The ameliorative effect of hyaluronic acid-astaxanthin nanoparticles on colitis through reducing oxidative stress, enhancing colon barrier, and reshaping intestinal microbiota.

Astaxanthin (AST) is recognize as the most potent antioxidant found in nature; however, its practical applications have been limited due to its structural instability. In this study, hyaluronic acid (HA) was used to stabilize AST, and they were both covalently linked via ethylenediamine to synthesis the hyaluronic acid-astaxanthin complex, which was subsequently formulated into hyaluronic acid-astaxanthin nanoparticles (HA-ASTNPs) in PBS. HA-ASTNPs was spherical with a particle size of 172.

Efficacy of traditional Chinese medicine nursing in stroke: a systematic review and meta-analysis.

Objective: Some clinical studies have suggested that traditional Chinese medicine (TCM) nursing techniques may promote better recovery in stroke patients compared to conventional neurological nursing. However, high-quality evidence-based research is still lacking. This study selected two outcome indicators-motor function and activities of daily living (ADL)-to systematically evaluate the efficacy of TCM nursing techniques in the rehabilitation of stroke patients.

The burden and trend prediction of atrial fibrillation and flutter associated with lead exposure: insights from the global burden of disease study 2021.

Background: Atrial fibrillation and flutter (AF/AFL) are increasingly recognized as major contributors to global cardiovascular morbidity and mortality. Emerging evidence implicates environmental lead exposure as a modifiable risk factor for AF/AFL, yet the global burden and trends of AF/AFL attributable to lead exposure remain poorly characterized.

Methods: We used data from the Global Burden of Disease Study 2021 to estimate mortality, disability-adjusted life years (DALYs), and temporal trends in AF/AFL attributable to lead exposure from 1990 to 2021, with projections to 2030.

Colloidal Nanoparticle Metasurfaces: Principles, Fabrication, and Applications.

Metasurfaces, a class of two-dimensional metamaterials, exhibit notable optical properties, making them attractive candidates for applications in fields such as the cloaking, biophotonics, and imaging. The realization of these applications is dependent on advancements in fabrication techniques. Conventional "top-down" lithography often faces limitations, such as polycrystallinity and surface roughness.

Predictive modeling of antioxidant synergies in fruits and vegetables: A multi-objective optimization approach for functional food design.

Complex interactions among phytochemicals in fruits and vegetables underpin their antioxidant benefits. Here, we introduce a multi-objective optimization framework to predict optimal functional-food combinations. Twelve key phytochemicals were evaluated at nine ratios using DPPH and ABTS assays, revealing ratio-dependent synergy or antagonism (e.

Giant Panda Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promote Dermal Fibroblast Proliferation and Wound Healing.

Umbilical cord mesenchymal stem cell-derived exosomes (UC-MSC-Exos) represent a potential therapeutic solution for captive giant pandas. The aim of this study was elucidating the proteomic and microRNA (miRNA) profiles and discerning their functional roles constitutes an essential step towards comprehending their therapeutic mechanisms and optimizing their application in giant pandas. UC-MSC-Exos, isolated from the culture supernatant of giant panda umbilical cord mesenchymal stem cells (UC-MSCs) using classic ultracentrifugation, were characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blotting (WB).

Global Pediatric Epilepsy Burden: Analysis of the Global Burden of Disease Database (1990-2021) With Projections to 2035.

Background: To examine the trends in epilepsy prevalence, incidence, mortality, and disability-adjusted life years (DALYs) among children aged 0-14 years from 1990 to 2021, and projected the epidemiological patterns for the next decade to 2035.

Methods: Employing standardized Global Burden of Disease approaches, our study evaluated the burden of pediatric epilepsy in 204 countries and regions from 1990 to 2021. Our objective was to provide a comprehensive assessment of the health impact of pediatric epilepsy by incorporating four critical epidemiological indicators-prevalence, incidence, mortality, and DALYs-including their trends and projecting them for the next decade.

Poly (ADP-Ribose) Glycohydrolase-Dependent dePARylation of PCNA Is Essential for DNA Replication.

Poly (ADP-ribosyl)ation (PARylation) plays a crucial role in DNA replication, particularly during S phase, where it is detected at replication sites on the lagging strand to facilitate Okazaki fragment processing. However, the role of dePARylation in DNA replication remains elusive. In this study, we demonstrate that poly (ADP-ribose) glycohydrolase (PARG) is actively involved in degrading poly (ADP-ribose) at DNA replication sites during S phase.

A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression.

Lung adenocarcinoma (LUAD), the most predominant subtype of lung cancer, is a leading cause of cancer-related death worldwide. However, its underlying molecular mechanisms remain poorly understood. In this study, we identified that SERPINH1, a member of the serine protease inhibitor (serpin) superfamily, is upregulated in LUAD tissues and cells.

Early nursing interventions for neurogenic bowel dysfunction in acute-phase spinal cord injury patients: A non-concurrent controlled trial.

Background: Traumatic spinal cord injury (SCI) often leads to neurogenic bowel dysfunction (NBD), causing significant gastrointestinal issues that adversely affect patients' quality of life (QoL). The current study evaluates the effectiveness of early nursing interventions in managing NBD among SCI patients.

Methods: A non-concurrent controlled trial design included 125 participants with acute-phase SCI.

RNA-Binding Protein Rbm38 as a Multifaceted Post-Transcriptional Regulator in Zebrafish Pancreatic Development.

RNA-binding motif protein 38 (Rbm38), also known as RNPC1, is a major regulator of post-transcriptional gene expression. It represents a potential candidate gene linked to the susceptibility of type 2 diabetes, and decreased RBM38 expression can enhance the proliferation of pancreatic cancer cells in humans. However, its role in pancreatic development remains elusive.

From Soil to Table: A Comprehensive Review of Selenium-Fortified Foods.

Selenium, an essential trace element with a narrow nutritional window, plays critical roles in human health primarily through selenoproteins. Its dual nature, being vital yet potentially toxic, underscores the importance of precise intake. Geographical disparities in soil Se content lead to widespread dietary deficiencies, driving the advancement of Se-fortified foods.

PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules.

Stress granules (SGs) are cytoplasmic, membraneless organelles that modulate mRNA metabolism and cellular adaptation under stress, yet the mechanisms by which they regulate cancer cell survival remain unclear. Here, we identify Poly(A)-Binding Protein Cytoplasmic 1 (PABPC1), a core SG component, as stress-inducible SUMOylation target. Upon various stress conditions, SUMOylated PABPC1 promotes SG assembly and enhances cancer cell survival.

Optimization of aquaculture wastewater treatment systems: based on the isolation of the strain Acinetobacter sp. LF10.

A highly efficient denitrifying bacterial strain (Acinetobacter sp. LF10) was isolated in this study, strain LF10 efficiently removed ammonium (98.02 ± 0.

Tumour budding in gastric and colorectal cancers: A review.

Tumour budding (TB), characterized by the presence of individual or small clusters of tumor cells at the infiltrative margins of malignant tumors, represents a critical aspect of tumor metastasis and progression. This review synthesizes current research on TB in gastric and colorectal cancers, focusing on its occurrence, biological characteristics, and clinical significance. We discuss the methodologies used for observing and grading TB, its association with the aggressiveness of digestive tract tumors, and the underlying molecular mechanisms, particularly epithelial-mesenchymal transition.

Antithrombotic therapy for lower limb peripheral arterial disease: A deep dive into guideline quality and recommendation diversity.

Background: This study systematically evaluates clinical practice guidelines (CPGs) addressing antithrombotic management in lower limb peripheral arterial disease (PAD), aiming to synthesize evidence-based insights for clinical decision-making.

Methods: We systematically identified CPGs published between January 2020 and January 2025 from electronic databases, guideline repositories, and professional association websites. Guideline quality and recommendation validity were assessed using the Appraisal of Guidelines for Research & Evaluation II (AGREE II) and the Appraisal of Guidelines for Research and Evaluation-Recommendation Excellence (AGREE-REX), respectively.

Hypoxia-Activated and Light-Amplified Paclitaxel Release for Potentiated Photodynamic and Chemotherapy.

Iridium(III) complexes exhibit strong phosphorescence, tunable emission, and spatiotemporally controlled light-activation properties, making them ideal candidates for photodynamic therapy (PDT). Herein, self-amplified nanoparticles combining polycarbonate-iridium(III) conjugates (PC-Ir) and hypoxia-responsive paclitaxel prodrugs (PTX-Azo) were engineered. Upon 660 nm laser irradiation, PC-Ir generates substantial reactive oxygen species (ROS) via both type I and type II photodynamic pathways.

The peripheral tumor neuro-microenvironment: Deciphering neural landscape and mechanistic insights for therapeutic innovation.

As the nascent field of cancer neuroscience experiences explosive growth, the critical importance of the peripheral nervous system (PNS) in the onset, progression, and therapeutic approaches of cancer has garnered considerable attention from researchers in recent years. The neural-tumor interactions mediated by PNS components in the tumor microenvironment (TME) constitute the neural landscape of peripheral cancers, where neural activity regulates metastatic competence through structural innervation networks, neurochemical signaling cascades, and immune microenvironment remodeling. Within the TME, the synergistic interplay among cancer cells, neurons, and schwann cells establishes a dynamic neural ecological niche that orchestrates both oncogenic expansion and aberrant neural reorganization.

Development and Validation of the CHD-PEBBS: A Scale to Assess Perceived Exercise Benefits and Barriers in Coronary Heart Disease Patients.

Background: The level of perceived exercise benefits and barriers is one of the key influencing factors of cardiac exercise rehabilitation (CER). There is a lack of validated tools to assess coronary heart disease (CHD) patients' exercise perception.

Purpose: The aim of this study is to develop a scale assessing CHD patients' perceived exercise benefits and barriers (CHD-PEBBS) and test its reliability and validity.

Lymph node metastasis in patients with hepatocellular carcinoma using machine learning: a population-based study.

Aim: This study aims to develo\p a population-adapted machine learning-based prediction model for hepatocellular carcinoma (HCC) lymph node metastasis (LNM) to identify high-risk patients requiring intensive surveillance.

Methods: Data from 23511 HCC patients in the SEER database and 57 patients from our hospital were analyzed. Seven LNM risk indicators were selected.

N/S co-doping engineered flattened hollow carbon anode for high-performance sodium ion batteries.

Structurally-engineered hollow carbon nanomaterials have emerged as frontier materials for advanced energy storage technologies, because of their inherent architectural merits, including expansive specific surface area and interconnected porosity, which enable efficient sodium ion storage mechanisms. Hollow carbon shells with flattened circular shapes were prepared using FeO as templates. By precisely tuning the N/S doping ratios, the electronic structure and surface properties of hollow carbon nanomaterials can be effectively modified.

Identification of a missense variant (c.877G>T) disrupting canonical splicing and contributing to female infertility.

Background: deficiency is a significant cause of female infertility. Although multiple missense variants have been reported in prior studies, a number of these variants remain classified as variants of uncertain significance (VUS).

Methods: We present a patient of primary infertility characterized by oocyte maturation disorders and fertilization failure.

C4-HSL drives rapid biofilm formation in low-temperature aquaculture effluent: strengthening structural stability of biofilm and improving nitrogen removal efficiency.

During the centralized discharge of winter aquaculture wastewater, low temperature (≤15 °C) and low C/N ratio (≤5) result in delayed initiation of the biofilm process and decreased nitrogen removal efficiency.The quorum sensing (QS) communication system serves as the core mechanism regulating biofilm formation. This study examined how adding N-butyyl-L-homo-serine lactone (C4-HSL) affects the start-up and nitrogen removal in sequential batch biofilm reactors (SBBR) operated at 14 °C with a C/N ≤ 5.

GrSrNMF: dynamic community detection with graph and symmetry bi-regularized non-negative matrix factorization.

Community detection in dynamic networks has become an interesting and popular research direction in recent years, widely used in electronic commerce, social media, and other fields. Evolutionary clustering is a classical and effective framework for dynamic community detection. Most current evolutionary clustering frameworks do not directly model the evolutionary pattern of dynamic networks, but only discover their change points.