Intermittent fasting and exercise: a dual intervention for orchestrating glycolipid conversion and utilization in healthy mice.

Intermittent fasting (IF) and exercise can reverse the impaired glycolipid conversion ability caused by obesity. However, the effects of IF and exercise combination on glycolipid conversion ability in normal individuals remain to be determined. In this study, male KM mice were subjected to IF (including alternate-day fasting (ADF), time-restricted fasting (TRF)), treadmill exercise, and a combination of the two interventions for 6 weeks.

Self-assembling RADA16-I peptide in situ hydrogel loaded with Celastrol boost immunogenic cell death in oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck and is characterized by high heterogeneity and high recurrence rates. In particular, the serious side effects of radiotherapy and chemotherapy are the main obstacles in OSCC treatment. It is worth noting that immune infiltration is associated with the occurrence of OSCC.

Physicochemical properties and stability of OPO emulsions stabilized by whey protein isolate: Effects of environmental stresses and natural antioxidants.

The stability of whey protein isolate (WPI)-stabilized emulsions is affected by oil phase composition. An appropriate content of 1,3-dioleoyl-2-palmitoylglycerol (OPO) may enhance emulsion stability by balancing oil loading and stress resistance. Therefore, WPI-stabilized emulsions containing 0 %-20 % OPO were prepared, and their particle size, Zeta potential, and stability under thermal, NaCl, and pH stresses were systematically evaluated.

Melatonin: a natural guardian in cancer treatment.

Melatonin (MLT), a naturally occurring hormone produced by the pineal gland, exhibits significant anticancer effects. It has superior antioxidant, inhibit tumor cell proliferation, migration, angiogenesis-inhibiting, and tumor cell apoptosis-inducing functions. Mechanistically, melatonin inhibits tumor development through epigenetic regulation, metabolic reprogramming, immune micro-environment, and regulation of important signaling pathways (PI3K/AKT).

Sodium alginate/carboxymethyl chitosan/gelatin-naringenin pH-responsive hydrogel beads for oral delivery of traditional Chinese herbal medicines.

Stomach disorders are a common category of digestive system diseases. With the increasing emphasis on traditional medicine, the use of herbal medicines in treating gastric diseases has attracted much attention. However, direct administration of herbal medicines with short half-life leads to low drug utilization.

Audiovisual integration of simple stimuli: spatial congruency effects unaffected by working memory load.

The present study sought to investigate whether working memory (WM) load influences the spatial congruency effect in audiovisual (AV) integration using simple stimuli. Participants completed an AV localization task under three WM load conditions (0-back, 1-back, 2-back), Spatially congruent AV stimuli consistently facilitated responses regardless of working memory (WM) load. Statistical analyses found no significant interactions between WM load and audiovisual integration for reaction time (RT), accuracy, sensitivity (), or auditory enhancement effects ( < 0.

Preparation of cellulose based hydrogel 3D SERS flexible substrate for the detection of urea in sweat.

Au NRs/HA/CMC-PVA hydrogel membranes were successfully prepared by mixing sodium hyaluronate (HA) and carboxymethyl cellulose (CMC) solutions for immersion crosslinking on the basis of freeze-thaw crosslinking of polyvinyl alcohol (PVA) with gold nanorods (Au NRs). By adjusting the density of Au NRs and the concentrations of CMC and HA, more 'hot spots' could be generated to enhance the SERS signals, thus improving the sensitivity and homogeneity of the hydrogels (low detection limit of 10 mol/L Rhodamine 6G (R6G), RSD = 3.04 %).

Au(I)-based compounds inhibit nsp14/nsp10 and nsp13 (helicase) to exert anti-SARS-CoV-2 properties.

Au(I) compounds have long been associated with medicine for the treatment of various diseases, especially auranofin has been used for the treatment of rheumatoid arthritis. In addition, Au(I) based compounds also exhibit anti-cancer, anti-bacteria properties. The recent prevalence of the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has aroused attention to investigate the antiviral potential of Au(I) compounds.

Evaluation of ethanolic extract of Clinacanthus nutans leaves in C2C12 myotubes: anti-exercise fatigue activity.

Clinacanthus nutans (Burm.f.) Lindau has antioxidant and anti-inflammatory properties due to its enrichment in natural active components.

Effect of linseed oil and oleogels on the thermal aggregation behavior of myofibrillar protein from Nemipterus virgatus.

The impact of 1 % linseed oil or 1.08 % oleogels prepared using γ-oryzanol and β-sitosterol on the thermal aggregation behavior of myofibrillar protein (MP) was explored. The results showed that the turbidity and particle size of MP solution significantly increased after heating for 40 min.

Wavelength-Selective Control of Visible Light Absorption through Capping-Assisted Oxygen Migration in Oxide Heterostructures.

Oxygen concentration critically determines the physical properties of transition metal oxides. In this work, we realized a subtle modulation of the oxygen concentration in heterostructures composed of perovskite SrTiO (STO) and brownmillerite SrCoO (BM-SCO) by deliberately promoting oxygen migration from the oxygen reservoir to BM-SCO with the assistance of STO capping. A small increase in the oxygen concentration was demonstrated to exclusively change the interorbital transition that is mostly related to the O 2p states in BM-SCO.

Two sesquiterpenoids and a steroid produced by an endophytic fungus Aspergillus sp. YUD20004 and their bioactivity.

Two new sesquiterpenoids asperpenoids A-B (1-2) and one new ergostane-type steroid aspergteroid (3) were isolated from the fungus Aspergillus sp. YUD20004 which was derived from the tuber of Zingiber officinale Roscoe. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, electronic circular dichroism (ECD) spectra and consideration of the biogenetic origins.

Effects of Time-Restricted Fasting-Nicotinamide Mononucleotide Combination on Exercise Capacity via Mitochondrial Activation and Gut Microbiota Modulation.

Background/objectives: Athletic performance matters for athletes and fitness enthusiasts. Scientific dietary intervention may boost athletic performance alongside training. Intermittent fasting, like time-restricted fasting (TF), may enhance metabolic health.

Interface self-assembly preparation of Nylon66-Ag for monitoring of HO and AA in serum.

Monitoring the redox status in vivo is important for maintaining redox homeostasis and understanding related pathological processes. In this study, based on an interfacial self-assembly method, a silver-coated nylon film (Nylon66-Ag) was prepared as a SERS substrate and a single-molecule specific SERS probe, 2-mercapto-1,4-diphenol (2-MHQ), was modified on the silver nanoparticles for sensitive detection of HO and AA in human serum. Remarkably, this method, without the introduction of internal standard signaling molecules, only one Raman signaling reporter molecule, 2-MHQ, was able to sensitively detect HO and AA, and thus monitor the redox reactions in human serum, with LODs as low as 4.

Role in Preventing Alcoholic Liver Disease Progression: A Comparative Study of Whole-Component Finger Citron Essential Oil and Its Major Component D-Limonene.

: Chronic alcohol overconsumption triggers alcohol liver injury, and therapeutic strategies targeting alcohol-triggered oxidative stress and hepatic inflammatory responses represent potential approaches to ameliorating alcohol-related hepatotoxicity. This study aimed to determine the hepatoprotective activity of finger citron essential oil (FCEO) in alcoholic liver disease (ALD)-afflicted rats and explore its underlying mechanisms. In order to identify the effective components, we compared the effects of FCEO and D-limonene.

Numerical calculation method for the probability of target damage caused by fragment swarm under random retention time series.

Addressing the issue of uncertainty in calculating the damage effectiveness of aerial maneuvering targets due to the random intersection with warhead fragment clusters formed by projectile proximity explosions, this paper puts forward a numerical calculation method of the aerial maneuvering target damage probability under the intersection between the warhead fragment group and the target with random dwell time sequence (RDTS) characteristics. Leveraging the random scattering characteristics of warhead fragment clusters and incorporating the vulnerability characteristics of the aerial maneuvering target, a model for calculating the probability of hitting and damaging an aerial maneuvering target with a warhead fragment cluster from a single projectile's explosive is established. Factors related to the random dwell time of the target possibly falling into the effective damage area of the warhead fragment cluster from the projectile's proximity explosion are introduced, resulting in the development of a model for calculating the damage probability of an aerial maneuvering target under RDTS.

Novel Polyketides with Agricultural Bioactivity Produced by sp. HDSJ-28, an Endophytic Fungus Derived from .

Phomopsisols A and B ( and ), possessing an unprecedented highly oxygenated isobenzofuran dimer core, along with one new tenellone derivative (), and two new polyketides ( and ), as well as 11 known compounds, were isolated from the endophytic sp. associated with . The structures were determined mainly by the NMR, MS, ECD, and optical rotation calculations and single-crystal X-ray diffraction analyses.

Retraction: VEGF gene transfection restores the angiogenesis of oral submucous fibrosis in mice.

[This retracts the article DOI: 10.21037/atm-21-2213.].

Transcutaneous auricular vagus nerve stimulation does not modulate working memory capacity but alters pupillary responses in the change detection task.

Transcutaneous vagus nerve stimulation (taVNS) offers an effective, non-invasive alternative to implantable vagus nerve stimulation and it is considered to be a promising cognitive modulation tool. However, at present, the effect of taVNS on working memory is not clear, Simultaneously, the potential pupillary responses stemming from taVNS require more empirical inquiry. Herein, we investigated the influence of taVNS on working memory capacity and its link to pupillary responses during the change detection task.

Tonic and Event-Related Phasic Transcutaneous Auricular Vagus Nerve Stimulation Alters Pupil Responses in the Change-Detection Task.

Background: Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a potential modulator of cognitive behavior by activating the locus ceruleus-noradrenaline (LC-NA) system. Previous studies explored both phasic and tonic taVNS by investigating their impact on LC-NA markers such as pupil dilation and heart rate variability (HRV).

Objective: Inconsistencies persist in the identification of reliable markers for assessing the effects of taVNS on noradrenergic activity.

Metabolites, Biotransformation, and Plant-Growth Dual Regulatory Activity from Uncovered by the Fermentation Interaction with a Host.

One new azaphilone derivative () from in ordinary medium, one new phthalide derivative (), a microbial transformation product of ingredients by , a pair of new austdiol enantiomers (+)- and (-)-, one new epsilon-caprolactone derivative (), and one new ophiobolin-type sesterterpenoid () from the in host medium were reported. The structures were determined by spectroscopic analysis and single-crystal X-ray diffraction. Compounds - could completely inhibit the germination of rice seeds at 50 μg/mL, which is higher than that of the positive control.

Competing endogenous RNAs network dysregulation in oral cancer: a multifaceted perspective on crosstalk and competition.

Oral cancer progresses from asymptomatic to advanced stages, often involving cervical lymph node metastasis, resistance to chemotherapy, and an unfavorable prognosis. Clarifying its potential mechanisms is vital for developing effective theraputic strategies. Recent research suggests a substantial involvement of non-coding RNA (ncRNA) in the initiation and advancement of oral cancer.

Exogenous methyl jasmonate (MeJA) mediated carbohydrate metabolism in apple fruit during ripening.

Carbohydrate metabolism plays an essential role in mediating quality and ripening of postharvest fruit. Previous work has demonstrated the regulatory role of methyl jasmonate (MeJA) in ripening of apple fruit. However, the role of MeJA in mediating carbohydrate metabolism of ripening apple fruit is unexplored.