Highly selective synthesis of interlocked carbazole-based cages and their applications in photothermal seawater desalination.

The design and assembly of interlocked supramolecular cages is of interest due to their exquisite topological configuration and excellent performance in a variety of applications. We introduce two carbazole-based ligands L1 and L2, they combine with four distinct half-sandwich rhodium building blocks to form three molecular-tweezer-like compounds, three interlocked cages, tetranuclear macrocycle, and hexanuclear cage. Stacking interactions between carbazole groups facilitate the formation of interlocked structures.

Dual-channel fluorescence biosensor for simultaneous miR-133a and ATP detection in living muscle cells.

Muscle injuries present a significant challenge in sports and physical activity, necessitating advanced diagnostic tools. Current invasive methods, such as muscle biopsies, are limited by procedural risks and lack of dynamic data. In this study, we developed a dual-channel fluorescent biosensor based on MoS nanosheets and fluorescence resonance energy transfer (FRET) for the simultaneous detection of miR-133a and ATP in living mouse myoblast cells.

Femtosecond laser direct writing fractional-order vortex beam generator with longitudinal light field evolution.

Owing to the distinctive attributes of radially notched intensity profile and carrying non-integral orbital angular momentum, fractional-order vortex beams (FVBs) have stimulated tremendous research interest. Traditional methods for generating FVBs either necessitate bulky optical components or are only capable of producing a specific type of FVB. These limitations hinder their application in integrated micro-optics.

Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer.

Background: Tumor cells manipulate the tumor-associated antigens presentation to escape immune surveillance; however, the molecular mechanism is not exactly clear and the measure to intervene is missing.

Methods: Annexin A2 was knockout by the CRISPR-Cas9 or blocked by the small-molecule matrine, PY60, and hexapeptide. Chemically and genetically induced primary liver cancer models, and the orthotopically implanted liver tumor model were used.

Fe-Doped Carbon Dots Control the Biodegradation Behaviors of Zr-Based Metal-Organic Framework for Tumor-Specific Chemotherapy and Ferroptosis Enhanced Sono-Chemodynamic Therapy.

Zr-based metal-organic frameworks (Zr-MOF) with proper bandgap structure and excellent biocompatibility has recently been identified as a desired drug carrier and sonosensitizers for the application of drug delivery and sonodynamic therapy (SDT). However, the fast degradable behaviors of Zr-MOF not only in acidic tumor microenvironment (TME) but also in normal physiological conditions can lead to strong off-target toxicity. To realize tumor-specific drug release, herein, it reports for the first time the regulation of degradation behaviors of Zr-MOF using Fe-doped carbon dots (Fe-CDs) with excellent chemodynamic/sonodynamic activities as a protection layer.

Compositional doping and structure insights for high-performance aqueous Zn-ion batteries.

Mn-based materials are considered as promising cathode candidates for aqueous Zn-ion batteries (AZIBs). Herein, Mg incorporation is developed to stabilize MnO, which can promote the reaction kinetics and improve the electrochemical performance. In addition, Mg-doped MnO exhibits 80.

Make PBR Materials Tileable With Latent Diffusion Inpainting.

Physically-based-rendering (PBR) materials are crucial in modern rendering pipelines, and many studies have focused on acquiring these materials from reality or images. However, existing methods may result in non-tileable results, since the realistic inputs usually have seams. Compared to non-tileable materials, tileable PBR materials have more universal application scenarios.

Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway.

Perforator flap transplantation is an important technique in flap reconstructive surgery, but flap necrosis limits its clinical effectiveness. Thymoquinone (TQ), a natural bioactive plant quinone found in black seed, exhibits anti-inflammatory, angiogenic, and antimicrobial properties. This study investigates the therapeutic effects of TQ in a perforator flap model through and experiments.

Breaking the synergism of iron overload and miR-122 to rescue lipid accumulation and peroxidation in MASLD.

MASLD is a multifactorial disease with specific subtypes being featured by hepatic iron overload and loss of miR-122, a liver-specific microRNA regulating hepatic lipid homeostasis. Previously we reported the mechanism of iron overload decreasing miR-122. Interestingly, we found that mice lacking miR-122 were highly sensitive to iron overload-induced steatosis and fibrosis.

Mapping the Knowledge Landscape of and Emerging Future Trends in Stem Cell Therapy for Osteoarthritis: A Bibliometric Analysis of the Literature From 1998 to 2024.

Objective: The purpose of this study was to conduct a bibliometric analysis of the literature on stem cell therapy for osteoarthritis (OA) to visualize recent developments, identify hot spots, and determine trends in the field.

Background: OA is a chronic disease that affects the joints and their surrounding tissues, leading to progressive damage to the articular cartilage and ultimately to the subchondral bone and the surrounding synovial structures. OA is a disabling disease with an increasing incidence and prevalence in the general population.

Highly sensitive and selective carbon dot sensor for hydrogen sulfide based on dual quenching effect.

Due to the serious impact of hydrogen sulfide (HS) on the environment and human health, a series of sensors have been increasingly used in industrial production and daily life. In this work, we introduce a novel, to the best of our knowledge, detection method for trace HS in the liquid and gaseous phases based on the dual-quenching mechanism (DQE) of silver ion-doped nitrogen-sulfur co-doped carbon dots (N, S-CDs@Ag). Ag could significantly enhance the fluorescence intensity and detection sensitivity.

Prolonged tamoxifen treatment induces iron deposition and ferroptosis in the liver.

Tamoxifen is an inhibitor of estrogen receptors and was originally developed for breast cancer therapy. Besides, tamoxifen is widely used for Cre-estrogen receptor-mediated conditional knockout in transgenic mice. However, we found that the 3-month feeding of 0.

Highly Selective Construction of Unique Cyclic [4]Catenanes Induced by Multiple Noncovalent Interactions.

The synthesis of high-ordered mechanically interlocked supramolecular structures is an extremely challenging topic. Only two linear [4]catenanes have been reported so far and there is no defined strategy to obtain cyclic [4]catenane. Herein, two unprecedented cyclic [4]catenanes, 1 and 2, were prepared in high yields.

Vacancy-rich NiFe-LDH/carbon paper as a novel self-supporting electrode for the electro-Fenton degradation of polyvinyl chloride microplastics.

Electrochemically upcycling polyvinyl chloride (PVC) into high-value small molecules represents a sustainable strategy for mitigating plastic pollution. Herein, a cost-effective self-supporting electrode with abundant vacancies, i.e.

Green One-Pot Synthesis of Thiazole Scaffolds Catalyzed by Reusable NiFeO Nanoparticles: Binding Affinity and Anticancer Activity Studies.

A facile, green, one-pot multicomponent synthesis strategy was employed to fabricate novel thiazole scaffolds incorporating phthalazine, pyridazine, and pyrido-pyridazine derivatives (-). This synthetic route entailed the reaction of an α-halo carbonyl compound () with thiosemicarbazide () and various anhydrides (-), utilizing NiFeO nanoparticles as a reusable catalyst in an ethanol:water (1:1) solvent system. The cytotoxicity of the synthesized compounds was meticulously assessed against three cancer cell lines, A375, HeLa, and MCF-7, employing IC values (μM) as the benchmark, and compared to the reference drug erlotinib.

Baicalein Targets MAPK9 to Induce Apoptosis of Hepatocellular Carcinoma Cells.

Hepatocellular carcinoma (HCC) is a significant global health concern. However, there are limited effective treatments available for it. The use of natural products in the management and treatment of HCC is gaining more attention.

Angular-Inertia Regulated Stable and Nanoscale Sensing of Single Molecules Using Nanopore-In-A-Tube.

Nanopore is commonly used for high-resolution, label-free sensing, and analysis of single molecules. However, controlling the speed and trajectory of molecular translocation in nanopores remains challenging, hampering sensing accuracy. Here, the study proposes a nanopore-in-a-tube (NIAT) device that enables decoupling of the current signal detection from molecular translocation and provides precise angular inertia-kinetic translocation of single molecules through a nanopore, thus ensuring stable signal readout with high signal-to-noise ratio (SNR).

Exosomal lncRNA TUG1 derived from BMSC ameliorate collagen-induced arthritis via BLIMP1-mediated Th17/Treg balance.

Background: Aberrant differentiation of Th17 cells has been identified as a critical factor in the development of rheumatoid arthritis (RA). BLIMP1 plays a key role in regulating plasma cell differentiation, T helper cell differentiation and Treg cell differentiation. Treatment with exosome injection or bone marrow mesenchymal stem cell (BMSC) transplantation reduce joint damage in RA.

Digital modelling method of coal-mine roadway based on millimeter-wave radar array.

The roadway space of coal mine is narrow, and the illumination is low and uneven. Dynamic mining is accompanied by dust and water mist. The accuracy and reliability of roadway data collected by vision and laser sensors are poor.

Exploration of the application of augmented reality technology for teaching spinal tumor's anatomy and surgical techniques.

Background: Augmented reality (AR) technology is gradually being applied in surgical teaching as an innovative teaching method. Developing innovative teaching methods to replicate clinical theory and practical teaching scenarios, simulate preoperative planning and training for bone tumor surgery, and offer enhanced training opportunities for young physicians to acquire and apply clinical knowledge is a crucial concern that impacts the advancement of the discipline and the educational standards for young orthopedic physicians.

Objective: This study explores the application effect of augmented reality technology in anatomy teaching and surgical clinical teaching for spinal tumor.

1,2,4-Triazolo-quinazolinones as Effective Antifoulants: Molecular Design, Synthesis, and Biological Evaluation.

A series of 1,2,4-triazolo-quinazolinones and 1,2-benzisothiazolone derivatives (S1-S12) were successfully synthesized as environmentally friendly alternatives to copper-based antifouling paints using -alkylation, cyclocondensation, and one-pot three-component and amide coupling reactions. The monoclinic structure of single-crystal 1,2,4-triazolo-quinazolin-acetic acid (S8) was confirmed by single-crystal X-ray diffraction analysis. All the synthesized molecules were studied for their in silico molecular docking interactions with three target proteins, namely, RbmA, ToxR, and Bap.

Coupled photothermal vortices for capture, sorting, and transportation of particles.

Optofluidic techniques have evolved as a prospering strategy for microparticle manipulation via fluid. Unfortunately, there is still a lack of manipulation with simple preparation, easy operation, and multifunctional integration. In this Letter, we present an optofluidic device based on a graphite oxide (GO)-coated dual-fiber structure for multifunctional particle manipulation.

In-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules.

Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the accurate discrimination of the molecules. Here, we show the use of inertial-kinetic translocation induced by spinning an in-tube micro-pyramidal silicon nanopore fabricated using photovoltaic electrochemical etch-stop technique for biomolecular sensing.

Broadband wavelength designable achromatic grating based on a cholesteric liquid crystal template.

Liquid crystal (LC) gratings have played important roles in light field control due to the advantages of being lightweight, low cost, having no moving parts, and low power consumption. However, the chromatic aberration limits the bandwidth of the LC device and affects the efficiency of the grating. To solve the chromatic aberration issue, a broadband wavelength designable achromatic grating is proposed.