides with the ultimate goal of achieving room-temperature superconductivity under ambient conditions. In this review, we present a comprehensive summary of the current strategies and progress towards this goal in hydride materials.

MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species.

Pyruvate kinase (PK), as a key rate-limiting enzyme in glycolysis, has been widely used to assess the stress tolerance and sensitivity of organisms. However, its phosphorylation regulatory mechanisms mainly focused on human cancer research, with no reports in marine organisms. In this study, we firstly reported a conserved PK Ser11 phosphorylation site in mollusks, which enhanced enzyme activity by promoting substrate binding, thereby regulating divergent thermal metabolism of two allopatric congeneric oyster species with differential habitat temperature.

Research on ride comfort optimization of the vehicle considering the subframe.

When the vehicle is in motion, the elastic deformation of the flexible subframe significantly influences ride comfort. Therefore, it is crucial to investigate the impact of flexible subframes on vehicle ride comfort. In order to enhance the reliability and optimization efficiency of our research, this paper incorporates the concept of elastic deformation in the flexible subframe into the investigation of vehicle ride comfort, and proposes a multi-objective optimization approach to enhance the overall vehicle ride comfort.

Genome-wide identification, characterization, and evolutionary analysis of the barley TALE gene family and its expression profiles in response to exogenous hormones.

Three-amino-loop-extension (TALE) family belongs to the homeobox gene superfamily and occurs widely in plants, playing a crucial role in regulating their growth and development. Currently, genome-wide analysis of the TALE family has been completed in many plants. However, the systematic identification and hormone response analysis of the TALE gene family in barley are still lacking.

Unpacking the hazards: An analytic study of injury patterns and risk factors in urban instant delivery.

The rapid growth of urban instant delivery, facilitated by digital platforms and characterized by on-demand, short-term, task-based labor, has raised concerns about safety, particularly with the increasing frequency of instant delivery crashes (IDCs). This study addresses knowledge gaps in understanding injury patterns and risk factors associated with IDCs. Utilizing data extracted from judicial verdicts on IDC disputes in China, encompassing demographic, contextual, crash, and injury information, the research employs ordered logit regression to identify significant factors affecting injury patterns, the number of injuries per person (IPP), and injury severity.

Superconducting ternary hydrides: progress and challenges.

Since the discovery of the high-temperature superconductors HS and LaH under high pressure, compressed hydrides have received extensive attention as promising candidates for room-temperature superconductors. As a result of current high-pressure theoretical and experimental studies, it is now known that almost all the binary hydrides with a high superconducting transition temperature ( ) require extremely high pressure to remain stable, hindering any practical application. In order to further lower the stable pressure and improve superconductivity, researchers have started exploring ternary hydrides and had many achievements in recent years.

The Performance of Spot Photoscreener in 6 to 10 Weeks Infants in China: A Cross-Sectional Study.

Purpose: To compare the refractive errors measured by the Spot photoscreener (with or without cycloplegia) to cycloplegic retinoscopy in 6- to 10-week-old infants.

Materials And Methods: 101 right eyes from 101 healthy infants aged 6 to 10 weeks were recruited for this cross-sectional observational study. Refractive errors were measured using Spot photoscreener before and after cycloplegia, as well as cycloplegic retinoscopy.

Open-Framework Vanadate as Efficient Ion Exchanger for Uranyl Removal.

The elimination of uranium from radioactive wastewater is crucial for the safe management and operation of environmental remediation. Here, we present a layered vanadate with high acid/base stability, [MeNH]VO, as an excellent ion exchanger capturing uranyl from highly complex aqueous solutions. The material possesses an indirect band gap, ferromagnetic characteristic and a flower-like morphology comprising parallel nanosheets.

Superconductivity of thulium substituted clathrate hexahydrides at moderate pressure.

Due to the BCS theory, hydrogen, the lightest element, would be the prospect of room-temperature superconductor after metallization, but because of the difficulty of the hydrogen metallization, the theory about hydrogen pre-compression was proposed that the hydrogen-rich compounds could be a great option for the high T superconductors. The superior properties of TmH, YbH and LuH indicated the magnificent potential of heavy rare earth elements for low-pressure stability. Here, we designed XTmH (X = Y, Yb, Lu, and La) to obtain higher T while maintaining low pressure stability.