Prioritized SNP Selection from Whole-Genome Sequencing Improves Genomic Prediction Accuracy in Sturgeons Using Linear and Machine Learning Models.

Genomic prediction has emerged as a powerful tool in aquaculture breeding, but its effectiveness depends on the careful selection of informative single nucleotide polymorphisms (SNPs) and the application of appropriate prediction models. This study aimed to enhance genomic prediction accuracy in Russian sturgeon () by optimizing SNP selection strategies and exploring the performance of linear and machine learning models. Three economically important traits-caviar yield, caviar color, and body weight-were selected due to their direct relevance to breeding goals and market value.

Mechanistic insights into the renoprotective effects of artesunate in cisplatin-induced acute kidney injury.

Acute kidney injury (AKI) is a severe clinical syndrome marked by rapid renal function decline. Cisplatin (Cis) is a commonly used chemotherapy agent; however, its clinical application has been restricted due to its nephrotoxicity. Artesunate (ART), derived from Artemisia annua, has potent anti-inflammatory and antioxidant properties.

The Clinical and Metabolic Profiles in Menstrual Changes Among Reproductive-Aged Women Post-COVID-19.

Menstruation is a key indicator of female reproductive health, yet clinical features and underlying mechanisms associated with menstrual changes following the coronavirus disease 2019 (COVID-19) infection remain unclear. Here, we recruited 253 participants through questionnaires, and 73 individuals underwent metabolomic analysis of blood serum. Over 60% reported menstrual changes, primarily experiencing longer cycle and lighter bleeding, which were significantly associated with age, general medical conditions, perceived stress, anxiety scores, and depression scores, as well as COVID-19 symptoms including fatigue and headache.

Environmental drivers affecting the dormancy of Paranosema locustae.

Aims: As a gastrotoxic biocontrol agent employed for locust outbreak management, the infectivity of Paranosema locustae demonstrates significant dependence on pre-ingestion environmental exposure conditions, particularly temperature fluctuations, humidity levels, and UV radiation intensity, making the systematic investigation of these abiotic factors crucial for optimal field application.

Methods And Results: In this study, we simulated key environmental parameters (temperature, humidity, and UV radiation) that critically influence P. locustae viability during the pre-infection phase of host exposure.

Longitudinal associations between pain and cognitive decline in middle-aged and older Chinese adults: the mediating role of depressive symptoms.

Objective: The primary aim of this scholarly investigation was to elucidate the correlation between Number of Pain Sites and cognitive decline within the older adult population. Additionally, the study sought to examine the potential mediating influence of depressive symptoms in moderating the association between pain and cognitive deterioration.

Methods: We analyzed 8,835 participants aged 45 and above, with data collected from 2011 to 2018.

Brucella lipopolysaccharide deficiency with lipid A induces robust T cells immune response.

Brucella, an opportunistic intracellular parasitic bacterium, is classified as a Gram-negative organism. Lipopolysaccharide (LPS), as primary virulence factor of Brucella, includes lipid A, O-antigen, and core polysaccharide, with lipid A being the principal component. The atypical structure of Brucella LPS, noted for its very-long-chain fatty acids, may suppress the host immune response, thus facilitating chronic disease development.

Development and Application of a Multiplex PCR Assay for Simultaneous Detection of Tomato Yellow Leaf Curl Virus and Tomato Leaf Curl New Delhi Virus.

Tomato leaf curl New Delhi virus (ToLCNDV) and tomato yellow leaf curl virus (TYLCV) are two important viral pathogens that severely affect and plants. In order to reduce the further spread of these viruses, it is crucial to establish an efficient and reliable method to accurately detect the viruses. In this study, a multiplex PCR assay for the simultaneous detection of TYLCV and ToLCNDV was established.

High-throughput screening unveils AMG 837 and RORγt 13 as the potent Brucella inhibitor by targeting BacA.

Brucellosis poses a major threat to the global animal husbandry, yet effective prevention and control measures remain elusive. Through High-Throughput Screening techniques, two potential anti-Brucella compounds are identified from a library comprising FDA-approved and known biological activity in this study. We unveil AMG 837 calcium hydrate and RORγt inverse antigen 13 can strongly bind with BacA, which mutants lacking BacA greatly reduce the survival rate of Brucella in macrophages.

miR-542-3p attenuates corticosterone-induced hippocampal neuronal damage in depressive mice by modulating PTEN/AKT/GSK3β/β-catenin pathway.

Depression is a common psychological disease, and nerve injury is the key link of depression. The molecular mechanism involved in this link needs to be explored. miR-542-3p can reduce the degree of hippocampal neuronal damage in rats, but its mechanism in the neural damage of depression is still unclear.

Circ_DLG1 facilitates cell proliferation and metastasis of esophageal squamous cell carcinoma via upregulating MAP3K9.

Background: Circ_DLG1 is found to be aberrantly expressed in esophageal squamous cell carcinoma (ESCC) tissues, but its role in the progression of ESCC remains to be elucidated.

Methods: The expression of circ_DLG1, miR-338-3p and mitogen-activated protein kinase kinase kinase 9 (MAP3K9) was measured by qRT-PCR. Cell cycle, viability, migration and invasion were investigated using flow cytometry, MTT assay and transwell assay, respectively.

Prediction of the potential distribution area of endangered medicinal plant in China under the background of climate change.

is an endangered medicinal plant. Due to climate change and human activities, as well as the low reproductive capacity, the wild resources of are extremely scarce and it has been listed in the Chinese National Second Level Protected Plant List. Predicting the potential suitable distribution area of is crucial for the conservation and sustainable utilization.

Effects of lithium carbonate combined with olanzapine on glucose and lipid metabolism in the treatment of bipolar disorder and gender differences.

To explore the effect of lithium carbonate combined with olanzapine on glucose and lipid metabolism, as well as gender differences in treating bipolar disorder (BD). 110 BD patients admitted to the Fifth People's Hospital of Luoyang from February 2022 to January 2024 were retrospectively included in the study. Patients were categorized into two groups based on treatment: The single group (lithium carbonate, n = 50) and the coalition group (lithium carbonate + olanzapine, n=60).

Transcriptomic analysis of the gonads of (Orthoptera: Acrididae) following infection with .

is an environmentally friendly parasitic predator with promising applications in locust control. In this study, transcriptome sequencing was conducted on gonadal tissues of males and females infected and uninfected with at different developmental stages. A total of 18,635 differentially expressed genes (DEGs) were identified in female ovary tissue transcriptomes, with the highest number of DEGs observed at 1 day post-eclosion (7141).

Nonintrusive and Effective Volume Reconstruction Model of Swimming Sturgeon Based on RGB-D Sensor.

The sturgeon is an important commercial aquaculture species in China. The measurement of sturgeon mass plays a remarkable role in aquaculture management. Furthermore, the measurement of sturgeon mass serves as a key phenotype, offering crucial information for enhancing growth traits through genetic improvement.

The psychological side of menopause: evidence from the comorbidity network of menopausal, anxiety, and depressive symptoms.

Objective: Numerous studies have uncovered a correlation between menopausal, anxiety, and depressive symptoms. How these symptoms interrelate and influence each other, however, remains unclear. This study aimed to identify the associations between menopausal, anxiety, and depressive symptoms using network analysis.

Effect of RNAi mediated silencing of DIB, JHE, and CAM on the diapause termination of Calliptamus italicus (Orthoptera: Acrididae) eggs.

Background: Calliptamus italicus L. is a major pest in Xinjiang grassland. The diapause overwintering strategy is one of the important reasons for the large population of this pest.

Cost-effective genomic prediction of critical economic traits in sturgeons through low-coverage sequencing.

Low-coverage whole-genome sequencing (LCS) offers a cost-effective alternative for sturgeon breeding, especially given the lack of SNP chips and the high costs associated with whole-genome sequencing. In this study, the efficiency of LCS for genotype imputation and genomic prediction was assessed in 643 sequenced Russian sturgeons (∼13.68×).

The synergistic impact of probiotics and dietary fiber on constipation management in chlorpromazine-induced schizophrenia patients: exploring the modulation of intestinal microbiota and neurotrophic factors.

Objective: To explore the improvement effect of probiotics combined with dietary fiber on constipation in patients with schizophrenia.

Methods: To compare the improvement scores of constipation, constipation symptoms, quality of life, neurotrophic factors-related indicators, and clinical efficacy between the two groups.

Results: There was no statistically significant difference in Cleveland Constipation Scoring System (CCS) scores in the control group before and after treatment ( > 0.

polyGBLUP: a modified genomic best linear unbiased prediction improved the genomic prediction efficiency for autopolyploid species.

Given the universality of autopolyploid species in nature, it is crucial to develop genomic selection methods that consider different allele dosages for autopolyploid breeding. However, no method has been developed to deal with autopolyploid data regardless of the ploidy level. In this study, we developed a modified genomic best linear unbiased prediction (GBLUP) model (polyGBLUP) through constructing additive and dominant genomic relationship matrices based on different allele dosages.

Lack of associations between thyroid dysfunction and obstructive sleep apnea-hypopnea syndrome: A meta-analysis.

Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a comprehensive syndrome with endocrine and metabolic complications. This review aims to explore the correlation between thyroid hormone levels and the severity of OSAHS in patients.

Methods: The protocol for this meta-analysis has been registered on PROSPERO.

The immune response of Locusta migratoria manilensis at different times of infection with Paranosema locustae.

Paranosema locustae is an entomopathogenic microsporidia with promising potential for controlling agricultural pests, including Locusta migratoria manilensis. However, it has the disadvantage of having a slow insecticidal rate, and how P. locustae infection impacts the host immune response is currently unknown.