Lactylation modification in lung cancer: A review of current research and future directions (Review).

Lung cancer is a common malignancy that poses risks to human health and quality of life. The primary treatment options currently available include surgery, chemotherapy and radiotherapy. However, the aggressive metastatic nature of the disease combined with the development of drug and radiation resistance results in suboptimal survival outcomes.

An RCT META analysis based on the efficacy of Tai Chi exercise therapy on blood pressure and blood lipids in patients with essential hypertension.

Objective: Tai Chi is a form of physical and mental exercise. Hypertension, characterized by persistently elevated blood pressure, is a prevalent cardiovascular condition. At present, the effect of Tai Chi exercise cycle on improving the prognosis of patients with essential hypertension, as well as its impact on patients at different stages of hypertension, has not yet been demonstrated.

An atomic surface of an aluminum alloy induced by novel green chemical mechanical polishing using hybrid rare earth abrasives and mechanisms unraveled.

An aluminum (Al) alloy is a soft, plastic-like metal that is prone to embedding abrasives, scratches, corrosion pits, and deformation. Achieving an atomically smooth surface on an Al alloy presents a significant challenge. This study introduces a novel green chemical mechanical polishing (CMP) technique using hydrogen peroxide, tyrosine, sodium carbonate, and hybrid abrasives composed of silica, yttria, and ceria.

Cyclic tetraadenylate binding induces dimerization of protein dimers to activate a CRISPR-associated PIN nuclease.

Type III CRISPR-Cas systems synthesize cyclic oligoadenylates (cOAs), the second messengers that bind to the CARF (CRISPR-associated Rossman fold) sensor domain and allosterically activate the effector domain of CRISPR ancillary effectors to mediate antiviral defense. An arsenal of such effectors has been identified, but only a minority of them have been characterized thus far. Here, CaPN (a CRISPR-associated PIN domain nuclease), a novel effector protein encoded by Saccharolobus islandicus, was characterized.

Association of Body Mass Index and Metabolic Health Status With Cerebrovascular Diseases in 617 755 Chinese Older People.

Background: Previous studies have not fully elaborated the association of body mass index (BMI) and metabolic status with cerebrovascular diseases in the older population.

Methods And Results: Data were sourced from a cross-sectional study in Jiangsu province of China. A total of 617 755 older adults aged ≥65 years were included in this study.

Heat shock protein A1L restricts influenza A virus by ubiquitination of NA.

Neuraminidase (NA) protein of influenza A virus (IAV), a tetrameric envelope glycoprotein critical for viral release and spread, has well-characterized enzymatic functions but poorly resolved host-pathogen interactions. However, host factors targeted by NA or those regulating NA activity are largely uncharacterized. Here, we identified host heat shock protein A1L (HSPA1L) as a novel NA-binding partner that suppresses IAV replication.

Development and test of recurrence risk perception assessment scale for patients after radiofrequency ablation of atrial fibrillation.

The objective is to create a scale for evaluating the perceived risk of recurrence in patients following radiofrequency ablation for Atrial fibrillation (AF), while also assessing the scale's reliability and validity. The research was completed under the guidance of Health Belief Model and Risk Perception Attitude Framework. The initial measurement was developed after literature review and qualitative interviews.

Using secondary prevention strategies in patients after PCI: a narrative review.

Objective: The objective of this review is to integrate the content and effectiveness of secondary prevention interventions in post-PCI patients so that provide direction for the selection of more effective secondary prevention measures in the future.

Method: A narrative review was performed, which included a literature search without language and study design restrictions in PubMed, Embase, and MEDLINE from January 1, 2000, to May 15, 2023. Search terms included free-text words for the key concepts of "Percutaneous Coronary Intervention" "PCI" and "secondary prevention".

Efficient Microbial Production of Selenium Nanoparticles by Selenium-Tolerant Alcaligenes sp. HZ-9-3-3.

Selenium (Se) is a crucial trace element for human and animal health, contributing significantly in various physiological processes. However, its uneven global distribution leads to widespread deficiencies. Nano-selenium (selenium nanoparticles, SeNPs), with low toxicity and high bioavailability, emerges as a promising alternative, and microbial synthesis is the preferred method for its production.

Development and Internal-External Validation Models for Cervical Cancer Overall Survival Prognosis: A SEER-Based Study and Chinese Data.

Objective: The study aims to develop a model to predict overall survival (OS) in cervical cancer (CC).

Methods: A total of 13,592 CC patient records were obtained from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2020. These patients were randomized with a 7:3 ratio into a training cohort (TC, n = 9,514) and an internal validation cohort (IVC, n = 4,078).

API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs.

Ubiquitin-mediated selective autophagy is essential for innate immune responses against pathogens. However, the role of apoptosis inhibitor 5 (API5), in governing both ubiquitin-mediated autophagy and antiviral immunity, are poorly defined. Here, it is found that the serine/arginine-rich protein kinase 1 (SRPK1)-dependent phosphorylation of API5 at S464 site is essential for priming antiviral immune responses during diverse RNA virus infection.

Stable and uniform self-assembled organic diradical molecules for perovskite photovoltaics.

Organic self-assembled molecules (SAMs), which are widely used in perovskite solar cells (PSCs), should exhibit enhanced performance to support the ongoing advancement of perovskite photovoltaics. We designed diradical SAMs through a coplanar conjugation of a donor-acceptor strategy to facilitate hole transport across the SAMs. The diradical SAMs exhibited high photothermal and electrochemical stability as well as improved assembly uniformity and large-area solution processability attributed to molecular steric hindrance design.

MARCH1, transcriptionally regulated by POU2F2, facilitates acute myeloid leukemia progression via inducing MYCT1 degradation.

Acute myeloid leukemia (AML) is a heterogeneous clonal disease. Membrane-associated ring-CH type finger 1 (MARCH1), a membrane-anchored E3 ubiquitin ligase, is highly expressed in AML. However, its role in AML remains unclear.

Single Nanoparticle Collision Electrocatalysis Driven by Ultrafast High-Temperature Precision Synthesis.

The single nanoparticle (NP) collision strategy offers a promising alternative to traditional ensemble methods in electrocatalysis, providing unique insights into catalytic behavior that cannot be captured by ensemble-based techniques. However, synthesizing colloidal NP catalysts with tunable composition, uniform size, and near-pristine surfaces remains a significant challenge. Here, using PtRu alloys as a model system, we propose an innovative strategy that combines ultrafast high-temperature precision synthesis with ultrasonic exfoliation.

Drug Repurposing: Unique Carbon Dot Antibacterial Films for Fruit Postharvest Preservation.

Fruit spoilage caused by oxidation and microbial infection exacerbates resource wastage. Although starch films including chitosan possessed admirable biocompatibility owing to great biodegradability compared with conventional plastics, deficient antibacterial and antioxidant capacity restricted food shelf life. Herein, an environmentally friendly antibacterial film (CS/G-CDs) was constructed by carbon dots derived from (CDs), which was formed through high affinity resulting from hydrogen bonding between chitosan molecules and hydroxyl originating from CDs.

Multimodal Framework in Lung Cancer Management: Integrating Liquid Biopsy with Traditional Diagnostic Techniques.

Lung cancer is one of the most lethal malignancies worldwide, making early diagnosis and targeted treatment crucial for improving patient outcomes. Liquid biopsy, a rapidly advancing non-invasive diagnostic tool, has shown significant potential in lung cancer management through dynamic monitoring. This review explores the integration of liquid biopsy with traditional diagnostic techniques in lung cancer management.

Factors influencing vaginal cuff dehiscence after laparoscopic hysterectomy and the psychological state of the patients.

Background: Despite laparoscopic total hysterectomy provided more benefits to patients and has become one of the most commonly used surgical methods for total hysterectomy. However, vaginal cuff dehiscence is a serious complication after laparoscopic total hysterectomy and so far, there are limited studies on vaginal cuff dehiscence after a total hysterectomy.

Aim: To investigate the factors influencing vaginal cuff dehiscence after laparoscopic hysterectomy and the psychological state of the patients.

Synergistic Entropy Engineering with Oxygen Vacancy: Modulating Microstructure for Extraordinary Thermosensitive Property in ReNbO Materials.

The pursuit of high precision and stability simultaneously in high-temperature thermistor fields is longstanding. However, most spinel or perovskite-structured thermosensitive materials struggle to tolerate prolonged high-temperature environments at the expense of sensitivity and stability. Here, a novel entropy engineering strategy involving vacancies is proposed to balance sensitivity and stability for fergusonite-structured ReNbO (Re is a rare earth element) material in extreme environments.

Magnetic Field-Accelerated Nonthermal Plasma Digestion for Field Pretreatment and Determination of Heavy Metals in Biological Samples.

Field analysis of heavy metals in biological samples is essential for assessing their potential threats to human health. The development of portable pretreatment and detection devices is crucial to address this challenge. Herein, a magnetic field-accelerated nonthermal plasma digestion device using dielectric barrier discharge (DBD) is designed for the rapid and environmentally friendly pretreatment of biological samples and subsequently combined with point discharge-optical emission spectrometry (PD-OES) for sensitive determination of heavy metals.

Development of a cost-effective confocal Raman microscopy with high sensitivity.

Confocal Raman microscopy is a powerful technique for identifying materials and molecular species; however, the signal from Raman scattering is extremely weak. Typically, handheld Raman instruments are cost-effective but less sensitive, while high-end scientific-grade Raman instruments are highly sensitive but extremely expensive. This limits the widespread use of Raman technique in our daily life.

Accelerating the Discovery of Efficient High-Entropy Alloy Electrocatalysts: High-Throughput Experimentation and Data-Driven Strategies.

High-entropy alloys (HEAs) present both significant potential and challenges for developing efficient electrocatalysts due to their diverse combinations and compositions. Here, we propose a procedural approach that combines high-throughput experimentation with data-driven strategies to accelerate the discovery of efficient HEA electrocatalysts for the hydrogen evolution reaction (HER). This enables the rapid preparation of HEA arrays with various element combinations and composition ratios within a model system.

Comparative analysis of biomechanical characteristics between the new Tai Chi elastic band exercise for opening and closing movement and elastic band resistance training for the reverse fly movement.

Background: The objective of this study was to compare and analyze the representative opening and closing movement of Tai Chi elastic band exercise with the reverse fly movement of elastic band resistance training. The aim was to explore the biomechanical differences between the two exercises and provide theoretical support for the application of Tai Chi elastic band exercise in health intervention.

Methods: A total of 26 male participants were recruited and randomly divided into two groups in a 1:1 ratio.

Vapor Growth of All-Inorganic 2D Ruddlesden-Popper Lead- and Tin-Based Perovskites.

The 2D Ruddlesden-Popper (RP) perovskites CsPbICl (Pb-based, = 1) and CsSnICl (Sn-based, = 1) stand out as unique and rare instances of entirely inorganic constituents within the more expansive category of organic/inorganic 2D perovskites. These materials have recently garnered significant attention for their strong UV-light responsiveness, exceptional thermal stability, and theoretically predicted ultrahigh carrier mobility. In this study, we synthesized Pb and Sn-based = 1 2D RP perovskite films covering millimeter-scale areas for the first time, utilizing a one-step chemical vapor deposition (CVD) method under atmospheric conditions.