Development of Grouting Materials from Shield Sludge via Alkaline Hydrothermal Activation: A Resource Utilization Approach.

Frequently, the viscous mixture from shield operations is disposed of because its significant water ratio and the presence of polymers like foaming agents result in subpar structural qualities, contributing to the unnecessary consumption of land and the squandering of soil assets. Therefore, these problems urgently need to be solved economically and effectively. This study relies on the shield sludge produced by Qingdao Metro Line 6 project, and sand and shield sludge were used as the raw materials for synchronous grouting.

Persistent exanthema mainly on the trunk with pathologically dermal interstitial mucin as anti-HMGCR myopathy-associated skin rash: Case series.

Antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) form a newly identified distinct serological marker for necrotizing autoimmune myopathy. Although anti-HMGCR myopathy is currently classified into polymyositis, skin involvement has been reported, with its characteristics only vaguely described. We retrospectively examined the clinical and histological features of non-dermatomyositis-like persistent exanthema in five anti-HMGCR myopathy patients followed up in the neurology and dermatology clinic of Huashan Hospital between December 2020 and September 2024.

Pigmented pathological type and depth of follicular extension as predictors of treatment failure in 5-aminolevulinic acid photodynamic therapy for actinic keratosis: A retrospective, matched nested case-control study.

Background: While 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is widely used to treat actinic keratosis (AK), treatment resistance and recurrence after ALA-PDT remain clinical challenges.

Methods: This single-site, retrospective, matched case-control study included 119 patients with histologically confirmed AK to identify clinical and pathological predictors for effectiveness of ALA-PDT. Patients received four consecutive ALA-PDT sessions at intervals of 1 or 2 weeks.

Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage-Mediated Mitotic Catastrophe.

Despite the promise of cold atmospheric plasma (CAP) for cancer treatment, the challenges associated with the treatment of solid tumors and penetration depth limitations remain, restricting its clinical application. Here, biological evidence is provided that the killing effect of CAP treatment is confined to less than 500 µm subcutaneously and the actual biological dose decreased gradually with depth for the first time, indicating that the limited penetration depth has become an urgent problem that demands immediate solutions. Significantly, it is showed that different from high-dose treatments, CAP decreased the doses to the low-dose range but still exhibited anti-tumor effects via mitotic catastrophe.

ALA-PDT combined with CO laser in the treatment of malignant hidroacanthoma simplex: A case report.

Hidroacanthoma simplex (HS) is a rare skin appendage tumor that typically appears on the trunk and lower limbs in the elderly. Although HS is a predominantly benign condition, the presence of cellular atypia and dermal infiltration on histological examination indicates malignant HS (MHS). 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) uses a photosensitizer and corresponding light source to cause irreversible damage or death of target cells through a photochemical reaction.

Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer.

The gas therapy is drawing increasing attention in the treatment of many diseases including cancer. As one of gas signaling molecules, carbon monoxide (CO) has been proved to exert anti-cancer effects via triggering multiple cell death types, such as autophagy, apoptosis and necrosis. Here, we showed that low concentration CO delivered from CO-releasing molecule 3 (CORM-3) effectively induced ferroptosis, known as a novel proinflammatory programmed cell death, in vitro and in vivo.

A Two-Stage End-to-End Deep Learning Framework for Pathologic Examination in Skin Tumor Diagnosis.

Neurofibromas (NFs), Bowen disease (BD), and seborrheic keratosis (SK) are common skin tumors. Pathologic examination is the gold standard for diagnosis of these tumors. Current pathologic diagnosis is primarily based on microscopic observation, which is laborious and time-consuming.

Clinical, histopathological and prognostic features of primary cutaneous acral CD8 T-cell lymphoma and other dermal CD8 cutaneous lymphoproliferations: results of an EORTC Cutaneous Lymphoma Group workshop.

Background: The differential diagnosis of atypical dermal nonepidermotropic CD8 lymphocytic infiltrates includes a heterogeneous spectrum of lymphoproliferations with overlapping histological and phenotypic features, but divergent clinical manifestations and prognoses. As these neoplasms are rare, more data on their clinicopathological presentation and course are needed.

Objectives: To assess the clinical, histological and immunophenotypic features; outcomes of; and differences between dermal CD8 lymphoproliferations.

Optimization of Membrane Electrode Assembly of PEM Fuel Cell by Response Surface Method.

The membrane electrode assembly (MEA) plays an important role in the proton exchange membrane fuel cell (PEMFC) performance. Typically, the structure comprises of a polymer electrolyte membrane sandwiched by agglomerate catalyst layers at the anode and cathode. Optimization of various parameters in the design of MEA is, thus, essential for reducing cost and material usage, while improving cell performance.

Entropy Generation and Heat Transfer Performance in Microchannel Cooling.

Owing to its relatively high heat transfer performance and simple configurations, liquid cooling remains the preferred choice for electronic cooling and other applications. In this cooling approach, channel design plays an important role in dictating the cooling performance of the heat sink. Most cooling channel studies evaluate the performance in view of the first thermodynamics aspect.

Pipe flow of pumping wet shotcrete based on lubrication layer.

Wet shotcrete can reduce dust and improve supporting strength, however, safe and efficient pipage is a key technical part of wet shotcrete process. The paper studied the pipe flow law of wet shotcrete based on lubrication layer by build the experimental pumping circuit of wet shotcrete that can carry out a number of full-scale pumping tests. The experimental results show there was a linear relationship between pressure loss and flow rate.

Microarray-based identification of differentially expressed genes in extramammary Paget's disease.

Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy accounting for approximately 1-2% of vulvar cancers. The rarity of this disease has caused difficulties in characterization and the molecular mechanism underlying EMPD development remains largely unclear. Here we used microarray analysis to identify differentially expressed genes in EMPD of the scrotum comparing with normal epithelium from healthy donors.

Effective treatment of d-penicillamine induced elastosis perforans serpiginosa with ALA-PDT.

A case of D-penicillamine(DPA) induced elastosis perforans serpiginosa(EPS) in a 32-year-old Chinese man was reported. The presentation lasted two years and was refractory to traditional medical treatment. He was then commenced on 7.

Identification of melanoma biomarkers based on network modules by integrating the human signaling network with microarrays.

Background: Melanoma is a leading cause of cancer death. Thus, accurate prognostic biomarkers that will assist rational treatment planning need to be identified.

Methods: Microarray analysis of melanoma and normal tissue samples was performed to identify differentially expressed modules (DEMs) from the signaling network and ultimately detect molecular markers to support histological examination.

Clinical analysis and etiology of porokeratosis.

The present study was performed in order to define the clinical manifestations of porokeratosis, with particular emphasis on genital porokeratosis. A total of 55 cases of porokeratosis were retrospectively reviewed between 2000 and 2007 from Huashan Hospital (Shanghai, China). Out of 55 cases, there were 22 cases of porokeratosis of Mibelli, 17 cases of disseminated superficial actinic porokeratosis (DSAP), 15 cases of disseminated superficial porokeratosis and one case of linear porokeratosis.

Clinical and pathological study of 328 cases of actinic keratosis in eastern chinese patients.

Background: Actinic keratosis (AK) is prevalent and has been widely studied in fair-skinned populations. However, this is not the case in eastern countries. AK in Asians has not been so thoroughly investigated.

Mycobacterium tuberculosis infection is associated with the development of erythema nodosum and nodular vasculitis.

Background: Mycobacterium tuberculosis (MTB) infection has been suggested to contribute to the pathogenesis of erythema nodosum (EN) and nodular vasculitis (NV), the classic forms of panniculitis. However, there is little evidence to demonstrate the presence of MTB in the skin lesions. This study is aimed at evaluating the association between MTB infection and the development of EN and NV in a Chinese population.

Multicentric reticulohistiocytosis associated with liver carcinoma: report of a case.

We report a unique case of multicentric reticulohistiocytosis (MRH) associated with liver carcinoma. A 61-year-old man presented with a 4-month history of nonpruritic, generalized, ruby-red papules and nodules, accompanied by fever, joint swelling and difficulty in swallowing. Skin histology showed polymorphic histiocyte infiltration with typical 'ground glass' cytoplasm.

Lymphatic invasion is independently prognostic of metastasis in primary cutaneous melanoma.

Purpose: Lymphatic invasion (LI) in primary cutaneous melanomas was recently found to be common. In this study, we evaluated LI as an independent prognostic factor.

Experimental Design: This study included 251 patients with vertical growth phase (VGP) primary cutaneous melanomas who had paraffin-fixed lesional tissue and were in a prospective cohort seen between 1972 and 1991, had no clinical evidence of regional nodal disease at diagnosis, and had at least ten years of follow-up.

Granulomatous slack skin: assessment of disease progression and treatment response using positron emission tomography/computed tomography.

Granulomatous slack skin (GSS) is an extremely rare subtype of cutaneous T-cell lymphoma. A 14-year-old boy had suffered from progressive infiltrative erythema and plaques that gradually evolved into lax masses and pendulous skin on his axilla, anterior wall of the abdomen, bilateral inguinal region, and thighs. Histopathologic examination of the skin lesion and inguinal lymph node demonstrated granulomatous infiltration with multinucleated giant cells.