A strain-programmed lignin-based Janus patch for rapid healing of postoperative rectal wounds.

Clinically, patients experience severe pain, frequent bleeding, and delayed wound healing after hemorrhoidectomy due to recurrent fecal contamination during postoperative dressing changes and bowel movements, which exacerbate wound irritation. : In this study, we developed a strain-programmed lignin-based multifunctional Janus patch (S-SFR@AGL) to accelerate rectal wound repair. This patch features a pre-stretched fluorinated silicone rubber side with robust anti-biofouling and strain-programmed properties, paired with a lignin-based hydrogel side offering potent antibacterial, antioxidant, bioadhesive, and hemostatic capabilities.

FDX1 facilitates elesclomol-induced cuproptosis and promotes glioblastoma development via transcription factor NFKB1.

Ferredoxin 1 (FDX1) played a key role in mediating elesclomol-induced cuproptosis against cancer cells. Although previous studies revealed its prognostic significance and regulatory effect on immune responses in glioblastoma, the underlying mechanisms by which FDX1 modulating tumor progression and cuproptosis remained unclear. In this study, FDX1 was either overexpressed or knocked down in glioblastoma cells.

Amlodipine synergizes with temozolomide against glioma stem cells by modulating MGMT expression through downregulation of the AKT/GSK3β/β-catenin axis.

Temozolomide (TMZ) is the primary chemotherapeutic agent used for the treatment of glioblastoma. However, the high chemoresistance observed in glioblastoma remains a significant clinical challenge, which is associated with the repair of DNA alkylation sites by O6-methylguanine-DNA methyltransferase (MGMT). Exploring new strategies to enhance the tumoricidal activity of TMZ against chemoresistant glioma stem cells (GSCs), is crucial for improving patient outcomes.

Repetitive peripheral magnetic stimulation for pain, disability, and kinesiophobia in patients with chronic musculoskeletal pain: a systematic review and meta-analysis.

Introduction: Repetitive peripheral magnetic stimulation (rPMS) is a non-invasive and painless approach developed for therapeutic intervention in clinical rehabilitation. Chronic musculoskeletal pain (CMP) originates from the musculoskeletal system and leads to disability and fear of pain. It may be an option for CMP treatment, but its effectiveness is still unclear.

Efficacy and safety of spinal manipulative therapy in the management of acute neck pain: a systematic review and meta-analysis.

Background: Spinal manipulative therapy (SMT) is frequently used to manage neck pain; however, its efficacy and safety in treating acute neck pain (ANP) remain uncertain and require further investigation.

Objectives: This study aims to comprehensively evaluate the efficacy and safety of SMT in the treatment of ANP.

Databases And Data Treatment: A thorough search was conducted in PubMed, Embase, Web of Science, PEDro, and Cochrane Library databases, covering all studies from inception to March 20, 2023.

Revealing Trapped Carrier Dynamics at Buried Interfaces in Perovskite Solar Cells via Infrared-Modulated Action Spectroscopy with Surface Photovoltage Detection.

Interfacial engineering is a proven strategy to enhance the efficiency of perovskite solar cells (PeSCs) by controlling surface electronic defects and carrier trapping. The trap states at the "top" interface between the perovskite and upper charge extraction layers are experimentally accessible and have been extensively studied. However, the understanding of the unexposed "bottom" surface of the perovskite layer remains elusive, due to the lack of selective and non-destructive tools to access buried interface.

The kinase CPK5 phosphorylates MICRORCHIDIA1 to promote broad-spectrum disease resistance.

In Arabidopsis (Arabidopsis thaliana), MICRORCHIDIA 1 (MORC1), a member of the MORC family of evolutionarily conserved GHKL-type ATPases, plays important roles in multiple layers of plant immunity. However, the molecular mechanism by which MORC1 regulates plant immunity remains obscure. Here, we report that the pathogen-responsive kinase CALCIUM-DEPENDENT PROTEIN KINASE 5 (CPK5) directly interacts with and phosphorylates MORC1, thereby promoting its stability and nuclear translocation.

Efficacy and safety of repetitive transcranial magnetic stimulation with different frequencies on neuropathic orofacial pain: a systematic literature review and meta-analysis.

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive technique used to treat neuropathic orofacial pain (NOP). This study aimed to evaluate the efficacy and safety of rTMS in managing NOP and reducing health risks. A comprehensive literature search was conducted in various databases, including PubMed, Physiotherapy Evidence Database (PEDro), the Cochrane Library, Web of Science, Embase and Clinical Trials.

A self-healing, long-lasting adhesive, lignin-based polyvinyl alcohol organo-hydrogel for strain-sensing applications.

Hydrogel-based flexible sensors have garnered considerable interest in the fields of soft electronics, robotics, and human-machine interfaces. For better practical applications, integrating multiple properties-such as self-adhesive, anti-freeze, anti-volatile, self-healing, and antibacterial-into a single gel for flexible sensors remains a challenge. In this paper, a multifunctional lignin-based polyvinyl alcohol gel, containing dynamic covalent bonds, hydrogen bonds, and coordination bonds, is constructed by a simple one-pot method, in which ethylene glycol/water chosen as a binary solvent and KI as a conductive medium.

Effect of guar gum on the physicochemical properties and in vitro digestive characteristics of extruded starches.

The present study assessed the impact of guar gum (GG) on the physical and chemical attributes and the in vitro digestibility of maize starch (MS), pea starch (PS), and sweet potato starch (SPS) subjected to extrusion treatment. Starch with 25 % moisture content and combined with GG in a 9:1 ratio was selected for extrusion. Scanning electron microscopy and differential scanning calorimetry reveal that extrusion disrupts the ordered structure of starch and induces aggregation of starch granules, resulting in a more cohesive structure, and GG addition led to the further evolution of this structure into a more intricate and irregular form.

Rapid flotation of mediated by high light exposure: implications for surface scum formation and cyanobacterial species succession.

Increasing occurrences of surface scum have been observed in the context of global climate change and the increase in anthropogenic pollution, causing deteriorating water quality in aquatic ecosystems. Previous studies on scum formation mainly focus on the buoyancy-driven floating process of larger colonies, neglecting other potential mechanisms. To study the non-buoyancy-driven rapid flotation of , we here investigate the floating processes of two strains of single-cell species ( and ), which are typically buoyant, under light conditions (150 μmol photons s m).

Effect of extracellular polymeric substances on the colony size and morphological changes of .

Surface blooms of colony-forming are increasingly occurring in aquatic ecosystems on a global scale. Recent studies have found that the colonial morphology is a crucial factor in the occurrence, persistence, and dominance of blooms, yet the mechanism driving its morphological dynamics has remained unknown. This study conducted a laboratory experiment to test the effect of extracellular polymeric substances on the morphological dynamics of .

Operando dynamics of trapped carriers in perovskite solar cells observed via infrared optical activation spectroscopy.

Conventional spectroscopies are not sufficiently selective to comprehensively understand the behaviour of trapped carriers in perovskite solar cells, particularly under their working conditions. Here we use infrared optical activation spectroscopy (i.e.

A modified nucleoside O6-methyl-2'-deoxyguanosine-5'-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner.

Resistance to temozolomide (TMZ), the frontline chemotherapeutic agent for glioblastoma (GBM), has emerged as a formidable obstacle, underscoring the imperative to identify alternative therapeutic strategies to improve patient outcomes. In this study, we comprehensively evaluated a novel agent, O6-methyl-2'-deoxyguanosine-5'-triphosphate (O6-methyl-dGTP) for its anti-GBM activity both in vitro and in vivo. Notably, O6-methyl-dGTP exhibited pronounced cytotoxicity against GBM cells, including those resistant to TMZ and overexpressing O6-methylguanine-DNA methyltransferase (MGMT).

A simple and low-energy strategy for the separation of water and acetonitrile.

As acetonitrile is a widely used solvent for the chemical industry, the recovery of acetonitrile from acetonitrile wastewater is significant for both industrial cost reduction and environmental protection. In this article, a simple, low-energy, and low-cost strategy is proposed for the effective separation of acetonitrile from high-concentration acetonitrile wastewater. The approach is based on a sequential combination of two steps: salt-induced phase separation and hydrophobic filtration.

Effect of Repetitive Peripheral Magnetic Stimulation on Patients With Low Back Pain: A Meta-analysis of Randomized Controlled Trials.

Objective: The purpose of this meta-analysis was to investigate the effects of repetitive peripheral magnetic stimulation (rPMS) on pain intensity, functional mobility, and kinesiophobia in individuals with low back pain (LBP).

Data Sources: The PubMed, Physiotherapy Evidence Database, Embase, Cochrane Library, and Web of Science databases were systematically searched from inception until November 25, 2022.

Study Selection: Eligible randomized controlled trials contained information on the population (LBP), intervention (rPMS), and outcomes (pain intensity, functional mobility, and kinesiophobia).

Effects of repetitive peripheral magnetic stimulation on spasticity evaluated with modified Ashworth scale/Ashworth scale in patients with spastic paralysis: A systematic review and meta-analysis.

Background: Spasticity is a common motor disorder resulting from upper motor neuron lesions. It has a serious influence on an individual's motor function and daily activity. Repetitive peripheral magnetic stimulation (rPMS) is a non-invasive and painless approach developed for therapeutic intervention in clinical rehabilitation.

The Effectiveness of High-Frequency Repetitive Transcranial Magnetic Stimulation on Patients with Neuropathic Orofacial Pain: A Systematic Review of Randomized Controlled Trials.

Background: Repetitive transcranial magnetic stimulation (rTMS) has been widely used in the treatment of neuropathic orofacial pain (NOP). The consistency of its therapeutic efficacy with the optimal protocol is highly debatable.

Objective: To assess the effectiveness of rTMS on pain intensity, psychological conditions, and quality of life (QOL) in individuals with NOP based on randomized controlled trials (RCTs).

The Expression of miR-34a in Gingival Crevicular Fluid of Chronic Periodontitis and Its Connection with the TLR/NF-B Signaling Pathway.

Objective: This study analyzed the expression of miR-34a in gingival crevicular fluid (GCF) of patients with chronic periodontitis and its connection with the Toll-like receptor (TLR)/nuclear factor kappa-B (NF-B) signaling pathway.

Methods: We collected the GCF of the two groups of subjects, using RT-PCR to detect the expression of miR-34a and NF-B p65 mRNA and TLR4 mRNA and ELISA to detect the inflammatory factor degree in GCF, and performed periodontal examinations on both groups.

Results: The gingival index, bleeding index, probe depth, and attachment loss indexes of periodontal examination in the observation group were remarkably superior to those in the control group ( < 0.

Computed Tomography Three-Dimensional Reconstruction Algorithm in the Diagnosis of Periodontitis and Its Correlation with Hypertension.

This study was aimed at exploring the value of iterative reconstruction (IR) algorithm to treat the periodontitis using computed tomography (CT) image and analyze the relationship between periodontitis and hypertension. 95 patients with periodontitis were selected, including 43 patients with periodontitis, 41 patients with advanced periodontitis and hypertension, and 11 patients with periodontitis and nonhigh blood pressure (NBP). The IR algorithm was introduced to the CT image scanning of them to reduce the noise.

Incubating green turtle (Chelonia mydas) eggs at constant temperatures: Hatching success, hatchling morphology and post-hatch growth.

Past studies applying constant-temperature incubation of eggs have involved all species of sea turtles, but rarely can we find a single one incubating eggs at three or more temperatures. Here, we incubated green turtle (Chelonia mydas) eggs from Ganquan Island, South China Sea, at five constant temperatures (26, 28, 30, 32 and 34 °C) to determine hatching success, incubation length and hatchling phenotype at each test temperature and temperatures optimal for embryonic development. Temperature affected hatching success, incubation length and all seven examined hatchlings traits, and clutch origin affected three (head length, fore-flipper length and hind-flipper length) of the seven.

Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis.

Circular RNA (circRNA) plays a regulatory role in periodontitis. This study explored whether circ_0138959 affected lipopolysaccharide (LPS)-induced pyroptosis in human gingival fibroblasts (HGFs). The periodontal ligament (PDL) tissues and HGFs were derived from patients with periodontitis and healthy volunteers.

Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities.

The opioid and neuropeptide FF pharmacophore-containing chimeric peptide 0 (BN-9) was recently developed and produced potent nontolerance forming analgesia. In this study, 11 analogues of 0 were designed and synthesized. An in vitro cAMP assay demonstrated that these analogues behaved as multifunctional agonists at both opioid and NPFF receptors.

Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice.

Neuropeptide FF (NPFF) system has recently been reported to modulate cannabinoid-induced antinociception. The aim of the present study was to further investigate the roles of NPFF system in the antinociceptive effects induced by intracerebroventricular (i.c.