Publications by authors named "Joo Hoon Lee"
Development of a prediction tool for kidney function decline in children with chronic kidney disease.
Kidney Res Clin Pract
August 2025
Background: A paucity of literature exists on the development of predictive tools for the decline of kidney function in pediatric chronic kidney disease (CKD). The objective of this study is to develop and internally validate a tool for the short-term prediction of a kidney function decline in pediatric patients with CKD.
Methods: A total of 539 patients participating in the KNOW-PedCKD (KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease) were evaluated for 48 variables related to sociodemographic characteristics, laboratory data, and treatment use.
Wearable sensors allow non-invasive monitoring of sweat metabolites, but their reliance on molecular recognition elements limits both physiological coverage and temporal resolution. Here we report an all-flexible chronoepifluidic surface-enhanced Raman spectroscopy (CEP-SERS) patch for label-free and chronometric profiling of sweat metabolites. The CEP-SERS patch integrates plasmonic nanostructures in epifluidic microchannels for chronological sweat sampling and molecular analysis.
View Article and Find Full Text PDFPediatric nephrotic syndrome is a clinical condition characterized by severe proteinuria, hypoalbuminemia, hyperlipidemia, and generalized edema, most commonly affecting children aged 2 and 6 years. Although standard oral steroid therapy is effective in managing most cases, relapses are common during childhood. Nephrotic syndrome presents significant challenges due to frequent relapses and the potential side effects of long-term drug therapy.
View Article and Find Full Text PDFGenotype of PAX2-related disorders correlates with kidney and ocular manifestations.
Eur J Hum Genet
April 2025
PAX2-related disorders encompass renal coloboma syndrome (RCS) and hereditary focal segmental glomerulosclerosis (FSGS) type 7. We retrospectively analyzed 27 Korean patients with PAX2 pathogenic variants detected between 2004 and 2022 and conducted a literature review of 328 cases, including 301 previously reported. In our cohort, 19 had RCS, 4 had FSGS, and 4 had isolated congenital anomalies of the kidneys and urinary tract.
View Article and Find Full Text PDFBackground: Hypertension is one of the most important complications of chronic kidney disease (CKD) as it exacerbates disease progression in children. The aim of this study is to identify characteristics and factors associated with hypertension in children with CKD.
Methods: This is a cross-sectional study using baseline data from the 10-year ongoing cohort study named KNOW-PedCKD (Korean Cohort Study for Outcome in Patients with Pediatric Chronic Kidney Disease).
Genotype-phenotype correlations in children with Gitelman syndrome.
Clin Exp Nephrol
August 2024
Article Synopsis
- The study focused on understanding the genotype-phenotype relationships in children with Gitelman syndrome (GS) by analyzing genetic variations in the SLC12A3 gene in 50 Korean children.
- The median age for diagnosis was 10.5 years, with 68% having biallelic variants; those with truncating variants experienced more severe electrolyte imbalances compared to those without.
- Findings suggest that children with monoallelic SLC12A3 variants exhibited similar clinical symptoms and treatment responses as those with biallelic variants.
Background: The natural course of chronic kidney disease (CKD) progression in children varies according to their underlying conditions. This study aims to identify different patterns of subsequent decline in kidney function and investigate factors associated with different patterns of estimated glomerular filtration rate (eGFR) trajectories.
Methods: We analyzed data from the KNOW-Ped CKD (KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease), which is a longitudinal, prospective cohort study.
Long-term outcomes and associated prognostic risk factors of childhood-onset lupus nephritis.
Kidney Res Clin Pract
March 2025
Article Synopsis
- This study focused on childhood-onset lupus nephritis (LN), examining the clinical features, kidney outcomes, and risk factors related to prognosis in 216 patients across South Korea.
- Most patients presented with nephrotic syndrome or hematuria, and the most common kidney damage was WHO class IV LN, with nearly 15% developing advanced chronic kidney disease (CKD) after an average follow-up of about 8 years.
- Key risk factors identified for advanced CKD included being male and not achieving remission within the first year of treatment, indicating the need for careful monitoring of these patients to improve their long-term outcomes.
Kidney involvement in children during the SARS-CoV-2 Omicron variant pandemic.
BMC Pediatr
September 2023
Article Synopsis
- The COVID-19 pandemic, particularly with the Omicron variant, has led to a notable increase in kidney-related issues among children, as observed from January to August 2022 in a Korean study.
- A total of fifteen pediatric patients experienced kidney problems post-Omicron infection, mostly without severe respiratory symptoms, with symptoms typically appearing about 3 days after infection.
- Although most kidney issues were mild and resolved with treatment, patients with pre-existing kidney conditions like nephrotic syndrome showed more severe relapses, while new cases included conditions such as Henoch Schönlein Purpura nephritis.
[This corrects the article DOI: 10.3389/fped.2023.
View Article and Find Full Text PDFBackground: Dyslipidemia can cause cardiovascular disease and increase the fatality rate among children with chronic kidney disease (CKD); this makes early screening and treatment of dyslipidemia crucial. This study aimed to assess the association between the changes in serum total cholesterol levels over time and the degree of CKD progression in children.
Methods: From April 2011 to August 2021, 379 of the 432 participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric CKD (KNOW-PedCKD) were included and divided into 4 categories based on total cholesterol levels (< 170 mg/dL, acceptable; 170-199, borderline; 200-239, high; and ≥ 240, very high).
Corrigendum: Long-term outcome of Bartter syndrome in 54 patients: a multicenter study in Korea.
Front Med (Lausanne)
May 2023
[This corrects the article DOI: 10.3389/fmed.2023.
View Article and Find Full Text PDFGenetic diagnosis of kidney disease by whole exome sequencing and its clinical application.
Clin Genet
September 2023
Article Synopsis
- Researchers studied 172 people with kidney diseases using a special test called whole exome sequencing (WES) to find genetic problems.
- They discovered that WES could diagnose genetic diseases in 63 of those patients, which is about 36.6%.
- The testing was most helpful for younger patients (under 6 years old), and it even changed the way 10 of the patients were treated after finding their genetic issues.
Article Synopsis
- - This study examined the relationship between genotype and phenotype in X-linked Alport syndrome (XLAS) among 216 Korean patients, finding that males experience earlier onset and more severe kidney failure than females.
- - About 60% of male patients developed kidney failure by the age of 25, with significant differences in kidney survival based on their genetic group, while only 20% of female patients experienced kidney failure by age 50.
- - The results suggest a clear genotype-phenotype correlation in both male and female patients, highlighting the need for better understanding of XLAS in women, who tend to have a later onset of symptoms.
Long-term outcome of Bartter syndrome in 54 patients: A multicenter study in Korea.
Front Med (Lausanne)
March 2023
Introduction: Bartter syndrome (BS) is a rare salt-wasting tubulopathy caused by mutations in genes encoding sodium, potassium, or chloride transporters of the thick ascending limb of the loop of Henle and/or the distal convoluted tubule of the kidney. BS is characterized by polyuria, failure to thrive, hypokalemia, metabolic alkalosis, hyperreninemia, and hyperaldosteronism. Potassium and/or sodium supplements, potassium-sparing diuretics, and nonsteroidal anti-inflammatory drugs can be used to treat BS.
View Article and Find Full Text PDFPurpose: This study aimed to assess the association of dietary quality and surgical satisfaction with the amount of total weight loss (TWL) 1 year after laparoscopic sleeve gastrectomy (LSG) using the food tolerance score (FTS) and Bariatric Analysis and Reporting Outcome System (BAROS) questionnaires.
Materials And Methods: This single-center retrospective study included patients who underwent LSG due to morbid obesity. Only those who have 1-year follow-up data were included and divided into 2 groups: suboptimal TWL (STWL) ≤20% and optimal TWL (OTWL) >20%.
Article Synopsis
- Children with chronic kidney disease (CKD) are prone to mineral bone disorder (MBD), which can cause serious health issues like fractures and growth problems, and this study aimed to investigate these conditions in Korean pediatric patients.
- The research analyzed data from 431 children with CKD, measuring various factors related to MBD, including calcium, phosphate, vitamin D levels, and bone density across different stages of CKD.
- Findings showed that abnormalities in mineral metabolism significantly increased as CKD progressed, with higher rates of hyperphosphatemia and hyperparathyroidism, and increased use of medications aimed at managing these issues in advanced stages of the disease.
Unlabelled: We introduce a lateral flow assay (LFA) integrated with a modified isothermal nucleic acid amplification procedure for rapid and simple genetic testing. Padlock probes specific for the target DNA were designed for ligation, followed by rolling circle amplification (RCA) using capture ligand-modified oligonucleotides as primers. After hybridization with detection linker probes, the amplified target DNA is flowed through an LFA membrane strip for binding of gold nanoparticles as the substrate for colorimetric detection.
View Article and Find Full Text PDFA child with crescentic glomerulonephritis following SARS-CoV-2 mRNA (Pfizer-BioNTech) vaccination.
Pediatr Nephrol
January 2023
Background: There are few reports on kidney complications after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination, especially in the pediatric population. We report a pediatric case diagnosed with crescentic glomerulonephritis (CrGN) after the second dose of the SARS-CoV-2 mRNA vaccine.
Case-diagnosis/treatment: A 16-year-old girl was admitted due to dyspnea and headache approximately 6 weeks after receiving the second SARS-CoV-2 mRNA vaccine (Pfizer-BioNTech).
Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races.
Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected.
Purpose: We aimed to evaluate therapeutic response and long-term renal outcomes of childhood idiopathic steroid-resistant nephrotic syndrome (iSRNS).
Methods: We retrospectively reviewed treatment regimens, especially calcineurin inhibitor (CNI), pathologic diagnoses, and long-term renal outcomes of iSRNS patients for 30 years.
Results: Of 516 patients with idiopathic NS, 52 (10.
Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea.
Kidney Res Clin Pract
December 2021
Article Synopsis
- This study focused on pediatric rhabdomyolysis in South Korea, analyzing 880 cases from 23 hospitals to identify characteristics and risk factors related to acute kidney injury (AKI).
- The most affected age group was children aged 3 to 5, with neurological disorders and infections being common causes of rhabdomyolysis, and an 11.3% incidence rate of AKI was noted among the patients.
- Key risk factors for AKI were identified, including multiorgan failure and specific laboratory findings, which could help in early detection and intervention for at-risk pediatric patients.