Ocean surface waves impact on global air-sea CO flux.

Unlabelled: Ocean surface gravity waves facilitate gas exchanges primarily in two ways: (1) the formation of bubbles during wave breaking increases the surface area available for gas exchange, promoting CO transfer, and (2) wave-current interaction processes alter the sea surface partial pressure of CO and gas solubility, consequently affecting the CO flux. This study tests these influences using a global ocean-ice-biogeochemistry model under preindustrial conditions. The simulation results indicate that both wave-current interaction processes and the sea-state-dependent gas transfer scheme-which explicitly accounts for bubble-mediated gas transfer velocity-influence the air-sea CO flux, with substantial spatial and seasonal variations.

GC-PGE: A novel deep learning model for tumor drug resistance prediction and core resistance gene extraction based on graph and signaling pathways.

Motivation: Drug resistance is the main cause of tumor treatment failure and recurrence. Existing models exhibit limitations in accurately predicting tumor drug resistance and identifying resistance-associated genes. Furthermore, they often fail to effectively integrate multidimensional omics data and pathway-level information, lacking biological interpretability.

Charged multivesicular body protein 7 was identified as a prognostic biomarker correlated with metastasis in colorectal cancer.

Background: Metastasis is the main reason leading to death in colorectal cancer (CRC) and about 25% of CRC patients developed metastasis when first diagnosed. Thus, unveiling biomarkers of CRC metastasis is of great significance.

Aim: To reveal biomarkers of CRC metastasis.

Hyaluronic acid coated GSH-responsive Mn(III)-pMOF-based nanosonosensitizers for cascade-catalytic enhancement of sonodynamic therapy against hepatocellular carcinoma.

Reactive oxygen species (ROS)-mediated sonodynamic therapy (SDT) has shown potential in treating deep-seated solid tumors owing to its precise targeting capabilities and non-invasive nature. However, the clinical translation of SDT is hindered by conventional sonosensitizers, which fail to effectively penetrate the complex tumor microenvironment and generate sufficient ROS. In this study, we developed a novel nanosonosensitizer system, termed Mn(III)-TCPP@Nic/HA (MTNH).

Progress analysis of multi-dimensional perspective research on green ships: A knowledge graph-based approach.

With the increased global focus on environmental protection, green ships have emerged as the cornerstone to the maritime industry's long-term development. Based on the knowledge graph method, this paper uses bibliometric analysis to examine the research progress of green ships in a multidimensional perspective. Firstly, sort out the definition and connotation of green ships, and clarify their greening requirements in the whole life cycle.

Design, synthesis and in vitro and in vivo biological evaluation of matrine derivatives as efficient anticancer agents with the characteristics of endoplasmic reticulum stress induction and apoptosis activation.

Natural products have made significant contributions to the prevention and treatment of malignant tumors. However, natural products often suffer from low efficacy and potential toxicity. Therefore, modifying and optimizing lead compounds derived from natural products is a crucial strategy in drug development.

PathSynergy: a deep learning model for predicting drug synergy in liver cancer.

Cancer is a major public health problem while liver cancer is the main cause of global cancer-related deaths. The previous study demonstrates that the 5-year survival rate for advanced liver cancer is only 30%. Few of the first-line targeted drugs including sorafenib and lenvatinib are available, which often develop resistance.

Centipeda minima extract exhibits anti-liver cancer effects via the ER stress/HMOX1/Fe/ROS pathway.

Background: Centipeda minima (CM), also known as Ebushicao, has been traditionally utilized in Chinese medicine over thousands of years to address rhinitis, nasal allergies, and cancers. However, the active compounds and mechanism of CM against liver cancer have not been elucidated.

Purpose: To reveal the anticancer effects and the molecular mechanism of CM against liver cancer.

γ-polyglutamic acid-encapsulated metformin-loaded Ga-Car-MOF and hydrocaffeic acid-modified chitosan double-layer microneedle patch for accelerated bacterial-infected wound healing.

Bacteria deep in the wound can cause prolonged inflammation and dysfunctional angiogenesis, impeding healing and potentially leading to chronic conditions, disability, or even death. To address this, we developed a double-layer metal-organic framework (MOF) microneedle (MN) patch system (GCM-MN-CSH), designed to accelerate the healing of infected wounds through programmed therapy. The GCM-MN-CSH system consists of a hydrocaffeic acid-modified chitosan (CSH) hydrogel patch and a metformin (Met)-loaded Ga-Car-MOF (GCM)-based γ-polyglutamic acid matrix MN array (GCM-MN).

Metal-organic framework microneedles for precision transdermal drug delivery: design strategy and therapeutic potential.

Metal-organic frameworks (MOFs) are porous materials renowned for their high porosity, large specific surface area, biocompatibility, and biodegradability. Hydrogel microneedles (MNs) is an emerging technology that minimally disrupts the skin or mucosal membranes, bypassing gastrointestinal absorption and the rapid metabolism typical of oral drug delivery. Over the past few decades, both MOFs and MNs have found applications across a range of fields.

Centipeda minima extracts and the active sesquiterpene lactones have therapeutic efficacy in non-small cell lung cancer by suppressing Skp2/p27 signaling pathway.

Ethnophamacological Relevance: Centipeda minima (L.) A. Braun & Asch (C.

Knockdown of RFC4 inhibits cell proliferation of oral squamous cell carcinoma in vitro and in vivo.

Oral squamous cell carcinoma (OSCC) is the one of the most common types of malignant tumor found in the head and neck area. Replication factor C subunit 4 (RFC4), an oncogene active in various human cancers, has been rarely studied in OSCC. In the present study, bioinformatics analysis identified RFC4 as a potential key target in OSCC progression.

Lianhua Qingwen exerts anti-liver cancer effects and synergistic efficacy with sorafenib through PI3K/AKT pathway: Integrating network pharmacology, molecular docking, and experimental validation.

Liver cancer is one of the most lethal malignancies and sorafenib resistance is the main treatment obstacle for patients with advanced liver cancer. Developing drugs that sensitize liver cancer patients to sorafenib is of great importance. Lianhua Qingwen (LHQW), a sort of Traditional Chinese Medicine (TCM) approved by the Chinese Food and Drug Administration (CFDA), is reported to exert synergistic effects with oseltamivir against Influenza virus.

A high-speed microscopy system based on deep learning to detect yeast-like fungi cells in blood.

Blood-invasive fungal infections can cause the death of patients, while diagnosis of fungal infections is challenging. A high-speed microscopy detection system was constructed that included a microfluidic system, a microscope connected to a high-speed camera and a deep learning analysis section. For training data, the sensitivity and specificity of the convolutional neural network model were 93.

Identification of arnicolide C as a novel chemosensitizer to suppress mTOR/E2F1/FANCD2 axis in non-small cell lung cancer.

Background And Purpose: The mammalian target of rapamycin (mTOR) pathway plays critical roles in intrinsic chemoresistance by regulating Fanconi anaemia complementation group D2 (FANCD2) expression. However, the mechanisms by which mTOR regulates FANCD2 expression and related inhibitors are not clearly elucidated. Extracts of Centipeda minima (C.

Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis.

Liver cancer is one of the most lethal malignancies with an annual death of over 830,000 cases. Although targeted therapeutic drugs have achieved certain clinical efficacy, only sorafenib and lenvatinib are currently marketed as first-line targeted drugs to treat patients with advanced liver cancer. Therefore, developing more drugs are urgently needed.

Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL/6 J mouse.

Although adequate intake of manganese (Mn) is essential to humans, Mn in excess is neurotoxic. Exposure to extremely high doses of Mn results in "manganism", a condition that exhibits Parkinson-like symptoms. However, the mechanisms underlying its neurotoxic effects in Mn-induced parkinsonism pathogenesis are unclear.

A cuproptosis random forest cox score model-based evaluation of prognosis, mutation characterization, immune infiltration, and drug sensitivity in hepatocellular carcinoma.

Background: Hepatocellular carcinoma is the third most deadly malignant tumor in the world with a poor prognosis. Although immunotherapy represents a promising therapeutic approach for HCC, the overall response rate of HCC patients to immunotherapy is less than 30%. Therefore, it is of great significance to explore prognostic factors and investigate the associated tumor immune microenvironment features.

The expression, immune infiltration, prognosis, and experimental validation of OSBPL family genes in liver cancer.

Background: Liver cancer is the third most deadly malignant tumor in the world with poor prognosis and lacks early diagnostic markers. It is urgent need to explore new biomarkers and prognostic factors. The oxysterol-binding protein-like family proteins (OSBPLs) are essential mediators of lipid transportation and cholesterol balancing which has been reported to participate in cancer progression.

Nursing Assistant Staffing Model: Implementation and Outcome Evaluation in Taiwan Hospitals.

Background: A key policy of the Taiwan healthcare system is promoting the hiring of nursing assistants (NAs) to reduce the workload of nurses. However, few studies in the literature have compared the relative effectiveness of different nurse staffing policies, and no studies have addressed the impact of the NA staffing (NAS) model.

Purpose: This study explored the current status of the NAS model as implemented in Taiwan hospitals and to investigate the methods used to evaluate the outcomes of NAS model implementation.

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma in vitro and in vivo.

Nasopharyngeal carcinoma (NPC) is a malignant tumor that mainly occurs in East and Southeast Asia. Although patients benefit from the main NPC treatments (e.g.

Characteristic and Synthesis of High-Temperature Resistant Liquid Crystal Epoxy Resin Containing Boron Nitride Composite.

Five liquid crystal epoxy resins and composites containing flat boron nitride (f-BN) and spherical boron nitride (s-BN) were successfully synthesized. The chemical structures, crystal diffraction, and thermal conductivity of the liquid crystal (LC) epoxy composites were measured using Nuclear Magnetic Resonance (NMR), Differential Scanning Calorimetry (DSC), X-ray, and Discovery Xenon Flash. In this study, the molecular arrangement of five LC epoxy resins and the thermal conductivity of their composites were carefully discussed.

Integrated analysis identified NPNT as a potential key regulator in tumor metastasis of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the lethal malignancies worldwide. Tumor metastasis is the main cause of HCC related death. Although progress has been made in the mechanism study of HCC in the past decades, the underlying mechanism of HCC metastasis has not been fully illustrated.

8-Formylophiopogonanone induces ROS-mediated apoptosis in nasopharyngeal carcinoma CNE-1 cells.

Cancer is one of the leading causes of death in the world. It is very important to find drugs with high efficiency, low toxicity, and low side effects for the treatment of cancer. Flavonoids and their derivatives with broad biological functions have been recognized as anti-tumor chemicals.

Marine Power on Cancer: Drugs, Lead Compounds, and Mechanisms.

Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each year.