Genetic origins and climate-induced erosion in economically important Asian walnuts.

The global climate is undergoing unprecedented changes, posing significant threats to species persistence. However, the spatiotemporal impacts on genetic diversity remain poorly understood, hindering species conservation and management. Walnuts, generally referred to as Juglans regia and J.

Unveiling postpartum PTSD: predicting risk factors using decision trees and logistic regression in Chinese women.

Background: While traditional logistic regression emphasizes main effects with limited capacity for interaction detection, emerging decision trees excel in uncovering complex associations. However, no studies have yet integrated both approaches to investigate postpartum posttraumatic stress disorder (PP-PTSD). This study aims to explore the factors associated with postpartum posttraumatic stress disorder (PP-PTSD) in Chinese women using decision tree and logistic regression models, while also comparing the predictive performance of both approaches.

Nonpharmacological interventions for childbirth-related post-traumatic stress disorder and accompanying symptoms: A network meta-analysis of randomized controlled trials.

Background: Childbirth-related post-traumatic stress disorder (CB-PTSD) often coexists with depression and anxiety, but there's a lack of tailored, comparative non-pharmacological treatments.

Objective: This study investigated the efficacy of non-pharmacological interventions in the prevention and alleviation of symptoms associated with CB-PTSD and its accompanying symptoms.

Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, the Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang, and China Biology Medicine, up to September 2024.

Intra-layer Na and inter-layer K doping synergistically enhance photocatalytic activity of g-CN.

Graphitic carbon nitride (g-CN) has garnered significant interest in photocatalytic technology for addressing energy crisis and environmental pollution, owing to its remarkable structural stability and photocatalytic properties. Nevertheless, the photocatalytic performance of g-CN is limited by its low efficiency in carrier separation. This study synthesizes Na and K co-doped g-CN hollow spheres (NaK-CN) with an ultra-thin shell through high-temperature calcination, substantially improving its photocatalytic activity in hydrogen production from water splitting.

Effects of mindfulness-based interventions on mental health among women with fetal loss: A systematic review and meta-analysis.

Background: Mindfulness-based interventions (MBIs) have shown potential in reducing maternal negative emotions, but their effectiveness for women with fetal loss requires further investigation. This study aimed to evaluate the effects of MBIs on mental health outcomes among these women.

Methods: Randomized controlled trials (RCTs) on MBIs for women with fetal loss were retrieved from eight databases, covering literature from inception to .

Tissue-resident microbiota signature in nasopharyngeal carcinoma.

Background: Emerging evidence reveals that microbiota plays a crucial role in multiple cancers. Nasopharyngeal carcinoma (NPC) tissues harbour microbiota, highlighting the need to investigate the clinical implications of tissue-resident microbiota in the development of NPC. Here, we aim to clarify the specific profile of tissue-resident microbiota and its influence on NPC outcomes.

Chinese postpartum mothers' perspectives about the usage of donor milk and human milk banks: A qualitative study.

Introduction: Human milk banks (HMBs) were established to provide safe human milk for infants in need. However, the number and volume of donors are insufficient in China. This study aimed to explore Chinese postpartum mothers perspectives on the use of donor milk and the implementation of HMBs.

Cu doping induced asymmetric Cu-Vs-In active sites in InS for efficient photocatalytic CH conversion from CO.

Selective reduction of CO to value-added C-chemical fuels, (such as CH) holds great promise for directly converting solar energy into chemical energy. However, the weak adsorption of CO on photocatalysts directly affects its conversion efficiency. Here we use Cu doping to create asymmetric Cu-S-vacancies-In (Cu-V-In) sites in the two-dimensional InS, which greatly improves CO adsorption, achieving efficient photocatalytic reduction of CO to CH.

Exploring the therapeutic potential of simvastatin in pancreatic neuroendocrine neoplasms: insights into cell cycle regulation and apoptosis.

Background: Pancreatic neuroendocrine neoplasm (pNEN) poses significant challenges in clinical management due to their heterogeneity and limited treatment options. In this study, we investigated the potential of simvastatin (SIM) as an anti-tumor agent in pNEN.

Methods: We conducted cell culture experiments using QGP-1 and BON-1 cell lines and assessed cell viability, proliferation, migration, and invasion following SIM treatment.

Effectiveness and safety of brucea javanica oil assisted TACE TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials.

The effectiveness and safety of using Brucea javanica oil (BJO) in combination with Transarterial Chemoembolization (TACE) for liver cancer treatment are subjects of debate. This study aims to assess the comparative effectiveness and safety of BJO-assisted TACE TACE alone and quantifies the differences between these two treatment methods. A systematic search was conducted in multiple databases including PubMed, Cochrane, CNKI, and Wanfang, until 1 July 2023.

LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein.

Gemcitabine (GEM) based induction chemotherapy is a standard treatment for locoregionally advanced nasopharyngeal carcinoma (NPC). However, approximately 15 % of patients are still resistant to GEM-containing chemotherapy, which leads to treatment failure. Nevertheless, the underlying mechanisms of GEM resistance remain poorly understood.

T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin.

T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB designed to target mesothelin (MSLN), a glycosylphosphatidylinositol (GPI)-linked glycoprotein highly expressed in various cancers, and evaluated its efficacy against solid tumors. CDR walking and phage display techniques were used to improve affinity of the parental antibody M912, resulting in a pool of antibodies with different affinities to MSLN.

Correction: Zhao et al. Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN). 2020, , 559.

In the original publication [...

The regulation of microRNAs on chemoresistance in triple-negative breast cancer: a recent update.

Triple-negative breast cancer (TNBC) has negative expressions of ER, PR and HER2. Due to the insensitivity to both endocrine therapy and HER2-targeted therapy, the main treatment method for TNBC is cytotoxic chemotherapy. However, the curative effect of chemotherapy is limited because of the existence of acquired or intrinsic multidrug resistance.

Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis.

Objective: To explore the protective effect and the underlying mechanism of silibinin (SIB), one of the active compounds from Silybum marianum (L.) Gaertn in endotoxemia.

Methods: Mouse peritoneal macrophage were isolated via intraperitoneally injection of BALB/c mice with thioglycolate medium.

Transcription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma.

Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients' survival and became the first-line treatment for advanced nasopharyngeal carcinoma (NPC), not all patients could benefit from this therapy. The mechanism underlying the TPF chemoresistance remains unclear. Here, by analyzing gene-expression microarray data and survival of patients who received TPF chemotherapy, we identify transcription factor ATMIN as a chemoresistance gene in response to TPF chemotherapy in NPC.

Galactagogue Food Consumption, Perception of Insufficient Milk Supply, and Exclusive Breastfeeding in Chinese Postpartum Women: An Analysis of Repeated Measures.

Introduction: Little research has explored galactagogue food consumption in China. This study aims to investigate consumption patterns and how they relate to perceived insufficient milk supply and exclusive breastfeeding.

Methods: Data were collected from postpartum women in China at six time points: baseline demographic questionnaire before hospital discharge (T0), galactagogue food questionnaire at 1 month postpartum (T1), Hill and Humenick Lactation Scale at 6 weeks postpartum (T2), and breastfeeding practices at 1, 2, 3 and 4 months postpartum (T1, T3, T4, T5).

The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment.

Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear. Here, using single-cell RNA sequencing and T cell and B cell receptor sequencing of matched, treatment-naive and post-GP chemotherapy NPC samples (n = 15 pairs), we show that GP chemotherapy activated an innate-like B cell (ILB)-dominant antitumor immune response.

Synthesis and antitumor activity of some cholesterol-based selenocyanate compounds.

The introduction of selenium-containing functional groups into steroids to study the biological activities of related derivatives is rarely reported in the literature. In the present study, using cholesterol as raw material, four cholesterol-3-selenocyanoates and eight B-norcholesterol selenocyanate derivatives were synthesized, respectively. The structures of the compounds were characterized by NMR and MS.

TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models.

Although radiotherapy can promote antitumour immunity, the mechanisms underlying this phenomenon remain unclear. Here, we demonstrate that the expression of the E3 ubiquitin ligase, tumour cell-intrinsic tripartite motif-containing 21 (TRIM21) in tumours, is inversely associated with the response to radiation and CD8 T cell-mediated antitumour immunity in nasopharyngeal carcinoma (NPC). Knockout of TRIM21 modulates the cGAS/STING cytosolic DNA sensing pathway, potentiates the antigen-presenting capacity of NPC cells, and activates cytotoxic T cell-mediated antitumour immunity in response to radiation.

Chemotherapy-Induced Senescence Reprogramming Promotes Nasopharyngeal Carcinoma Metastasis by circRNA-Mediated PKR Activation.

Senescence is associated with tumor metastasis and chemotherapy resistance, yet the mechanisms remain elusive. Here, it is identified that nasopharyngeal carcinoma (NPC) patients who developed distant metastasis are characterized by senescence phenotypes, in which circWDR37 is a key regulator. CircWDR37 deficiency limits cisplatin or gemcitabine-induced senescent NPC cells from proliferation, migration, and invasion.

Breastfeeding Practices of Women Returning to Full-Time Employment in China: Prevalence and Determinants.

Background: Returning to work after childbirth is a common reason for women to stop breastfeeding. This study aimed to assess breastfeeding practices and breastfeeding support available to employed women in China, and factors affecting breastfeeding duration.

Methods: A cross-sectional survey of 1,243 breastfeeding women employed full-time was conducted.