Impact of rhizosphere quantitative microbiome and soil properties on alkaloid levels in Lycoris aurea herb.

Lycoris aurea Herb is a plant renowned for its striking appearance and medicinal properties, particularly the production of alkaloids such as lycorine and galanthamine, which have therapeutic potential in treating diseases. Understanding the interaction between L. aurea and its rhizosphere microbiome is crucial, as the microbiome influences plant health, nutrient availability, and metabolite biosynthesis.

Potential role of hemopexin in venous thromboembolism (VTE) mediated through effects on apoptosis-related proteins.

Objective: The limited understanding of venous thromboembolism (VTE) has hindered the development of novel treatment approaches. This study aimed to identify critical factors underlying VTE.

Methods: The isobaric tags for relative and absolute quantitation (iTRAQ) method was applied to identify differentially expressed proteins in plasma samples from patients with VTE and healthy volunteers.

Photoinduced Cobaloxime-Catalyzed Regio- and Diastereoselective Hydrogen-Evolution C(sp)-H Phosphorylation of Bicyclo[1.1.0]butanes.

Radical-initiated functionalization of bicyclo[1.1.0]butanes (BCBs) is a straightforward approach to accessing diverse cyclobutane derivatives.

Transcriptome Proffling, Physiological and Biochemical Analyses Reveal Comprehensive Insights into Cadmium Stress in .

With the expansion of cities and the development of industries, heavy metal pollution has caused a serious negative impact on the growth and development of animals and plants, which has become a global economic and social problem. Cadmium (Cd) is one of the main heavy metals that threaten the growth and development of plants, and it can lead to the imminent extinction of plants in severe cases. The part of upper reaches of the Yangtze River in China from Yibin to the Three Gorges Reservoir has been contaminated with varying degrees of Cd, and a rare and endangered plant called also lives in this area.

Switchable Divergent Electrochemical Hydrodehalogenation of -Dihalocyclopropanes.

A comprehensive and effective electrochemical methodology is introduced for the diverse hydrodechlorination of -dichlorocyclopropanes and the ring cleavage hydrodefluorination of -difluorocyclopropanes under uniform electrochemical conditions. Moreover, the water content allows for the adjustable monohydrodechlorination or dihydrodechlorination of -dichlorocyclopropanes with exceptional chemoselectivity. Additionally, the mildness and practicality of this protocol facilitate its application to the late-stage functionalization of bioactive molecules.

Multi-Omics Analysis Reveals Molecular Responses of Alkaloid Content Variations in Lycoris aurea Across Different Locations.

Lycoris aurea, celebrated for its visually striking flowers and significant medicinal value due to the presence of alkaloids such as lycorine and galanthamine, has intricate yet poorly understood regulatory mechanisms. This study provides a detailed examination of the transcriptomic, metabolomic and ecological dynamics of L. aurea, aiming to elucidate the underlying molecular mechanisms of alkaloid biosynthesis.

2-Isopropylthioxanthone-Catalyzed Divergent Functionalization of Bicyclo[1.1.0]butanes under Visible-Light Irradiation.

1,3-Functionalized cyclobutane structural motifs are ubiquitous in natural products and pharmaceuticals. Photoinduced alkylation of bicyclo[1.1.

Photoinduced Three-Component Carboarylation of Unactivated Alkenes with Protic C(sp)-H Feedstocks.

A general and mild strategy involving three-component carboarylation of unactivated alkenes with protic C(sp)-H feedstocks via photoredox catalysis was reported. This catalytic system is compatible with a broad range of unactivated alkenes, cyano-substituted arenes, and diverse protic C(sp)-H feedstocks. The synthetic value of this protocol was demonstrated by the late-stage functionalization of complex molecules and the synthesis of the antiallergies including pheniramine, chlorpheniramine, and brompheniramine.

Contrasting Responses of Multispatial Soil Fungal Communities of Thuja sutchuenensis Franch., an Extremely Endangered Conifer in Southwestern China.

Thuja sutchuenensis Franch. is an endangered species in southwest China, distributed sporadically in mountainous areas. Soil property and soil fungal community play a crucial role in plant growth and survival.

Comparative Analyses of Rhizosphere Bacteria Along an Elevational Gradient of .

Franch. is an endangered species in southwestern China, primarily distributed in 800-2,100 m of inaccessible mountainous areas. Rhizosphere soil physicochemical properties and bacterial communities play an essential role in managing plant growth and survival.

Extracorporeal Membrane Oxygenation Therapy for Critically Ill Coronavirus Disease 2019 Patients in Wuhan, China: A Retrospective Multicenter Cohort Study.

Currently, little in-depth evidence is known about the application of extracorporeal membrane oxygenation (ECMO) therapy in coronavirus disease 2019 (COVID-19) patients. This retrospective multicenter cohort study included patients with COVID-19 at 7 designated hospitals in Wuhan, China. The patients were followed up until June 30, 2020.

The complete chloroplast genome of (Pentaphylacaceae).

The complete chloroplast (cp) genome of Dunn. has been reported in this study. The cp genome has a total length of 157,218 bp with the typical quadripartite structure, containing two inverted repeats (IRs) of 25,883 bp separated by a large single-copy (LSC) region of 87,248 bp and a small single-copy (SSC) region of 18,204 bp.

The complete chloroplast genome of (Plantaginaceae): an endemic and Endangered species from China.

This study was the first report about the complete chloroplast genome of (Plantaginaceae). The circular whole cp genome of was in a total length 164,976 bp with the typical quadripartite structure of angiosperms, containing two inverted repeats (IRs) of 38,644 bp separated by a large single-copy (LSC) region and a small single-copy (SSC) region of 82,972 and 4716 bp, respectively. The plastid genome of contains 113 genes, including 79 protein-coding genes, 4 ribosomal RNA genes, and 30 transfer RNA genes.

Characterization of the complete chloroplast genome sequence of (Balsaminaceae): an endemic species from China.

This study was the first report about complete chloroplast genome of (Balsaminaceae). The plastome of was found to possess a total length 152,487 bp with the typical quadripartite structure of angiosperms, containing two inverted repeats (IRs) of 25,684 bp separated by a large single-copy (LSC) region and a small single-copy (SSC) region of 83,290 and 17,829 bp, respectively. The plastid genome of contains 113 genes, including 79 protein-coding genes, 4 ribosomal RNA genes, and 30 transfer RNA genes.

Microtubing-Reactor-Assisted Aliphatic C-H Functionalization with HCl as a Hydrogen-Atom-Transfer Catalyst Precursor in Conjunction with an Organic Photoredox Catalyst.

Chlorine radical, which is classically generated by the homolysis of Cl under UV irradiation, can abstract a hydrogen atom from an unactivated C(sp )-H bond. We herein demonstrate the use of HCl as an effective hydrogen-atom-transfer catalyst precursor activated by an organic acridinium photoredox catalyst under visible-light irradiation for C-H alkylation and allylation. The key to success relied on the utilization of microtubing reactors to maintain the volatile HCl catalyst.

Eosin Y as a Direct Hydrogen-Atom Transfer Photocatalyst for the Functionalization of C-H Bonds.

Eosin Y, a well-known economical alternative to metal catalysts in visible-light-driven single-electron transfer-based organic transformations, can behave as an effective direct hydrogen-atom transfer catalyst for C-H activation. Using the alkylation of C-H bonds with electron-deficient alkenes as a model study revealed an extremely broad substrate scope, enabling easy access to a variety of important synthons. This eosin Y-based photocatalytic hydrogen-atom transfer strategy is promising for diverse functionalization of a wide range of native C-H bonds in a green and sustainable manner.

Photoinduced Nickel-Catalyzed Chemo- and Regioselective Hydroalkylation of Internal Alkynes with Ether and Amide α-Hetero C(sp)-H Bonds.

A direct hydroalkylation of disubstituted alkynes with unfunctionalized ethers and amides was achieved in an atom-efficient and additive-free manner through the synergistic combination of photoredox and nickel catalysis. The protocol was effective with a wide range of internal alkynes, providing products in a highly selective fashion. Notably, the observed regioselectivity is complementary to conventional radical addition processes.

Sensitive immunosensing of squamous cell carcinoma antigen based on a nanocomposite of poly{3-amine-N-[3-(N-pyrrole)propyl]imidazole bromide} ionic liquid and gold nanoroots.

Squamous cell carcinoma antigen (SCCA) is a good specific antigen for cancer diagnosis specifically for squamous cell carcinomas. In this study, 3-amine-N-[3-(N-pyrrole)propyl]imidazole bromide (APPIBr) ionic liquid was successfully synthesized and characterized by H NMR, HPLC-MS and FTIR. APPIBr ionic liquid is a unique functional material with a pyrrole moiety which can be polymerized by using electrochemical technique and an amine group for immobilizing biomolecules; thus, it is ideal for the fabrication of biosensors.

[Karyotype and evolutionary trend analysis of Scutellaria species in Jinyun mountain, Chongqing].

Traditional squash method was used to analyze chromosome number and karyotypes of four Scutellaria species in Chongqing Jinyun Mountain Natural Reserve： Scutellaria tsinyunensis, S.yunnanensis, S.franchetiana and S.

Direct allylation of quinones with allylboronates.

Allylboronates undergo C-H allylation of unsubstituted or monosubstituted benzoquinone and naphthoquinone substrates. In the case of 2,5- or 2,6-disubstituted quinones addition involving the substituted carbon takes place. Allylation with stereodefined allylboronates occurs with retention of the configuration.

Allylic sp3 C-H borylation of alkenes via allyl-Pd intermediates: an efficient route to allylboronates.

Palladium catalyzed allylic C-H functionalization was performed using exocyclic alkene substrates. Multi-component synthesis of stereodefined homoallylic alcohols could be performed using a reaction sequence involving allylic C-H borylation and allylation of aldehydes.

Endoscopic radial artery harvesting does not compromise graft patency for coronary artery bypass graft: a meta analysis of 2782 patients.

Background: Endoscopic radial artery harvesting is a favourable harvesting technique which provides excellent cosmetic result and low incidence of incision related complications, however the impact of this technique on graft quality is less well-explained. We sought to evaluate the impact of harvesting technique on graft patency and relevant clinical outcomes in patients undergoing coronary artery bypass graft (CABG).

Method: A systematic literature search was conducted to identify publications containing comparisons between different sampling skills in CABG, data was extracted and analysed with Revman, Downs and Black score was applied to evaluate the methodological quality of included studies.