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Article Abstract
Monitoring the redox status in vivo is important for maintaining redox homeostasis and understanding related pathological processes. In this study, based on an interfacial self-assembly method, a silver-coated nylon film (Nylon66-Ag) was prepared as a SERS substrate and a single-molecule specific SERS probe, 2-mercapto-1,4-diphenol (2-MHQ), was modified on the silver nanoparticles for sensitive detection of HO and AA in human serum. Remarkably, this method, without the introduction of internal standard signaling molecules, only one Raman signaling reporter molecule, 2-MHQ, was able to sensitively detect HO and AA, and thus monitor the redox reactions in human serum, with LODs as low as 4.03 × 10 M for HO and 9.42 × 10 M for AA. The detection limits are significantly lower than the concentration ranges of endogenous HO and AA in the blood of healthy individuals. The SERS strategy proposed in this paper is expected to be used to study signaling pathways related to redox kinetics.
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| http://dx.doi.org/10.1016/j.saa.2025.126238 | DOI Listing |
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