RNFT2 promotes malignancy of triple-negative breast cancer and predicts poor outcomes.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer, and has a high recurrence rate. RING finger transmembrane-domain containing protein 2 (RNFT2) is a RING-finger E3 ubiquitin ligase that exerts oncogene functions in multiple malignant tumors such as bladder cancer and gastric cancer. However, RNFT2's role in TNBC is still unclear.

Insight on the functionalization of hesperidin: Encapsulated by the complex of soybean protein isolate and polysaccharides.

Protein-polysaccharide complexes exhibit distinctive attributes that render suitable for encapsulating active ingredients. In this study, chitosan (CT), guar gum (GG), and xanthan gum (XG) were employed as ionic/non-ionic polysaccharides, in conjunction with soybean protein isolate (SPI), to encapsulate hesperidin (HP). When the ratio of protein to polysaccharide was 3:1 (w/w), the SPI/XG complex demonstrated an encapsulation efficiency of 90.

Mo-O Dual-Doped Argyrodite Electrolyte Enables Stable All-Solid-State Lithium Batteries.

Sulfide solid electrolytes are one of the most promising solid electrolytes for all-solid-state lithium batteries due to their relatively high ionic conductivity and favorable mechanical properties. Nevertheless, their inferior moisture stability and lithium metal compatibility hinder the practical applications. Herein, a Mo-O dual-doped argyrodite LiP MoS O Cl sulfide electrolytes are synthesized to enhance both moisture stability and electrochemical characteristics.

A novel cathode Li-supplement additive for high-energy and long-lifespan LIBs.

A novel cathode Li-supplement additive, LiSiO@rGO, has been developed; it features high capacity (820 mA h g), high air stability, and feasible Li-supplement potential (4.3 V). Its integration in NCM622‖graphite improves the energy density by 9% and enhances the capacity retention from 27.

An Innovative Method to Prevent Guidewire Access to the Ipsilateral Internal Jugular Vein During Pediatric Subclavian Vein Cannulation.

Objectives: To investigate whether an innovative method of occluding the internal jugular vein (IJV) by applying temporary pressure at the IJV just above the clavicle could help prevent catheter misplacement into the IJV, which often occurs during pediatric subclavian vein (SCV) catheter placement.

Design: This was a randomized controlled trial.

Settings: This study was conducted in a single medical center.

Effect of echocardiography on prognosis in patients with type 2 diabetes mellitus.

Objective: There was a lack of studies on the relationship between the presence or absence of echocardiography and the prognosis of type 2 diabetes mellitus (DM) patients. Therefore, we used the Medical Information Mart for Intensive Care (MIMIC)-IV database to explore the relationship between them.

Method: The patient information was obtained from the MIMIC-IV database.

Controlled hydrolysis and EGCG conjugation enhance the ADH/ALDH activation activity of chia seed meal protein hydrolysates: Fabrication and structural characterization.

This study examines the effects of hydrolysis duration (20-100 min using flavourzyme) and EGCG conjugation on the structure and bioactivity of chia seed meal protein hydrolysates (CSPH) through multi-spectroscopic techniques and physicochemical property evaluation. Subsequently, the activation effects of EGCG-conjugated peptides on alcohol metabolism-related enzymes were further analyzed through the integration of peptidomics, bioinformatics, and computational chemistry. It was found that with the extension of hydrolysis time, the thermal stability of CSPH diminishes, its rigid structure becomes more flexible, and its crystallinity decreases (by up to 27.

AMPK: An energy sensor for non-small cell lung cancer progression and treatment.

Lung cancer (LC) is the leading cause of cancer-related morbidity and mortality in China, with non-small cell lung cancer (NSCLC) accounting for 85 % of the overall lung cancer cases. AMP-activated protein kinase (AMPK) is a key regulator of energy balance and homeostasis, and its dysregulation is a common feature in various malignancies, particularly in NSCLC with mutations in Liver kinase B1 (LKB1). Studies have shown that the AMPK signalling pathway has a dual role in NSCLC progression, both inhibiting and promoting the progression of malignant tumours.

PPARβ/δ agonist GW0742 mitigates acute liver damage induced by acetaminophen overdose in mice.

Liver damage caused by acetaminophen (APAP) overdose remains a worldwide medical problem. New therapeutic medicines for APAP poisoning are needed as the efficacy of the only antidote, N-acetyl-cysteine (NAC), significantly decreases if administered after 8 h of APAP intake and massive APAP overdose remains to induce hepatotoxicity despite the timely administration of NAC. Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) possesses versatile roles including regulation of lipid homeostasis and anti-inflammation in the liver.

PEG-based-ultrasound-microwave synergistic extraction of mucilage polysaccharides from chia seed: Structural characterization and bioactivity.

In this study, the effects of microwave, ultrasound, ultrasound-microwave synergy, and polyethylene glycol (PEG)-200 on the chia seed mucilage's (CSM) structural, thermal, and functional properties have been evaluated by modern spectroscopic techniques, crystal diffraction, and thermal analyses. The results showed that CSM, extracted by PEG-200 aqueous solution has the largest particles (1120-1231 μm), and the smallest size (44.06-317.

Comparison of extraction process, physicochemical properties, and in vitro digestion characteristics of chia seed mucilage polysaccharide.

The study explored five (acidic, alkaline, heating, ionic liquid, and urea solvent) extraction methods' effects on chia seed mucilage polysaccharide (CSM), an anionic polymeric macromolecule, regarding its physicochemical properties, structure, and digestion behavior. The results showed that extraction parameters have a considerable effect on modulating CSM properties. Significant differences emerged in the predominant chemical compositions: the carbohydrates and protein content ranged from 49.

Skimmed milk intake reduces the risk of ER- breast cancer: a Mendelian randomization analysis.

Background: In prior observational investigations, it has been demonstrated that the consumption of milk is associated with the incidence of breast cancer (BC). Despite the existence of a two-sample Mendelian randomization (MR) that suggests a causal relationship between milk intake and breast cancer risk, the outcomes still lack a definitive conclusion. This ambiguity may be attributed to variables such as the variety of milk ingested, estrogen levels, the specific type of BC, and potential confounding factors.

Exploring Enzyme Encapsulation Efficiency in MOFs Using Eco-Friendly Approaches.

The encapsulation of protein enzymes in metal-organic frameworks (MOFs) has been recognized as an effective enzyme immobilization approach. In this study, we demonstrated the influence of enzyme amount and the isoelectric points (pI) of different enzymes on the enzyme loading capacity in both mechanochemical (ball-milling) and water-based approaches. We found that increasing enzyme amounts enhances MOF enzyme loading without compromising activity, while the MOF shell protects encapsulated enzymes from proteinase K degradation through its size-sheltering mechanism.

Electron-injection-engineering induced dual-phase MoOF/MoOF heterostructure for magnesium storage.

Rechargeable magnesium batteries (RMBs) have received increased attention due to their high volumetric capacity and safety. Nevertheless, the sluggish diffusion kinetics of highly polarized Mg in host lattices severely hinders the development of RMBs. Herein, we report an electron injection strategy for modulating the Mo 4d-orbital splitting manner and first fabricate a dual-phase MoOF/MoOF heterostructure to accelerate Mg diffusion.

Analyzing political party positions through multi-language twitter text embeddings.

Traditional monolingual word embedding models transform words into high-dimensional vectors which represent semantics relations between words as relationships between vectors in the high-dimensional space. They serve as productive tools to interpret multifarious aspects of the social world in social science research. Building on the previous research which interprets multifaceted meanings of words by projecting them onto word-level dimensions defined by differences between antonyms, we extend the architecture of establishing word-level cultural dimensions to the sentence level and adopt a Language-agnostic BERT model (LaBSE) to detect position similarities in a multi-language environment.

PromptFix: Few-shot Backdoor Removal via Adversarial Prompt Tuning.

Pre-trained language models (PLMs) have attracted enormous attention over the past few years with their unparalleled performances. Meanwhile, the soaring cost to train PLMs as well as their amazing generalizability have jointly contributed to few-shot fine-tuning and prompting as the most popular training paradigms for natural language processing (NLP) models. Nevertheless, existing studies have shown that these NLP models can be backdoored such that model behavior is manipulated when trigger tokens are presented.

Challenges of COVID-19 Case Forecasting in the US, 2020-2021.

During the COVID-19 pandemic, forecasting COVID-19 trends to support planning and response was a priority for scientists and decision makers alike. In the United States, COVID-19 forecasting was coordinated by a large group of universities, companies, and government entities led by the Centers for Disease Control and Prevention and the US COVID-19 Forecast Hub (https://covid19forecasthub.org).

Comparison of postoperative analgesia in children following ropivacaine and lidocaine surgical field infiltration with epinephrine for cleft palate repair: A double-blinded, randomized controlled trial.

Study Objective: The study aimed to evaluate the efficacy of ropivacaine in providing postoperative analgesia for children undergoing cleft palate repair.

Methods: A double-blinded, randomized controlled trial was conducted on sixty-four children scheduled for cleft palate repair. The patients received either local infiltration with 1% lidocaine or 0.

Dynamic Behavior of Spatially Confined Sn Clusters and Its Application in Highly Efficient Sodium Storage with High Initial Coulombic Efficiency.

Advanced battery electrodes require a cautious design of microscale particles with built-in nanoscale features to exploit the advantages of both micro- and nano-particles relative to their performance attributes. Herein, the dynamic behavior of nanosized Sn clusters and their host pores in carbon nanofiber) during sodiation and desodiation is revealed using a state-of-the-art 3D electron microscopic reconstruction technique. For the first time, the anomalous expansion of Sn clusters after desodiation is observed owing to the aggregation of clusters/single atoms.

Modified nusinersen intrathecal injection method: inclusion of a septal needle-free closed infusion connector.

Objective: Nusinersen, an extremely expensive biologic drug (around 100,000 US$ per dose) that needs to be administered intrathecally, is approved for the treatment of 5q-spinal muscular atrophy (SMA). Because of the low muscle tone of the back muscles of pediatric SMA patients, especially type 1 SMA patients, the safe, effective, and fast execution of sheath injection is needed. Therefore, a modified intrathecal injection method was developed accordingly.

Anaesthesia of a parturient with uncorrected pentalogy of Fallot undergoing caesarean section and postpartum sterilisation.

Pentalogy of Fallot is a rare congenital cyanotic heart disease; few patients with uncorrected disease survive to childbearing age. Cardiovascular changes during pregnancy and delivery can lead to haemodynamic instability, while anaesthesia can cause right-to-left shunting and worsen hypoxaemia.We present the learning points from the anaesthetic management of an obstetric patient with uncorrected pentalogy of Fallot.

Prophylactic Epidural Blood Patch or Prophylactic Epidural Infusion of Hydroxyethyl Starch in Preventing Post-Dural Puncture Headache - A Retrospective Study.

Background: Post-dural puncture headache (PDPH) is particularly likely to happen in patients under obstetric care due to an unintentional dural puncture (UDP). There is as yet no ideal strategy for preventing UDP-induced PDPH.

Objectives: The primary objective of this study was to assess whether a prophylactic epidural blood patch (EBP) or prophylactic epidural infusion of hydroxyethyl starch (HES) is effective in preventing PDPH for parturients with UDP compared with conservative treatments.