Preparation and evaluation of anti-hepatocellular carcinoma activity of oridonin nanoparticles using Angelica sinensis polysaccharide and ursodeoxycholic acid as carrier.

Hepatocellular carcinoma (HCC) poses a serious threat to human life and health. Nowadays, liver-targeting drug delivery systems have been proven as a promising strategy in treating HCC. Angelica sinensis polysaccharide (ASP), a plant polysaccharide with good biocompatibility, has excellent aqueous solubility and intrinsic liver-targeted capability.

Predicting Heterosis and Selecting Superior Families and Individuals in spp. Based on Growth Traits and Genetic Distance Coupling.

spp. is one of the most important salt-alkali resistant tree species in the Yellow River region of China. However, the limited number of superior families and individuals, as well as the lack of a well-established parent selection system for hybrid breeding, have seriously constrained the improvement of seed orchards and the construction of advanced breeding populations.

Case Report: A novel compound heterozygosity of the 2 gene identified in a Chinese pedigree with congenital heart defect.

Background: Congenital heart defects (CHDs) represent the leading cause of neonatal mortality among congenital abnormalities. Genetic factors, such as 2 gene mutations and other genetic alterations, constitute a major cause of CHD. Thus, determining the genetic etiology of fetal CHDs is crucial for optimizing pregnancy management and informing future reproductive decisions.

Study on the improvement of image interpretation skill of non-radiology residents based on an image case database in gastroenterology department.

Background: Medical imaging plays a very important role in the diagnosis, treatment and prognosis of digestive diseases. This manuscript aimed to explore the value of a teaching model based on an image case database in improving the image interpretation skills of non-radiology residents training in gastroenterology department.

Methods: From October 2023 to March 2024, all the residents training in the gastroenterology department were selected as the research subjects.

Improve the chitosan particle-stabilized oil-water interface by dual reinforcement and its effect on the structure and properties of emulsion.

This study investigated the enhancement of chitosan particle-stabilized oil-water interface stability by incorporating cinnamaldehyde in the oil phase and sodium alginate in the water phase. The effects of varying concentrations of these additives on emulsion microstructure and stability were examined. Sodium alginate and cinnamaldehyde contributed to a thicker, more uniform interface.

Effects of keto acid crosslinking on the structure and properties of chitosan based casted and hot-pressed films.

Crosslinking is one of the most effective ways to enhance the performance of bio-based films, and suitable crosslinking agents are crucial for the enhancement. In this study, four α-ketoacids, namely glyoxylate, pyruvate, oxaloacetate, and α-ketoglutarate were used to crosslink chitosan at room temperature. The effects of crosslinking on the structure and properties of chitosan films were studied, and the reaction mechanism was explored.

Effects of Feed Restriction on Growth Performance, Nutrient Utilisation, Biochemical Parameters, and the Caecum Microbiota and Metabolites in Rabbits.

The main objective of this research was to observe the effects of feed restriction on caecum microbiota and metabolites in rabbits. Forty-eight male 8-week-old rabbits with similar body weights (1872.11 ± 180.

Application of preoperative ultrasound combined with indocyanine green lymphography in lymphaticovenular anastomosis of the lower limb-A retrospective study research.

BackgroundWe evaluated the application of preoperative ultrasound (US) combined with indocyanine green (ICG) lymphography in lymphaticovenular anastomosis (LVA) of the lower limb.Methods66 patients with lower limb lymphedema were selected as study subjects and divided into research ( = 35) and control groups ( = 31). The patients were treated with LVA using ICG lymphography combined with US and simple ICG lymphography as the positioning method.

ADH1B Gene Promotes Gastric Cancer Tumorigenesis and its Cisplatin Resistance through the EMT Pathway.

Background: Cisplatin resistance significantly affects the outcome of gastric cancer treatment. In this study, genes associated with cisplatin resistance were investigated and discussed.

Methods: We analyzed the sequencing data of GSE14208 patients from the GEO database using differential and enrichment analyses.

Enhancing the Hydrophobicity of Chitosan Films Through Hierarchical Plant Wax Particles and Dilute Chitosan Solution Coatings.

The strong hydrophilicity of chitosan-based films limits their practical applications. To enhance the hydrophobicity of these films, hierarchical carnauba wax particles were prepared using the Pickering emulsion method and subsequently coated onto the film surfaces. The wax was stabilized with various types and concentrations of TiO.

Encapsulation of oleanolic acid into cyclodextrin metal-organic frameworks by co-crystallization: Preparation, structure characterization and its effect on a zebrafish larva NAFLD model.

Oleanolic acid (OA) is a common pentacyclic triterpenoid and has been used to relieve metabolic-related diseases. However, its low water solubility severely limits its clinical application. In this study, OA was encapsulated by a cyclodextrin metal-organic framework material (CD-MOF) using the co-crystallization method to obtain the OA and CD-MOF inclusion complex (OA@CD-MOF).

Nanotechnology-based drug delivery system for targeted therapy of ulcerative colitis from traditional Chinese medicine: A review.

Ulcerative colitis (UC) is a chronic autoimmune disease and seriously affects the normal life of patients. Conventional therapeutic drugs are difficult to meet clinical needs. Traditional Chinese medicine (TCM) ingredients could effectively alleviate the symptoms of UC by anti-inflammatory, anti-oxidative, regulating the gut microbiota, and repairing the colonic epithelial barrier, but their low solubility and bioavailability severely limit their clinical application.

A starch‑sodium alginate interpenetrating network enhances the structure, texture, and starch digestibility of extruded buckwheat noodles: Regulatory effects of mannuronate/guluronate ratios and calcium ion concentrations.

The regulatory effects of different mannuronate/guluronate ratios in sodium alginate (SA) and calcium ion (Ca) concentrations on the structure and properties of starch-SA interpenetrating polymer network (IPN)-enhanced extruded buckwheat noodles were investigated. The thermal stability of buckwheat noodles was improved by increasing the G block proportion, and 1% Ca concentration led to the highest thermal stability. With increasing G proportion and Ca concentration, cooking loss and elongation at break of extruded noodles gradually decreased.

Comparative Study on Growth Characteristics and Early Selection Efficiency of Hybrid Offspring of 'DD-109' and in Liaoning, China.

Poplar is an important tree species for timber supply and ecological protection in northern China. Cultivating and selecting high-quality varieties and germplasm resources suitable for cultivation are key factors in enhancing the quality and productivity of poplar plantations in the arid and semi-arid northern regions with shorter growing seasons. This study conducted a field cultivation experiment on 10 progeny clones from the direct cross (D × M) of imported 'DD-109' with and 7 progeny clones from the reciprocal cross (M × D) using one-year-old rooted cuttings planted at a 4 m × 8 m spacing.

Case Report: Charcot-marie-tooth disease caused by a gene mutation - novel insights into pathogenicity and treatment.

Charcot-Marie-Tooth disease (CMT) is a hereditary peripheral neuropathy involving approximately 80 pathogenic genes. Whole-exome sequencing (WES) and confirmatory Sanger sequencing analysis was applied to identify the disease-causing mutations in a Chinese patient with lower limb weakness. We present an 18-year-old male with a 2.

Genetic Evaluation of Water Use Efficiency and Nutrient Use Efficiency in Bartr. ex Marsh. Seedlings in China.

Bartr. ex Marsh. represents a valuable genetic resource for fast-growing plantations in temperate regions.

Small reservoirs can enhance the terrestrial carbon sink of controlled basins in karst areas worldwide.

The concentration of Greenhouse Gas (GHG) in the atmosphere has sharply increased since the Industrial Revolution, leading to climate warming and severe environmental problems. It has become a consensus that GHG emissions of large reservoirs essentially constitute inland aquatic GHG emissions. However, questions remain regarding whether small karst reservoir (SKR) is only a substantial source of GHG emissions like large reservoirs, and how much GHG emission it can offset by affecting the terrestrial carbon sink (TCS) of its controlled basin.

Insights into the effect mechanism of freeze-thaw cycles on starch gel structure and quality characteristics of frozen extruded whole buckwheat noodles.

The effects of freeze-thaw cycles (FTC) on starch gel structure and quality characteristics of frozen extruded whole buckwheat noodles (FEWBN) were studied. The repeated FTC treatments induced the retrogradation of amylose which increased the compactness, crystallinity, hardness, and cooking time of FEWBN. However, with the increasing number of freeze-thaw cycles, the larger volume of ice crystals formed in the noodles destroyed the starch gel network structure to a certain extent, and led to the dehydration and syneresis of the noodles, and the quality deterioration.

Effects of fatty acids and glycerides on the structure, cooking quality, and in vitro starch digestibility of extruded buckwheat noodles.

This study aimed to explore the effects of various lipids on the structure, cooking quality, and in vitro starch digestibility of extruded buckwheat noodles (EBNs) with and without 20% high-amylose corn starch (HACS). Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction revealed that lauric acid bound more strongly to starch than did stearic acid and oleic acid, and the binding capacity of fatty acids with starch was stronger than that of glycerides. The presence of HACS during extrusion facilitated increased formation of starch-lipid complexes.

Application of the process-based teaching based on SPARK case database in the practice teaching of radiology in the musculoskeletal system for undergraduate medical students.

Background: Process-based teaching is a new education model. SPARK case database is a free medical imaging case database. This manuscript aimed to explore the application of the process-based teaching based on SPARK case database in the practice teaching of radiology in the musculoskeletal system.

Fabrication of cinnamon essential oil nanoemulsions with high antibacterial activities via microfluidization.

The high volatility and hydrophobicity of cinnamon essential oils (CiEO) limited their practical application. To enhance their stability and antibacterial activity, nanoemulsions encapsulating CiEO were prepared using hydroxypropyl-β-cyclodextrin/lauroyl arginate (HPCD/LAE) inclusion complexes through high-pressure microfluidization (HPM). Effects of HPM parameters on the stability and antibacterial properties of nanoemulsion were investigated.

Artificial intelligence model system for bone age assessment of preschool children.

Backgroud: Our study aimed to assess the impact of inter- and intra-observer variations when utilizing an artificial intelligence (AI) system for bone age assessment (BAA) of preschool children.

Methods: A retrospective study was conducted involving a total sample of 53 female individuals and 41 male individuals aged 3-6 years in China. Radiographs were assessed by four mid-level radiology reviewers using the TW3 and RUS-CHN methods.

From phenotype to mechanism: Prenatal spectrum of NKAP mutation-related disorder and its pathogenesis inducing congenital heart disease.

NKAP mutations are associated with Hackmann-Di Donato-type X-linked syndromic intellectual developmental disorder (MRXSHD, MIM: #301039). Here, we elucidate the potential prenatal manifestation of NKAP mutation-associated disorder for the first time, alongside revealing the relationship between NKAP mutations and congenital heart defect (CHD) in the Chinese population. An NKAP mutation (NM_024528.

A novel frameshift mutation in a Chinese pedigree with polydactyly: A case report.

Background: gene mutations can result in various forms of polysyndactyly, such as Greig cephalopolysyndactyly syndrome (GCPS, MIM: #175700), Pallister-Hall syndrome (PHS, MIM: #146510), and isolated polydactyly (IPD, MIM: #174200, #174700). Reports on IPD-associated mutations are rare. In this study, a novel mutation was identified in a Chinese family with IPD.