Leukemia Burden Impacts the Efficacy and Toxicity of Blinatumomab in Pediatric B-Cell Acute Lymphoblastic Leukemia.

Background: Blinatumomab has been approved for the treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to investigate the association between leukemia burden and the efficacy of blinatumomab in real-world applications.

Methods: A real-world study was conducted by enrolling patients aged 0-18 years who were diagnosed with CD19-positive B-ALL and treated with blinatumomab between January 2021 and May 2023 from 14 centers in China.

Interfacial engineering of poly (lactic acid) composite films using esterified cellulose nanocrystals/curcumin hybrid nanofiller for improved mechanical and antibacterial performance.

Polylactic acid (PLA), as a biodegradable material, is considered an ideal alternative to petroleum-based plastics. The intrinsic mechanical fragility and lack of multifunctional characteristics significantly constrain its practical utilization in advanced applications. This study designed and prepared a ternary PLA composite material with uniform surface and enhanced functionality by uniformly dispersing esterified CNC (ECNC) Curcumin (Cur) hybrid nanostructures in the polymer matrix.

Companionship and Sharing Create Social Connections of an Online Community-Based Intervention for Patients with Cancer Receiving Outpatient Care: Pilot Study.

Background: Online communities, platforms that facilitate social connections, have gained attention in the medical field, particularly for their potential to support patients. However, there is currently no online community specifically designed for patients with cancer receiving outpatient care. This study introduces a customized online community aimed at providing companionship and sharing to enhance the quality of life (QOL) among these patients.

Influence of multiple long-term conditions on outcome after thrombolysis for acute ischemic stroke: secondary analysis of the ENCHANTED trial.

Background: The influence of multiple long-term conditions on the outcomes from acute ischemic stroke (AIS) are not well defined. This study aimed to determine the association of multiple long-term conditions in participants of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).

Methods: ENCHANTED was an international, multicenter, 2 x 2 quasi-factorial, open, randomised controlled, blinded endpoint assessed, trial that assessed the effectiveness and safety of intensive blood pressure lowering and low-dose thrombolysis against standard of care in adults with AIS.

nut peptides regulate lipid-II inhibitors in high-fat diet-fed mice.

Plant-derived bioactive peptides have drawn increasing attention in the field of nutrition and food science due to their biological activities, low cost, safety, and ease of industrial production. Functional peptides from are being investigated due to their potential as dietary supplements. This study focuses on nut peptides that regulate LIPID-II inhibitor in mice fed a high-fat diet.

Current status of transcriptome sequencing technology in ruminants.

In many parts of the world, safe ruminant production underpins food security, while ruminant meat and milk are important agricultural commodities and a major source of protein requirements in the human diet. In order to maintain the sustainability of such agricultural products, animal production should be made more efficient through better management and production techniques. Ruminating animals such as cows and sheep have been used for the synthesis of dairy products, the production of high-quality meat, and the study of reproductive mechanisms.

Effects of blood pressure lowering in relation to time in acute intracerebral haemorrhage: a pooled analysis of the four INTERACT trials.

Background: Uncertainty remains about the effects of intensive blood pressure (BP) lowering in acute intracerebral haemorrhage, particularly the impact of treatment timing. This study aimed to assess the safety and effectiveness of early intensive BP-lowering treatment and its dependence on timing in patients with intracerebral haemorrhage.

Methods: We undertook an individual patient-data pooled analysis of the four Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials: INTERACT1 (n=404), INTERACT2 (n=2829), INTERACT3 (n=7036), and INTERACT4 (n=1043).

Investigation on the printability of integrated with hydrocolloids as edible inks for extrusion-based 3D printing.

() is a nutrient-dense nut containing multifarious beneficial components. However, the limited processing methods of restrict its consumption diversification. 3D food printing is an advanced food processing method to realize customizable food products with improved taste and flavor, yet its research in is rarely studied.

Clinical effect of ePRO-based symptom monitoring and management on improving survival outcomes in patients with advanced cancer: a single-centre, prospective, randomised controlled trial protocol.

Introduction: Symptom management is crucial in cancer care, yet patient symptoms are often overlooked in routine care. There is some evidence that electronic symptom monitoring and management can improve patients' physical function, symptom control, quality of life and survival outcomes. However, the evidence of the impact on survival outcomes in patients with advanced cancer is still limited and debated.

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung-Associated Enterocolitis.

Hirschsprung-associated enterocolitis (HAEC) is the most common and severe complication in patients with Hirschsprung's disease (HSCR) and is characterized by high morbidity, frequent recurrence and substantial mortality. The formation of macrophage extracellular traps (METs), a novel inflammatory mode of cell death, plays a significant role in the progression of various inflammatory diseases. However, the mechanisms underlying METs formation and their role in the progression of HAEC remain unclear.

Integrated transcriptome and metabolome analyses reveal regulation mechanism of biomass and non‑structural carbohydrate allocation in Oliv. under shade.

Unlabelled: The adaptability of Oliv. to shade in the forest is a crucial intrinsic driving force for its natural renewal. Elucidating the influence of shade on biomass and non-structural carbohydrate (NSC) accumulation and allocation in leaf, stem and root will help to understand the endangerment mechanism of Results showed that invested more biomass in leaf than in stem and root under shade.

Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial.

Background: The universally accepted best practice protocol for monitoring patients who receive intravenous thrombolysis for acute ischaemic stroke was established in the 1990s. However, the protocol is burdensome for nurses, disrupts the sleep of patients, and is potentially less relevant in patients at low risk of symptomatic intracerebral haemorrhage. We aimed to assess whether implementing a low-intensity monitoring protocol would be as safe and effective as standard high-intensity monitoring for patients with acute ischaemic stroke at low risk.

Durable remission achieved in pediatric patients with -positive relapsed / refractory B-cell acute lymphoblastic leukemia by dual CD19 and CD22-targeted chimeric antigen receptor T-cell therapy.

Not available.

Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique.

The development of small-diameter vascular grafts has been a global endeavor, with numerous research groups contributing to this field. Animal experimentation plays a pivotal role in assessing the efficacy and safety of vascular grafts, particularly in the absence of clinical applications. Compared to alternative animal models, the mouse implantation model offers several advantages, including a well-defined genetic background, a mature method for disease model construction, and a straightforward surgical procedure.

Surface Work Function-Induced High-Entropy Solid Electrolyte Interphase Formation for Highly Stable Potassium Metal Anodes.

The failure of the solid electrolyte interphase (SEI) layer is a key issue limiting the practical application of potassium metal batteries. Herein, a novel high-entropy SEI layer rich in inorganic components is designed and constructed via in situ electrochemical conversion of the SnO/SnS interfacial layer on a porous scaffold. Theoretical studies and experimental techniques reveal that the SnO/SnS heterostructure, with its low work function and weak Sn─O/S bond, significantly enhances reactivity with the electrolyte, thereby facilitating the in situ formation of the high-entropy SEI layer.

Relationships Between Insomnia and Quality of Life in Patients With Advanced Liver Cancer: A Secondary Analysis of a Multicenter Cross-Sectional Study.

Background: This study aims to evaluate the symptom burden of advanced liver cancer, explore factors related to quality of life (QoL), and investigate the relationship between insomnia and QoL.

Methods: This is a secondary analysis of a multicenter cross-sectional study that included data from patients with advanced liver cancer (n = 364) recruited from 10 cancer centers across China. Participants were required to complete Patient Health Questionnaire-9 (PHQ-9), MD Anderson Symptom Inventory (MDASI), Insomnia Severity Index (ISI), 5-level EQ-5D (EQ-5D-5L).

Interaction of brain imaging features and effects of intensive blood pressure lowering after endovascular treatment for acute ischaemic stroke: the pre-specified secondary analyses of ENCHANTED2/MT trial.

Background: The second Enhanced Control of Hypertension and Thrombectomy Stroke Study (ENCHANTED2/MT) was terminated early when the intensive blood pressure lowering to a systolic level of 120 mm Hg or lower, compared to 140-180 mm Hg, was harmful in patients who received successful endovascular therapy for acute ischaemic stroke due to large-vessel occlusion. We aimed to determine the interaction of key brain imaging features and the effect of treatment on clinical outcomes.

Methods: ENCHANTED2/MT was a prospective, randomised, open-label, blinded-endpoint, controlled trial that aimed to assess the effectiveness of different intensities of blood pressure control on the functional independence in patients who had received successful endovascular therapy for acute ischaemic stroke from large-vessel occlusion at 44 hospitals in China between July 20, 2020 and March 7, 2022.

Improved Aerial Surface Floating Object Detection and Classification Recognition Algorithm Based on YOLOv8n.

The water surface environment is highly complex, and floating objects in aerial images often occupy a minimal proportion, leading to significantly reduced feature representation. These challenges pose substantial difficulties for current research on the detection and classification of water surface floating objects. To address the aforementioned challenges, we proposed an improved YOLOv8-HSH algorithm based on YOLOv8n.

GREM1 deficiency induced bone marrow adipose niche promotes B-cell acute lymphoblastic leukemia disease progression.

Relapse and disease progression are the primary causes of treatment failure and subsequent mortality in children with B-cell acute lymphocytic leukemia (B-ALL). At diagnosis and during treatment, dyslipidemia and the bone marrow adipose microenvironment are commonly observed in pediatric leukemia. However, the intricate connection between these factors and disease progression remains largely unexplored.

A New Algorithm for Visual Navigation in Unmanned Aerial Vehicle Water Surface Inspection.

Water surface inspection is a crucial instrument for safeguarding the aquatic environment. UAVs enhance the efficiency of water area inspections due to their high mobility and extensive coverage. This paper introduces two UAV inspection methodologies for the characteristics of rivers and lakes, along with an efficient semantic segmentation algorithm, WaterSegLite (Water Segmentation Lightweight algorithm), for UAV visual navigation.

Factorial design study of self-management using Dnurse App in T2DM patients.

Background: With the popularity of smart phones and the development of information technology, more and more patients are adopting diabetes APPs for self-management. However, at present, there are few research reports on the effect of those APPs coming from China.

Objective: The purpose of this study was to evaluate the effectiveness and applicability of an APP for blood glucose control that is widely popular among Chinese patients with type 2 diabetes mellitus (T2DM).

Effects of Intensive Blood Pressure Lowering on Brain Swelling in Thrombolyzed Acute Ischemic Stroke: The ENCHANTED Results.

Background: Cerebral swelling in relation to cytotoxic edema is a predictor of poor outcome in acute ischemic stroke (AIS) and elevated blood pressure (BP) promotes its development. Whether intensive BP-lowering treatment reduces cerebral swelling is uncertain. We aimed to determine whether intensive BP lowering reduces the severity of cerebral swelling after thrombolysis for AIS.