Feasibility of laryngeal mask airway ventilation in selected pediatric pulmonary artery sling surgeries: a retrospective review.

Background: Pulmonary artery sling (PAS) is a rare congenital anomaly of the great vessels, often accompanied by tracheal stenosis and various intracardiac malformations. Traditionally, PAS surgeries have been performed using tracheal intubation and extracorporeal circulation. In 2015, our center began using laryngeal mask airway (LMA) ventilation combined with extracorporeal circulation to facilitate PAS surgeries.

Clinical and molecular spectrum of patients with methylmalonic acidemia and homocysteinemia complicated by cardiovascular manifestations.

Background: To investigate the clinical characteristics, treatment response, and prognosis of patients with methylmalonic acidemia (MMA) and homocysteinemia complicated by cardiovascular manifestations and to raise awareness regarding MMA and homocysteinemia.

Methods: A total of 16 children diagnosed with MMA and homocysteinemia with cardiovascular manifestations who were admitted to the Department of Pediatrics of the Second Hospital of Hebei Medical University from June 2018 to October 2024 were retrospectively analyzed.

Results: All 16 patients had varying degrees of neurological manifestations, and all had cardiovascular manifestations, 3 patients were diagnosed with MMA and homocysteinemia by newborn screening and received conventional treatment, the remaining 13 patients had nausea, vomiting, anemia, recurrent pneumonitis, respiratory distress, and lethargy as their first symptoms.

HSF1 in macrophages suppressed the progression of asthma via modulating SIRPα/SHP2-Dectin-1/ SYK mediated ROS and inflammatory responses.

HSF1, SIRPα, and Dectin-1 play crucial roles in immune regulation and inflammatory responses, their rols in asthma remained unclear, thereby the study was carried on. Twenty-one SPF-grade C57BL/6 mice were randomly divided into three groups: sham group, Model group, and Model + HSF1A group, with seven mice in each group. Except for the sham group, the other two groups were induced with OVA to establish an asthma model.

Does ureteral stent drainage prior to radical nephroureterectomy increase the risk of intravesical tumor recurrence?

Purpose: To investigate whether ureteral stent drainage (USD) increases the risk of intravesical recurrence in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU).

Methods: This retrospective study was conducted involving 2,756 upper tract urothelial carcinoma (UTUC) patients treated with RNU between 2000 and 2022, of whom 77 had a history of USD. The primary endpoint was to assess the association between USD and post-RNU bladder recurrence-free survival (BRFS).

Contemporary outcomes of the Fontan operation: a single-institution cohort from China.

Background: The Fontan procedure is the established benchmark for palliating single-ventricle (SV) heart conditions. This study aimed to assess the midterm outcomes of Fontan operations (FOs), focusing on identifying contemporary risk factors for early mortality and Fontan failure.

Methods: All patients who underwent FOs between 2005 and 2023 were divided into three cohorts: 2005-2010 (Era I), n=34; 2011-2017 (Era II), n=84; and 2018-2023 (Era III), n=55.

Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-Release Tablets on Somatic Symptoms of Major Depressive Disorder: A Prospective, Single-Arm, Multicenter Clinical Study.

Importance: Depression is a significant global public health issue, with somatic symptoms being a common and challenging aspect of its management.

Objective: This study aimed to evaluate the efficacy and safety of toludesvenlafaxine hydrochloride sustained-release tablets (Roxylin) for somatic symptoms of major depressive disorder (MDD).

Design Setting And Participants: Prospective, single-arm, multicenter clinical study conducted between June 1, 2023 and May 1, 2024, enrolling patients diagnosed with MDD with somatic symptoms at four hospitals across China.

Camrelizumab Plus Famitinib versus Camrelizumab Alone and Investigator's Choice of Chemotherapy in Recurrent or Metastatic Cervical Cancer: A Randomized, Phase II Study.

Purpose: To compare camrelizumab (an anti-PD-1 monoclonal antibody) plus famitinib (a multitarget receptor tyrosine kinase inhibitor) versus camrelizumab and chemotherapy in recurrent or metastatic cervical cancer (R/M CC).

Methods: Patients with pretreated R/M CC were randomly assigned to receive camrelizumab (200 mg intravenously once every 3 weeks) plus famitinib (20 mg orally once daily), camrelizumab, or investigator's choice of chemotherapy. The primary end point was comparison of objective response rate (ORR) per blinded independent central review (BICR) for camrelizumab-famitinib versus camrelizumab in the intention-to-treat population.

Should follow-up cystoscopy be performed in upper-tract urothelial carcinoma patients managed with radical nephroureterectomy after a five-year bladder tumor-free period?

There is a lack of consensus regarding the follow-up schedule for patients with upper-tract urothelial carcinoma (UTUC) who remain bladder recurrence-free for 5 years after radical nephroureterectomy (RNU). In this study, we aimed to identify the risk factors for late recurrence in UTUC patients who remained bladder recurrence-free for at least 5 years post-RNU. Data from a large single-center Chinese institution were retrospectively analyzed.

Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response and models.

Objectives: Many countries in the world are entering society with an aging population. The kidney is one of the most sensitive organs in the body to aging. Kidney function gradually declines with aging.

Association of neutrophil to high-density lipoprotein cholesterol ratio with overactive bladder: a population-based study.

Background: Inflammation is involved in the progression of overactive bladder (OAB). This study aimed to investigate the association between the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and OAB.

Methods: Data from seven cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 were analyzed to examine the relationship between NHR and OAB.

Aerobic Capacity Beyond Cardiorespiratory Fitness Linking Mitochondrial Function, Disease Resilience and Healthy Aging.

Aerobic capacity is conventionally equated with cardiorespiratory fitness (CRF), but its physiological essence extends far beyond cardiopulmonary performance. Aerobic capacity is an integrative physiological indicator reflecting the entire process from oxygen uptake and transport to mitochondrial energy conversion, with mitochondrial function constituting its molecular core. Emerging evidence reveals robust associations between diminished aerobic capacity and increased risks of non-communicable chronic diseases and age-related functional decline.

Ginsenoside Rk1 improves mitochondrial function and alleviates myocardial ischemia-reperfusion injury by regulating SIRT3.

Myocardial ischemia/reperfusion (I/R) injury can lead to heart damage and poor prognosis. The potential value of natural medicines in combating I/R damage is receiving increasing attention, however, more effective medicines still need to be developed to further improve I/R damage. Ginsenoside Rk1 is a major rare saponin obtained from hot processed ginseng, which has a variety of biological effects.

Epitope molecularly imprinted polymers based on host-guest interaction: specific recognition of CD59.

The detection of CD59 is of great clinical importance since it is an important glycoprotein that can serve as a biomarker related to kinds of cancers. In this work, we prepared host-guest interaction based oriented epitope molecularly imprinted polymer (hg-EMIP) for the immobilization of CD59 N-terminal epitopes. Cucurbit[7]uril (CB[7]) and l-phenylalanine (L-phe) were employed as the host and guest; and tannic acid (TA) with abundant hydroxyl groups and diethylenetriamine (DETA) were chosen as the functional monomer and crosslinking agent, respectively.

Chronic Alcohol Exposure Modulates Atherosclerotic Plaque Vulnerability in ApoE Knockout Mice.

Aim: This study aimed to examine the effect of chronic alcohol consumption on the development and progression of atherosclerosis in apolipoprotein E-knockout (ApoE) mice.

Method: Male ApoE mice, aged 8 weeks, were randomly assigned to four groups: control, model, low-dose alcohol, and high-dose alcohol. The mice were fed a normal chow or high-fat diet for 14 weeks, with water provided alongside 1% (v/v) or 5% (v/v) alcohol solutions.

Growth characteristics of children with 21-hydroxylase deficiency and the value of steroid hormones in height assessment.

Background: Impaired height is a common complication of 21-hydroxylase deficiency (21OHD), yet sensitive monitoring indicators remain limited. This study aims to elucidate growth characteristics and identify effective monitoring parameters for 21OHD children.

Methods: Cross-sectional data from 111 patients were categorized into four groups based on age and developmental stage: 0 - 2 years, 2 years old to pre-pubertal initiation, puberty initiation to pre-epiphyseal closure, and post-epiphyseal closure, named groups A to D, respectively.

Association of aberrant gray matter neurite density with neurovegetative symptom in atypical depression.

Background: The heterogeneity of symptoms in major depressive disorder is impeding progress toward patient-specific treatment strategies and course trajectories. Origins of such differential clinical manifestations likely have dissociable pathophysiologies, but neural substrates associated with specific atypical depressive symptoms remain elusive.

Methods: The muti-shell diffusion MRI images were acquired from 50 patients with atypical depression (AD), 97 patients with non-atypical depression (non-AD), and 50 healthy controls (HCs).

Estimated glucose disposal rate mediates the association between Life's Crucial 9 and congestive heart failure: a population-based study.

Background: Life's Crucial 9 (LC9) is the latest indicator of cardiovascular health (CVH), and the estimated glucose disposal rate (eGDR) is a non-invasive indicator of insulin resistance (IR). However, the relationships between LC9 and eGDR and congestive heart failure (CHF) remain unknown.

Methods: In this cross-sectional study, participants aged ≥20 years in the NHANES database from 2005 to 2018 were analyzed.

Differential patterns of axonal loss associated with threat-related adversity in atypical depression and non-atypical depression.

Background: Major depressive disorder (MDD) encompasses a broad spectrum of heterogeneous symptoms arising from distinct etiological mechanisms. Phenotypic markers of psychopathology are most likely influenced by exposure to childhood maltreatment, yielding distinct subtypes within conventional diagnostic boundaries. However, the biological interactions between MDD subtypes and types of childhood trauma remain unclear.

STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer.

In the clinic, anti-tumor angiogenesis is commonly employed for treating recurrent, metastatic, drug-resistant triple-negative, and advanced breast cancer. Our previous research revealed that the deubiquitinase STAMBPL1 enhances the stability of MKP-1, thereby promoting cisplatin resistance in breast cancer. In this study, we discovered that STAMBPL1 could upregulate the expression of the hypoxia-inducible factor HIF1α in breast cancer cells.

Exogenous GABA Alleviates Tourette Syndrome-Like Behavior in Sprague-Dawley Rats by Altering Gut Microbiota and Striatum Metabolism.

Context: Tourette syndrome (TS) is a common chronic neuropsychiatric disorder with a prevalence of approximately 1% in children and adolescents. TS is characterized by sudden involuntary motor tics along with vocal tics. A pathological study on postmortem patients has reported a 50-60% reduction in striatal gamma-aminobutyric acidergic (GABAergic) interneurons, suggesting a role for GABAergic system imbalances in tic disorder development.

The outcomes of reoperation for congenital mitral valve diseases in children.

Backgrounds: We aimed to study the outcomes of mitral valve (MV) reoperations in children with congenital MV diseases and to summarize our treatment experience.

Methods: In this single-center retrospective study, we enrolled 24 patients aged < 18 years who underwent MV reoperation from among 265 patients who underwent MV repair between January 2013 and July 2023. MV reoperations were based on the types of MV disease.

High expression and regulatory mechanisms of ANGPT1 and HOXA3 in acute myeloid leukemia.

Objective: Acute Myeloid Leukemia (AML) is a type of leukemia characterized by the malignant clonal proliferation of hematopoietic stem cells in the bone marrow. This study aims to investigate the role of ANGPT1 and HOXA3 in the leukemia cell line KG-1a.

Methods: The expression patterns of ANGPT1 and HOXA3 in AML patients were determined by analyzing the TCGA database and clinical samples.

Retrospective evaluation of mild encephalitis/encephalopathy with a reversible splenial lesion in children.

Background: Comprehensive documentation on consecutive years of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in children is lacking. This study aims to provide an in-depth analysis of the clinical profiles of MERS in children across different age groups, focusing on pathogens and recovery time.

Methods: In this retrospective study, 43 patients diagnosed with MERS were enrolled between December 2017 and November 2021.

ProCeSa: Contrast-Enhanced Structure-Aware Network for Thermostability Prediction with Protein Language Models.

Proteins play a fundamental role in biology, and their thermostability is essential for their proper functionality. The precise measurement of thermostability is crucial, traditionally relying on resource-intensive experiments. Recent advances in deep learning, particularly in protein language models (PLMs), have significantly accelerated the progress in protein thermostability prediction.