Nano-FeO guided synthesis of an F,N-coordinated FeCo bimetallic catalyst H-mediated reductive pyrolysis for the oxygen reduction reaction.

To address the critical challenges of insufficient active site exposure, compromised stability, and sluggish mass transport kinetics in non-precious metal catalysts for the oxygen reduction reaction (ORR), a hierarchical FeCo bimetallic catalyst (FN/FeCoNC-H-700) was developed through synergistic engineering of ZIF-67 pyrolysis. This strategy integrates hydrogen-induced defect generation, F/N dual-heteroatom coordination, and temperature-controlled phase reconstruction. The introduction of hydrogen reduces FeO to generate highly dispersed Fe nanoparticles, which combine with Co and N to form a stable Co-Fe alloy and Fe-N active centers, concurrently enhancing the graphitization degree of the catalyst (/ = 0.

A self-monitoring analysis and reporting technology dataset of 147,496 hard disks.

In order to study hard disk failure prediction,this paper introduces SMART-Z, a dataset comprising 147,496 pieces of hard disk SMART data periodically collected by a large distributed video data center in China in the enterprise application environment from March 2017 to February 2018. There are 65 types of hard disk models, including 712 failure disks and the rest are healthy disks. To minimize business interference,data acquisition utilized predefined peak-hour exclusion lists, multi-dimensional monitoring, and an intelligent fuse strategy to effectively guarantee the stable operation.

Dansylated Amino Acid-Modified Long-Acting PSMA Derivatives Ga/Lu-LNC1011 as Prostate Cancer Theranostics.

Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy has demonstrated promising potential for treating metastatic castration-resistant prostate cancer. Recently, albumin-binding motif-modified PSMA radioligands with prolonged blood circulation were developed to improve tumor uptake and therapeutic effectiveness, properties which, however, were associated with an increased risk of bone marrow toxicity. This study presents new PSMA-targeted radioligands incorporating dansylated amino acids as relatively weak and preferable albumin binders to achieve a fine balance between increased tumor accumulation, safety, and diagnostic efficacy, facilitating a unified approach to theranostics within a single molecular framework.

Development of [Ac]Ac‑LNC1011 for targeted alpha-radionuclide therapy of prostate cancer.

Purpose: Prostate-specific membrane antigen (PSMA) radioligand therapy (PRLT) has become a promising option for treating metastatic castration-resistant prostate cancer (mCRPC). Radioligands labelled with the Ga/Lu theranostic pair have been most widely used in the clinic for diagnosis and therapy, respectively. This study aims to develop a novel PSMA-targeted radioligand, LNC1011, radiolabeled with alpha-emitter Ac, to optimise pharmacokinetic properties and assess its potential for targeted alpha therapy (TAT) in prostate cancer treatment.

Small-Molecule Radiotracers for Visualization of V-Domain Immunoglobulin Suppressor of T Cell Activation.

V-domain immunoglobulin suppressor of T cell activation (VISTA) plays a critical role in regulating innate and adaptive immune responses within the tumor immune microenvironment. Quantifying VISTA expression is necessary to determine whether patients respond to a related combination immunotherapy. This study developed two Ga-labeled small-molecule probes ([Ga]Ga-DCA and [Ga]Ga-DNCA) for visualizing and differentiating VISTA expression.

Development and Evaluation of [Ga]Ga-Labeled Riboflavin Derivative for RFVT3-Targeted PET Imaging of Melanoma in Mice.

The limited progress in treatment options and the alarming survival rates in advanced melanoma emphasize the significant research importance of early melanoma diagnosis. RFVT3, a crucial protein at the core of energy metabolism reprogramming in melanoma, might play a pivotal role in early detection. In this study, [Ga]Ga-NOTA-RF, based on riboflavin (RF), was rationally developed and validated, serving as an innovative tool for positron emission tomography (PET) imaging of RFVT3 expression in melanoma.

MicroPET Imaging of Riboflavin Transporter 3 Expression in Myocardial Infarction/Reperfusion Rat Models with Radiofluorinated Riboflavin.

Riboflavin transporter 3 (RFVT3) represents a potential cardioprotective biotarget in energetic metabolism reprogramming after myocardial infarction/reperfusion (MI/R). This study investigated the feasibility of noninvasive real-time quantification of RFVT3 expression after MI/R with an radiolabeled probe F-RFTA in a preclinical rat model of MI/R. The tracer F-RFTA was radio-synthesized manually and characterized on the subjects of radiolabeling yield, radiochemical purity, and stability .

Progressive Optimization of Lanthanide Nanoparticle Scintillators for Enhanced Triple-Activated Radioluminescence Imaging.

Lanthanide nanoparticle (LnNP) scintillators exhibit huge potential in achieving radionuclide-activated luminescence (radioluminescence, RL). However, their structure-activity relationship remains largely unexplored. Herein, progressive optimization of LnNP scintillators is presented to unveil their structure-dependent RL property and enhance their RL output efficiency.

Development of small-molecular-based radiotracers for PET imaging of PD-L1 expression and guiding the PD-L1 therapeutics.

Purpose: Programmed cell death protein ligand 1 (PD-L1) is a crucial biomarker for immunotherapy. However, nearly 70% of patients do not respond to PD-L1 immune checkpoint therapy. Accurate monitoring of PD-L1 expression and quantification of target binding during treatment are essential.

Development of F-Labeled Acridone Analogue for Tumor Imaging via Stimulator of Interferon Genes Targeting.

The stimulator of interferon genes (STING) is a pivotal protein in the production of STING-dependent type I interferon, which has the potential to enhance tumor rejection. The visualization of STING in the tumor microenvironment is valuable for STING-related treatments, but few STING imaging probes have been reported to date. In this study, we developed a novel F-labeled agent ([F]F-CRI1) with an acridone core structure for the positron emission tomography (PET) imaging of STING in CT26 tumors.

Simplified one-pot F-labeling of biomolecules with generated fluorothiophosphate synthons in high molar activity.

Conventional F-labeling methods that demand substrate pre-modification or lengthy radiosynthesis procedures have impeded the visualization and translation of numerous biomolecules, as biomarkers or ligands, using modern positron emission tomography techniques . Moreover, F-labeled biomolecules in high molar activity (A) that are indispensable for sensitive imaging could be only achieved under strict labeling conditions. Herein, F-labeled fluorothiophosphate (FTP) synthons in high A have been generated rapidly in reaction solutions with < 5% water nucleophilic substitution by wet [F]F, which required minimal processing from cyclotron target water.

Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics.

T cells play a determining role in the immunomodulation and prognostic evaluation of cancer treatments relying on immune activation. While specific biomarkers determine the population and distribution of T cells in tumours, the in situ activity of T cells is less studied. Here we designed T-cell-targeting fusogenic liposomes to regulate and quantify the activity of T cells by exploiting their surface redox status as a chemical target.

Direct F-Labeling of Biomolecules via Spontaneous Site-Specific Nucleophilic Substitution by F on Phosphonate Prostheses.

We describe a high radiochemical yield late-stage direct F-labeling of bare biomolecules containing common active groups. Spontaneity and site-selectivity are attributed to the remarkably higher rates of nucleophilic substitution reactions on phosphonates than on other electrophiles by F at various hydrogen bond forms. Rapid access to many medicinally significant F-labeled biomolecules is achieved at 21-68% radiochemical yields and 35.

Biocompatible Croconaine Aggregates with Strong 1.2-1.3 μm Absorption for NIR-IIa Photoacoustic Imaging in Vivo.

Although photoacoustic imaging (PAI) in the second near-infrared (NIR-II) region (1.0-1.7 μm) is admired for deeper penetration and higher contrast, few organic NIR-II absorbers are available as exogenous contrast agents in vivo.

Rapid one-step F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors.

Currently, only a few F-radiolabeling methods were conducted in aqueous media, with non-macroelement fluoride acceptors and stringent conditions required. Herein, we describe a one-step non-solvent-biased, room-temperature-driven F-radiolabeling methodology based on organophosphine fluoride acceptors. The high water tolerance for this isotope-exchange-based F-labeling method is attributed to the kinetic and thermodynamic preference of F/F over the OH/F substitution based on computational calculations and experimental validation.