Publications by authors named "Seon Hee Lim"

Pediatric kidney disease has a relatively lower prevalence than do other pediatric conditions and has a notably different etiology from kidney diseases observed in adults. Furthermore, the pediatric population is unique in that they experience ongoing growth and development, distinguishing them from adult patients. Consequently, pediatric patients with kidney disease require more specialized and meticulous nutritional management than do adults.

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Background: Urinary tract infections (UTI) are the leading cause of severe bacterial infection in children under 24 months. Increasing antimicrobial resistance, particularly to third-generation cephalosporins, is a growing concern. This study examines recent resistance trends in young children with UTI in Korea.

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Serological tests for needs local validation as the diagnostic accuracy may vary depending on the prevalence of . . This study examined the diagnostic performance of two ELISA, GastroPanel (GastroPanel ELISA; Biohit Oyj) and GENEDIA (GENEDIA .

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This study evaluated the impact of differing false positive (FP) rates in two computer-aided detection (CADe) systems on the clinical effectiveness of artificial intelligence (AI)-assisted colonoscopy. The primary outcomes were adenoma detection rate (ADR) and adenomas per colonoscopy (APC). The ADR in the control, system A (3.

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A longer cecal intubation time (CIT) occurs during colonoscopy under difficult insertion conditions, which may hinder meticulous mucosal observation. However, whether a longer CIT has detrimental effects on the detection of adenomas remains unclear. We evaluated the effects of CIT on the detection and miss rates of colorectal neoplasms in asymptomatic participants.

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Article Synopsis
  • A study was conducted to explore how user experience and characteristics of polyps affect interactions with computer-aided detection (CADe) systems during colonoscopy.
  • The CADe system, built using YOLOv4 and trained on nearly 18,000 images, showed an improvement in polyp detection accuracy from 69.7% to 77.7% when assisted by CADe, although misdetections could decrease accuracy.
  • The results indicated that less experienced users (like nurses) benefited more from CADe assistance compared to experts, and while overall sensitivity improved for easier polyp detection, it was lower for more challenging lesions like sessile serrated lesions (SSLs).
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  • SAVI is a rare autoinflammatory disease that can present similarly to systemic lupus erythematosus (SLE), as seen in a Korean patient with early-onset interstitial lung disease and symptoms like recurrent fever and skin ulcers.
  • The patient was misdiagnosed with SLE due to positive antibody tests but was later confirmed to have SAVI through genetic testing at age 29.
  • Despite multiple treatments, including immunosuppressive therapy and tofacitinib, her lung condition deteriorated, emphasizing the need for timely diagnosis and intervention for better outcomes in cases of SAVI.
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Background: People with group O blood are considered universal organ donors compatible with any other blood group. However, in the case of minor ABO-incompatible transplantation, immune-mediated hemolysis may occur due to concomitant transfer of donor B lymphocytes together with the allograft. These passenger lymphocytes can produce antibodies in the recipients erythrocytes, causing hemolytic anemia known as passenger lymphocyte syndrome (PLS).

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  • Confusion in high and low confidence decisions during optical diagnosis complicates its use in clinical settings, prompting a study on the impact of a 3-second decision rule for endoscopists.
  • The study involved eight gastroenterologists, comparing standard optical diagnosis with a 3-second rule over different phases, examining decision accuracy and performance metrics.
  • Results showed noteworthy improvements in confidence accuracy for nonexperts, while experts showed slight enhancements, indicating the rule's effectiveness, particularly for those with less experience.
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  • - This study examined the relationship between genotype and phenotype in X-linked Alport syndrome (XLAS) among 216 Korean patients, finding that males experience earlier onset and more severe kidney failure than females.
  • - About 60% of male patients developed kidney failure by the age of 25, with significant differences in kidney survival based on their genetic group, while only 20% of female patients experienced kidney failure by age 50.
  • - The results suggest a clear genotype-phenotype correlation in both male and female patients, highlighting the need for better understanding of XLAS in women, who tend to have a later onset of symptoms.
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Purpose: This study aimed to assess the feasibility of contrast-enhanced ultrasound (CEUS) for the diagnosis of acute pyelonephritis (APN) in pediatric patients with febrile urinary tract infection (UTI).

Materials And Methods: Between March 2019 and January 2021, study participants with suspected UTI were assessed for APN using ultrasound. Parenchymal echogenicity changes, renal pelvis dilatation, and the presence of a focal suspected lesion were assessed using conventional grayscale ultrasound.

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Background: The association between Helicobacter pylori (HP) infection and coronary heart disease (CHD) is controversial. This study aimed to investigate the effect of H. pylori eradication on CHD, especially in terms of age and sex.

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Objective: Although the incidence of colorectal adenomas increases with obesity, the role of various body compositions is still unknown. We aimed to determine which body composition best reflects the risk of colorectal adenomas.

Methods: Patients aged 50-75 years who underwent colonoscopy and a bioelectrical impedance analysis (BIA) for a health check-up from 2017 to 2019 were retrospectively enrolled.

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Background/aims: (HP) infection is positively associated with metabolic syndrome (MS). However, the long-term effects of eradication therapy on MS and sex differences have not been thoroughly studied. We aimed to investigate the long-term effects of HP eradication on MS and sex differences.

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Background: Topological data analysis (TDA) can generate patient-patient similarity networks by analyzing large, complex data and derive new insights that may not be possible with standard statistics.

Objectives: The purpose of this paper was to discover novel phenotypes of chronic primary mitral regurgitation (MR) patients and to analyze their clinical implications using network analysis of echocardiographic data.

Methods: Patients with chronic moderate to severe primary MR were prospectively enrolled from 11 Asian tertiary hospitals (n = 850; mean age 56.

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Background: Non-alcoholic fatty liver disease (NAFLD) and () infection have a close association with an increased risk of cardiovascular disease. Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by metabolic dysfunction in NAFLD. We investigated the synergistic effects of NAFLD/MAFLD and infection on the risk of arterial stiffness in an asymptomatic population.

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Article Synopsis
  • Computer-aided detection (CADe) systems aim to improve the detection of polyps in colonoscopy, especially sessile serrated lesions (SSLs), which are often missed due to their flat appearance.
  • Current CADe systems struggle to detect SSLs effectively, prompting researchers to propose a new approach that leverages the morphological characteristics of SSLs.
  • They utilized a generative adversarial network (GAN) to create realistic, high-resolution endoscopic images for training the CADe system, resulting in a 17.5% increase in sensitivity for detecting these challenging polyps.
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Background/aims: The long-term effect of Helicobacter pylori eradication on the metabolic syndrome or diabetes are unclear. The aim of this study was to evaluate the effect of H. pylori eradication on glycemic control in type 2 diabetes mellitus (T2DM) or prediabetes mellitus (preDM).

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Unlabelled: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease associated with various metabolic disorders. Metabolic dysfunction-associated fatty liver disease (MAFLD) emphasizes metabolic dysfunction in NAFLD. Although the relationship between NAFLD and colorectal adenomas has been suggested, the effect of MAFLD on colorectal adenoma has yet to be investigated.

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As risk of colorectal neoplasm is varied even in persons with "average-risk," risk evaluation and tailored screening are needed. This study aimed to evaluate the risk factors of high-risk adenoma (HRA) in healthy individuals and determine the characteristics of advanced neoplasia (AN) among individual polyps. Asymptomatic adults who underwent the first lifetime screening colonoscopy at the Seoul National University Hospital Healthcare System Gangnam Center (SNUH GC) were recruited from 2004 to 2007 as SNUH GC Cohort and were followed for 10 years.

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A mercury sphygmomanometer (MS) has been the gold standard for pediatric blood pressure (BP) measurements, and diagnosing hypertension is critical. However, because of environmental issues, other alternatives are needed. Noninvasive BP measurement devices are largely divided into auscultatory and oscillometric types.

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Article Synopsis
  • X-linked hypophosphatemia (XLH) is a common type of rickets caused by gene mutations, with a study analyzing the effects of these mutations in 81 patients.
  • The research grouped patients into nontruncating and truncating mutation categories and found no significant differences in early symptoms or test results between the two groups.
  • However, over time, patients with truncating mutations had lower phosphate levels, higher rates of nephrocalcinosis, and more frequent orthopedic surgeries than those with nontruncating mutations, suggesting potential genotype-phenotype correlations in disease outcomes.
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