Experiences and Needs in the Dietary Management of Chronic Kidney Disease: A Qualitative Study of Patient, Caregiver and Healthcare Professionals' Perspectives.

Dietary management is crucial in the disease management of patients with chronic kidney disease (CKD). However, there is still a lack of research on the genuine experiences and needs of patients, caregivers, and healthcare professionals involved in CKD dietary management, especially in the Chinese context. To explore the experiences and needs of Chinese patients with CKD, caregivers, and healthcare professionals regarding dietary management.

A single N-rich covalent organic framework-based sensor for electrochemical sensing of 2,4,6-trichlorophenol.

2,4,6-trichlorophenol (TCP), a widely used pesticide ingredient, poses the hazardous harm to the surrounding environment and human health due to its persistence and toxicity. In this work, a single free-metal nitrogen-rich (N-rich) covalent organic framework (COF), denoted as COF, was synthesized and then assembled with the glass carbon electrode (GCE) to fabricate a COF/GCE sensor. Benefiting from its porous structure, large electrochemical surface area and abundant nitrogen-containing active sites, thus, the prepared COF/GCE sensor demonstrated excellent performance towards the oxidation of TCP with the wide linear range and an outstanding limit of detection.

Thermal-shock-processed thin proton exchange membranes for efficient and durable water electrolysis with reduced hydrogen crossover.

This work presents a Joule-heating strategy to create thin proton exchange membranes (PEMs) with high proton conductivity and low H crossover. The treated PEMs assembled electrolyzer achieves a record current density of 3.72 A cm at 1.

Synergistic Photothermal Ice Inhibition Strategy for Scalable Cryopreservation of Macroscopic Spheroids and Immune Cells in Advanced Immunotherapy.

Scalable and effective cryopreservation of human immune cells and biological samples is challenging for advanced cellular therapeutics. However, current cryoprotectants are limited due to trade-offs between robust ice inhibition and uniform thermal management to mitigate Ostwald ripening. Herein, we develop a nonpermeable nanocryoprotectant (PVA@PPy) by combining antifreezing poly(vinyl alcohol) (PVA) with photothermal polypyrrole (PPy).

Isopropyl paraben targets type III secretion to inhibit serovar typhimurium infection.

, a food- and water-borne pathogen, triggers food poisoning and enteric infections. The effectiveness of antibiotics against infections is decreasing due to bacterial resistance. Developing novel antimicrobial agents is crucial and urgent.

Beyond Cutting: CRISPR-Driven Synthetic Biology Toolkit for Next-Generation Microalgal Metabolic Engineering.

Microalgae, with their unparalleled capabilities for sunlight-driven growth, CO fixation, and synthesis of diverse high-value compounds, represent sustainable cell factories for a circular bioeconomy. However, industrial deployment has been hindered by biological constraints and the inadequacy of conventional genetic tools. The advent of CRISPR-Cas systems initially provided precise gene editing via targeted DNA cleavage.

Macrophage Derived Galectin-3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGFβ1 Signaling.

Over 30% of patients with type 2 diabetes develop diabetic kidney disease (DKD), which has emerged as a major contributor to end stage renal disease. Renal fibrosis represents the final pathological outcome of most chronic kidney disease, particularly DKD. This study demonstrates elevated levels of Galectin-3 (Gal3), a lectin associated with inflammatory and fibrotic conditions, in the plasma and kidneys of DKD mice.

Machine perfusion prevents early tumor recurrence in liver transplantation for hepatocellular carcinoma: a multicenter retrospective cohort study.

There is controversy regarding whether the machine perfusion (MP) prevents hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). This study aimed to explore the impact of MP on HCC recurrence. We included data from the United Network for Organ Sharing (UNOS) database on HCC patients spanning from April 2015 and January 2024.

Effects of different amylose/amylopectin ratio combination diets in the early and late stages on growth performance and dynamic changes of glycolipid metabolism of growing geese.

This study evaluated the effects of varying dietary amylose/amylopectin ratios (AR) during starter (1-28 d) and grower (29-63 d) phases on growth performance, nutrient metabolism, and related molecular mechanisms in Jiangnan White geese. A total of 330 one-day-old male goslings were allocated to six groups in a 2 × 3 factorial design: two starter AR diets (0.34 or 0.

Effects of belimumab on peripheral blood Breg cells and cytokines in childhood systemic lupus erythematosus.

To evaluate the therapeutic effectiveness of belimumab (BLM) in childhood systemic lupus erythematosus (cSLE) by analyzing peripheral blood Breg cell subsets and related cytokines at multiple time points post-treatment, compared with conventional therapy. From January 2023 to August 2023, 36 cSLE patients receiving BLM plus standard therapy (BLM group) and 35 receiving standard therapy alone (conventional group) were enrolled. Thirty age- and sex-matched healthy children were included as controls.

Correction: The immediate pain relief of low-level laser therapy for burning mouth syndrome: a retrospective study of 94 cases.

[This corrects the article DOI: 10.3389/froh.2024.

Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis.

Saponins associated with Panax notoginseng (P. notoginseng) demonstrate significant therapeutic efficacy across multiple diseases. However, certain high-yield saponins face limited clinical applications due to their reduced pharmacological efficacy.

Evaluation and analysis of risk factors for fractured vertebral recompression post-percutaneous kyphoplasty: a retrospective cohort study based on logistic regression analysis.

Background: Vertebral recompression after percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) may lead to recurrent pain, deformity, and neurological impairment, compromising prognosis and quality of life.

Objective: To identify independent risk factors for postoperative recompression and develop predictive models for risk assessment.

Methods: We retrospectively analyzed 284 OVCF patients treated with PKP, grouped by recompression status.

Kissing Spine and Other Imaging Predictors of Postoperative Cement Displacement Following Percutaneous Kyphoplasty: A Machine Learning Approach.

Objective: To investigate the risk factors associated with postoperative cement displacement following percutaneous kyphoplasty in patients with osteoporotic vertebral compression fractures and to develop predictive models for clinical risk assessment.

Methods: This retrospective study included 198 patients with osteoporotic vertebral compression fracture who underwent percutaneous kyphoplasty. Imaging and clinical variables were collected.

Cancer Screening Uptake and Usual Source of Care Among Hispanic Survivors of Adolescent and Young Adult Cancer.

This study examines cancer screening rates and the usual source of care among Hispanic survivors of adolescent and young adult (AYA, aged 15-39) cancer, a group at increased risk for poor health outcomes, including secondary cancers. National Health Interview Survey data were analyzed to identify Hispanic survivors of AYA cancer and Hispanic age- and sex-matched non-cancer controls. Breast, cervical, and colorectal screening (ever screened and up-to-date according to the U.

Body-mind exercise for cancer-related cognitive impairment in breast cancer patients: a network meta-analysis.

Purpose: Cancer-related cognitive impairment (CRCI) is one of the most common adverse effects in breast cancer patients, which seriously affects their quality of life. Existing studies have shown that mind-body exercise (MBE) can improve CRCI in breast cancer patients, but the differences in efficacy between various MBEs have not been clarified. This review aimed to evaluate the efficacy of different types of MBEs on CRCI in breast cancer patients through network meta-analysis, and identify the optimal MBE intervention.

The effectiveness of Valsalva Maneuver-Assisted percutaneous vertebroplasty in reducing cement leakage in osteoporotic vertebral compression fractures.

Objectives: Percutaneous vertebroplasty (PVP) is a highly practical treatment of osteoporotic vertebral compression fractures (OVCFs). However, cement leakage (CL) after PVP remains a challenging problem. There is a lack of effective methods to reduce CL.

Cultural and ethical barriers to implementing end-of-life advance care planning among oncology nursing professionals: a content analysis of open-ended questions.

Background: Advance care planning (ACP), a cornerstone of ethical end-of-life care, upholds patient autonomy. However, its practice in Confucian-influenced societies, like China, is significantly shaped by cultural norms where family preferences often precede individual choice. This study explored cultural and ethical barriers to ACP implementation among oncology nursing professionals, focusing on tensions between patient-centered care and deeply rooted social norms.

Navigating Social Influences: The Impact of Anticipated HPV Vaccination Stigma from Friends and Family on College Students' HPV Vaccination Intent.

Background: Family and friends play a dual role in supporting and hindering young adults' decisions about the human papillomavirus (HPV) vaccine. However, the mechanisms by which anticipated HPV vaccination stigma from these social circles affects vaccination intent remain largely understudied. This study applied the Information-Motivation-Behavioral Skills model to examine how anticipated HPV vaccination stigma from family and friends influences vaccination intent and its underlying mechanisms.

TNF‑α induces premature senescence in tendon stem cells via the NF‑κB and p53/p21/cyclin E/CDK2 signaling pathways.

Achilles tendinitis (AT) is a complex disorder that affects tendon tissue and often responds poorly to non‑steroidal anti‑inflammatory drugs. Tumor necrosis factor‑α (TNF‑α), a proinflammatory cytokine involved in cell death and immune regulation, serves a central role in AT progression. The present study investigated the effects of TNF‑α on tendon stem cells (TSCs) and evaluated potential therapeutic strategies for AT.

Bimetallic Fe, Ru-doped Zn-Centered Organic Framework Mesoporous Carbon for Single-Wavelength Near-Infrared-Induced Photothermal/Photodynamic Synergistic Therapy.

Single-wavelength synergistic photothermal/photodynamic therapy (PTT/PDT) is gradually emerging in cancer treatment, with the key limitation being the photosensitizer. In this work, a metal-organic framework-derived mesoporous carbon with zinc centers and doped with iron and ruthenium, exhibiting porphyrin-like properties (denoted as Fe-Ru-ZIF), was successfully synthesized via a green, simple, and mild hydrothermal reaction. The effects of various Fe:Ru doping ratios on the morphology, structure, and PTT/PDT of Fe-Ru-ZIF were studied.

Risk of Pancreatic Cancer in Glycemically Defined New-Onset Diabetes: A Prospective Cohort Study.

Background & Aims: The increased 3-year incidence of pancreatic cancer after new-onset diabetes observed in retrospective studies needs prospective validation. It is unknown whether incidence varies by race and ethnicity.

Methods: In a prospective, observational study using active real-time surveillance of electronic health records, we identified 18,838 adults 50 years or older with glycemically defined new-onset diabetes (GNOD).

One-Step Detection of RNA in Small Extracellular Vesicles from Plasma for Diseases Diagnosis by a Multisatellites@planets Molecular Imprinting Platform.

RNA in small extracellular vesicles (sEVs) from plasma is a reliable biomarker for disease diagnosis. However, the cumbersome steps and operator dependency for extraction and analysis of sEVs RNA in plasma have limited their application. Here, we developed a multisatellites@planets molecular imprinting detection platform for sEVs capture and RNA analyzation in a one-step process directly from a small amount of plasma.

Nested Case-Control Study of Intervention in Early Infancy to Prevent Tuberous Sclerosis Complex-Associated Renal Angiomyolipoma.

Introduction: In current studies, treatment of tuberous sclerosis complex (TSC)-related renal angiomyolipoma (RAML) was initiated only after clinical progression or the onset of symptoms, rather than at an earlier stage in the disease process. However, the previous case report indicated that early mammalian target of rapamycin (mTOR) inhibition in patients with TSC might prevent the development of TSC lesions. We performed this nested case-control study to evaluate whether prophylactic sirolimus initiation in early infancy prevented TSC-related RAML (TSC-RAML).

Establishment of a prediction model for long-term infections in patients undergoing peritoneal dialysis.

Background And Objective: Peritoneal dialysis (PD)-associated infections are the primary contributors to PD technique failure and patient mortality. Given these reasons, this study aims to identify independent risk factors for long-term infections in PD individuals and to construct an effective clinical prediction model using multivariate analysis.

Methods: This study retrospectively analyzed 214 participants with ESRD who underwent PD catheterization at Wuxi No.