LIMK1 as a Novel Kinase of β-Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5.

Metastasis is a major cause of cancer deaths, but the underlying molecular mechanisms remain largely unknown. Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with poor survival, yet the key kinases driving ESCC metastasis and their biological function have not been fully discovered. Here, a kinase-substrate map of metastatic ESCC is presented for the first time by conducting a phosphoproteomics analysis of 60 clinical specimens.

[Experimental study on the stimulation effect of temperature and capsaicin on oral mucosa of rats].

Purpose: This study evaluated the effect of hot etching with two acid solutions on the surface topography and bond strength of zirconia.

Methods: Firstly, twenty-four pieces of zirconia with a size of 10 mm×10 mm×2 mm and 20 pieces of zirconia with a size of 3 mm×3 mm×2 mm were prepared. Then pieces were divided into four groups, and dealt with separately according to the following groups: no treatment (group A), sandblasting (group B), hot etching with HCl(group C), hot etching with HF(group D).

[Column-integrated Aerosol Optical Properties Determined Using Ground-based Sun Photometry Measurements in the Hangzhou Region].

To investigate the optical properties of aerosols in the Hangzhou region (Hangzhou, Tonglu, Jiande, and Chun'an), the aerosol optical depth (AOD), Ångström exponent (AE), single scattering albedo (SSA), and aerosol size distribution (ASD) were measured using CIMEL sun-photometers in 2012. The results showed that the annual average values of AOD in Hangzhou, Tonglu, Jiande, and Chun'an were 0.94±0.