Design and verification of a piezoelectric-driven locking and handover mechanism for space-based gravitational wave detection.

Space inertial sensors, comprising a test mass and its surrounding framework, are pivotal for high-precision gravitational wave detection. The precise locking and handover of the test mass are crucial, particularly during launch and orbital insertion phases. Given the necessity for ultra-stable locking mechanisms in space inertial sensors to ensure mission success, this paper presents a novel locking and handover mechanism driven by a rotating piezoelectric motor and lead screw.

Novel polycyclic meroterpenoids with protein tyrosine phosphatase 1B inhibitory activity isolated from desert-derived fungi Talaromyces sp. HMT-8.

Seven previously undescribed polycyclic meroterpenoids talarines K-Q (1-7), along with five known ones (8-12), were isolated from desert-derived fungi Talaromyces sp. HMT-8. The structure of the novel compounds were elucidated using spectroscopic methods, including electronic circular dichroism (ECD), HRESIMS and nuclear magnetic resonance (NMR) spectroscopy.

The association between exposure to phthalates and cardiovascular disease: A comprehensive study utilizing NHANES data from 2005 to 2018 and network toxicology.

Phthalates are widely recognized endocrine-disrupting chemicals. This study investigates the association between phthalate exposure and cardiovascular disease (CVD), with a particular focus on elucidating the underlying molecular mechanisms. First, an epidemiological analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2018 to assess the relationship between phthalate metabolites and CVD.

ADP-Based Orbit Tracking Control for Deep Space Probe Flying Around Unknown Asteroid.

This article investigates the orbit tracking control problem for the deep space probe flying around an unknown asteroid under completely unknown dynamics. First, an orbit tracking control model for the relative motion of the probe to the asteroid is established. Then, a model-based controller is designed for the optimal tracking control problem and the asymptotic stability of the closed-loop system is proved.

inhibition enhances colorectal cancer progression epidermal growth factor receptor/extracellular signal-regulated kinase pathways.

Background: In patients with colorectal cancer (CRC), tumour metastasis is the leading cause of death. The search for key genes involved in metastasis of CRC is imperative for improved prognoses and treatments. has been implicated in the development of CRC, however, its mechanism of action remains unclear.

Tricellulin facilitates colorectal cancer metastasis through activation of the TGFβ/SMAD2/3 signalling pathway.

Background: Tricellulin belongs to the TAMP family of proteins and is primarily localized at the tricellular tight junctions. While its role in the progression of cancer has been reported, its importance in the progression of colorectal cancer (CRC) remains unclear.

Objective: This study aimed to determine the function and mechanism of tricellulin in CRC progression.

Amino and Fatty Acids Composition, Volatile Compounds and Antioxidant Activity of Medicinal Mushroom Pholiota limonella (Agaricomycetes) from China.

Fruiting bodies of mushrooms represent an important functional food owing to various beneficial health enhancing effects. The edible mushroom Pholiota limonella (Strophariaceae, Agaricomycetes) has been found to contain various bioactive components. In this study, the proximate amino and fatty acids, as well as volatile compounds of P.

The transcription factor WRKY41-FLAVONOID 3'-HYDROXYLASE module fine-tunes flavonoid metabolism and cold tolerance in potato.

Cold stress adversely affects crop growth and productivity. Resolving the genetic basis of freezing tolerance is important for crop improvement. Wild potato (Solanum commersonii) exhibits excellent freezing tolerance.

Development and Validation of a GULP-Based Predictive Model for Dehydration in Elderly Patients with Post-Stroke Dysphagia.

The background for establishing and verifying a dehydration prediction model for elderly patients with post-stroke dysphagia (PSD) based on General Utility for Latent Process (GULP) is as follows: For elderly patients with PSD, GULP technology is utilized to build a dehydration prediction model. This aims to improve the accuracy of dehydration risk assessment and provide clinical intervention, thereby offering a scientific basis and enhancing patient prognosis. This research highlights the innovative application of GULP technology in constructing complex medical prediction models and addresses the special health needs of elderly stroke patients.

Debranched Lentil Starch-Sodium Alginate-Based Encapsulated Particles of GG: Morphology, Structural Characterization, In Vitro Release Behavior, and Storage Stability.

Starches with different degrees of debranching (DBS30, DBS60, and DBS90) and sodium alginate were used as the wall material for encapsulating particles of GG (LGG). The structural characteristics of these encapsulated particles were examined, along with the impact of varying levels of debranching on the encapsulation efficiency, the in vitro release of LGG under the simulated gastrointestinal environment, and the storage stability of the encapsulated particles. The results revealed a transformation in the crystalline polymorph from C- to B+V-type following debranching and retrogradation.

Transcription factor CaPHR3 enhances phosphate starvation tolerance by up-regulating the expression of the CaPHT1;4 phosphate transporter gene in pepper.

Plants frequently encounter phosphate (Pi) starvation due to its scarce availability in soil, necessitating an adaptive phosphate starvation response (PSR). This study explores this adaptation in pepper (Capsicum annuum L.) under low-Pi stress, focusing on the PHOSPHATE STARVATION RESPONSE (PHR) gene family.

Immunogenicity and Safety of Omicron-Containing Multivalent COVID-19 Vaccines in Unvaccinated and Previously Vaccinated Adults.

The SARS-CoV-2 evolution trajectory remains uncertain, and the antigenic characteristics of future variants are highly unpredictable. We report the immunogenicity and safety of multivalent COVID-19 vaccines, SCTV01E and SCTV01E-1, against Omicron BA.5.

Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer invasiveness by activation of target of rapamycin kinase/autophagy signaling.

Background: Monopolar spindle-binding protein 3B (MOB3B) functions as a signal transducer and altered MOB3B expression is associated with the development of human cancers.

Aim: To investigate the role of MOB3B in colorectal cancer (CRC).

Methods: This study collected 102 CRC tissue samples for immunohistochemical detection of MOB3B expression for association with CRC prognosis.

Clypeasterol, a novel aromatic ergosterol skeleton from the mushroom .

Chemical investigation of the wild mushroom led to the isolation of one new A-nor B-aromatic C28 steroid (), along with eight known compounds (-) from this mushroom. As far as we know, compound represents an unprecedented type of natural product. The structure of the new compound was elucidated based on extensive spectroscopic data analysis of HR-ESI-MS, 1D, and 2D NMR, while the relative configuration was confirmed by NOESY correlations.

Isolation and target identification of antihepatoma polyprenylphenols from the edible mushroom .

Eight polyprenylphenol derivatives were isolated from the wild edible mushroom , including seven novel compounds, named suillin F-L (2-8), and one previously identified compound (1). The structures of the new compounds were elucidated using HR-ESI-MS and 1D and 2D NMR data. The absolute configuration of compound 8 was assigned based on the comparison of the experimental and calculated ECD data.

Anti-Hyperglycemic Effect of the Brown Slime Cap Mushroom Chroogomphus rutilus (Agaricomycetes) Crude Polysaccharide In Vitro and In Vivo.

The prevalence of diabetes is increasing worldwide, and it is very important to study new hypoglycemic active substances. In this study, we investigated the hypoglycemic effect of Chroogomphus rutilus crude polysaccharide (CRCP) in HepG2 cells and streptozotocin-induced diabetic mice. A glucose consumption experiment conducted in HepG2 cells demonstrated the in vitro hypoglycemic activity of CRCP.

Bioassay-guided isolation of three new alkaloids from and preliminary mechanism against ginseng root rot.

In order to control the occurrence of ginseng root rot caused by (Mart.) Sacc., the antifungal compounds of the mushroom were investigated.

Six new polyphenolic metabolites isolated from the and their cytotoxicity against HepG2 cells.

Edible mushrooms are an important source of nutraceuticals and for the discovery of bioactive metabolites as pharmaceuticals. In this work, six new polyphenolic metabolites suillusol A-D (-), suillusinoic acid (), ethyl suillusinoate (), were isolated from the . The structures of new compounds were elucidated using high-resolution electrospray ionization mass spectroscopy, nuclear magnetic resonance data, and single-crystal X-ray diffraction analysis.

Advances of NOTCH2NLC Repeat Expansions and Associated Diseases: A Bibliometric and Meta-analysis.

The unclear pathogenic mechanisms of neurodegenerative disorders stemming from NOTCH2NLC GGC repeat expansions drive focused research. Thus, a bibliometric and meta-analysis was conducted to uncover research trends and positivity rates in NOTCH2NLC. We conducted systematic searches in the Web of Science, PubMed, Embase, and Scopus databases for studies related to NOTCH2NLC up until August 2, 2023.

ALOX15 M2 macrophages contribute to epithelial remodeling in eosinophilic chronic rhinosinusitis with nasal polyps.

Background: Epithelial remodeling is a prominent feature of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP), and infiltration of M2 macrophages plays a pivotal role in the pathogenesis of eCRSwNP, but the underlying mechanisms remain undefined.

Objective: We sought to investigate the role of ALOX15 M2 macrophages in the epithelial remodeling of eCRSwNP.

Methods: Digital spatial transcriptomics and single-cell sequencing analyses were used to characterize the epithelial remodeling and cellular infiltrate in eCRSwNP.

Chemical Compounds, Bioactivities, and Potential Applications of the Mushroom Species of Genus Suillus (Agaricomycetes): A Review.

The genus Suillus, also known as "Song mo," falls under the order Boletales and consists of various higher fungi. It establishes mycorrhizae primarily with pine trees and has a good taste and medicinal values. Herein, we reviewed the chemical compounds present in the genus Suillus, including polysaccharides, steroids, phenols, polyprenyl phenol derivatives, fatty acids, organic acids, and amino acids, and their reported bioactivities and potential applications.

Research progress of ferroptosis in Parkinson's disease: a bibliometric and visual analysis.

Background: In recent years, the role of ferroptosis in Parkinson's disease (PD) has become a research hotspot based on evidence of abnormal iron deposition and lipid peroxidation damage in the brains of PD patients. This study aims to examine the relevant research on ferroptosis and PD from a bibliometric perspective.

Methods: Original research and review articles related to ferroptosis and PD were retrieved from the Web of Science Core Collection (WOSCC) database.