Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
has evolved resistance to many biological insecticides, resulting in significant annual agricultural and economic losses. Glutathione -transferases (GSTs) are one of the major insect detoxification enzyme systems. However, the detoxification metabolism of GSTs in against biological insecticides remains poorly understood. In this study, We identified five key genes (, and ) by screening from the comparative transcriptomes of two regional populations of in Xinjiang, China. Among the five GSTs, exhibited a significantly high expression level during the larval stage of following exposure to the LC dose of spinetoram. This gene was subsequently cloned, and its expression was knocked down using RNA interference to further analyse its role in the detoxification of spinetoram, as well as in the growth and development of . The results showed that contains a typical gene domain and was highly conserved within the Lepidoptera clade. Silencing of the gene led to a significant increase in the susceptibility of to spinetoram, as evidenced by an extension in the duration of leaf-mining and in the development time from the 2 to the 4 instar larval stage, which were 35.7% and 19.6% longer, respectively, than those of ddHO and ds controls. Furthermore, the mortality rate of larvae treated with ds reached 57.3% by the 7th day. These findings indicate that plays a crucial role in the detoxification of spinetoram and in the growth and development of larvae.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1017/S0007485325100321 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diosgenin-loaded Silver Nanoparticles: Dual Protective Role and Enhanced Radiosensitivity against ENU-induced Leukemia and γ-irradiation-induced Liver Toxicity.
Recent Pat Anticancer Drug Discov
September 2025
Department of Biophysics, Faculty of Applied Health Sciences, October 6 University, Egypt.
Introduction: Leukemia and radiation-induced liver toxicity are significant health challenges requiring effective therapeutic strategies. This study aimed to evaluate the therapeutic efficacy and radiosensitizing effects of Diosgenin-loaded silver nanoparticles (Dio-AgNPs) in ENU-induced leukemic mice, with a focus on their dual role in mitigating leukemia progression and γ-irradiation-induced hepatotoxicity.
Methods: Dio-AgNPs were synthesized and characterized using TEM, UV-Vis spectroscopy, FT-IR spectroscopy, and encapsulation efficiency analysis.
The cytoplasmic N- and C-termini are dispensable for SLAH3 to mediate nitrate-dependent ammonium detoxification in Arabidopsis.
Biochem Biophys Res Commun
August 2025
Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China; Key Laboratory of Gene Editing for Breeding, School of Life Sciences, Lanzhou University, Lanzhou, Gansu, 730000, China. Electronic address: xiaochb@lz
Ammonium (NH) toxicity significantly limits nitrogen use efficiency (NUE) in agriculture. Nitrate (NO) supplementation mitigates this toxicity, with the anion channel SLAH3 playing a central role by mediating NO efflux to counteract NH-induced rhizosphere acidification. SLAH3, a plasma membrane protein with ten transmembrane domains and cytosolic N- and C-termini, is intrinsically silent.
View Article and Find Full Text PDFAldehyde dehydrogenase 2 deficiency impairs liver progenitor cell proliferation in alcohol-fed mice.
Am J Pathol
September 2025
Department of Hepatology, Center of Infectious Diseases and Pathogen Biology, the First Hospital of Jilin University, Changchun, China; Jilin Provincial Key Laboratory of Metabolic Liver Diseases, Jilin University, Changchun, China; China-Singapore Belt and Road Joint Laboratory on Liver Disease Res
Aldehyde dehydrogenase 2 (ALDH2) is a critical enzyme involved in the detoxification of acetaldehyde. Although numerous studies have demonstrated the significance of ALDH2 in alcohol-associated liver disease (ALD), its role in alcohol-induced activation of liver progenitor cells (LPCs) has not been thoroughly investigated. Proteomic analysis of serum samples from patients with either normal ALDH2 genotype or ALDH2 mutation following alcohol consumption revealed that ALDH2 deficiency may suppress LPC proliferation.
View Article and Find Full Text PDFMolecular insights into the role of ferroptosis in cardiorenal cross-talk: Mechanisms and future directions.
Life Sci
September 2025
Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India. Electronic address:
Cardiorenal syndrome (CRS) is a bidirectional relationship shared between the heart and kidneys, both in physiological and pathophysiological perspectives. The metabolic, hemodynamic, and neurohormonal alterations between the heart and kidneys drive this dual-organ damage and are responsible for one of the highest medical concerns around the globe. From a pathophysiological perspective, activation of the renin-angiotensin system, persistent inflammation, oxidative stress, and reactive fibrosis are accountable for the damage to the heart and kidneys.
View Article and Find Full Text PDFFOXO1- mediated argininosuccinate lyase transcription inhibits ammonia metabolism and breast cancer cell metastasis.
J Biol Chem
September 2025
School of Life Sciences, Ningxia University, Yinchuan, China,750021. Electronic address:
Cancer cells exhibit altered and elevated metabolic processes to meet their increased bioenergetic and biosynthetic demands, leading to the production of ammonia as a byproduct. However, the mechanisms by which tumor cells manage excess ammonia remain poorly understood, despite its critical role in nitrogen metabolism. The urea cycle, a central pathway for ammonia detoxification, has been insufficiently explored in the context of cancer metabolism.
View Article and Find Full Text PDF