Enhanced selective oxidation capacity and utilization efficiency of Fe(VI) initiated by HBT for contaminant oxidation: Identification of HBT radicals and function.

Studies on the Ferrate [Fe(VI)] process have focused on enhancing contaminant oxidation by adding reductants to generate Fe(V/IV), yet have overlooked significant reactive iron species loss caused by reductants, which ultimately reducing Fe(VI) utilization efficiency. Here, the redox mediator 1-hydroxybenzotriazole (HBT) was introduced into the Fe(VI) system and significantly improved the utilization efficiency and selective oxidation capacity of Fe(VI). The amount of sulfamethoxazole (SMX) oxidized by each μmol Fe(VI), namely ΔSMX/ΔFe(VI), was 0.

Enantioselective Synthesis of γ-Butyrolactones Bearing γ-Quaternary Stereocenters via Nickel-Catalyzed Reductive Coupling of Acrylates with Ketones.

γ-Butyrolactones with γ-quaternary stereocenters are essential structural components in numerous natural products with significant biological activities. While chiral organocatalysis has seen considerable advancements, the development of intermolecular strategies using transition-metal catalysis has remained limited. Here, we describe a nickel-catalyzed, enantioselective reductive coupling strategy to synthesize chiral γ-butyrolactones by reacting acrylates with ketones.

Nickel-Catalyzed Hydrocarbamoylation of Alkenes with Isocyanates.

The hydrocarbamoylation of alkenes with isocyanates is a promising method for synthesizing amides. However, applying this strategy to more inert, simple alkenes, such as styrenes, α-olefins, and internal alkenes, poses significant challenges. Here, we report the first nickel-catalyzed hydrocarbamoylation of alkenes with isocyanates, facilitated by triethoxysilane to reduce nickelacycle intermediates.

The risk of propofol infusion syndrome on epilepsy patients:Insights from FAERS data and published case reports.

Objective: PRIS has been documented in epilepsy patients treated with propofol. But the clinical features associated with the occurrence of PRIS in patients with epilepsy remain incompletely elucidated. This study aimed to investigate the relationship between epilepsy, antiepileptic drugs, and PRIS and draw conclusions about its clinical features.

Adverse events associated with inclisiran: a real-world pharmacovigilance study of FDA adverse event reporting system (FAERS).

Objective: To gain an improved comprehension of inclisiran safety in real-world settings by data mining from FAERS.

Methods: Data were gathered between 1 December 2020 and 31 December 2023. The Medical Dictionary for Regulatory Activities (MedDRA) corresponding preferred term (PT) and system organ class (SOC) were used to categorize adverse medication reactions in AE reports (AERs).

Fluoroquinolone antibiotics trigger selective oxidation in the trace-Cu(II)/peroxydisulfate system: The synergistic effect of dual reactive sites in chemical structure.

Research on transition metal-triggered advanced oxidation processes (TM-AOPs) has primarily focused on the regulation of catalysts and oxidants, but the alternative route that involves utilizing pollutant-derived electrons to enhance TM-AOPs has been largely overlooked. This study presents a case of selective degradation using fluoroquinolone antibiotics, with ofloxacin (OFX) selected as the model pollutant. Under the presence of PDS and trace Cu(II) (10 μM or 0.

Unexpected chloride-triggered organics removal in the zirconium oxide activated peroxymonosulfate system.

Chloride ion (Cl) is ubiquitous in diverse water bodies, yet poses a longstanding challenge in water pollution control by hindering the efficiency of pollutant degradation. Herein, we proposed a novel concept involving the direct utilization of endogenous Cl ions in water for rapid water purification within a non-redox zirconium oxide (ZrO)-activated peroxymonosulfate (PMS) system. In this process, PMS was complexed on the ZrO surface through inner-sphere coordination, and effectively activated by the partial electron cloud deviation from Zr(IV) sites to PMS, thereby forming a metastable surface complex with an elevated redox potential.

Anti-hypertensives associated with survival in cancer patients receiving immunotherapy: new evidence from a real-world cohort study and meta-analysis.

Background: The efficacy of immune checkpoint inhibitors (ICIs) in cancer patients taking anti-hypertensive drugs is still not well established.

Objective: To elucidate the effect of anti-hypertensive drugs on the clinical outcome of cancer patients receiving immunotherapy.

Design: A retrospective cohort study and meta-analysis.

Ligand-Controlled Regiodivergent Nickel-Catalyzed Hydroaminoalkylation of Unactivated Alkenes.

Ligand modulation of transition-metal catalysts to achieve optimal reactivity and selectivity in alkene hydrofunctionalization is a fundamental challenge in synthetic organic chemistry. Hydroaminoalkylation, an atom-economical approach for alkylating amines using alkenes, is particularly significant for amine synthesis in the pharmaceutical, agrochemical, and fine chemical industries. However, the existing methods usually require specific substrate combinations to achieve precise regio- and stereoselectivity, which limits their practical utility.

Hollow-structured amorphous prussian blue decorated on graphitic carbon nitride for photo-assisted activation of peroxymonosulfate.

Heterogeneous activation of peroxymonosulfate (PMS) is one of the most promising techniques for wastewater treatment. Herein, an ingenious system by coupling of photocatalysis and PMS activation was developed, using hollow-structured amorphous prussian blue (A-PB) decorated on graphitic carbon nitride (g-CN) as the catalyst. Degradation of bisphenol A (BPA) via the A-PB-g-CN mediated PMS activation under visible light (Vis) was systematically investigated.

Targeting the R domain of coagulase by active vaccination protects mice against lethal Staphylococcus aureus infection.

Coagulase (Coa) secreted by Staphylococcus aureus is associated with the establishment of staphylococcal disease, which activates host prothrombin and generates fibrin shields. The R domain of Coa, consisting of several conserved repeats, is important in immune evasion during S. aureus infection.

Relative Quantitative Proteomic Analysis of Reveals Metabolic Adaptation to Multiple Environmental Stresses.

spp. are facultative intracellular pathogens that cause chronic brucellosis in humans and animals. The virulence of primarily depends on its successful survival and replication in host cells.

A comprehensive proteogenomic study of the human Brucella vaccine strain 104 M.

Background: Brucella spp. are Gram-negative, facultative intracellular pathogens that cause brucellosis in both humans and animals. The B.

Monoclonal Antibody Targeting Staphylococcus aureus Surface Protein A (SasA) Protect Against Staphylococcus aureus Sepsis and Peritonitis in Mice.

Epidemic methicillin-resistant Staphylococcus aureus (MRSA) imposes an increasing impact on public health. Due to multi-antibiotics resistance in MRSA strains, there is an urgent need to develop novel therapeutics such as effective monoclonal antibodies (mAbs) against MRSA infections. Staphylococcus aureus surface protein A (SasA), a large surface-located protein (~240 kDa), is one of MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) and a potential target for immunotherapeutic approaches against S.