High resolution building facade dataset for facade elements parsing.

This paper introduces a high-resolution building facade dataset-hznu_facade, designed to provide rich data support for urban modeling, digital twin city construction, and facade analysis tasks. The dataset comprises facade images of 624 buildings from Hangzhou, China, covering diverse architectural styles from both commercial and residential areas. Additionally, it offers twin versions of the facade images with perspective correction.

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first-line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge. Recent research has revealed a strong link between aerobic glycolysis and drug resistance in HCC.

Clinical aspect of combined immunotherapy and radiotherapy effect on tumor immune microenvironment in hepatobiliary and pancreatic cancers.

Hepatobiliary and pancreatic cancers (HBPCs) remain among the most aggressive nature and lethal malignancies, presenting formidable challenges in their treatment. Surgical resection remains the cornerstone of curative treatment for early-stage HBPCs; however, advanced cases often necessitate a multidisciplinary systematic approach incorporating radiotherapy and immunotherapy. In recent years, innovations in radiotherapy technology have facilitated the precise and targeted delivery of tumoricidal doses, minimizing damage to surrounding normal tissue and expanding the application of radiotherapy in treating HBPCs.

Statistical Learning-Assisted Dual-Signal Sensing Arrays Based on Conjugated Molecules for Pathogen Detection and Identification.

Pathogenic microbial infections pose a serious threat to human health and safety. Therefore, rapid detection and accurate identification of pathogenic microorganisms are critical for effective diagnosis and prevention. However, clinical testing often faces challenges such as processing large sample volumes and achieving a high detection efficiency.

Provoking tumor disulfidptosis by single-atom nanozyme via regulating cellular energy supply and reducing power.

Disulfidptosis, a recently identified form of programmed cell death, is initiated by depletion of endogenous nicotinamide adenine dinucleotide phosphate (NADPH) under glucose starvation. Tumor cells, owing to their heightened requirements of energy and nutrients, are more susceptible to disulfidptosis than normal cells. Here, we introduced an effective strategy to induce tumor disulfidptosis via interrupting cellular energy supply and reducing power by integrating a copper single-atom nanozyme (CuSAE) and glucose oxidase (GOx).

Does resource recovery and utilization improve environmental and economic performance of rural wastewater treatment plants? A case study in Xiamen, China.

Wastewater treatment (WWT) has been recognized as a major source of greenhouse gas emissions. Rural WWT often lags behind urban areas due to insufficient infrastructure construction and lack of funding to maintain operation. Selection of optimal WWT technologies in rural areas requires that environmental impacts and costs are traded-off across the entire lifecycle, including the construction, operation, and demolition phases.

Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis.

Objective: Although the role of circular RNAs (circRNAs) in tumor progression and immune regulation is well-known, the specific circRNA molecules that mediate immune responses after radiotherapy (RT) and the underlying mechanisms have not been identified.

Methods: Cytometry with time-of-flight (CyTOF) was used to analyze blood samples from patients with liver cancer exhibiting abscopal effects (AEs) after stereotactic body radiotherapy (SBRT) to quantify the number of dendritic cells (DCs) and CD8 T cells and interferon-beta (IFN-β) level. circTMEM56 and IFN-β levels were measured in 76 patients with liver cancer using qPCR and ELISA.

Artificial Intelligence-Enabled Quantitative Assessment and Intervention for Heart Inflammation Model Organoids.

Inflammation plays a crucial role in progression of cardiovascular diseases (CVDs); thus, the discovery of rapid and precise analytical tools to assess inflammation related to CVDs is highly desirable for their diagnosis and therapeutic discovery. However, a straightforward and systematic method for quantitative assessment of inflammation levels in heart organoids has yet to be developed. Herein, we describe the construction of human heart inflammatory organoids with intricate structures and diverse cell lineages and the development of an artificial intelligence (AI)-enabled method for quantitative assessment of inflammation levels in this model.

Pharmacodynamic Modeling of Cinacalcet in Secondary Hyperparathyroidism: Efficacy and Influencing Factors Analysis.

Context: Cinacalcet, the first FDA-approved calcimimetic agent for treating secondary hyperparathyroidism (SHPT), has unclear factors influencing its therapeutic efficacy in clinical practice.

Objective: To establish a pharmacodynamic model for cinacalcet use in SHPT, analyze drug effect distribution and influencing factors, and determine optimal treatment strategy.

Methods: We searched public databases for randomized trials on cinacalcet for SHPT, modeling changes in serum parathyroid hormone (PTH), calcium, and phosphorus postintervention.

Biofilm-disrupting DNA nanomedicines for targeted elimination of resistant wound microbiota.

Biofilms are complex bacterial communities that significantly hinder the treatment of chronic and recurrent infections by enhancing bacterial virulence and conferring resistance to antimicrobial therapies. To address this challenge, an intelligent DNA nanomedicine has been engineered to dismantle biofilms and target resistant bacteria, offering an innovative solution for chronic wound infections. These nanomedicines initiate biofilm degradation through in situ generation of potent oxidative radicals, enabling deep biofilm penetration and precise bacterial targeting.

The Association Between Hyponatremia and Prognosis in Traumatic Brain Injury: A Comprehensive Meta-Analysis.

This meta-analysis aimed to assess the impact of hyponatremia on prognosis in patients with traumatic brain injury (TBI), specifically regarding mortality and length of hospital stay. A systematic literature search was conducted in PubMed and Web of Science up to October 2024, using comprehensive search terms to cover all potential synonyms related to TBI and hyponatremia. Inclusion criteria required studies to be case-control in design, focus on TBI patients, and report on at least one outcome: mortality, length of stay, neurological scores (e.

Chemiluminescence Resonance Energy Transfer for Targeted Photoactivation of Ion Channels in Living Cells.

The regulation of oxidative stress in living cells is essential for maintaining cellular processes and signal transduction. However, developing straightforward strategies to activate oxidative stress-sensitive membrane channels in situ poses significant challenges. In this study, we present a chemiluminescence resonance energy transfer (CRET) system based on a conjugated oligomer, oligo(p-phenylenevinylene)-imidazolium (OPV-Im), designed for the activation of transient receptor potential melastatin 2 (TRPM2) calcium channels in situ by superoxide anion (O⋅) without requiring external light sources.

Performance of the multi-U-style structure based flow field for polymer electrolyte membrane fuel cell.

The design of the reactant gas flow field structure in bipolar plates significantly influences the performance of proton exchange membrane fuel cells (PEMFCs). In this study, we introduced four innovative U-shaped flow field designs, namely: In-Out Multi-U, Out-In Multi-U, Distro In-Out Multi-U, and Distro Out-In Multi-U. To investigate the impact of these various flow fields on PEMFC performance, we conducted computational fluid dynamics (CFD) numerical simulations, validated through model experiments.

Nanozymes in Biomedical Applications: Innovations Originated From Metal-Organic Frameworks.

Nanozymes exhibit significant potential in medical theranostics, environmental protection, energy development, and biopharmaceuticals due to their exceptional catalytic performance. Compared with natural enzymes, nanozymes have the advantages of simple preparation and purification, convenient production and low cost. Therefore, it is very important to prepare nanozymes quickly and efficiently, which not only helps to expand their application scope, but also can further exert their great potential in various fields.

Regulation of Cell Membrane Potential through Supramolecular System for Activating Calcium Ion Channels.

The regulation of the cell membrane potential plays a crucial role in governing the transmembrane transport of various ions and cellular life processes. However, and on-demand modulation of cell membrane potential for ion channel regulation is challenging. Herein, we have constructed a supramolecular assembly system based on water-soluble cationic oligo(phenylenevinylene) (OPV) and cucurbit[7]uril (CB[7]).

Study on fissure evolution of overlying rock in lower protective mining.

Protective layer mining is the most effective and economical technical measure to prevent coal and gas outburst accidents. At present, in the study of multiple concentrated coal layer stress, plastic damage and mining pressure discharge range, there are problems such as less research on the protection effect of protective layer and less measured measurement points resulting in large experimental error. In view of the above problems, taking the 2305 working face of a Shanxi mine as the test mine, the crack evolution characteristics of downhole drilling were detected by this method, by means of the deep base point technology, and study the plastic damage, pressure relief characteristics and expansion characteristics in the mining process of protective layer, the findings suggest that, the crack development of the protective layer is mainly characterized by small width and quantity, after protective exploitation, the number of width and number of cracks were significantly increased, the injection is three times higher than before the protective mining, the degree of fissure development is greatly improved.

Rational Design of Conjugated Polymers for Photocatalytic CO Reduction: Towards Localized CO Production and Macrophage Polarization.

Light presents substantial potential in disease treatment, where the development of efficient photocatalysts could enhance the utilization of photocatalytic systems in biomedicine. Here, we devised a novel approach to designing and synthesizing photocatalysts of conjugated polymers for photocatalytic CO reduction, relying on a multiple linear regression model built with theoretically calculated descriptors. We established a logarithmic relationship between molecular structure and CO yield and identified the poly(fluorene--thiophene) deviant (PFT) as the optimal one.

Therapeutic Drug Monitoring of Linezolid in Drug-Resistant Tuberculosis Patients: Clinical Factors and Hematological Toxicities.

Purpose: Previous studies have indicated that the development of severe adverse events is associated with linezolid peak concentration (C), but the factors affecting linezolid C and evidences on therapeutic drug monitoring to anticipate toxicity in drug-resistant tuberculosis (DR-TB) patients have not been clarified clearly. This study aimed to explore the factors influencing linezolid C and investigate the association between linezolid concentration and hematological toxicity.

Patients And Methods: This study included patients with drug-resistant tuberculosis treated with linezolid from January 2022 to September 2023.

Effectiveness of transforaminal approach spinal endoscopy in the treatment of patients with lumbar disc herniation and the factors affecting its efficacy.

Objective: To compare the surgical metrics, improvement of functional scores, and clinical efficacy of percutaneous endoscopic transforaminal discectomy (PETD) and percutaneous endoscopic interlaminar discectomy (PEID) and to analyze the independent risk factors affecting the therapeutic efficacy of PETD.

Methods: The clinical data of LDH (lumbar disc herniation) patients who underwent treatment in Shaanxi Provincial Nuclear Industry 215 Hospital from May 2020 to May 2022 were retrospectively collected, including 70 PEID cases and 74 PETD cases. The two groups were compared in terms of surgical indexes, such as operation time and bleeding volume, as well as changes in functional scores, such as preoperative and postoperative Visual Analogue Scale (VAS) scores and Oswestry Disability Index (ODI).

Immunological nanomaterials to combat cancer metastasis.

Metastasis causes greater than 90% of cancer-associated deaths, presenting huge challenges for detection and efficient treatment of cancer due to its high heterogeneity and widespread dissemination to various organs. Therefore, it is imperative to combat cancer metastasis, which is the key to achieving complete cancer eradication. Immunotherapy as a systemic approach has shown promising potential to combat metastasis.

Carrier-Free Self-Assembly Nano-Sonosensitizers for Sonodynamic-Amplified Cuproptosis-Ferroptosis in Glioblastoma Therapy.

Cuproptosis is a newly discovered form of programmed cell death significantly depending on the transport efficacy of copper (Cu) ionophores. However, existing Cu ionophores, primarily small molecules with a short blood half-life, face challenges in transporting enough amounts of Cu ions into tumor cells. This work describes the construction of carrier-free nanoparticles (Ce6@Cu NPs), which self-assembled by the coordination of Cu with the sonosensitizer chlorin e6 (Ce6), facilitating sonodynamic-triggered combination of cuproptosis and ferroptosis.

Safety, efficacy, and pharmacokinetics of nirmatrelvir and ritonavir in patients with severe COVID-19 and renal impairment: A case report.

Nirmatrelvir/ritonavir (N/r) has received emergency use authorization for mild-to-moderate COVID-19 treatment in adult and pediatric patients (aged and weighing at least 12 years and 40 kg, respectively) presenting positive direct SARS-CoV-2 viral testing results and a high risk of disease progression to severe COVID-19. However, information remains limited concerning the corresponding drug safety, efficacy, and pharmacokinetics in patients with severe renal impairment. In this study, we present the case of a 91-year-old Chinese man who, despite exhibiting recurrent positive SARS-CoV-2 results and progression to severe COVID-19, was treated with N/r.