The burden and trend prediction of atrial fibrillation and flutter associated with lead exposure: insights from the global burden of disease study 2021.

Background: Atrial fibrillation and flutter (AF/AFL) are increasingly recognized as major contributors to global cardiovascular morbidity and mortality. Emerging evidence implicates environmental lead exposure as a modifiable risk factor for AF/AFL, yet the global burden and trends of AF/AFL attributable to lead exposure remain poorly characterized.

Methods: We used data from the Global Burden of Disease Study 2021 to estimate mortality, disability-adjusted life years (DALYs), and temporal trends in AF/AFL attributable to lead exposure from 1990 to 2021, with projections to 2030.

Time trends in mortality of congenital heart disease in children aged 0-14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease study.

Introduction: Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.

Methods: This study utilized the Global Burden of Disease (GBD) database to examine trends in CHD-related mortality among children aged 0-14 from 1990 to 2021.

Results: We report a 55.

Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990-2021): results from the global burden of disease study.

Introduction: Pediatric pulmonary arterial hypertension (PAH) is a rare and severe disorder characterized by obstructive vascular changes that can lead to right heart failure. The clinical presentation and underlying causes of pediatric PAH differ significantly from those in adults, often involving congenital heart disease and developmental lung disorders, such as bronchopulmonary dysplasia (BPD). Despite advances in treatment, pediatric PAH remains underrecognized globally.

Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.

Background: Congenital heart disease (CHD) is a leading cause of morbidity and mortality in children globally, with significant variations in outcomes across different regions.

Objective: To provide comprehensive estimates of CHD prevalence, mortality, and disability-adjusted life years (DALYs) among children under five years old globally from 1990 to 2021.

Methods: Using data from the Global Burden of Disease (GBD) study, trends in CHD prevalence, mortality, and DALYs were analyzed.

Corrigendum: Epidemiological analysis of turner syndrome in children aged 0-14 years: global, regional, and national perspectives (1990-2021).

[This corrects the article DOI: 10.3389/fendo.2025.

Epidemiological analysis of turner syndrome in children aged 0-14 years: global, regional, and national perspectives (1990-2021).

Background: Turner syndrome (TS), a chromosomal disorder (45, X) affecting approximately 1 in 2,000 female births, results in multisystem morbidity. This study aims to report global trends in the prevalence and disability-adjusted life years (DALYs) of childhood TS from 1990 to 2021.

Methods: This study analyzed the prevalence and DALYs of TS in children aged 0-14 years using data from the Global Burden of Disease (GBD) database.

Evaluating the global, regional, and national burden of congenital heart disease in infants younger than 1 year: a 1990-2021 systematic analysis for the GBD study 2021.

Background: Previous estimates of congenital heart disease (CHD) have been constrained by limited data sources, narrow geographic focus, and a lack of specific assessment of infants younger than 1 year. As part of the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2021, this research provides comprehensive estimates of mortality, prevalence, and disability attributable to CHD in infants under 1 year. The study encompasses data from 204 countries and territories, covering the period from 1990 to 2021.

Analysis of global trends in acute lymphoblastic leukemia in children aged 0-5 years from 1990 to 2021.

Background: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with a significant global burden. This study evaluates global, regional, and national trends in the prevalence, mortality, and disability-adjusted life years (DALYs) of childhood ALL from 1990 to 2021, providing insights into disparities and progress across different socio-demographic and geographic contexts.

Methods: Data were sourced from the Global Burden of Disease study.

Ghrelin Relieves Obesity-Induced Myocardial Injury by Regulating the Epigenetic Suppression of miR-196b Mediated by lncRNA HOTAIR.

Introduction: Obesity has been believed to be closely linked with many kinds of diseases including atherosclerosis, hypertension, cerebrovascular thrombosis, and diabetes. Ghrelin and Homeobox transcript antisense RNA (HOTAIR) were believed to be involved in the regulation of myocardial injury.

Methods: The obesity mice model was established through feeding mice (C57BL/6J, male, eight-week-old) with high-fat diet and palmitate (PA)-induced cardiomyocyte injury.

Anatase and Rutile TiO Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway.

Purpose: To evaluate the effects of anatase and rutile TiO nanoparticles (NPs) on the growth and development of bones in young rats and explore their possible mechanisms.

Methods: Three-week-old male rats were orally administered anatase TiO NPs and rutile TiO NPs for 28 days. The indicators of rat growth and development, liver function, bone metabolism, and insulin-like growth factor-1 (IGF-1) levels were evaluated.