Systemic Inflammatory Burden Causes Liver Injury in H1N1-Infected Mice.

Clinical evidence has associated H1N1 influenza with liver impairment, yet the underlying mechanisms remain poorly understood. Here, we investigated H1N1-induced liver damage and its potential mechanisms using a BALB/c mouse infection model. Pathological examination and serum aspartate transaminase (AST) and alanine transaminase (ALT) were assessed.

Diagnostic performance of "pons chocolate chip sign" in heterozygous HTRA1-related cerebral small vessel disease.

Background And Purpose: Heterozygous HTRA1-related cerebral small vessel disease (hHTRA1-CSVD) presents diagnostic challenges due to its clinical and imaging similarities with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and sporadic cerebral small vessel disease (CSVD). Recently, the "chocolate chip sign" around the midbrain has been proposed as a potential imaging marker for hHTRA1-CSVD. However, the diagnostic value of similar findings around the pons remains unclear.

Whole Genome Sequencing-Based Taxonomic Identification of Dulcitol-Positive Cronobacter dublinensis subsp. beijingensis subsp. nov. and Cronobacter dublinensis subsp. infanticibi subsp. nov. from Infant Cereals in China.

Cronobacter, a Gram-negative opportunistic pathogen, poses a significant risk to neonates. The taxonomic position of strains CFSA2021A14 and CFSA2021A84, isolated from cereal-based infant noodles in China, was investigated. Phenotypic and genotypic analyses identified both strains as novel subspecies of Cronobacter dublinensis, with dulcitol utilization attributed to the presence of the gatYZABCD gene cluster.

Upregulation of SQSTM1 Regulates Ferroptosis and Oxidative Stress in Müller Cells of the Diabetic Neural Retina by Modulating ACSL4.

Diabetic retinopathy (DR), a leading cause of vision impairment worldwide, is characterized by early neuronal damage in the retina, termed diabetic neuropathy in the retina (DNR). This condition is marked by neuronal apoptosis and glial activation. Müller glia are retinal cells highly susceptible to diabetic metabolic stress that may undergo ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation.

The efficacy of Chinese herbal medicine on anxiety and depression in patients with chronic prostatitis complicated by sexual dysfunction: a systematic review and meta-analysis protocol.

Background: Chronic Prostatitis (CP) is often accompanied by urinary symptoms such as dysuria and frequency, as well as sexual dysfunction including erectile dysfunction and reduced libido. Men with CP are at a significantly greater risk of developing anxiety and depression compared to healthy controls. Chinese Herbal Medicine (CHM) provides a holistic approach by simultaneously targeting inflammation, pelvic microcirculation, and neuropsychiatric pathways, which aligns with the multifactorial nature of CP.

Bifunctionalized core-shell structured FeO-Zr/Eu MOF achieves highly selective detection and rapid removal of gossypol.

Gossypol (Gsp) is a polyphenolic phytotoxin that can cause serious harm to human health and the environment. Therefore, it is necessary to develop a multifunctional sensing material that can efficiently detect and remove Gsp. Herein, a new strategy based on FeO coated with Zr/Eu metal-organic framework (MOF) is proposed for highly selective detection and rapid removal of Gsp.

Licochalcone D mitigates intracerebral hemorrhage-induced ferroptosis of neurons through COX2 inhibition.

Objective: This study aims to assess LCD's neuroprotective pharmacological effects against SBI post-ICH and identify its ferroptosis-inhibiting targets.

Methods: Animal models of ICH and cellular models of SBI were established. Subsequently, gradient concentrations of LCD were administered at both the animal and cellular/molecular levels.

Analysis of red blood cell lifespan and associated influencing factors in anemic dialysis patients.

Introduction: Renal anemia is one of the most common complications in dialysis patients. The shortened red blood cell (RBC) lifespan is an important mechanism of renal anemia. This study aims to investigate the RBC lifespan and its influencing factors in anemic dialysis patients.

Topography-guided subconjunctival oblique limbus incisions (SCOLI) in manual cataract surgery for astigmatism correction.

Purpose: To assess the safety and efficacy of two SCOLI designs (Yang's I/II) for astigmatism correction in manual cataract surgery and define incision size-astigmatism relationships.

Methods: A total of 72 eyes from 64 cataract patients who accept manual cataract extraction surgery via a SCOLI technique. The two different types of incision: Yang's I and II incisions were applied in this study.

Kynurenine monooxygenase : a key regulator of growth, pathogenicity, and disease control in .

Kynurenine monooxygenase, a vital rate-limiting enzyme in the kynurenine pathway metabolic branch, has shown promise as a drug target for treating human neurodegenerative diseases. However, the role of kynurenine monooxygenase in plant pathogens and its potential as a molecular target have received limited attention. In this study, we identified a novel kynurenine monooxygenase gene, , in .

The efficacy and safety of Yiqi Huoxue Huatan granule in the treatment of stable COPD with chronic respiratory failure: A randomized, double-blind, placebo controlled trial.

Ethnopharmacological Relevance: Yiqi Huoxue Huatan granule is an empirical traditional Chinese medicine formula that has been widely used for the treatment of respiratory diseases. However, whether Yiqi Huoxue Huatan granule has a therapeutic effect on patients with stable COPD complicated with chronic respiratory failure remain unclear.

Aim Of The Study: To evaluate the efficacy and safety of Yiqi Huoxue Huatan granule in treating this population.

Establishment of a novel alloxan-induced rabbit model exhibiting unique diabetic retinal neuropathy features assessed via ERG + VEP.

Background: Diabetic retinal neuropathy (DRN) leads to significant visual impairment; however, no existing animal model fully replicates its neural alterations, and inconsistent induction protocols with high mortality rates hinder long-term investigations.

Methods: Adult male rabbits were randomly assigned to four experimental groups, each receiving a single intravenous injection of varying doses of alloxan and one control group. The safety and efficacy of alloxan in inducing diabetes were evaluated to determine the optimal dose.

Effects of an environmental chemical mixture on early-stage embryo development: In vitro evidence from human embryonic stem cells.

Environmental chemicals are known risk factors for adverse pregnancy outcomes. However, the effects of environmentally relevant concentrations of chemical mixtures are less studied. This study investigated the effects of a mixture containing 23 chemicals reported in blood samples of Nunavik pregnant women, termed the Nunavik Chemical Mixture (NCM), on embryo development using human embryonic stem cells (hESCs).

Source attribution studies of foodborne pathogens, 2010-2023: a review and collection of estimates.

Identifying the most important sources and transmission routes of foodborne pathogens is crucial for developing food safety strategies at both national and regional levels. Various source attribution approaches and methods have been applied worldwide. This review aims to provide an overview of available studies that estimate the attribution of foodborne illnesses globally, regionally, and nationally, compiled by pathogen and region.

Chikungunya virus drives gut microbiota shifts and IFN-Mediated intestinal repair: insights into microbiota-immune interplay.

Chikungunya virus (CHIKV) infection causes joint damage and gastrointestinal clinical symptoms, including vomiting and diarrhea, particularly in elderly populations, reflecting the potential role of gut immunity in infection. However, the mechanisms by which CHIKV induces gastrointestinal diseases remain largely unexplored. This study investigated the characteristics of fecal and gut microbiota, gut metabolites, and gut immunity post-infection using multi-omics analysis.

Life-long impacts of nanoplastics to rice plant (Oryza sativa L.): Decreased grain yield with perturbed metallome and soil microbiome.

Approximately 367 million metric tons of plastic were produced globally in 2020, and it is projected that the global plastic waste will reach around 12,000 metric tons by 2050. Plastic waste can be fragmented into nanoplastics (NPs). Despite their widespread presence in the environment and even within the human body, the long-term risks of NPs to plants, animals, and humans remain poorly understood.

Molecularly imprinted polymer coated Eu-BCA MOF for highly selective detection of Zearalenone in corn oil.

Based on the strategy of rare-earth MOF coated with molecular imprinted polymer (MIP), a high-performance fluorescent colorimetric sensor was constructed for the detection of Zearalenone (Zen). Bisquinoline acid was selected as the organic ligand to construct the Eu-BCA MOF with europium nitrate, then the quinoline-N in the ligand of MOFs was used to participate in the construction of the SiO molecularly imprinted layer to form the Eu-BCA@SiO-MIP, which can respond quickly to trace Zen in the range of 0-1.56 × 10 mol L, and the detection limit is as low as 1.

Kynureninase from Botrytis cinerea regulates the growth, development, pathogenicity, and stress response of B. cinerea through the kynurenine pathway.

The kynurenine pathway was first identified in mammals. It is the main pathway for tryptophan catabolism, participates in many important biological processes, and is a target for the treatment of neurodegenerative diseases. However, this pathway and its function have not been reported in Botrytis cinerea.

Current-Carrying Wear Behavior of the Laser-Alloyed Al/W Composite Layer Under Different Currents.

The Al/W composite layer was fabricated on the surface of the aluminum alloy using laser alloying technology to enhance the current-carrying wear resistance. Additionally, the current-carrying wear behaviors of the Al/W composite layer and the aluminum alloy substrate were investigated under different currents. The results indicate that the presence of hard phases such as W and AlW in the composite layer significantly enhanced the wear resistance of the material.

Disparities in screening, diagnosis, treatment, and outcomes for diabetic retinopathy among people with lived experience of homelessness in Canada.

Objective: To estimate the rates of screening, diagnosis, treatment, and outcomes related to diabetic retinopathy among persons with diabetes who have experienced homelessness compared with a matched cohort of nonhomeless controls.

Methods: A propensity score-matched cohort study was conducted using administrative health data from Ontario. Eligible persons required a diagnosis of diabetes and at least 1 hospital encounter between April 2006 and March 2019.

The health impacts and genetic architecture of food liking in cardio-metabolic diseases.

We evaluated temporal and genetic relationships between 176 food-liking-traits and cardio-metabolic diseases using data from the UK Biobank (N = 182,087) for observational analyses and summary-level GWAS data from FinnGen and other consortia (N = 406,565-977,323) for genetic analyses. Integrating observational and genetic results, we identified two detrimental food-liking-traits (bacon and diet-fizzy-drinks) and three protective food-liking-traits (broccoli, pizza, and lentils/beans). These food-liking-traits are associated with habitual food intake and influence cardio-metabolic proteins and biological processes.

DNA damage and repair (DDR) gene mutation profiles in driver gene wild-type advanced non-small cell lung cancer and the predictive role of response to platinum-based chemotherapy.

Background: Platinum-based chemotherapy is an important therapeutic approach for patients with advanced non-small cell lung cancer (NSCLC) without driver gene mutations. DNA damage and repair (DDR) gene can mitigate platinum-induced DNA damage and induce resistance to platinum agents. The status of DDR gene in advanced driver gene wild-type NSCLC and their role in determining response and prognosis to platinum-based chemotherapy need to be investigated.