Huoxiang-Shihu herbal formula attenuates alcoholic-induced gastric injury by regulating the HIF-1α/VEGF pathway and inhibiting oxidative stress.

Ethnopharmacological Relevance: The main ingredient of the Huoxiang Shihu Chinese Medicine Formula (HS) is Chimonanthus salicifolius H. It is the first medicine of the She ethnic group. HS is a classical prescription for treating alcoholic gastritis, although its therapeutic mechanism remains uncertain.

Luteolin phospholipid complexes improves the bioavailability of luteolin and exhibits potent protection and high safety in mice with gouty nephropathy.

This study sought to improve luteolin (Lut) solubility and bioactivity luteolin phospholipid complex (Lut-PC) preparation. Lut-PC was synthesised using solvent evaporation and characterised by multiple techniques. The optimal complexation efficiency reached 95.

Esculin delivery system based on phospholipid complex technology: research on solubility optimization and antibacterial activity improvement.

Esculin (ES) has antibacterial effects, but its low solubility and bioavailability limit applications. This study prepared an esculin phospholipid complex (ES-PC) solvent evaporation. SEM, FTIR, XRD and H-NMR verified its amorphous structure formed by intermolecular forces.

Review of Gelatin Hydrogel Dressings Based on Cross-Linking Technology in the Healing of Hemorrhagic Wounds: Mechanism Exploration, Application Research, and Future Perspectives.

Bleeding represents a critical challenge across diverse medical scenarios, underscoring the urgent need for the development of advanced hemostatic materials. This review focuses on gelatin-based hemostatic hydrogels, which exert hemostatic effects through multiple mechanisms: physical hemostasis, physiological hemostasis, and synergistic hemostasis. These mechanisms enhance hemostatic efficacy for cutaneous wounds via distinct pathways.

Thermal-activated Polydopamine bilayer film exhibits dual-mode synergistic antibacterial properties for enhanced salmon preservation.

Foodborne pathogens threaten food safety and human health, prompting the need for innovative preservation solutions. Polydopamine endowed with photothermal properties represents a novel material for the inhibition of foodborne pathogens. This study develops a bilayer antibacterial film using polydopamine-berberine nanoparticles (PDA-BBR), leveraging dual-mode synergistic antibacterial effects through chemical and photothermal mechanisms.

Simulation and analysis of the medical radioisotope Lu production based on a high-intensity DT neutron generator.

Lu is one of the medical radioisotopes with wide application prospects. To explore the Lu production besides using reactors, a concept of utilizing high-enriched cylindrical Lu based on a high-intensity DT neutron generator via the direct neutron capture reaction has been proposed. The production of Lu in aLuO solid shell target has been simulated considering layers of neutron multiplier, moderator, and reflector around itself.

Solubilisation of quercetin in phospholipid complex improves its anti-hyperuricaemia activity in mice.

Previous studies have confirmed that quercetin (Que) has a good therapeutic effect on lowering uric acid and hyperuricaemia. However, due to its poor water solubility, the bioavailability is low with limited application. This research aimed to prepare quercetin phospholipid complex (Que-PC) to improve the solubility, and the physicochemical properties and anti-hyperuricaemia activity of Que-PC were investigated.

DO-GMA: An End-to-End Drug-Target Interaction Identification Framework with a Depthwise Overparameterized Convolutional Network and the Gated Multihead Attention Mechanism.

Identification of potential drug-target interactions (DTIs) is a crucial step in drug discovery and repurposing. Although deep learning effectively deciphers DTIs, most deep learning-based methods represent drug features from only a single perspective. Moreover, the fusion method of drug and protein features needs further refinement.

Screening of active components of melastoma dodecandrum lour. against diabetic osteoporosis using cell membrane chromatography-mass spectrometry.

Background: Melastoma dodecandrum Lour. (MD), a traditional botanical drug known for its hypoglycemic, antioxidant, and anti-inflammatory properties, is commonly used to treat diabetes, osteoarthritis, and osteoporosis. However, its specific active components against diabetic osteoporosis remain unclear.

Identifying key components from Melastoma dodecandrum in TNF-α-induced osteoblast injury model through a combination of cell membrane chromatography and mass spectrometry.

Ethnopharmacological Relevance: Melastoma dodecandrum (MD), a traditional ethnomedicine, has been widely used for the treatment of fractures, osteoarthritis, and osteoporosis due to its remarkable anti-inflammatory activity. However, the specific active components responsible for its therapeutic effects on orthopedic conditions remain unidentified.

Aim Of The Study: This study aimed to screen and identify key active components in MD using a combination of cell membrane chromatography and mass spectrometry, followed by cellular validation.

Melastoma dodecandrum lour. Protects against cerebral ischemia-reperfusion injury by ameliorating oxidative stress and endoplasmic reticulum stress.

Ethnopharmacological Relevance: Melastoma dodecandrum Lour. (MD), a traditional Chinese medicine used by the She ethnic group, has been used to treat cerebral ischemia-reperfusion (CIR) injury due to its efficacy in promoting blood circulation and removing blood stasiss; however, the therapeutic effects and mechanisms of MD in treating CIR injury remain unclear.

Aim: To investigate the protective effects of MD on CIR injury, in addition to its impact on oxidative stress, endoplasmic reticulum (ER) stress, and cell apoptosis.

MGNDTI: A Drug-Target Interaction Prediction Framework Based on Multimodal Representation Learning and the Gating Mechanism.

Drug-Target Interaction (DTI) prediction facilitates acceleration of drug discovery and promotes drug repositioning. Most existing deep learning-based DTI prediction methods can better extract discriminative features for drugs and proteins, but they rarely consider multimodal features of drugs. Moreover, learning the interaction representations between drugs and targets needs further exploration.

Overview of the pharmacokinetics and pharmacodynamics of URAT1 inhibitors for the treatment of hyperuricemia and gout.

Introduction: Hyperuricemia is a common metabolic disease, which is a risk factor for gouty arthritis and ureteral stones and may also lead to cardiovascular and chronic kidney disease (CDK). Therefore, hyperuricemia should be treated early. Xanthine oxidase inhibitors (XOIs) and uricosuric agents (UAs), which target uric acid, are two types of medications that are used to treat gout and hyperuricemia.

Phase regulation enabling dense polymer-based composite electrolytes for solid-state lithium metal batteries.

Solid polymer electrolytes with large-scale processability and interfacial compatibility are promising candidates for solid-state lithium metal batteries. Among various systems, poly(vinylidene fluoride)-based polymer electrolytes with residual solvent are appealing for room-temperature battery operations. However, their porous structure and limited ionic conductivity hinder practical application.

Improving the High-Temperature Energy Storage Performance of Epoxy Films: Moderately Reducing Unsaturation for Extremely High Efficiency.

The rapid development of renewable energy systems, electric vehicles, and pulsed equipment requires energy storage media to have a high energy storage density and efficiency in a wide temperature range. The state-of-the-art biaxially oriented polypropylene (BOPP) film is insufficient to meet the growing demand for energy storage devices due to its low energy storage density and working temperature, which make it a research hotspot for developing dielectric energy storage materials. In this manuscript, based on the epoxy materials that have been shown as a potential energy storage medium, we aim to reduce the influence of the benzene ring delocalization structure on the energy storage losses and enhance the efficiency by gradually replacing them with cyclohexane structures to adjust the segment unsaturation of epoxy materials.

Specific Adsorption-Oxidation Strategy in Cathode Inner Helmholtz Plane Enabling 4.6 V Practical Lithium-Ion Full Cells.

Increasing the cutoff voltage effectively maximizes the available capacity of the state-of-art layered-oxide cathodes (LiTMO). However, the spontaneous dehydrogenation-oxidation of carbonates in the cathode inner Helmholtz plane (C-IHP) under high voltage/temperature leads to side effects, including weak cathode electrolyte interphase (CEI) and cathode structural collapse. Here, we report a specific adsorption-oxidation (Ad-O) mechanism that dominates the later CEI formation through molecular regulation in C-IHP.

Electrocrystallization Regulation Enabled Stacked Hexagonal Platelet Growth toward Highly Reversible Zinc Anodes.

Realizing durative flattened and dendrite-free zinc (Zn) metal configuration is the key to resolving premature battery failure caused by the internal short circuit, which is highly determined by the crystal growth in the electrocrystallization process. Herein, we report that regulating the molecular structure of the inner Helmholtz plane (HIP) can effectively convert the deposition into activation control by weakening the solvated ion adsorption at the interface. The moderated electrochemical reaction kinetics lower than the adatom self-diffusion rate steers conformal stratiform Zn growth and dominant Zn (0001) texture, achieving crystallographic optimization.

The ITS analysis and identification of Actinidia eriantha and its related species.

The dried plant material of medically important plant Actinidia eriantha especially when it remains in the form of powder often look morphologically similar to its related species. The lack of efficient methods to distinguish the authentic material from other similar species leads to chances of adulteration. The molecular authentication of herbal plant materials such as the internal transcribed spacer (ITS) sequences is considered as more reliable method compared to morphological traits.

Excellent Vacuum Pulsed Flashover Characteristics Achieved in Dielectric Insulators Functionalized by Electronegative Halogen-Phenyl and Naphthyl Groups.

Designing electrical insulation materials with excellent surface flashover strength in a vacuum environment is crucial for high-power equipment and aerospace devices. In the present paper, the effect of two types of electronegative groups, the halogen-phenyl groups and the aromatic π-conjugated naphthyl groups, is used to greatly improve the vacuum flashover characteristics of polystyrene (PS), a commonly used polymer dielectric material in high-power devices. By polymerization of the monomers containing these electronegative groups, the bulk insulation material as a whole is modified expediently.

Enhancing the Surface Flashover Strength of Polystyrene in Vacuum by Secondary Electron Emission Suppression through Cross-Linking.

Insulation materials with excellent dielectrics-vacuum interface breakdown strength are irreplaceable in equipment such as particle accelerators, fusion ignition, and related aerospace devices. In this article, the segment structure of a typical insulation polymer, polystyrene, has been modified by introducing divinylbenzene to form cross-linking junctures and adjust the cross-linking density. The influence of cross-linking on its electron absorb-emit feature and further on the vacuum pulsed flashover characteristics has been systematically studied.