Innovative SIFSIX-1-Cu-based microwave sensor with directionally ordered interconnected nanochannels: Revolutionizing high-performance SO detection.

SO sensors generally face challenges such as gas corrosion, poor selectivity, competition from water molecules, and high recovery costs. Metal-organic frameworks (MOFs), which offer excellent chemical stability, structural diversity, and low-cost reactivation, have emerged as ideal candidates for sensing materials. However, MOFs typically exhibit poor conductivity, making them unsuitable for traditional gas detection devices.

12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis.

Background: Disturbed flow regions in the vasculature are predisposed to endothelial dysfunction and atherosclerotic plaque formation. The enzyme 12/15-lipoxygenase (12/15-LOX, encoded by ALOX15) has emerged as a promising therapeutic target for atherosclerosis. However, the relationship between 12/15-LOX and disturbed flow-induced atherosclerosis remains uncharacterized.

Occurrence, exposure and health risk assessment of heavy metals in green tea samples cultivated in Hangzhou area.

The concentration of heavy metals in 120 green tea samples grown in Hangzhou area were investigated by inductively coupled plasma mass spectrometry (ICP-MS). Except for mercury (Hg) (69.2%), Sb (98.

Waveguide microwave gas sensor based on monolithic InO for enhanced ammonia detection.

For commonly used chemical resistance sensors, achieving room-temperature detection often results in reduced performance. Microwave gas sensors have been rapidly expanding in recent years, attributed to their advantages of room-temperature operation and low power consumption. Waveguide, as a three-dimensional microwave circuit with separated electric and magnetic field distributions, resulting in high quality factor, is expected to significantly enhance the sensitivity of microwave sensors.

Visual quantitative point-of-care immunoassay based on signal transduction amplification and hue-recognition analysis.

Visual based immunoassay employs both human eye interpretation and machine-vision (smartphone imaging) quantification for equipment-independent diagnosis of biomarkers, fitting a variety of scenarios such as home-testing. Here we use hue-recognition strategy to create vivid and sensitive color changes against C-reactive protein (CRP) for accurate visual analysis. The red-to-green tonality gradient presentation was realized by ratiometric fluorescent probe using dual-emissive quantum dots (QDs) structure.

Evolution of static fracture mechanics and energy dissipation characteristics of composites based on different interface angles.

This study aims to investigate the mechanical properties and energy characteristics of coal-rock combinations during uniaxial compression, specifically focusing on variations in interface inclination angles. Each of the stress-strain curves of the CRC (Coal-Rock-Like Material Combination) with varying interface inclination angles were obtained using the DYD-10 universal testing machine and a high-definition camera system. Subsequently, the energy of the CRC was calculated using a specific formula.

Wearable Self-Powered Pressure Sensors Based on alk-TiCT Regulating Contact Barrier Difference for Noncontact Motion Object Recognition.

Wearable self-powered pressure sensors present tremendous potential for object recognition. However, the fluctuated approach speed and distance may compromise the device output, thus affecting the recognition accuracy. Herein, a wearable self-powered pressure sensor with high sensitivity (1.

Oxygen vacancy and interface effect dual modulation of SnS/SnO heterojunction for boosting formaldehyde detection at low temperature.

Formaldehyde (HCHO) is a harmful volatile organic pollutant, which is commonly found in interior decoration and furniture products. Therefore, it is necessary to develop a gas sensor that can quickly and accurately detect formaldehyde for human health and environmental protection. In order to achieve this goal, in this work, SnS/SnO heterostructure was synthesized by in-situ sulfurization process on the basis of SnO nanospheres, and its formaldehyde sensing performance was studied.

A simply synthesized, silver ions-doped porous gold microparticles-based SERS aptamer sensor for ultrasensitive and broad-range quantitative detection of IL-6.

Background: The multifunctional cytokine interleukin-6 (IL-6) plays a pivotal role in chronic and acute inflammatory responses, underscoring the importance of accurately determining IL-6 levels for early diagnosis, prevention, and treatment of inflammation.

Results: This study developed a versatile and innovative single-particle surface-enhanced Raman spectroscopy (SERS) sensing platform for the precise and sensitive quantification of IL-6 in complex samples using a novel one-pot synthesized, silver ions-doped three-dimensional porous gold microparticles (PGMs) with abundant hot spots for robust SERS enhancement. By rationally designing rich cytosine-Ag-cytosine base pairs between IL-6 aptamers and complementary chains on the PGMs, we harnessed the SERS-enhancing effect to achieve highly sensitive and specific IL-6 quantification within a wide range of 10 to 10 mg/mL and a limit of detection (LOD) of 0.

Waveguide-Based Microwave Nitric Oxide Sensor for COVID-19 Screening: Mass Transfer Modulation Effect on Hollow Confined WO Structures.

Serious acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a tremendous threat to global public health. Recently, the Food and Drug Administration approved the emergency use of volatile organic components as detection biomarkers for COVID-19, ushering in a new era of portable, simple, and rapid epidemiological screening based on breath diagnosis. Nitric oxide (NO) is an important biomarker indicating the degree of inflammation in the respiratory tract.

Epicardial adipose tissue volume and density are associated with heart failure with improved ejection fraction.

Background: Heart failure (HF) with improved ejection fraction (EF, HFimpEF) is a distinct HF subtype, characterized by left ventricular (LV) reverse remodeling and myocardial functional recovery. Multiple cardiometabolic factors are implicated in this process. Epicardial adipose tissue (EAT), emerging as an endocrine and paracrine organ, contributes to the onset and progression of HF.

Co-Doped Porous Carbon/Carbon Nanotube Heterostructures Derived from ZIF-L@ZIF-67 for Efficient Microwave Absorption.

Carbon-based magnetic metal composites derived from metal-organic frameworks (MOFs) are promising materials for the preparation of broadband microwave absorbers. In this work, the leaf-like co-doped porous carbon/carbon nanotube heterostructure was obtained using ZIF-L@ZIF-67 as precursor. The number of carbon nanotubes can be controlled by varying the amount of ZIF-67, thus regulating the dielectric constant of the sample.

Confinement Enrichment Effect in HoMS-BaTiO Microwave Gas Sensors for the Detection of 10 ppb-0.55 v/v% Ammonia at Room Temperature.

The construction of ammonia gas sensors with wide detection ranges is important for exhalation diagnosis and environmental pollution monitoring. To achieve a wide detection range, sensitive materials must possess excellent spatial confinement and large active surfaces to enhance gas adsorption. In this study, an ammonia microwave gas sensor with a wide detection range of 10 ppb-0.

Predicting pediatric Crohn's disease based on six mRNA-constructed risk signature using comprehensive bioinformatic approaches.

Crohn's disease (CD) is a recurrent, chronic inflammatory condition of the gastrointestinal tract which is a clinical subtype of inflammatory bowel disease for which timely and non-invasive diagnosis in children remains a challenge. A novel predictive risk signature for pediatric CD diagnosis was constructed from bioinformatics analysis of six mRNAs, adenomatosis polyposis downregulated 1 (APCDD1), complement component 1r, mitogen-activated protein kinase kinase kinase kinase 5 (MAP3K5), lysophosphatidylcholine acyltransferase 1, sphingomyelin synthase 1 and transmembrane protein 184B, and validated using samples. Statistical evaluation was performed by support vector machine learning, weighted gene co-expression network analysis, differentially expressed genes and pathological assessment.

Long-term glycemic variability predicts compromised development of heart failure with improved ejection fraction: a cohort study.

Background: A substantial portion of heart failure (HF) patients adherent to guideline-directed medical therapies have experienced improved ejection fraction (EF), termed HFimpEF. Glycemic variability (GV) has emerged as a critical cardiometabolic factor. However, the relation between long-term GV and the incidence of HFimpEF is still unclear.

Protein profiles reveal MSH6/MSH2 as a potential biomarker for hepatocellular carcinoma with microvascular invasion.

Aim: Microvascular invasion (MVI) is an independent risk factor for postoperative recurrence and metastasis in hepatocellular carcinoma (HCC). However, the specific protein expression profiles that differentiate HCC with MVI from those without MVI remain unclear.

Methods: The profiles of proteins in early-stage HCC tissues and normal liver tissues were characterized by quantitative proteomics techniques.

In Situ Fabrication of SnS/SnO Heterostructures for Boosting Formaldehyde-Sensing Properties at Room Temperature.

Formaldehyde, as a harmful gas produced by materials used for decorative purposes, has a serious impact on human health, and is also the focus and difficulty of indoor environmental polution prevention; hence, designing and developing gas sensors for the selective measurement of formaldehyde at room temperature is an urgent task. Herein, a series of SnS/SnO composites with hollow spherical structures were prepared by a facile hydrothermal approach for the purpose of formaldehyde sensing at room temperature. These novel hierarchical structured SnS/SnO composites-based gas sensors demonstrate remarkable selectivity towards formaldehyde within the concentration range of sub-ppm (0.

Epidemiological analysis of syphilis surveillance among entry-exit population at Shanghai Port, China from 2014 to 2022.

Objective: To investigate the epidemiological characteristics of syphilis cases detected among entry-exit personnel at Shanghai ports from 2014 to 2022 and the changing trend of the syphilis epidemic in the region so as to provide data support for the scientific and effective prevention and control of syphilis at ports.

Methods: From January 2014 to December 2022, the subjects of syphilis screening at Shanghai port were selected. Physical examination and serological testing were used to confirm syphilis.

Differences in right ventricular function and response to targeted therapy between patients with IPAH and PAH-CHD.

Pulmonary arterial hypertension (PAH) is a chronic pulmonary vascular disorder characterized by elevated pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP). Right heart failure is a life-threatening complication of PAH and predicts a poor prognosis. PAH associated with congenital heart disease (PAH-CHD) and idiopathic PAH (IPAH) are two prevalent PAH subtypes in China.

DYRK2 downregulation in colorectal cancer leads to epithelial-mesenchymal transition induction and chemoresistance.

Colorectal cancer (CRC) is among the most prominent causes of cancer-associated mortality in the world, with chemoresistance representing one of the leading causes of treatment failure. However, the mechanisms governing such chemoresistance remain incompletely understood. In this study, the role of DYRK2 as a mediator of CRC cell drug resistance and the associated molecular mechanisms were assessed by evaluating human tumor tissue samples, CRC cell lines, and animal model systems.

Serum Uric Acid Is Associated with the Progression of Left Ventricular Diastolic Dysfunction in Apparently Healthy Subjects.

Background: Left ventricular (LV) diastolic dysfunction (LVDD) is the defining feature of heart failure with preserved ejection fraction (HFpEF) and predicts subsequent incident heart failure (HF) and all-cause mortality. Mounting evidence reveals that cardiometabolic risk factors play critical roles in the development of LVDD. In this study, we sought to investigate the relation between serum uric acid (SUA) level and the progression of LVDD in apparently healthy patients.

Glutamic Acid and Poly-γ-glutamic Acid Enhanced the Heat Resistance of Chinese Cabbage ( L. ssp. ) by Improving Carotenoid Biosynthesis, Photosynthesis, and ROS Signaling.

Heat stress is one of the most common agrometeorological risks in crop production in the middle and lower reaches of the Yangtze River in China. This study aimed to investigate whether glutamic acid (Glu) or poly-γ-glutamic acid (γ-PGA) biostimulants can improve the thermotolerance of a cool-season Chinese cabbage ( L. ssp.

Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress.

Hemodynamic shear stress (SS), a frictional force generated by blood flow, regulates vascular homeostasis. High and steady SS maintains physiological function of endothelial cells while low and disturbed SS promotes disturbance of vascular homeostasis and the development of atherosclerosis. Endothelial microparticle (EMP), a vesicular structure shed from endothelial cells, has emerged as a surrogate biomarker of endothelial injury and dysfunction.

Insulin Resistance Is Associated With Heart Failure With Recovered Ejection Fraction in Patients Without Diabetes.

Background Because of advances in medical treatments, a substantial proportion of patients with heart failure (HF) have experienced recovery of ejection fraction (EF), termed HF with recovered EF (HFrecEF). Insulin resistance (IR) is prevalent in HF and tightly related with prognosis. This study investigates the relationship between IR and the incidence of HFrecEF in patients who are nondiabetic.