T-Shaped Fe-Based Multistoichiometry Stereoscopic Composite Catalyst with Ultrahigh Activity toward Fenton-like Water Treatment, Synthesized via Graphene-Controlled Growth.

We report an unusual T-shaped Fe-based multistoichiometry stereoscopic composite catalyst with multifunctional active sites, fabricated via a one-step graphene-controlled all-solid-state synthesis. This tailored catalyst can improve all three catalysis processes of H_{2}O_{2} adsorption, peroxide bond activation, and HO^{•} desorption, resulting in a novel catalytic framework where the two-dimensional (2D) Fe_{2}O_{3} nanosheets optimize H_{2}O_{2} adsorption, and the 2D FeOCl nanosheets vertically grown on the Fe_{2}O_{3} surface can facilitate both the generation and desorption of HO^{•}.

Active bacterial baths in droplets.

Suspensions of self-propelled objects represent a novel paradigm in colloidal science. In such "active baths," traditional concepts such as Brownian motion, fluctuation-dissipation relations, and work extraction from heat reservoirs, must be extended beyond the conventional framework of thermal baths. Unlike thermal baths, which are characterized by a single parameter, the temperature, the fundamental descriptors of an active bath remain elusive.

Bimetallic Fe, Ru-doped Zn-Centered Organic Framework Mesoporous Carbon for Single-Wavelength Near-Infrared-Induced Photothermal/Photodynamic Synergistic Therapy.

Single-wavelength synergistic photothermal/photodynamic therapy (PTT/PDT) is gradually emerging in cancer treatment, with the key limitation being the photosensitizer. In this work, a metal-organic framework-derived mesoporous carbon with zinc centers and doped with iron and ruthenium, exhibiting porphyrin-like properties (denoted as Fe-Ru-ZIF), was successfully synthesized via a green, simple, and mild hydrothermal reaction. The effects of various Fe:Ru doping ratios on the morphology, structure, and PTT/PDT of Fe-Ru-ZIF were studied.

Selective Sieving Effect of Multi-Atomic Bismuth Interfaces for Efficient Formate Electrosynthesis and Evolution at Industrial Current Density.

Constructing multi-atomic interfaces architectures is promising for electrocatalytic CO conversion, yet their synthesis and stability under industrial current densities remain challenging. Herein, multi-atomic Bi interfaces (Bi/Bi-O moiety) were precisely engineered by embedding atomically dispersed Bi centers, encompassing Bi single atoms and Bi atomic clusters into the substrate of porous BiO nanosheets. The composite showcases outstanding CO conversion performance across a wide pH range, attaining remarkable Faradaic efficiency for formate (FE) of 96.

Enhanced anticancer activity of graphene oxide quantum dot@Cu nanocomposites cation-π interactions.

Despite extensive efforts in the exploration of anticancer drugs, enhancing their anticancer activity and simultaneously overcoming drug resistance remains a challenge. Here, based on cation-π interactions, we prepared graphene oxide quantum dot@Cu (GOQD@Cu) nanocomposites and observed a transition in the valence state of copper ions from Cu to Cu on the graphite surface. As a result, the anticancer activity of GOQD@Cu nanocomposites against HeLa cells exhibited a 2-fold and 1.

Technological functionality and system architecture of mobile health interventions for diabetes management: a systematic review and meta-analysis of randomized controlled trials.

Introduction: Despite advancements in digital health, systematic evaluations of mobile applications (Apps) for diabetes management are limited.

Methods: Researchers conducted searches on PUBMED, EMBASE, COCHRANE, SCOPUS, and WEB OF SCIENCE from inception to August 2024. The researchers included randomized controlled trials (RCTs) that investigated the effectiveness of app-based interventions in health management among diabetic patients.

Contamination Characterization, Toxicological Properties, and Health Risk Assessment of Bisphenols in Multiple Media: Current Research Status and Future Perspectives.

Bisphenols (BPs) are ubiquitous environmental endocrine disruptors that cause various human health hazards and pollute water, soil, and the atmosphere to varying degrees. Although various studies have investigated the pollution characteristics and health hazards of BPs in different media, a systematic review of BPs in the broader environmental context is still lacking. This study highlights the pollution characteristics, detection methods, and risk assessment status of BPs by combining relevant studies from both domestic and international sources, and their environmental distribution characteristics are summarized.

Organic Molecules Induce the Formation of Hopper-Like NaCl Crystals under Rapid Evaporation As Microcatalytic Reactors To Facilitate Micro/Nanoplastic Degradation.

As representative examples of inorganic ionic crystals, NaCl and KCl usually form cubes during the natural evaporation process. Herein, we report the hopper-like NaCl and KCl crystals formed on the iron surface under rapid vacuum evaporation aided by organic molecules. Theoretical and experimental results indicate that it is attributed to the organic molecules alternating adsorption between {100} and {110} surfaces instead of adsorbing a single surface, as well as the fast crystal growth rate.

Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies.

Since decades after temozolomide was approved, no effective drugs have been developed. Undoubtedly, blood-brain barrier (BBB) penetration is a severe issue that should be overcome in glioblastoma multiforme (GBM) drug development. In this research, we were inspired by linezolid through structural modification with several bioactive moieties to achieve the desired brain delivery.

Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications.

Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a frequent and serious complication of sepsis that considerably impacts both short-term and long-term survival outcomes. In intensive care units (ICUs), the mortality rate of patients with SA-ALI remains high, mostly due to the absence of effective early diagnostic markers and suitable therapeutic strategies.

Reduced graphene oxide membrane with small nanosheets for efficient and ultrafast removal of both microplastics and small molecules.

The clogging of sieving pores due to the complex sewage system of mixed molecules and nanoparticles of different scales is a difficulty in the membrane-based separation process. When the holes are reduced to the point where they can repel small molecules in the contaminants, large-molecule contaminants can adsorb to the holes and decrease the permeability. A similar question remains in new promising graphene oxide (GO) membranes.

The impact of the subventricular zone invasion types and MGMT methylation status on tumor recurrence and prognosis in glioblastoma.

Purpose: The prognosis of isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) with the subventricular zone (SVZ) invasion is extremely unfavorable but the underlying mechanism remains unclear. We aimed to conduct a retrospective study to mainly investigate the prognostic value of SVZ invasion and MGMT status, and developed a novel clinical prediction model based on our findings.

Methods: 139 patients with IDH wild-type GBM were retrospectively studied.

The relationship between serum levels of LOX-1, hs-cTnT, NGAL, and renal function, and their diagnostic value in patients with chronic kidney disease: a retrospective study.

Background: The primary aim of this study is to explore the relationship between serum levels of LOX-1, hs-cTnT, and NGAL, and renal function in patients with CKD, as well as to evaluate their diagnostic value for early detection and monitoring of disease progression in CKD patients.

Methods: A retrospective study was conducted on 108 patients with chronic kidney disease admitted to our hospital from January 2023 to December 2023. The patients were divided into the mild renal insufficiency group (51 cases) and the severe renal insufficiency group (57 cases).

Twin-distortion modulated ultra-low coordination PtRuNi-O catalyst for enhanced hydrogen production from chemical wastewater.

The development of efficient and robust catalysts for hydrogen evolution reaction is crucial for advancing the hydrogen economy. In this study, we demonstrate that ultra-low coordinated hollow PtRuNi-O nanocages exhibit superior catalytic activity and stability across varied conditions, notably surpassing commercial Pt/C catalysts. Notably, the PtRuNi-O catalysts achieve current densities of 10 mA cm at only 19.

Electrochemical Synthesis of Metasequoia-Like Reduced Graphene Oxide Coated Cobalt-Silver Catalyst for Stable and Efficient Electrocatalytic Nitrate Reduction to Ammonia.

Electrocatalytic nitrate (NO ) reduction to ammonia (NH) is a green and efficient NH synthesis technology. Metallic silver (Ag) is one of the well-known electrocatalysts for NO reduction. However, under alkaline conditions, its poor water-splitting ability fails to provide sufficient protonic hydrogen required for NH synthesis, resulting in low NH selectivity.

A GO regulated bimetallic CoFe catalyst for efficient electrochemical nitrate reduction to ammonia under acidic conditions.

Electrocatalytic nitrate reduction to ammonia (ENRA) in acidic media is currently a challenge. Herein, we presented a CoFeO/GO catalyst that exhibited a high faradaic efficiency (95.51%) and ammonia yield rate (1268.

Bimetallic CuAg Nanotips for Ultrahigh Yield Rate of Nitrate-to-Ammonium.

Electrochemical reduction of nitrate to ammonia (NRA) offers a sustainable approach for NH production and NO removal but suffers from low NH yield rate (<1.20 mmol h cm). We present bimetallic CuAg nanotips with tailored local environment, which achieve an ultrahigh NH yield rate of 2.

HSP90/LSD1 dual inhibitors against prostate cancer as well as patient-derived colorectal organoids.

The rational installation of pharmacophores targeting HSP90 and LSD1 axes has achieved significant anti-cancer capacity in prostate and colorectal cancer. Among the series of hybrids, inhibitor 6 exhibited remarkable anti-proliferative activity against prostate cancer cell lines PC-3 and DU145, with GI values of 0.24 and 0.

Polyphenols in health and food processing: antibacterial, anti-inflammatory, and antioxidant insights.

Polyphenols, as subordinate metabolites of plants, have demonstrated significant antibacterial, anti-inflammatory, and antioxidant action in scientific learn. These compounds exert their effects through various mechanisms, containing interference with microbial cell structures, rule of host immune responses, and neutralization of free radicals. This multifaceted activity positions polyphenols as promising candidates for maintaining human health and treating related diseases.

NO-Sensitive SnO Nanoparticles Prepared Using a Freeze-Drying Method.

The n-type semiconductor SnO with a wide band gap (3.6 eV) is massively used in gas-sensitive materials, but pure SnO still suffers from a high operating temperature, low response, and tardy responding speed. To solve these problems, we prepared small-sized pure SnO using hydrothermal and freeze-drying methods (SnO-FD) and compared it with SnO prepared using a normal drying method (SnO-AD).

A single-center, open label, randomized, controlled study of hydroxychloroquine sulfate in the treatment of low risk PLAR-associated membranous nephropathy.

Objective: To evaluate the efficacy and safety of hydroxychloroquine sulfate (HCQ) in the treatment of low risk phospholipase A receptor (PLAR)-associated membranous nephropathy (MN).

Methods: A total of 110 patients with low risk PLAR-associated MN were included in the study. Patients who met the inclusion and exclusion criteria were assigned randomly to two groups: the HCQ treatment group and the control group.