Implications of imaging, morphologic, and immunohistochemical features of pancreatic perivascular epithelioid cell tumor: case report and comprehensive literature review.

Background: Perivascular epithelioid cell tumor (PEComa) of the pancreas is a rare tumor of pancreatic mesenchymal origin with malignant potential. Critical to appropriate clinical management is determining whether the tumor is benign or malignant. Because of its rarity, morphologic and histologic characteristics and limited patient follow-up of pancreatic PEComa have precluded precise definition of malignancy.

Therapeutic Potential of PDA@CeO2 in Suppressing Hepatic Stellate Cell Activation and Preventing Liver Fibrosis.

Objective: Liver fibrosis replaces healthy tissue with scar tissue, potentially leading to cirrhosis and cancer. ROS drive this process by activating hepatic stellate cells. This study tests the hepatoprotective effects of PDA@CeO nanoparticles in scavenging ROS, inhibiting HSC activation, and delaying fibrosis, using 2D-SWE to assess treatment efficacy.

Exploring the use of double-speed video playback in a fast-paced society through structural equation modeling.

In a fast-paced society, users habitually use double-speed function when playing videos. Exploring the influence mechanism of users' intention to use the double-speed function has applications for optimizing video platforms' double-speed function, enhancing the user experience, and alleviating time anxiety. On the basis of the Technology Acceptance Model, we integrated perceived entertainment, subjective norms, system quality, and content quality to construct a hypothetical model of users' intention to use the double-speed function.

Ferroptosis boosting system based on a sonodynamic therapy cascade-augmented strategy for triple-negative breast cancer therapy.

One of the novel forms of programmed cell death, ferroptosis, has recently emerged as a hopeful treatment strategy for triple-negative breast cancer (TNBC). However, insufficient levels of intracellular reactive oxygen species (ROS) and high levels of ROS scavengers in the tumor microenvironment (TME), such as glutathione (GSH), hamper the efficacy of ferroptosis therapy. In this study, the introduction of manganese dioxide nanoparticles (MnO NPs) generated cytotoxic hydroxyl radicals (⋅OH) in the TME.

Morphology-Controllable Liquid Metal/Diamond Sandwich-Structured Thermal Interface Material toward High-Efficiency Thermal Management.

With the exponential growth of AI computing power, the power density of electronic devices has exceeded 1 kW/cm, rendering traditional thermal management materials insufficient to handle the challenges of high heat flux density. Developing thermal interface materials (TIMs) with both high thermal conductivity (≥10 W m K) and interface compatibility is crucial. This study introduces a dual-level interface engineering strategy, constructing a thermally conductive adhesive layer with low interfacial thermal resistance (4 K mm W) and excellent electrical insulation properties (2.

Preparation of Diamond Nanofluids and Study of Lubrication Properties.

As an emerging two-dimensional nanomaterial, diamond nanosheets have the advantages of high hardness and chemical stability; exhibiting good tribological properties when used as lubricant additives. However, the dispersion stability of nanomaterials as additives in lubricants remains a significant challenge. In this study, fluidized and functionalized diamond nanofluids were prepared by grafting polyether amine on the surface of diamond nanosheets.

Ultrasound Trigger Ultrasmall Multifunction Nanobubbles for Thrombus Visual Treatment.

Intravenous injection of thrombolytic drugs is the prevailing strategy for the treatment of thrombotic disease. However, its applications are limited due to hemorrhagic risk and thrombus microenvironment. In pursuit of visualized thrombolysis and inspired by the excessive reactive oxygen species (ROS) and inflammatory factors within the thrombus site, an ultrasmall nanobubble (CeO/MnO@UK@PFP) for integration of imaging and therapy by low intensity pulse ultrasound (LIPUS) trigger is designed, which achieved the visual delivery of Urokinas (UK) and ROS scavenging agents to adjust thrombus microenvironment.

Asialoglycoprotein receptor-targeted perfluorooctylbromide as a targeted contrast agent for evaluating the severity of carbon tetrachloride-induced acute liver damage in rats.

Asialoglycoprotein receptor (ASGPR) is an endocytic C-type lectin receptor in hepatocytes. Acute and chronic liver diseases can result in the decreased expression and content of this receptor. The objective of this study was to determine whether ASGPR-targeted perfluorooctylbromide (PFOB) can enhance ultrasound imaging signals and evaluate the severity of carbon tetrachloride (CCl4)-induced acute liver damage in rats.

Depolymerase as a potent adjunct to polymyxin for targeting KL160 pandrug-resistant Acinetobacter baumannii in a murine bacteremia model.

Objectives: Acinetobacter baumannii bacteremia caused by pandrug-resistant strains poses a major challenge in intensive care units, necessitating novel therapeutic approaches. Phage-derived depolymerases offer a promising adjunct to conventional antibiotics. However, studies on A.

Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8 T cells.

Background: Although the immune response of host T cells to human immunodeficiency virus (HIV) significantly influences the progression of the infection, the development of T-cell-based vaccines and therapies, as well as the clinical evaluation of specific T-cell functions, is currently markedly hindered by the absence of broad-spectrum, functionally validated HIV T-cell epitopes that account for the polymorphisms of the human leukocyte antigen (HLA) within an indicated geographic population. This study aimed to identify T-cell epitopes derived from the GP160, GAG, and POL proteins of the HIV-1 strain, specifically linked to 12 prevalent HLA-A allotypes, that collectively represent approximately 91% of the total gene frequency in Northeast Asian populations.

Methods: A total of 134 epitopes were predicted and selected as potential candidates for further validation.

Light Weight Organic Composites with High Thermal Management Capability.

With the advancement of science and technology, effectively addressing the issue of heat dissipation in electronic equipment has become a key research topic. Polymers have attracted attention due to their low price, excellent flexibility, and lightweight characteristics, but thermal conductivity has a limitation. In this work, aiming for all-polymer composites with lightweight and high thermal conductivity, poly(p-phenylene benzobisoxazole) (PBO) fibers were used to construct a long-range ordered heat transfer path in the organosilicon matrix, and an all-organic composite material with a low density of 1.

A Novel Nanoscale Phase-Change Contrast Agent Evaluates the Hepatic Fibrosis Through Targeting Hepatic Stellate Cell Platelet-Derived Factor Beta Receptor by Ultrasound in Vitro.

Objective: As a reversible condition at its early stages, liver fibrosis can progress to cirrhosis and hepatocellular carcinoma, underscoring the importance of early detection for preventing severe outcomes and improving prognosis. To address this issue, we developed a platelet-derived growth factor receptor β (PDGFRβ)-targeted nanoscale phase-change contrast agent to target activated hepatic stellate cells (aHSC) and enable ultrasound imaging as a foundation for the early evaluation of liver fibrosis.

Methods: PDGFR-β antibody-modified phase-change contrast agents (PPCAs) were synthesized utilizing film hydration and ultrasonic emulsification with perfluoropentane (PFP) encapsulated.

Anticorrosive two-dimensional heterostructured nanocoatings self-assembled on steel with multiple desired merits.

In this study, an economic and controllable Marangoni self-assembly approach is designed to prepare the heterostructured nanocoatings (8-28 nm) consisting of alternately stacked mosaic nanosheets of hexagonal boron nitride (h-BN) and graphene. The resulting 2D nanocoatings exhibit a combination of advantageous properties, such as prevention of interfacial reactions, robust interfacial binding, a labyrinthine barrier effect, inhibition of galvanic corrosion, and alleviation of internal stress. The protective property of graphene/h-BN heterostructured nanocoatings is studied through potentiodynamic polarization curves and electrochemical impedance spectroscopy, with the theoretical support of first-principles calculations.

Engineering hierarchical interfaces in high-temperature polymer dielectrics for electrostatic supercapacitors.

Dielectric capacitors are pivotal elements in advanced pulsed power devices and high-voltage, high-capacity power electronic converters, crucial for efficient energy storage. However, a major challenge remains the significant reduction in energy density and charge-discharged efficiency of dielectric polymers under high temperatures, primarily due to heightened electrical conduction losses. This study introduces a universal approach of heterojunction interface engineering in polyethersulfone (PESU) composites, aimed at improving capacitive performance across a broad temperature range.

Ultra-Low Loading Fillers Induced Excellent Capacitive Performance in Polymer-Based Multilayer Nanocomposites under Harsh Environments.

Multilayer-structured nanocomposites are recognized as a prominent strategy for overcoming the paradox between the breakdown strength (E) and polarization (P) to achieve superior energy storage performance. However, current multilayer-structured nanocomposites involving substantial quantities of nanofillers (>10 vol.%) for high dielectric constant as polarization layer will inevitably deteriorate mechanical properties and breakdown strength.

Hepatocellular carcinoma and AIM2: Therapeutic potential through regulation of autophagy and macrophage polarization.

Objective: Hepatocellular carcinoma (HCC) poses a significant challenge to global health. Its pathophysiology involves interconnected processes, including cell proliferation, autophagy, and macrophage polarization. However, the role of Absent in Melanoma 2 (AIM2) in HCC remains elusive.

van der Waals-bonded graphene clusters enhance thermal conductivity of phase-change materials for advanced thermal energy management.

Organic phase-change materials possess immense application potential, but their low thermal conductivity (≤0.5 W m K) severely limits the thermal energy charge/discharge rate, impeding their practical implementation in the field of advanced energy. While incorporating thermally conductive fillers into the phase-change matrix can address this issue, achieving a thermal conductivity exceeding 10 W m K at a filler content below 30 vol% remains challenging, attributed to the absence of a well-designed filler interface and structure.

A Super-Adhesive 2D Diamond Smart Nanofluid with Self-Healing Properties and Multifunctional Applications.

Smart responsive materials are capable of responding to external stimuli and, compared to traditional materials, can be effectively reused and reduce usage costs in applications. However, smart responsive materials often face challenges such as the inability to repair extensive damage, instability in long-term performance, and inapplicability in extreme environments. This study combines 2D diamond nanosheets with organic fluorinated molecules to prepare a smart nanofluid (fluorinated diamond nanosheets, F-DN) with self-healing and self-adhesion properties.

Ultrasound-Responsive Nanodelivery System of GPC3-Targeting and Sonosensitizer for Visualized Hepatocellular Carcinoma Therapy.

Purpose: The incidence of hepatocellular carcinoma (HCC) is continuously increasing, and the mortality rate remains high. Thus, more effective strategies are needed to improve the treatment of HCC.

Methods: In this study, we report the use of a visualized glypican-3 (GPC3)-targeting nanodelivery system (named GC-NBs) in combination with sonodynamic therapy (SDT) to enhance the therapeutic efficacy for treating HCC.

Compressive Properties of Basalt Fibers and Polypropylene Fiber-Reinforced Lightweight Concrete.

With the development of high-rise and large-scale modern structures, traditional concrete has become a design limitation due to its excessive dead weight. High-strength lightweight concrete is being emphasized. Lightweight concrete has low density and the characteristics of a brittle material.

2D Materials-Based Thermal Interface Materials: Structure, Properties, and Applications.

The challenges associated with heat dissipation in high-power electronic devices used in communication, new energy, and aerospace equipment have spurred an urgent need for high-performance thermal interface materials (TIMs) to establish efficient heat transfer pathways from the heater (chip) to heat sinks. Recently, emerging 2D materials, such as graphene and boron nitride, renowned for their ultrahigh basal-plane thermal conductivity and the capacity to facilitate cross-scale, multi-morphic structural design, have found widespread use as thermal fillers in the production of high-performance TIMs. To deepen the understanding of 2D material-based TIMs, this review focuses primarily on graphene and boron nitride-based TIMs, exploring their structures, properties, and applications.

Phage therapy combats pan drug-resistant Acinetobacter baumannii infection safely and efficiently.

Phage therapy offers a promising approach to combat the growing threat of antimicrobial resistance. Yet, key questions remain regarding dosage, administration routes, combination therapy, and the causes of therapeutic failure. In this study, we focused on a novel lytic phage, ФAb4B, which specifically targeted the Acinetobacter baumannii strains with KL160 capsular polysaccharide, including the pan-drug resistant A.

Prognostic value of angiogenic T cells in hepatitis B-induced liver cirrhosis.

This study was performed to investigate the frequency of angiogenic T cells (CD4+ Tang cells) among CD4+ T cells in patients with hepatitis B-induced liver cirrhosis (HBV-LC) and to evaluate the predictive role of these cells in the clinical outcome. In total, 185 patients with HBV-LC were recruited to measure the frequency of CD4+ Tang cells and chemokine levels using flow cytometry. RESULTS: There was 11.