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Article Abstract
Myocardial ischemia/reperfusion (I/R) injury can lead to heart damage and poor prognosis. The potential value of natural medicines in combating I/R damage is receiving increasing attention, however, more effective medicines still need to be developed to further improve I/R damage. Ginsenoside Rk1 is a major rare saponin obtained from hot processed ginseng, which has a variety of biological effects. However, the role of ginsenoside Rk1 in myocardial I/R remains unclear. This study aims to uncover the potential role of Rk1 in I/R injury and elucidate its mechanism. Rk1 reduces H/ R-induced cardiomyocyte injury. It also alleviates mitochondrial damage in H/ R-induced cardiomyocytes. Rk1 reduces autophagy in H/ R-induced cardiomyocytes. Rk1 improves H/ R-induced cardiomyocyte injury by upregating SIRT3. Mechanically, Rk1 improves myocardial injury in I/R rats. In summary, Rk1 improves mitochondrial function damage and alleviates myocardial I/R by regulating SIRT3. We therefore thought Rk1 could serve as a promising drug of I/R injury.
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| http://dx.doi.org/10.1016/j.intimp.2025.114891 | DOI Listing |
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