Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

The present study aimed to investigate whether red blood cell distribution width (RDW) was an independent prognosis factor for patients with glioma after surgery. Potential studies were found in four databases including PubMed, Embase, China National Knowledge Infrastructure and the Cochrane Library on 21st July, 2022. To evaluate the prognosis after surgery, hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled to calculate the overall survival (OS) of patients with glioma. Stata V16.0 software was used for data analysis. A total of 8 studies were included, involving 1,468 patients. After collecting and analyzing the data, RDW was demonstrated to be a prognostic factor for OS of patients with glioma (HR=1.51; I=0.00%; 95% CI, 1.29-1.74; P<0.01). Patients with high preoperative RDW levels had a high risk of poor survival after neurosurgery. High preoperative RDW levels may be associated with poor prognosis and warrant further clinical attention.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365894PMC
http://dx.doi.org/10.3892/ol.2025.15217DOI Listing

Publication Analysis

Top Keywords

patients glioma
16
red blood
8
blood cell
8
cell distribution
8
distribution width
8
factor patients
8
patients
5
prognostic red
4
width patients
4
glioma
4

Similar Publications

Unraveling epigenetic drivers of immune evasion in gliomas: mechanisms and therapeutic implications.

Front Immunol

September 2025

Precision Pharmacy and Drug Development Center, Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

Gliomas are the most common primary malignant tumors of the central nervous system (CNS), and despite progress in molecular diagnostics and targeted therapies, their prognosis remains poor. In recent years, immunotherapy has emerged as a promising treatment modality in cancer therapy. However, the inevitable immune evasion by tumor cells is a key barrier affecting therapeutic efficacy.

View Article and Find Full Text PDF

Advances in neuroscientific mechanisms and therapies for glioblastoma.

iScience

September 2025

Department of Molecular Pathology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, QingDao, Shandong 266300, China.

Gliomas are common primary brain tumors in the central nervous system, characterized by invasiveness, heterogeneity, and drug resistance, posing a threat to patients' lives. Glioblastoma (IDH wild-type) exhibits the highest invasiveness and mortality rate, making it a challenging therapeutic target. This review first outlines the characteristics of gliomas and their impact on the nervous system, then explores the pathological mechanisms and unique behaviors of glioblastoma (IDH wild-type), as well as the influence of the nervous system on its occurrence and progression.

View Article and Find Full Text PDF

Background: The objective of this study is to investigate the predictive role of O6-methylguanine-DNA methyltransferase (MGMT) and isocitrate dehydrogenase (IDH) status on the efficacy of bevacizumab (BEV) in high-grade glioma (HGG), while excluding the interference of chemotherapy agents.

Methods: A retrospective, single-center analysis was conducted on 103 patients with HGG who received BEV treatment. The enrolled patients were grouped based on their different biomarker statuses.

View Article and Find Full Text PDF

Purpose: Amino acid PET with [F]-fluoroethylthyrosine ([F]FET-PET) is frequently utilized in gliomas. Most studies on prognostication based on amino acid PET comprise mixed cohorts of brain tumors with low- and high-grade features. The objective of this study was to assess the potential prognostic value of [F]FET-PET-based markers in the group of grade 2 adult-type diffuse gliomas, as defined by the WHO CNS 2021 classification.

View Article and Find Full Text PDF

Purpose: Glioblastoma (GBM) remains one of the most aggressive primary brain tumors with poor survival outcomes and a lack of approved therapies. A promising novel approach for GBM is the application of photodynamic therapy (PDT), a localized, light-activated treatment using tumor-selective photosensitizers. This narrative review describes the mechanisms, delivery systems, photosensitizers, and available evidence regarding the potential of PDT as a novel therapeutic approach for GBM.

View Article and Find Full Text PDF