Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis.

Calcium salt deposition in the kidney induces epithelial-to-mesenchymal transition (EMT) in renal tubular epithelial cells, which is the pathological basis for the progression to renal fibrosis in patients with renal stones; however, effective drugs to prevent and treat this disease have not been adequately investigated. In this study, we conducted a comprehensive analysis of fibrosis-related core genes by utilizing bioinformatics on RNA-seq data, along with web database information. Additionally, we designed both in vivo and in vitro experiments to elucidate the mechanisms and signaling pathways through which Desmodium styracifolium polysaccharides (Ds) mitigate renal fibrosis induced by nephrolithiasis.

Immunoglobulin G4 Smoldering Multiple Myeloma With Immunoglobulin G4-Related Autoimmune Hepatitis: A Rare Case Report.

Background: Multiple myeloma (MM) is a common malignant tumor of the hematological system caused by the malignant proliferation of plasma cells, characterized by the production of M proteins and CRAB symptoms. Among them, the Immunoglobulin G MM is the most common, while the IgG4-MM is extremely rare. Smoldering multiple myeloma refers to a state where there are no clinical symptoms.

Immunoglobulin G4-related autoimmune hepatitis with overlapping multiple autoimmune diseases: A case report.

Rationale: The prevalence of autoimmune liver disease in Sjogren syndrome (SS) ranges from 1.7% to 47%. Hematologic involvement is commonly observed in SS patients, with 1.

Clinical Characteristics and Treatment Outcomes of Fungal Endophthalmitis Caused by .

() is a common fungal pathogen that primarily affects plants but can also cause rare infections in humans. In recent years, sporadic cases have been reported worldwide. Here, we report the first case of endophthalmitis in China resulting from a corneal scratch caused by an infected dragon fruit.

Dual roles of GM-CSF in breast cancer: Immunomodulation and therapeutic implications.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor secreted by immune and non-immune cells. By binding to specific receptors on target cell surfaces, GM-CSF promotes hematopoiesis, activates immune cells, modulates inflammatory responses, participates in tissue repair, and regulating anti-tumor immunity. Breast cancer is the most prevalent malignancy among women worldwide and the leading cause of cancer-related mortality in females.

Structural characterization of polysaccharides from Lygodium japonicum (Thunb.) Sw. and its inhibition ability in calcium oxalate renal stone.

Background: Kidney stone is a prevalent abnormal mineralization disease characterized by high incidence and recurrence rates. Current pharmacological interventions for kidney stone predominantly rely on potassium citrate (PC), yet its clinical efficacy remains limited. Lygodium japonicum (Thunb.

Naringenin Attenuates Ox-LDL-induced Injury in HUVECs by Regulating Lipophagy Partly through the SOCE Pathway.

Objective: Naringenin (NAR) is a naturally occurring tiny molecule that has a significant role in lipid metabolism. However, the molecular mechanism by which NAR is involved in lipid metabolism to protect ECs is not clear. This study aims to investigate the effect of NAR on autophagy in oxidized low-density lipoprotein (ox-LDL)-treated human umbilical vein endothelial cells (HUVECs) and its potential molecular mechanisms.

Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with cardiovascular disease risk in patients with metabolic dysfunction-associated fatty liver disease: a cross-sectional NHANES analysis.

Objective: The relationship between the serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and cardiovascular disease (CVD) risk in patients with metabolic dysfunction-associated fatty liver disease (MAFLD) is unknown. This study aims to investigate the relationship between UHR and cardiovascular disease risk in patients with MAFLD.

Methods: Data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2017-2020, in which 3289 patients with MAFLD participated.

Toward improved descriptors by refining the complex reaction network in electrocatalysis.

Electrocatalysis is one of the key technologies for developing sustainable and fossil resource free routes to produce fuels and chemicals. The limiting potential (UL), defined by the reaction free energy of the most difficult electrochemical step in a given pathway, is an effective descriptor for establishing the activity trend of a set of electrocatalysts, allowing high throughput screening of new catalysts. However, the reaction network of electrocatalytic processes is rather complex, especially for the reactions with necessary thermochemical steps, e.

Understanding the Selectivity Differences of NO Electroreduction on Ag and Au Electrodes.

Although noble metals Ag and Au have similar chemical reactivities, their catalytic selectivity for NO electroreduction is significantly different. Namely, hydroxylamine is often considerably produced on Ag while not observed on the Au electrode. In this study, first-principles calculations and the electric field controlling constant potential (EFC-CP) method are adopted to unveil the underlying reasons.

Dimensional study of flexible protection device based on methane explosion protection mechanism.

Flexible materials deform during flame propagation, altering their blockage ratio and the force exerted on the fluid due to various influencing factors. This affects gas explosion characteristics, changes the flame structure, and reduces explosion overpressure and flame speed. To determine the impact of flexible protective devices on the protection mechanism against gas explosions, this experiment used flexible obstacles (polyurethane sponge) as the protective apparatus.

Cutting-Edge Therapy and Immune Escape Mechanisms in EBV-Associated Tumors.

Epstein-Barr virus (EBV), the first identified human tumor virus, significantly influences the immune microenvironment of associated cancers. EBV-induced expression of viral antigens by tumor cells triggers immune recognition and elicits a pro-inflammatory response. While mild inflammation may help eliminate malignant cells, intense inflammation can accelerate tumor progression.

A rule- and query-guided reinforcement learning for extrapolation reasoning in temporal knowledge graphs.

Extrapolation reasoning in temporal knowledge graphs (TKGs) aims at predicting future facts based on historical data, and finds extensive application in diverse real-world scenarios. Existing TKG reasoning methods primarily focus on capturing the fact evolution to improve entity temporal representations, often overlooking the alignment with query semantics. More importantly, these methods fail to generate explicit inference paths, resulting in a lack of explainability.

Smartphone-based urine colourimetric assay for home self-screening of HPV infection.

Currently, producing NPSH after HPV infection of cells has been confirmed. These NPSH-containing substances accumulate around the urethral opening and are subsequently washed out with urine. Therefore, indirect detection of HPV infection by assessing NPSH levels in urine is feasible, but it has not been reported in detail so far.

An Ultrasmall Self-Assembled Gallic-Acid-Based Natural Multifunctional Defense Networks for Therapeutic Application in Calcium Oxalate Nephropathies.

Kidney stones, which have high prevalence and recurrence rates, often cause severe oxidative damage and inflammation. The ultrasmall hydrodynamic diameter of nanoparticles is crucial for their enrichment in the kidneys to exert biological activity. However, integrating crystallization inhibition and therapeutic functions into a single ultrasmall nanoparticle is challenging.

Targeting membrane contact sites to mediate lipid dynamics: innovative cancer therapies.

Membrane contact sites (MCS) are specialized regions where organelles are closely interconnected through membrane structures, facilitating the transfer and exchange of ions, lipids, and other molecules. This proximity enables a synergistic regulation of cellular homeostasis and functions. The formation and maintenance of these contact sites are governed by specific proteins that bring organelle membranes into close apposition, thereby enabling functional crosstalk between cellular compartments.

Sulfated polysaccharides inhibit kidney stone formation through crystalline modulation and relieving cellular oxidative damage and inflammation.

: Calcium oxalate (CaOx) crystal deposition and its resultant cellular oxidative damage and inflammation are important causes of renal stone formation. It is clinically important to conduct research on multifunctional anti-stone drugs targeting these predisposing factors. : We modified natural polysaccharide (UPP0) by sulfation the sulfur trioxide-pyridine method, resulting in four sulfated polysaccharides with varying sulfate group (-OSO) contents: 1.

Lead-grouped multi-stage learning for myocardial infarction localization.

The electrocardiogram (ECG) is a ubiquitous medical diagnostic tool employed to localize myocardial infarction (MI) that is characterized by abnormal waveform patterns on the ECG. MI is a serious cardiovascular disease, and accurate, timely diagnosis is crucial for preventing severe outcomes. Current ECG analysis methods mainly rely on intra- and inter-lead feature extraction, but most models overlook the medical knowledge relevant to disease diagnosis.

Resveratrol promotes cholesterol efflux from dendritic cells and controls costimulation and T-cell activation in high-fat and lipopolysaccharide-driven atherosclerotic mice.

Cholesterol aggregation in dendritic cells (DCs) triggers an inflammatory response and accelerates the development of atherosclerosis (AS). Resveratrol (RES), a natural compound with anti-inflammatory and cholesterol metabolism regulatory properties, has been shown to influence the maturation and inflammatory functions of DCs. However, its relationship with cholesterol metabolism remains unclear.

Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits.

The tumor microenvironment (TME) is enriched with immunosuppressive factors that inhibit the recruitment and activation of dendritic cells (DCs), thereby reducing the efficacy of tumor immunotherapy. To address this challenge, we propose an innovative strategy involving the sequential administration of MCM magnetic nanoparticles carrying PROTAC drugs (MCM/ARV) and M-BMDCs in the TEM. This approach not only replenishes DCs in the TEM, but also increases antigen uptake through the attraction between the magnetic particles and promotes DC activation and antigen presentation, thus continuously enhancing the tumor immune cycle.

Association of dietary inflammatory index with sarcopenia in patients with Metabolic dysfunction-associated fatty liver disease: a cross-sectional study.

Background: Sarcopenia is a common complication of fatty liver, and sarcopenia increases the risk of advanced liver fibrosis in patients with Metabolic dysfunction-associated fatty liver disease (MAFLD). Chronic inflammation is the crucial link between sarcopenia and fatty liver. An anti-inflammatory diet is expected to be an essential measure to prevent sarcopenia in patients with fatty liver, and the dietary inflammatory index (DII) is a crucial tool for assessing the inflammatory potential of diets.

Parameter Adaptive Contrastive Hashing for multimedia retrieval.

With the emergence of massive amounts of multi-source heterogeneous data on the Internet, quickly retrieving effective information from this extensive data has become a hot research topic. Due to the efficiency and speed of hash learning methods in multimedia retrieval, they have become a mainstream method for multimedia retrieval. However, unsupervised multimedia hash learning methods still face challenges with the difficulties of tuning due to the excessive number of hyperparameters and the lack of precise guidance on semantic similarity.

Heat shock protein 22 alleviates doxorubicin-induced kidney injury by suppressing oxidative stress and apoptosis.

This study investigated the effects of heat shock protein 22 (HSP22) against doxorubicin (DOX)-induced kidney injury. Mice were randomly assigned to four groups: CON, ad-HSP22, DOX, and ad-HSP22 + DOX. Adeno-associated virus carrying the HSP22 gene (ad-HSP22) was administered via tail vein injection for four weeks, followed by intraperitoneal simulation with DOX (20 mg/kg) for another five days.