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Community detection in dynamic networks has become an interesting and popular research direction in recent years, widely used in electronic commerce, social media, and other fields. Evolutionary clustering is a classical and effective framework for dynamic community detection. Most current evolutionary clustering frameworks do not directly model the evolutionary pattern of dynamic networks, but only discover their change points. Therefore, some researchers introduce graph-regularization to generalize the evolutionary clustering. However, the corresponding problem is that the effect of graph regularization depends too much on the quality of dynamic networks. If the dynamic networks have too much noise or their structural organization is not obvious, the graph-regularization may not improve the model effect, and it may lead to the problem of being too smooth. Consequently, the depiction of distinct node characteristics is too uniform and challenging to discern. To solve this problem, a dynamic community detection framework based on Graph and Symmetry Bi-regularized Non-negative Matrix Factorization (GrSrNMF) is proposed. GrSrNMF can successfully identify community structures and appropriately address variations in the number of communities within network snapshots. This is particularly crucial in dynamic networks. analysis, as the number and structure of communities can vary over time. GrSrNMF can not only learn the symmetric structure of an undirected network well but also can capture the local structure of the graph. It improves the over-smoothing problem caused by graph-regularization, to mine the evolution pattern of dynamic networks and explore their temporal changes. Our proposed GrSrNMF outperforms some state-of-the-art models, like those based on evolutionary clustering and graph regularization, as well as sophisticated methods in exploring community detection in dynamic networks, utilizing two synthetic networks and two real networks.
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http://dx.doi.org/10.1038/s41598-025-09996-8 | DOI Listing |
Neurotrauma Rep
August 2025
Department of Radiology, Weill Cornell Medicine; New York, New York, USA.
Traumatic brain injury (TBI) impairs attention and executive function, often through disrupted coordination between cognitive and autonomic systems. While electroencephalography (EEG) and pupillometry are widely used to assess neural and autonomic responses independently, little is known about how these systems interact in TBI. Understanding their coordination is essential to identify compensatory mechanisms that may support attention under conditions of neural inefficiency.
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August 2025
Baptist Medical Center, Department of Behavioral Health, Jacksonville, FL, United States.
Introduction: This study investigates four subdomains of executive functioning-initiation, cognitive inhibition, mental shifting, and working memory-using task-based functional magnetic resonance imaging (fMRI) data and graph analysis.
Methods: We used healthy adults' functional magnetic resonance imaging (fMRI) data to construct brain connectomes and network graphs for each task and analyzed global and node-level graph metrics.
Results: The bilateral precuneus and right medial prefrontal cortex emerged as pivotal hubs and influencers, emphasizing their crucial regulatory role in all four subdomains of executive function.
J Biomed Opt
September 2025
Fraunhofer Institute for Microelectronic Circuits and Systems IMS, Duisburg, Germany.
Significance: The spatial and temporal distribution of fluorophore fractions in biological and environmental systems contains valuable information about the interactions and dynamics of these systems. To access this information, fluorophore fractions are commonly determined by means of their fluorescence emission spectrum (ES) or lifetime (LT). Combining both dimensions in temporal-spectral multiplexed data enables more accurate fraction determination while requiring advanced and fast analysis methods to handle the increased data complexity and size.
View Article and Find Full Text PDFChem Sci
August 2025
Engineering Research Center of Cell & Therapeutic Antibody (MOE), School of Pharmacy, Shanghai Jiao Tong University Shanghai 200240 China
Predicting Antibody-Antigen (Ab-Ag) docking and structure-based design represent significant long-term and therapeutically important challenges in computational biology. We present SAGERank, a general, configurable deep learning framework for antibody design using Graph Sample and Aggregate Networks. SAGERank successfully predicted the majority of epitopes in a cancer target dataset.
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September 2025
Institute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University Nanning Guangxi 530004 China
As a cutting-edge super-resolution imaging technique, structured illumination microscopy (SIM) has been widely used in cell biology research, especially in the analysis of subcellular organelles and monitoring of their dynamic processes. Through multiple illumination and reconstruction processes, SIM breaks through the resolution limitations of traditional microscopes and can observe the fine structures within cells in real time with nanoscale resolution. This provides strong technical support for in-depth analyses of molecular mechanisms, organelle functions, signaling networks, and metabolic regulatory pathways within cells.
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