Polydatin ameliorates hyperhidrosis by targeting Aqp5 in a mouse model.

Background: Primary focal hyperhidrosis (PFH) is a neurological dermatological disorder characterized by localized, excessive sweating. Current treatments have limitations, and postoperative compensatory hyperhidrosis remains a concern. Aquaporin 5 (AQP5) and neurologic factors such as Brain-Derived Neurotrophic Factor (BDNF) and Neuregulin-1 (NRG-1) are known to play key roles in sweat regulation.

Water-Based Nanoparticulate Formulation of Lambda-Cyhalothrin and Its Enhancement of Bioavailability.

Low efficacy and frequent use of conventional pesticide formulations have led to various food safety and ecological concerns. Green and effective nanoformulation offers promising solutions to water-insoluble pesticides. Herein, we prepared a water-based nanoparticulate formulation of lambda-cyhalothrin (LC WBNF) using high-gravity rotating packed bed (RPB) combined with lyophilization.

Instantaneous and Continuous Construction of Perovskite Heterojunctions with Intensified Built-in Electric Field for Efficient Photocatalytic CO.

Enhancing the built-in electric field (BIEF) in heterojunctions remains a pivotal challenge for developing efficient photocatalysts. Herein, a high-gravity-assisted approach utilizing rotating packed bed (RPB) is proposed to instantaneously and continuously construct CsBiBr/TiO (CBB/TiO) heterojunctions with intensified BIEF, intimate interfacial contact, and accelerated charge-transfer kinetics, overcoming the constraints of traditional electrostatic self-assembly techniques. Compared to the counterpart of batch-type stirred tank (ST), the optimized heterojunction exhibits a 1.

Multi-Institutional Survey of 4-Year Ultrasound Quality Control Findings.

Objectives: Periodic quality control (QC) testing of ultrasound (US) imaging systems is essential to ensure and maintain image quality and safety. The study aims to analyze QC findings from medical physics annual surveys of modern clinical US systems in a multi-institutional survey.

Methods: QC results from annual surveys between 2018 and 2021 were retrospectively collected from 12 medical physicists from 11 institutions or consulting companies (hereafter referred to as sites).

Expanding aorto-iliac calcification quantification in kidney transplant recipients: prognostic implications for survival and renal function.

Background: Aorto-iliac calcification (AIC) is increasingly recognized as a prognostic marker in kidney transplantation, yet its relationship with long-term outcomes remains unclear.

Purpose: To evaluate whether pre-transplant AIC scores independently predict post-transplant mortality and renal function (eGFR trajectory) in kidney transplant recipients.

Methods: We retrospectively analyzed 150 renal transplant recipients ≥ 40 years old who underwent pre-transplant abdominopelvic CT within 3 years of surgery (2005-2018).

Effect of gamma knife stereotactic radiotherapy on the hematological system in patients with advanced lung cancer and its therapeutic effect.

Objective: To evaluate the influence of Gamma Knife stereotactic body radiotherapy (SBRT) on the hematological system in patients with advanced lung cancer and to assess its clinical outcomes.

Methods: A retrospective analysis was conducted on the clinical data of 192 patients with advanced lung cancer. 108 patients who received conventional radiotherapy were included in the control group, and the rest 84 patients who received Gamma Knife SBRT were included in the experimental group.

Atomic Insights into pH-Dependent and Water Permeation of mRNA-Lipid Nanoparticles.

The exposure of mRNA to water is likely to contribute to the instability of RNA vaccines upon storage under nonfrozen conditions. Using atomistic molecular dynamics (MD) simulations, we investigated the pH-dependent structural transition and water penetration behavior of mRNA-lipid nanoparticles (LNPs) with the compositions of Moderna and Pfizer vaccines against COVID-19 in an aqueous solution. It was revealed that the ionizable lipid (IL) membranes of LNPs were extremely sensitive to pH, and the increased acidity could cause a rapid membrane collapse and hydration swelling of LNP, confirming the high releasing efficiency of both LNP vaccines.

Redox/pH Dual-Responsive Fluorescent Nanoparticles for Intelligent Pesticide Release and Visualization in Gray Mold Disease Synergistic Control.

An intelligent delivery nanoformulation could enhance the utilization efficacy, uptake, and translocation of pesticides in plants. Herein, a redox/pH-triggered and fluorescent smart delivery nanoformulation was designed and constructed by using hollow mesoporous organosilica nanoparticles (HMONs) and ZnO quantum dots as the nanocarrier and capping agent, respectively. Boscalid was further loaded to generate Boscalid@HMONs@ZnO with a loading rate of 9.

Trafficking circuit of CD8 T cells between the intestine and bone marrow governs antitumour immunity.

Immunotherapy elicits a systemic antitumour immune response in peripheral circulating T cells. However, the T cell trafficking circuit between organs and their contributions to antitumour immunity remain largely unknown. Here we show in multiple mouse leukaemia models that high infiltration of leukaemic cells in bone marrow (BM) stimulates the transition of CD8CD44CD62L central memory T cells into CD8CD44CD62L T cells, designated as inter-organ migratory T cells (T cells).

The role of in the tumor microenvironment and immunotherapy in pan-cancer using comprehensive single-cell and bulk sequencing.

has been identified as a participant in integrin-linked kinase signaling pathways, influencing epithelial-mesenchymal transition and thereby affecting tumor initiation, progression, and invasion. While the character of in the tumor microenvironment (TME) as well as its implications for immunotherapy remain unclear. Thus, we conducted a comprehensive analysis to assess the prognostic significance of using Kaplan-Meier analysis.

Redox/Near-Infrared Dual-Responsive Hollow Mesoporous Organosilica Nanoparticles for Pesticide Smart Delivery.

Extremely inefficient utilization of pesticides has prompted a study of low-cost, sustainable, and smart application systems. Herein, as a promising pesticide nanocarrier, hollow mesoporous organosilica nanoparticles (HMONs) were first synthesized by using inexpensive CaCO nanoparticles as the hollow templates. A redox/near-infrared light dual-triggered pesticide release system was further achieved via loading avermectin (AVM) into the HMONs and coating a layer of polydopamine (PDA).

[Experimental study on the stimulation effect of temperature and capsaicin on oral mucosa of rats].

Purpose: This study evaluated the effect of hot etching with two acid solutions on the surface topography and bond strength of zirconia.

Methods: Firstly, twenty-four pieces of zirconia with a size of 10 mm×10 mm×2 mm and 20 pieces of zirconia with a size of 3 mm×3 mm×2 mm were prepared. Then pieces were divided into four groups, and dealt with separately according to the following groups: no treatment (group A), sandblasting (group B), hot etching with HCl(group C), hot etching with HF(group D).

Reconstruction of complicated spinal tuberculosis with long-segment fibula transplantation: a case report.

Background: Treating complex cases of spinal tuberculosis (STB) that involve multiple vertebral bodies and cause destruction of the spinal structure, kyphotic deformity, and acute nerve injury can be challenging. This report describes the course of treatment and 5-year follow-up of a complex case of multisegmental STB.

Case Presentation: This report describes a case of tuberculosis affecting the vertebrae extending from thoracic 12 to lumbar 5 in a 60-year-old woman who suffered sudden paralysis in both lower extremities.

Visualizing interfacial collective reaction behaviour of Li-S batteries.

Benefiting from high energy density (2,600 Wh kg) and low cost, lithium-sulfur (Li-S) batteries are considered promising candidates for advanced energy-storage systems. Despite tremendous efforts in suppressing the long-standing shuttle effect of lithium polysulfides, understanding of the interfacial reactions of lithium polysulfides at the nanoscale remains elusive. This is mainly because of the limitations of in situ characterization tools in tracing the liquid-solid conversion of unstable lithium polysulfides at high temporal-spatial resolution.

Degradable PDA@PNIPAM-TA Nanocomposites for Temperature- and NIR light-Controlled Pesticide Release.

Controlled pesticide delivery systems offer many distinctive advantages over conventional pesticide formulations. In this work, degradable poly(-isopropylacrylamide) (PNIPAM)-tannic acid (TA) microgels and multifunctional PDA@PNIPAM-TA nanocomposites were prepared in a high-gravity rotating packed bed reactor (RPB) for smart pesticide delivery and release. The as-prepared microgels and nanocomposites showed reversible temperature-dependent swelling/deswelling behavior and irreversible pH-induced degradation.

Greatly Intensified Guest Exchange Strategy for Highly-Efficient Activation of Metal-Organic Frameworks.

The preservation and accessibility of pores are prerequisites to the application of metal-organic frameworks (MOFs). Activation is a key step to eliciting rich features of pores, but it needs a repeated solvent-exchange process which is tedious and time/cost-consuming. Herein, a facile strategy for highly-efficient activation of MOFs utilizing rotating packed bed is proposed.

Correlation between glycated hemoglobin A1c, urinary microalbumin, urinary creatinine, β2 microglobulin, retinol binding protein and diabetic retinopathy.

Background: Retinopathy is the most common microvascular disease of type 2 diabetes, and seriously threatens the life, health and quality of life of patients. It is worth noting that the development of diabetic retinopathy (DR) can be hidden, with few symptoms. Therefore, the preliminary screening of diabetic patients should identify DR as soon as possible, delay disease progression, and play a vital role in its diagnosis and treatment.

PAI1 inhibits the pathogenesis of primary focal hyperhidrosis by targeting CHRNA1.

Background: Primary focal hyperhidrosis (PFH) may be attributed to the up-regulation of the cholinergic receptor nicotinic alpha 1 subunit (CHRNA1) in eccrine glands. Plasminogen activator inhibitor-1 (PAI1, encoded by SERPINE1) is reported to inhibit the expression of CHRNA1, while the role of PAI1 in hyperhidrosis is unknown.

Methods: Serpine1 KO mice, Serpine1-Tg mice, and wild type BALB/c mice were intraperitoneally injected with pilocarpine hydrochloride to induce PFH.

Utility of methylene blue mixed with autologous blood in preoperative localization of pulmonary nodules and masses.

The value of CT-guided puncture with methylene blue mixed with autologous blood in preoperative localization of pulmonary nodules and masses was explored. A total of 113 patients with 146 nodules and masses were treated with methylene blue mixed with autologous blood for preoperative localization and thoracoscopic surgery in the Department of Thoracic Surgery, the First Affiliated Hospital of Fujian Medical University between October 2021 and October 2022. The localization effect, complications, and pathological conditions were observed.

Real-Time Imaging and Quantitative Evolution for Pyrolysis of Carbon Dots-Encapsulated Metal-Organic Frameworks at the Nanoscale by In Situ Environmental Transmission Electron Microscopy.

The pyrolysis of metal-organic frameworks (MOF) has been widely used approach to generate hierarchical structures with the corresponding metal, metal carbide, or metal oxide nanoparticles embedded in a porous carbon matrix with a high specific surface area for industrial catalysis, energy storage and transfer, etc. MOF-derived heterogeneous catalysts can be constructed by the encapsulation of carbon dots (CDs) with plenty of hydroxyl and amine groups to enhance the performance of the final product. Controlled formation of metallic carbon structures at the nanoscale, especially matter cycling and transformation on the nanoscale interface, is important for the production of industrial catalysts as well as the research of materials science and engineering progress.