A cross-sectional and bioinformatics-based analysis: perirenal fat thickness as a superior predictor of kidney stone disease.

Background: Kidney stone disease (KSD) is a growing global health concern, with obesity (OB) as a major risk factor linked to metabolic dysfunction and chronic inflammation. Although the common method for evaluating OB is body mass index (BMI), it is not specific enough when it comes to reflecting visceral fat. The perirenal fat thickness (PFT) might present better predictive capabilities.

Comparative Analysis of Testicular Transcriptional and Translational Landscapes in Yak and Cattle-Yak: Implications for Hybrid Male Sterility.

Cattle-yak, a hybrid of yak and cattle, exhibits significant heterosis but male infertility, hindering heterosis fixation. Although extensive research has been conducted on transcriptional mechanisms in the testes of cattle-yak, the understanding of their translational landscape remains limited. In this study, we characterized the translational landscape of yak and cattle-yak based on Ribo-seq technology integrated with RNA-seq data.

Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.

Background: Inflammaging plays a pivotal role in the pathogenesis of multiple age-related diseases, including periodontitis. Advanced glycation end products (AGEs) are known to induce inflammaging and exacerbate periodontitis. However, the mechanisms by which AGEs promote inflammaging remain unclear.

C3GAN: A brain-inspired memory consolidation for class-incremental learning.

Human cognition excels in lifelong learning, seamlessly acquiring, retaining, and transferring knowledge. In contrast, deep neural networks suffer from catastrophic forgetting, where training on new tasks rapidly erases previously acquired knowledge. In the human brain, memory reactivation is crucial for preserving memories over time.

Prognostic importance of red blood cell distribution width in patients with glioma: A meta-analysis.

The present study aimed to investigate whether red blood cell distribution width (RDW) was an independent prognosis factor for patients with glioma after surgery. Potential studies were found in four databases including PubMed, Embase, China National Knowledge Infrastructure and the Cochrane Library on 21st July, 2022. To evaluate the prognosis after surgery, hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled to calculate the overall survival (OS) of patients with glioma.

Ribo-Seq Analysis-Based Elucidation of the Dynamic Translation Landscape of Yak Ovarian Tissues in Different Reproductive Stages.

Translation, plays a critical regulatory role in follicular development, ovulation, and corpus luteum formation and degeneration in the ovaries. To better understand the molecular mechanisms of reproductive regulation at the translation level in yaks, the present study analyzed gene expression changes in the ovarian tissues of yaks in different reproductive stages by using ribosome profiling and integrating RNA sequencing data. The small open reading frames (sORFs) of the ovarian tissue were characterized, and the effect of the translation efficiency of the targeted genes on their sequence features was determined.

First application of a 6.3 Fr flexible ureteroscope in the treatment of bilateral staghorn calculi: A case report.

Rationale: Staghorn calculi are a challenging type of kidney stone traditionally treated with percutaneous nephrolithotomy (PCNL) or multiple endoscopic procedures. However, these methods are often associated with a higher risk of postoperative complications and prolonged recovery periods. Recent advancements in flexible ureteroscopy (fURS) technology have offered the potential for improving the management of kidney stones, but its application in treating complex staghorn stones remains limited due to technical and anatomical challenges.

Entropy-Driven Structural Evolution in Ceramic Oxides.

High-entropy ceramics, with five or more elements randomly occupying the same cation crystallographic sites, offer vast compositional diversity and unique properties for material design and applications. However, for many dissimilar elements, entropic stabilization cannot overcome the enthalpic barrier to cation substitution. As a result, most high-entropy ceramics incorporate only a few similar elements, limiting the in-depth exploration of the effect of entropy on ceramic properties.

Asymmetric Twinned-FCC Configuration Alone Cannot Effectively Induce Metallicity in ∼200-Atom Gold Nanoclusters: Design and Theoretical Study of Tetrahedral Au-Cored RS-AuNCs.

This study proposes a novel design strategy for thiolate-protected gold nanoclusters (RS-AuNCs) based on the truncated triangular Au unit on the [111] crystal plane. First, sandwich-type primary cores of Au, Au, and Au are constructed on the Au crystal plane, and then triangular Au units are introduced to obtain core structures of Au, Au, and Au, respectively. Finally, based on the Au core, four asymmetric twinned-FCC shell clusters (Au(SR), Au(SR), Au(SR), and Au(SR)) are successfully constructed through differentiated ligand protection modes.

Extracellular vesicle-hitchhiking nanoliposomes for cancer-associated fibroblast phenotype modulation impede metastasis progression.

Metastasis represents a crucial cancer progression and is promoted by cancer-associated fibroblasts (CAFs). Modulating CAFs in distant metastasis is challenging due to their diverse phenotypes and the lack of effective delivery strategies. Inspired by the tropism of tumor extracellular vesicles (Evs) expressing specific integrins toward fibroblasts, we developed a labeling strategy for both tumors and tumor-derived Evs.

Analysis of genomic selection characteristics of local cattle breeds in Gansu.

Background: The distinctive geography and climate of Gansu Province have given rise to three indigenous cattle breeds-Zaosheng, Anxi, and Yangba. Renowned for their superior meat quality and remarkable adaptability, these breeds are crucial for maintaining genetic diversity. However, they are under threat from intensive farming practices, environmental degradation, and genetic drift, which could lead to an irreversible loss of genetic resources.

Combining Retroperitoneal Laparoscopic Ureterolithotomy and Flexible Ureteroscopy for Effective Removal of a Large Ureteral Stone: A Case Report.

BACKGROUND Large ureteral stones (LUSs) pose significant health risks, including chronic obstruction and renal impairment. Timely intervention is critical to preserve kidney function. While the optimal treatment for LUS is debated, retroperitoneal laparoscopic ureterolithotomy (RLU) is often preferred over percutaneous nephrolithotomy (PCNL), ureteroscopy, or extracorporeal shockwave lithotripsy due to its effectiveness.

Core packing-dependent metallic transition in thiolate-protected gold nanoclusters: twinned-FCC pure-FCC configurations.

Herein, we computationally predict two FCC gold nanoclusters, Au(SR) and Au(SR), featuring octahedral Au cores at the 200-atom scale. Au(SR) exhibits superior structural stability compared to Au(SR). Spectroscopic and electronic analyses reveal that FCC-structured Au(SR) retains molecular-state characteristics, proving that the FCC configuration alone is insufficient to impart metallic properties in large RS-AuNCs.

Correlation of Coding and Non-Coding RNAs on the Fat Deposition of Yaks Under Different Feeding Systems.

The yak is a classic grazing livestock species on the Qinghai-Tibet Plateau, and fat deposition is indispensable for its survival and metabolism. Coding and non-coding RNAs (ncRNAs) play an important role in regulating fat deposition in livestock. In this study, the expression of mRNAs, lncRNAs, miRNAs, and circRNAs in the subcutaneous fat of yaks under grazing and stall feeding was measured using whole-transcriptome sequencing technology.

A review of immune checkpoint inhibitor-associated myocarditis: Epidemiology, pathogenesis, and biomarkers.

Immune checkpoint inhibitor (ICI) have demonstrated efficacy in treating various cancers by modulating the immune system, but this can lead to immune-related adverse events (irAEs), including myocarditis. ICI-associated myocarditis is a rare but highly lethal irAE with a short mean time to onset, and difficult to diagnose early due to nonspecific symptoms and lack of biomarkers. This review highlights the need for improved recognition and management of ICI-associated myocarditis, summarizing recent advances in immunology, pathology, and biomarker research.

Bovine lactoferricin exerts antibacterial activity against four Gram-negative pathogenic bacteria by transforming its molecular structure.

The emergence and development of pathogenic bacterial resistance to antibiotics pose significant challenges to human health. Antimicrobial peptides (AMPs) are considered promising alternatives to conventional antibiotics. Lactoferricin (Lfcin), a cationic AMP located in the N-terminal region of lactoferrin, serves as the antimicrobial active center of the intact protein.

Characteristic analysis of N-methyladenine in different parts of yak epididymis.

Background: The epididymis is essential for sperm maturation. During sperm maturation, markable alterations of the payload of small noncoding RNAs are observed in the epididymis, which indicated the role of epigenetic alterations in sperm maturation. However, the N-Methyladenosine (mA) modification profile of the epididymis remains unelucidated.

Theoretical study on a novel Au(SR) cluster sequence with symmetry.

The cluster sequences with analogous structures are of significant importance for elucidating the evolutionary patterns in both structural configurations and electronic architectures of RS-AuNCs. Despite substantial efforts devoted to synthesizing and characterizing a series of single-crystal structures of RS-AuNCs, the scarcity of well-defined single-crystal structures for large-sized cluster sequences has impeded comprehensive understanding of structure-property correlations within this size regime. This work presents a theoretical investigation of a novel series of Au(SR) (where = 0, 1, 2, 3) clusters exhibiting symmetry.

Practical research on the cultivation of inter-disciplinary undergraduate nursing talents in the context of "big health".

Objective: Exploring the construction and effectiveness of a inter-disciplinary undergraduate nursing talent cultivation model in the context of"great health".

Methods: Adopting cluster sampling method, undergraduate nursing students enrolled in 2019 and 2020 were selected as the research subjects. The students who entered the school in 2019 were selected as the control group, who was cultivated according to"applied talent"cultivation model, Correspondingly, the students who entered the school in 2020 were selected as the experimental group, who was cultivated according to"inter-disciplinary talent"cultivation model.

Enhancing Renal Stone Management: Tip-Flexible Ureteral Access Sheath in Cystine Stone Surgery.

BACKGROUND Cystinuria is a rare cause of urolithiasis. The condition is often inherited and controlled medically. A large symptomatic stone is indicated for surgery, and complete stone clearance is recommended to reduce the risk of infection and stone recurrence.

Dual-action membrane-chimeric liposomes with self-reinforcing targeting for acute lung injury treatment.

Acute lung injury (ALI) is a common acute and critical syndrome with high mortality. The uncontrollable feedback loop of inflammation is the primary cause of death in patients with ALI. Therefore, targeting the inflammatory site and breaking the inflammatory loop are key strategies for ALI treatment.

Whole-Genome Sequencing Unveils the Uniqueness of Yushu Yaks ().

The Yushu yak is one of China's distinctive yak breeds, primarily distributed in the Yushu Tibetan Autonomous Prefecture of Qinghai Province and its surrounding areas. Yushu yaks are not only economically and culturally significant but also play a crucial role in protecting the ecosystem of the Qinghai-Tibet Plateau and promoting sustainable development. However, there are no clear records regarding the ancestry, population structure, and unique traits of Yushu yaks.

Architectural Blueprint of FCC Gold Nanoclusters: Modular Assembly of Au(SR) and Au(SR) from Tetrahedral Au and Octahedral Au Geometric Modules.

Employing the fundamental building blocks of face-centered cubic (FCC) crystals, tetrahedral Au, and octahedral Au as innermost kernel structures, we predicted the geometric configurations of FCC-type Au(SR) and Au(SR) through core-shell growth patterns. Calculations of the average formation energy () demonstrate the favorable structural stability of Au(SR) and Au(SR). The density of states (DOS) plot reveals discrete orbital energy levels in both clusters and molecule-like multipeak features in their absorption spectra, indicating their classification as excitons.