NDUFS8 facilitates hepatocellular carcinoma growth by enhancing mitochondrial function and escaping HUWE1-dependent degradation.

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Although mitochondrial metabolism contributes to tumorigenesis, the specific roles of individual mitochondrial components remain unclear.NADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8), a key subunit of mitochondrial complex I, has been implicated in non-hepatic malignancies, but its functional relevance in HCC is unknown.

A semi-analytical method for two-dimensional sound propagation in subsonic parallel mean flow.

This paper presents a semi-analytical method, referred to as the linear-velocity-profile fast field program (LFFP), for predicting two-dimensional sound fields in ambient parallel mean flows. The proposed method incorporates the linear velocity layering method into the fundamental framework of fast field program (FFP) to achieve reduced computational costs and enhanced precision, particularly under high-velocity gradient conditions. The accuracy of LFFP is validated through a two-dimensional jet case by comparison with the linearized Euler equation in frequency-domain.

Comparative analysis of acute and chronic toxicological exposure effects of polystyrene nanoparticles on Macrobrachium rosenbergii: Implications for antioxidative defense and immunosuppression.

Global pollution by microplastics (MPs) and nano-plastics (NPs) disrupts aquatic ecosystems and compromises the health of aquatic animals. However, there is a significant gap in the literature regarding acute high-dose and chronic low-dose polystyrene nano-plastic (PS-NP) exposures that simulate point-source and non-point source pollution events, respectively. The PS-NP concentrations (10 mg/L for acute exposure and 1 mg/L for chronic exposure) were designed to simulate realistic environmental scenarios.

Research on asphalt pavement structure with cement treated large size macadam (CTB-50) base course.

Cement-treated large-size macadam base (CTB-50) has a high modulus, high strength, and good durability, which can increase the paving and rolling thickness, reduce the base layers, and enhance the overall structure of the pavement structure. However, there are no studies conducted on the mechanical response of asphalt pavement with a CTB-50 base course such that it can be promoted and applied in pavement engineering using CTB-50. This study analyzed the mechanical response and fatigue life of asphalt pavement structures with different base courses.

Accelerating water dissociation to achieve ampere-level hydrogen peroxide electrosynthesis in brine and seawater.

Ampere-level hydrogen peroxide (HO) electrosynthesis in brine and seawater via two-electron oxygen reduction reaction (2e ORR) is promising, but limited by the slow water dissociation and insufficient protons in neutral media. Hence, we design a multifunctional Ni(OH) nanoplates anchored on carbon nanotubes (CNTs) as 2e ORR catalyst towards HO electrosynthesis, where Ni(OH) nanoplates accelerate water dissociation and proton transfer, resolving the critical proton shortage for HO formation. Combined with exceptional chloride tolerance and suppressed hydrogen evolution, the catalyst achieves a high HO yield of 141 mol g h (14.

Integrated Transcriptomic Analysis Uncovers the Protective Effects of Berberine Hydrochloride in Enhancing Hepatic Caecum Response of Branchiostoma belcheri (Chinese lancelet) to Aeromonas hydrophila.

Berberine hydrochloride (BH), the derivative component of Coptidis chinensis, is widely used to treat bacterial infections due to its notable antibacterial properties. However, the underlying molecular mechanisms of its therapeutic effects remain largely unexplored. This study employed transcriptome sequencing to investigate berberine hydrochloride's therapeutic efficacy and molecular responses in Branchiostoma belcheri infected with Aeromonas hydrophila.

Global T-cell functionality evaluated by whole blood interferon-gamma release assay as a valuable indicator for immune reconstitution monitoring in pediatric allo-HSCT.

Background: Adequate T-cell immune reconstitution (IR) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is pivotal for the recovery and optimal outcomes of pediatric HSCT recipients. A thorough assessment of global T-cell functionality is a crucial component in monitoring T-cell IR during the post-transplant period. The purpose of this study is to provide a novel tool and strategy for assessing and monitoring T-cell IR after pediatric allo-HSCT.

Communication Preferences With Attending Surgeons Among Surgical Team Members.

BackgroundHigh quality surgical patient care requires coordination of multidisciplinary teams with hierarchical structures. Good team communication is essential for optimal patient safety. We examined preferred modes of communication with attending surgeons to develop methods for improved team communication.

Identification and Characterization of β-Glucosidase PpF26G Catalyzing the Conversion of Steroidal Saponins To Improve Quality of during Postharvest Process.

Steroidal saponins are a class of compounds abundant in plants of the and families, and some of them exhibit several bioactivities, such as antitumor, hemostatic, and anti-inflammatory effects. During postharvest processing of products like , furostanosides are partially converted into high-activity spirostanosides, but the underlying mechanism remains unclear. In this study, transcriptomics was employed to identify the key endogenous enzyme mediating this process: PpF26G.

Interface Engineering of NiO/CuO Heterojunction Enabling Built-In Electric Field for Efficient Electrocatalytic Ammonia Oxidation Reaction.

Electrocatalytic ammonia oxidation reaction (AOR), as a promising energy conversion technology, also offers ideas for the synthesis of high-value nitrogenous compounds such as nitrites and nitrates. However, the sluggish kinetics of AOR at the anode leads to high overpotential and elevated energy consumption, necessitating advanced catalysts. Here, we engineer a NiO/CuO heterojunction on a copper mesh (NiO/CuO@Cu), which generates a robust internal electric field at the NiO-CuO interface.

Identification of potential diagnostic markers and molecular mechanisms of asthma and ulcerative colitis based on bioinformatics and machine learning.

Backgrounds: Asthma and ulcerative colitis (UC) are chronic inflammatory diseases linked through the "gut-lung axis," but their shared mechanisms remain unclear. This study aims to identify common biomarkers and pathways between asthma and UC using bioinformatics.

Methods: Gene expression data for asthma and UC were retrieved from the GEO database, and differentially expressed genes (DEGs) were analyzed.

Novel association between E3 ubiquitin ligase MARCH8 and glucose transporter Glut1 in intracerebral hemorrhage.

Background: Intracerebral hemorrhage (ICH) leads to hematoma formation and neuroinflammation, resulting in severe neurological damage, with limited treatment options available. Membrane-associated RING-CH 8 (MARCH8) is known to be involved in inflammatory responses; however, its specific role in ICH remains unclear. This study investigates the function of MARCH8 in ICH, its mechanism in regulating neuroinflammation, and its potential value as a therapeutic target.

Carbon-Based Catalysts for Electrosynthesis of Hydrogen Peroxide.

Hydorgen peroxide (HO) is an eco-friendly and versatile chemical with extensive applications across various inductrial and househould scenario. Electrosynthesis of HO via the two-electron oxygen reduction reaction (2e ORR) offers an efficient and sustainable alterantives to conventional anthraquinone process. Carbon-based catalysts have garnered significant attention in this field due to their intrinsic advantages, including cost-effectiveness, structural tunability, high electrical conductivity, and abundant surface active sites.

Internal hydrogen-bond enhanced two-electron oxygen reduction reaction for π-d conjugated metal-organic framework to HO synthesis.

Tailoring the electronic structure of electrocatalysts for oxygen reduction reaction (ORR) has been widely adopted to optimize their performance. However, the steric effect originating from the layered or crystal structure of a catalyst is often neglected. Herein, we demonstrate the importance of such steric effect in a one-dimensional π-d conjugated metal-organic framework with Ni-(NH) nodes (Ni-BTA) for optimizing its electrocatalytic performance, where the activity and selectivity towards two-electron ORR for HO production are largely enhanced.

Humoral and Cellular Immune Response to SARS-CoV-2 in Children Undergoing Cardiac Surgery.

Evaluating the impact of cardiac surgery on humoral and cellular immunity in pediatric congenital heart disease patients with prior Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection or vaccination is crucial for postoperative care planning. This study enrolled 61 pediatric patients undergoing cardiac surgery with cardiopulmonary bypass at a single institution. Measurements were taken before the operation, immediately postoperation, and during the first follow-up examination at least 1 month later.

Efficacy of as a biological control agent for pupae: Effects of distance, developmental stage, and soil depth.

Asian corn borer, Guenée (Lepidoptera: Crambidae), is a major pest in corn production, and its management remains a significant challenge. Current control methods, which rely heavily on synthetic chemical pesticides, are environmentally detrimental and unsustainable, necessitating the development of eco-friendly alternatives. This study investigates the potential of the entomopathogenic nematode as a biological control agent for pupae, focusing on its infection efficacy and the factors influencing its performance.

Recent Progress in Oxygen Reduction Reaction Toward Hydrogen Peroxide Electrosynthesis and Cooperative Coupling of Anodic Reactions.

Electrosynthesis of hydrogen peroxide (HO) via two-electron oxygen reduction reaction (2e ORR) is a promising alternative to the anthraquinone oxidation process. To improve the overall energy efficiency and economic viability of this catalytic process, one pathway is to develop advanced catalysts to decrease the overpotential at the cathode, and the other is to couple 2e ORR with certain anodic reactions to decrease the full cell voltage while producing valuable chemicals on both electrodes. The catalytic performance of a 2e ORR catalyst depends not only on the material itself but also on the environmental factors.

Gradient Sodium Deficiency Optimization in O3-Type Cathode Materials for Superior Performance and Air Stability.

O3-type layered oxides are promising cathode materials for sodium-ion batteries due to their easy synthesis and high sodium content. However, complex phase transitions and poor air stability limit their practical applications. Introducing sodium deficiency suppresses reactions with air and improves phase stability, but often at the cost of significantly compromising the sodium storage capacity.

Evaluation of the reliability and validity of the health literacy scale for HPV vaccination among parents of girls aged 9-14.

To evaluate the reliability and validity of the Health Literacy Scale for HPV Vaccination among parents of girls aged 9-14. A total of 830 parents of girls in grades 3-8 were sampled using convenience sampling in March-April 2024 in a school in a district of Shanghai, China, and item analysis was conducted using the critical ratio method, the correlation coefficient method, and Cronbach's alpha coefficients; Cronbach's alpha coefficients, Spearman-Brown split-half coefficients, and re-test reliability correlation coefficients were used for reliability evaluation, and content validity and validity factor analysis for validity testing. The scale was analyzed by item analysis to remove one indicator: "Whether a doctor's advice affects vaccination," and the final version of the scale consisted of 34 items divided into three dimensions: medical services (11 items), disease prevention (15 items) and health promotion (8 items).

Recent advances in polysaccharide-dominated extracellular polymeric substances from microalgae: A review.

Microalgae are an environmentally friendly and sustainable alternative resource for future food and pharmaceutical production. Microalgal extracellular polymeric substances (EPMS) are polymers consisting of polysaccharides, proteins, lipids and nucleic acids secreted by microalgal cells. This review systematically summarizes the research progress of microalgal EPMS, including its composition, structure, formation, biological activity and application.

High-throughput Design of Single-atom Catalysts with Nonplanar and Triple Pyrrole-N Coordination for Highly Efficient HO Electrosynthesis.

Single-atom catalysts (SACs) with nonplanar configurations possess unique capabilities for tailoring the oxygen reduction reaction (ORR) catalytic performance compared with the ones with planar configurations, owing to the additional orbital rearrangement arising from the asymmetric coordination atoms. However, the systematic investigation of these nonplanar SACs has long been hindered by the difficulty in screening feasible nonplanar configurations and precisely controlling the coordination structures. Herein, we demonstrate a combined high-throughput screening and experimental verification of nonplanar SACs (ppy-MN) with metal atoms triple-coordinated by pyrrole-N, for highly active and selective 2e ORR electrocatalysis.

[Quality analysis of Xueshuan Xinmaining Tablets and Capsules based on UPLC-Q/TOF-MS and UPLC-QQQ-MS/MS].

Xueshuan Xinmaining Tablets and Capsules are two Chinese patent medicines with the same prescription, different preparation methods but the same function of replenishing Qi, activating blood, opening orifices, and relieving pain. Xueshuan Xinmaining Capsules were qualitatively analyzed by UPLC-Q/TOF-MS for the first time, and 61 compounds were identified, including 9 phenolic acids, 10 bufadienolides, 15 saponins, 5 bile acids, and 22 other compounds. The chemical composition was slightly different between Xueshuan Xinmaining Tablets and Capsules.