Novel Copper Superparticle-Based Bragg Scattering Coupling Luminescence Strategy for Detection of Ginseng Exosomal miRNA.

Ginseng exosomes are a kind of promising extracellular vesicle containing unique bioactive components. However, the investigation on ginseng-derived exosomes is still in the initial stage. This study developed a photonic crystal-based Bragg scattering coupling electrochemiluminescence (BSC-ECL) biosensor for detection of miRNA396a-3p in exosome-like nanoparticles (GENs) and ginseng exosomes (Gexos).

Recent advances in computational strategies for allosteric site prediction: Machine learning, molecular dynamics, and network-based approaches.

The landscape of allosteric drug discovery is undergoing a transformative shift, driven by the integration of three computational approaches: machine learning (ML), molecular dynamics (MD) simulations, and network theory. ML identifies potential allosteric sites from multidimensional biological datasets; MD simulations, empowered by enhanced sampling algorithms, reveal transient conformational states; and network analyses uncover communication pathways, further aiding in site identification. Their synergy enables rational allosteric modulator design.

FGFC1 overcomes Ara-C resistance in acute myeloid leukemia by inducing apoptosis and pyroptosis.

Acute myeloid leukemia (AML) is a hematologic malignancy with a high mortality rate and poor prognosis, largely attributed to the emergence of chemotherapy resistance. Cytarabine (Ara-C), the cornerstone chemotherapeutic agent for AML, faces significant challenges due to the development of resistance, creating an urgent need for novel therapeutic strategies. Pyroptosis as a new form of programmed cell death has emerged as a potential therapeutic target in tumor treatment.

Perceptions and Experiences of Dementia-Friendly Education Among Youth in Macao: A Qualitative Study.

BackgroundAs dementia emerges as a critical global health challenge, youth engagement is pivotal for building dementia-friendly communities. However, culturally sensitive dementia education models for Chinese youths remain underdeveloped. This study aims to explore the perceptions and experiences of a hybrid dementia education program among Macao youths.

Predicting Heterosis and Selecting Superior Families and Individuals in spp. Based on Growth Traits and Genetic Distance Coupling.

spp. is one of the most important salt-alkali resistant tree species in the Yellow River region of China. However, the limited number of superior families and individuals, as well as the lack of a well-established parent selection system for hybrid breeding, have seriously constrained the improvement of seed orchards and the construction of advanced breeding populations.

Investigation on Fuel Quality and Combustion Characteristics of Blended Fuel (Biomass and Lignite) Derived from Low-Temperature Co-Upgradation.

Co-combustion is regarded as an effective means for high-efficiency utilization of low-quality fuels. However, low-quality fuel has problems such as low energy density and high water content. The fuel quality and blending performance can be further optimized by the pretreatment of low-quality fuel, for example, calorific value, hydrophobicity, and NO conversion rate.

Special Regulation of in Ovules Increases the Size of Cotton Seeds.

Background: L. is one of the main economic crops worldwide, and increasing the size/weight of its seeds is a potential strategy to improve its seed-related yield. AINTEGUMENTA (ANT) is an organogenesis transcription factor mediating cell proliferation and expansion in , but little is known about its candidate function in upland cotton seed.

Development and validation of a risk identification model for frailty in stroke survivors: new evidence from CHARLS.

Background: Stroke survivors with frailty exhibit elevated rates of complications, mortality, disability, and hospital readmission. As frailty represents an early, reversible, and preventable stage of disability, developing a reliable risk identification model is essential. This study aimed to develop and validate a risk model for frailty among stroke survivors using data from the China Health and Retirement Longitudinal Study (CHARLS).

Outcomes following exposure to drug interactions with ibrutinib in patients with chronic lymphocytic leukaemia.

Ibrutinib is metabolized by cytochrome P450 3A (CYP3A) and poses challenges with drug interactions. We conducted a population-based cohort study of Ontario residents aged ≥66 years who initiated ibrutinib for chronic lymphocytic leukaemia (CLL) to evaluate the frequency of potential drug interactions involving moderate/strong CYP3A inhibitors and inducers and their association with overall survival (OS). Secondary analyses employed a nested case-control design examining hospitalizations for haemorrhage or infection as potential markers of ibrutinib toxicity.

ASPM Induces Radiotherapy Resistance by Disrupting Microtubule Stability Leading to Chromosome Malsegregation in Non-Small Cell Lung Cancer.

Radiotherapy (RT) resistance remains a substantial challenge in cancer therapy. Although physical factors are optimizing, the biological mechanisms for RT resistance are still elusive. Herein, we explored potential reasons for this difficult problem by generating RT-resistant models for in vitro and in vivo experiments.

Whole-Genome Sequencing for the Prenatal Evaluation of Fetal Structural Anomalies: A prospective multicenter study.

Background: The clinical validity of whole-genome sequencing (WGS) in postnatal settings is well documented, but studies of its use in prenatal settings are limited.

Objectives: The objective of this study was to prospectively evaluate the performance of whole-genome sequencing (WGS) for prenatal diagnosis of fetal structural anomalies compared with the commonly used testing strategy of copy-number variant sequencing (CNV-seq) plus exome sequencing (ES).

Study Design: WGS was performed in parallel with CNV-seq and ES for 96 parent-fetus trios with fetal structural anomalies.

T Cell Involvement in Neuroinflammation After Traumatic Brain Injury: Implications for Therapeutic Intervention.

Background: Traumatic brain injury (TBI) is a leading cause of death and disability across all age groups worldwide. After primary mechanical head injury, a cascade of molecular changes and immunological responses occur that are necessary for supporting tissue repair but also exacerbate the secondary loss of tissue caused by excessive neuroinflammation. To date, there are no targeted treatments that ameliorate the pathological neuroinflammation that is responsible for propagating secondary injury after TBI.

High-performance all-inorganic CdSe/CdS nanorod-based light emitting diodes enabled by controlled electrophoretic deposition.

Electrophoretic deposition can be used to form tightly assembled nanocrystal films at a macroscopic scale, offering tremendous possibilities to exploit the unique functional properties of nanocrystals at a device level. Herein, combining the experimentally measured electrophoretic deposition current time trace with an analytical model, we can estimate the effective single particle charge in solution and obtain information on the morphology and thickness of the film. Using this method, we formed vertically aligned, void-free CdSe/CdS nanorod (NR) films as the emissive layers in red-emitting all-inorganic NR light emitting diodes.

Predicting Chronic Kidney Disease After Cisplatin Treatment Using Population-Level Data.

Importance: Cisplatin is a widely used treatment for cancer that can permanently damage the kidneys. Treatment modifications and other strategies may prevent chronic kidney disease (CKD) in patients at risk; however, the incidence and predictability of CKD following cisplatin treatment remain poorly understood.

Objective: To characterize the incidence of CKD after cisplatin treatment and evaluate prediction models.

Functional role of in the detoxification of spinetoram and development of .

has evolved resistance to many biological insecticides, resulting in significant annual agricultural and economic losses. Glutathione -transferases (GSTs) are one of the major insect detoxification enzyme systems. However, the detoxification metabolism of GSTs in against biological insecticides remains poorly understood.

Multivalent At-Radiolabeled Fibroblast Activation Protein Inhibitors for Targeted Alpha-Therapy of Glioma.

Multivalent ligand strategy prevails recently in the design of radioligands for small-molecules due to its successes in enhancing the therapeutic efficacy of radiometallic ligands. In this work, At-FAPI-Dimer and At-APBA-FAPI-Dimer, two multivalent At-conjugated fibroblast activation protein inhibitors (FAPIs), were successfully synthesized with the expectation of narrowing the significant gap between extant radioastatinated FAPIs and clinical application. Cellular pharmacokinetic assessments show that the multivalent strategy could improve the cellular internalization and retention of the radioligand but compromise cellular uptake efficiency relative to monovalent FAPI ligand.

Frequency, barriers and facilitators of adherence to treatment among people with systemic lupus erythematosus in China: a scoping review.

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease requiring long-term therapy, where adherence critically impacts outcomes. Non-adherence remains a significant barrier to disease control, particularly in China, where healthcare disparities persist.

Objectives: This scoping review aimed to systematically map the existing evidence on the frequency, barriers and facilitators of treatment adherence among Chinese patients with SLE and to identify gaps to guide future research and interventions.

Coordination Confinement on the Decay Chains of Typical Medical α-Radionuclides.

The daughter nuclides in the long decay chain have clouded the translation of the corresponding α-radionuclide therapy. To achieve radioactivity confinement is, therefore, pivotal to the development of medical α-radiopharmaceuticals. Here, we proposed coordination confinement on the decay chains of medical α-radionuclides, employing a versatile crown-ether ligand to adaptively chelate with the decay daughters of typical medical α-radionuclides.

Postoperative anterior knee pain in robot assisted total knee arthroplasty: a propensity score matching analysis.

Background And Objective: Anterior knee pain (AKP) remains a prevalent complication following total knee arthroplasty (TKA), affecting 4-60 % of patients. While robot-assisted TKA (RA-TKA) has demonstrated superior precision in prosthesis alignment compared to conventional manual TKA in the medium- and long-term, its impact on postoperative AKP remains underexplored. This study aimed to evaluate the medium- and long-term effects of RA-TKA on AKP intensity, functional outcomes, and knee mobility compared to CM-TKA.

Transcriptionally up-regulation of CDKN1A/p21 by TFE3 fusion proteins worsened TFE3-rearranged renal cell carcinoma.

The TFE3-rearranged renal cell carcinoma (TFE3-rRCC), which is an uncommon and aggressive form of kidney cancer, has an unfavorable prognosis. It has been shown that CDKN1A/p21 is high-expressed in TFE3-rRCC, however, the exact mechanism and the role of CDKN1A/p21 in TFE3-rRCC remain unclear. Our results indicated that the TFE3 fusions exacerbated TFE3-rRCC by transcriptionally upregulating CDKN1A/p21 expression.

Generation and modulation of off-axis photonic nanojets via gradient-index microcylinders.

This work presents an innovative exploration of generating and modulating off-axis photonic nanojets (PNJs) using gradient refractive index (GRIN) microcylinders with asymmetric profiles. The modulation effects of refractive index gradient, average refractive index, environmental factors, and microcylinder rotation on off-axis PNJ properties are systematically investigated. Results show that the refractive index gradient is the core parameter for controlling PNJ deflection angles: increasing the gradient enhances off-axis displacement while reducing peak intensity and extending decay length.

HELLP Syndrome with Hepatic and Thoracic Complications: Insights From a Case of Spontaneous Liver Rupture.

BACKGROUND Spontaneous hepatic rupture during pregnancy is a rare but life-threatening complication, closely associated with HELLP (hemolysis, elevated liver enzymes, and thrombocytopenia) syndrome. The concomitant occurrence of thoracic hemorrhage can lead to catastrophic outcomes. Early recognition and multidisciplinary management are critical, yet diagnostic challenges often delay intervention.

Indocyanine green fluorescence-guided imaging enhances the efficiency and accuracy of inferior mesenteric artery lymph node dissection in rectal cancer.

Background: Indocyanine green fluorescence-guided imaging (ICG-FGI) enhances surgical precision in rectal cancer procedures; however, it is technically demanding. This study evaluated the effects of ICG-FGI on the efficacy of lymphadenectomy during radical rectal cancer surgery.

Methods: This multi-center retrospective cohort study analyzed patients who underwent laparoscopic radical resection for rectal cancer between January 2021 and December 2024.

Hierarchical relationship between neural mechanisms of ensemble and individual perception revealed through perceptual learning.

Ensemble perception is a critical cognitive function that enables individuals to rapidly comprehend overall situations and identify abnormal or potentially hazardous information. Understanding the neural mechanisms underlying ensemble perception is essential for elucidating how the visual system organizes complex information. Although extensive research has explored various aspects of ensemble perception, the relationship between ensemble and individual perception, as well as the existence of a universal mechanism across different subtypes of visual information, remains unclear.

Mechanical Agitation-Assisted Transmembrane Drug Delivery by Magnetically Powered Spiky Nanorobots.

Breaking through cell membrane barriers is a crucial step for intracellular drug delivery in antitumor chemotherapy. Hereby, a magnetic nanorobot, capable of exerting mechanical agitation on cellular membrane to promote intracellular drug delivery, was developed. The main body of the nanorobots was composed of nano-scaled gold nanospikes that were deposited with Ni and Ti nanolayers for magnetic activation and biocompatibility, responsively.