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Article Abstract
Esculin (ES) has antibacterial effects, but its low solubility and bioavailability limit applications. This study prepared an esculin phospholipid complex (ES-PC) solvent evaporation. SEM, FTIR, XRD and H-NMR verified its amorphous structure formed by intermolecular forces. The solubility in water and n-octanol increased by 13.8-and 7.3-fold respectively compared to ES, and its hydrophilicity improved as the octanol-water partition coefficient decreased. , ES-PC had a cumulative dissolution rate of over 85% within 4 h, much higher than ES. When used in a composite film for pork preservation, ES-PC inhibited bacterial growth, maintained low pH and TVB-N values, and extended the meat's shelf-life. This research provides a new way to develop delivery systems for insoluble drugs, expanding their applications.
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| http://dx.doi.org/10.1080/14786419.2025.2521388 | DOI Listing |
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