Modeling teacher education students' adoption of large language models through an extended technology acceptance framework.

With the deepening integration of artificial intelligence (AI) technologies in the education sector, large language models (LLMs) have become essential tools for supporting writing tasks. As the future backbone of the teaching profession, the acceptance of these technologies by teacher education students not only influences their professional development but also plays a critical role in the digital transformation of future educational practices. However, existing research has yet to fully uncover the underlying mechanisms and influencing factors driving technology adoption behaviors within this group.

Large language model guided automated reaction pathway exploration.

Fast and efficient automated exploration of reaction pathways is essential for studying reaction mechanisms and advancing data-driven approaches for reaction development and catalyst design. Here, we present a new program (utilizing Python and Fortran), capable of conducting automated, fast, and efficient exploration of reaction pathways for potential energy surfaces (PES) studies. This program integrates quantum mechanics and rule-based methodologies, underpinned by a Large Language Model-assisted chemical logic.

Symmetric Multi-Resonant TADF Emitters via Chiral Space Conjugation Toward Strong Chiroptical Responses and Narrowband Green Circularly Polarized Electroluminescence.

Developing thermally activated delayed fluorescence (TADF) materials with excellent chiroptical and photophysical properties is crucial for advancing optoelectronic applications. Herein, a chiral space conjugation strategy incorporating a typical [2.2]paracyclophane unit is proposed to construct a highly efficient chiral multi-resonant (MR) TADF emitter, R(S)-PCP-DBNO.

Experimental study on collision-induced rotational energy transfer between D2(1, 15) and N2.

The ro-vibrationally excited state D2(X1∑g+, v = 1, J = 15) was prepared using stimulated Raman pumping, and its collisional rotational relaxation behavior with D2 and N2 molecules was experimentally investigated at 297 K. The effective lifetime of D2(1,15) was determined by measuring time-resolved CARS signals in both pure D2 and D2-N2 systems. Combining the Stern-Volmer equation, the self-relaxation rate coefficient for D2-D2 collisions in the pure D2 system was calculated to be (2.

A Patient-Centric, Open-Label, Multicenter, Phase II Study of Lorlatinib Monotherapy in the First-Line Treatment of Patients With locally Advanced or Metastatic ALK-Positive Non-Small Cell Lung Cancer (CTONG2203).

Background: Lorlatinib is a potent third-generation ALK tyrosine kinase inhibitor (TKI). CROWN study demonstrated remarkable efficacy and manageable toxicity of first-line lorlatinib treatment for advanced non-small cell lung cancer (NSCLC) with ALK rearrangements. However, only 10 ALK-positive NSCLC patients were randomized to the lorlatinib group in China mainland.

Single-Cell Transcriptomic Profiling Reveals KRAS/TP53-Driven Neutrophil Reprogramming in Luad: A Multi-Gene Prognostic Model and Therapeutic Targeting of RHOV.

Objectives: The tumorigenic progression of Lung adenocarcinoma (LUAD), the predominant NSCLC subtype, is predominantly driven by co-occurring mutations in KRAS proto-oncogene (KRAS)/Tumor protein p53 (TP53). However, their impact on tumor microenvironment (TME) heterogeneity, particularly neutrophil dynamics, remains poorly understood. This present study aims to elucidate how KRAS/TP53 mutations reprogram the TME and develop a neutrophil-centric prognostic signature for LUAD.

Twist-Promoted Photoredox Catalysis in Metal-Organic Framework for Defluorination Reactions.

The relatively short excited-state lifetime is one main drawback of organic photosensitizers, resulting in their restricted catalytic capability and high catalyst loadings. We herein report the design of a twisted ligand N,N,N,N-tetrakis[(1,1'-biphenyl)-4-carboxylic acid]-9,10-anthracene diamine (HTCPDA). Its twisted geometry significantly elongates the lifetime of charge-transfer state as substantiated by detailed ultrafast transient absorption (TA) spectroscopic and electrochemical studies.

The essential oil from the rhizomes of attenuates the progression of vascular aging and atherosclerosis by regulating Nrf2-mediated mitochondrial quality.

Introduction: Atherosclerosis (AS), characterized by chronic inflammation within the vasculature, is linked to endothelial dysfunction and oxidative stress. The senescence of vascular endothelial cells (VECs) serves as a pathological basis for AS. Stahlianthus involucratus (King ex Baker) Craib ex Loes is a folk medicinal plant commonly used in Guangxi has its rhizome as the active component.

Clinical prediction model for anastomotic leakage in rectal cancer surgery: a single-center large-sample cohort study.

Background: Anastomotic leakage (AL) is a serious complication of surgery for rectal cancer. This study aimed to develop a reliable clinical prediction model based on the confirmed risk factors related to AL during the perioperative period.

Method: A retrospective analysis was conducted on 3765 patients.

Non-Covalent Interaction of Coconut Protein and Quercetin: Mechanism, Antioxidant, Bioaccessibility.

Understanding protein-polyphenol interactions is crucial for developing plant-based protein products. This study investigates the binding mechanisms and bioactivities of non-covalent complexes between quercetin (Que) and coconut protein (CP), aiming to explore the potential of polyphenols in modifying CP and expanding its applications in functional foods. Increased Que concentrations decreased CP fluorescence with a blue shift, indicating static quenching.

Investigation of changes in the interaction of cerebral cortex during the oral swallowing task.

Background: The main swallowing activities in the oral phase include chewing and tongue movements. Cortical control is essential for the initiation and coordination of swallowing activities in the oral phase.

Research Purposes: This study aims to further investigate whether there are differences neural mechanisms in cortical interactions underlying oral phase by simulating chewing and tongue movement.

Copper-Catalyzed Formal Aldehydic C-H Borylation Enabled by an sp-sp Diboron Reagent.

We have developed a copper-catalyzed formal aldehydic C-H borylation using a neutral sp-sp diboron reagent, LBH-Bpin (where L is a σ-donor), leading to the one-pot synthesis of diverse acylboranes. Notably, the BH moieties in the acylborane can be further used to construct boracycles. This protocol enables straightforward functional group (FG) replacement of commercial medicines with an acylboron motif.

DDX27: An RNA helicase regulating cancer progression and therapeutic prospects.

DDX27, a member of the DEAD-box RNA helicase family, plays a crucial role in RNA metabolism, inflammation, and cancer progression. Elevated expression of DDX27 has been observed in multiple cancers, including oral squamous cell carcinoma (OSCC), breast cancer (BC), colorectal cancer (CRC), gastric cancer (GC), and hepatocellular carcinoma (HCC), where it is associated with poor prognosis, tumor growth, metastasis, and chemoresistance. DDX27 regulates the NF-κB signaling pathway, which is central to inflammation and tumor progression, and influences key cellular processes such as cell cycle regulation, apoptosis, migration, and stemness.

Comprehensive management of MET tyrosine kinase inhibitor-induced peripheral edema in patients with -altered non-small-cell lung cancer: a narrative review.

Background And Objective: The mesenchymal-epithelial transition factor (MET) proto-oncogene plays an important role in the development of non-small cell lung cancer (NSCLC). MET tyrosine kinase inhibitors (TKIs) have shown promising antitumor activity in patients with NSCLC harboring MET alterations. Peripheral edema (PE), the most common adverse event of MET TKIs, has received increasing attention from clinicians.

Mechanistic insights into photocatalytic nitrene transfer reactions of benzoyl azide in the presence of phosphoric acid.

Computational studies were carried out to shed light on the mechanism of photocatalytic nitrene transfer reactions of benzoyl azide in the presence of phosphoric acid. The formed H-bonding complex of benzoyl azide with HPO would readily undergo single electron reduction with the excited *Ru(II) photocatalyst, followed by sequential proton transfer and N dissociation to give a key N-centered radical. The energy transfer mechanistic pathway leading to a protonated nitrenium species, however, might not be feasible.

Enhancing lncRNA-disease associations predictions by optimizing similarity on multiple heterogeneous networks.

Focusing on the problem about predicting long non-coding RNA(lncRNA)-disease associations, this article introduces an improved random walk with restart(RWR) model by optimizing similarity on multiple heterogeneous networks, referred to as OS-LDA. Most existing models for constructing heterogeneous networks only consider two types of networks(disease and lncRNA), neglecting the valuable information from other networks. Furthermore the construction of an accurate and reasonable similarity network is crucial to the effectiveness of model.

Acid-Responsive Disassembly of Nanomedicines for Extracellular Drug Delivery Reversing Glioblastoma Immunosuppressive Microenvironment by Targeting the Adenosine-A2AR Pathway.

The efficacy of checkpoint blockade immunotherapy for glioblastoma (GBM) is significantly influenced by the precise delivery of therapeutic agents that can penetrate the blood-brain barrier (BBB) and reprogram the tumor immune microenvironment. Conventional nanoscale carriers used for delivering immune checkpoint blockers are more likely to be internalized by tumor cells, leading to a loss of drug efficacy. This study presents a phosphatidylcholine (PC)-coated nanoparticle (PCNP) with an optimized PC ratio on its surface, achieving a balanced surface charge.

Development of N-centered radical scavengers that enables photoredox-catalyzed transition-metal-free radical amination of alkyl pinacol boronates.

In recent years, amination of alkylboronates through ionic copper catalysis or boron-ate complex 1,2-metalation has been well established, but complementary radical processes remain less studied before. Herein, based on rational design, we develop several imine-type N-centered radical scavengers and apply them to the radical amination of alkylboronates. The reaction proceeds under mild photoredox-catalyzed transition-metal-free conditions and features excellent functional group tolerance.

Total parietal peritonectomy and multivisceral resection for extensive cytoreductive surgery in pseudomyxoma peritonei: En bloc "Rolled-up carpet" technique and perioperative and oncologic outcomes.

Background: Patients diagnosed with pseudomyxoma peritonei (PMP) of appendiceal origin typically present with high tumor burden and require extensive cytoreductive surgery (CRS) to achieve optimal cytoreduction. This study describes an en bloc "rolled-up carpet" surgical technique for total parietal peritonectomy and multivisceral resection while also analyzing the perioperative and tumor outcomes of this technique.

Methods: The study reviewed the data of 7 patients underwent en bloc "rolled-up carpet" extensive CRS between August 2020 and April 2023.

Perioperative outcomes and hospitalization costs of radical vs. conservative surgery for hepatic cystic echinococcosis: A retrospective study.

Background: Surgical intervention is a crucial treatment for hepatic cystic echinococcosis. However, the choice between radical and conservative surgery remains controversial. This study aimed to compare the perioperative outcomes and hospitalization costs between radical and conservative surgery for hepatic cystic echinococcosis.

FLAIR: A Phase II, Open Label, Randomized Study of Osimertinib Plus Bevacizumab Versus Osimertinib in Recurrent or Metastatic Treatment-Naïve NSCLC Patients Harboring EGFR 21L858R Mutation.

Introduction: Osimertinib, the 3rd generation EGFR-TKI, has emerged as standard first-line treatment for patients with advanced EGFR mutated nonsmall cell lung cancer (NSCLC). Patients with exon 21 L858R mutation showed lower efficacy with EGFR-TKIs than those with 19Del mutation, even with osimertinib, it remains an unmet medical need to further improve the efficacy in L858R population. We present the rationale and design for FLAIR (NCT04988607), which will investigate the efficacy and safety of osimertinib plus bevacizumab versus osimertinib monotherapy in treatment-naïve recurrent or metastatic NSCLC patients harboring EGFR exon 21 L858R mutation.

Interaction between pea protein isolate and quercetin: Effects on protein conformation and quercetin activity.

Comprehensive comprehension of the interaction between proteins and polyphenols is crucial for advancing their utilization in food processing. This study investigated no-covalent interaction between pea protein isolate (PPI) and quercetin (Que) through spectroscopic analysis and molecular simulation. Fourier transform infrared spectroscopy and circular dichroism spectrum showed that the interaction between PPI and Que changed the secondary structure of the protein due to a decrease in α-helix content and an increase in the random coil.

Bionic aggregation-induced emission photosensitizer for enhanced cancer immunotherapy.

Cold exposure therapy (CE), as an inexpensive method, has shown great potential in cancer therapy. Exploring the combined anti-tumor mechanism of CE and traditional therapies (such as photodynamic therapy (PDT)) is exciting and promising. Here, a bionic aggregation-induced emission photosensitizer system (named THL) is designed for combined CE to enhance anti-tumor immunotherapy.