Publications by authors named "He-Ting Sun"

spp. is a globally distributed foodborne intestinal parasite with potential zoonotic risk. The Tibetan antelope (), an iconic wildlife species in China, is classified as a national first-class protected animal.

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As a natural accelerator of highly pathogenic avian influenza in wild birds, the H9 subtype of avian influenza poses a substantial threat to both humans and the poultry industry. A comprehensive meta-analysis is necessary to assess the current status of the global H9 outbreak. In this research, a literature review and meta-analysis are presented on the surveillance studies of the H9 subtype of avian influenza in wild birds worldwide up to 2024.

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Introduction: . and are common zoonotic pathogens threatening human and animal health. These parasites are widely distributed in birds, and substantial research on their prevalence has been conducted.

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Background: A significant increase in mitochondrial fatty acid oxidation (FAO) is now increasingly recognized as one of the metabolic alterations in diabetic cardiomyopathy (DCM). However, the molecular mechanisms underlying mitochondrial FAO impairment in DCM remain to be fully elucidated.

Methods: A type 2 diabetes (T2D) mouse model was established by a combination of high-fat diet (HFD) and streptozotocin (STZ) injection.

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Introduction: is a conditional pathogen that parasitizes the intestines of vertebrates and has been detected in various wild animals. However, its infection rate in Tibetan antelopes has not been previously studied.

Methods: In this study, 503 fecal samples from Tibetan antelopes were analyzed to determine the prevalence and molecular characteristics of .

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Article Synopsis
  • Myocardial ischemia-reperfusion injury (MIRI) is caused by restoring blood flow to heart tissue, leading to issues like oxidative stress and inflammation.
  • This study explores the effects of stachyose, a natural compound, on MIRI, finding that it improves heart function and reduces damage in models of the condition.
  • Stachyose works by enhancing protective pathways in heart cells and suppressing inflammatory responses in immune cells, suggesting it could be a promising treatment option for MIRI that needs further research.
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Avian malaria is a vector-borne parasitic disease caused by Plasmodium infection transmitted to birds by mosquitoes. The aim of this systematic review was to analyze the global prevalence of malaria and risk factors associated with infection in wild birds. A systematic search of the databases CNKI, WanFang, VIP, PubMed, and ScienceDirect was performed from database inception to 24 February 2023.

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Article Synopsis
  • Tsutsugamushi disease, caused by a zoonotic intracellular pathogen, has recently spread across China, especially north of the Yangtze River, raising public health concerns.
  • A meta-analysis of 55 studies indicated that the overall infection rate of this pathogen in rodents is 5.5%, with a notable decline in prevalence after 2013, and highlighted specific rodent species that show higher infection rates.
  • Seasonal changes affect rodent infection rates, peaking in autumn, and geographical factors such as temperature, altitude, precipitation, and humidity significantly influence infection probabilities, suggesting a need for preventive measures.
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Article Synopsis
  • The study investigates the presence of zoonotic enteric pathogens in wild rodents across six provinces in China, specifically focusing on the prevalence of certain bacteria and their potential risk to human health.
  • Out of 536 collected fecal samples, 11.6% tested positive for one pathogen and 3.4% for another, with varying prevalence rates across different regions.
  • This research is significant as it confirms the existence of these pathogens in wild rodents and highlights their potential role as a source of human infection, offering new data on their distribution and genetic diversity.
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spp., the causative agent of cryptosporidiosis, can infect a variety of hosts. So far, there has been limited information regarding spp.

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is a protozoan that parasitizes the intestines. A number of hosts of have been found, including human and animals. However, there has been no research on the prevalence of in Tibetan antelope.

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is an enteric parasite, which can infect multiple mammals including livestock and wildlife. Tibetan Antelope () is one of the most famous wildlife species, that belongs to the first class protected wild animals in China. However, it has not been known whether Tibetan Antelope is infected with so far.

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The genus Orthonairovirus, which is part of the family Nairoviridae, includes the important tick-transmitted pathogens Crimean-Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in Tamdy orthonairovirus of the Nairoviridae family.

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Article Synopsis
  • A study was conducted in northern China to investigate the prevalence and genetic diversity of a protozoan parasite found in domestic raccoon dogs, focusing on three provinces: Jilin, Liaoning, and Hebei.
  • Out of 337 tissue samples taken, 16 (4.75%) tested positive for the parasite using a specific nested PCR technique, with further genetic analysis identifying two distinct genotypes (ToxoDB Genotype #9 and #10).
  • The findings indicate that ToxoDB Genotype #9 is likely a primary reservoir for the parasite, highlighting potential risks for human infection related to these domestic raccoon dogs.
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Avian influenza viruses (AIVs) in wild birds pose a pandemic threat to humans and to the poultry industry. To assess AIV and AIV antibody prevalence in wild birds in China, a systematic review and meta-analysis were conducted. We searched PubMed, Google Scholar, Cochrane Library, Clinical Trial, VIP, CNKI, and WANFANG for published papers related to the prevalence of AIVs and their associated antibodies in wild birds in China from Mar.

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In order to survey the infectious situation of canine coronavirus (CCV) in giant panda population, a virus neutralization test detecting specific antibodies against CCV in giant panda's sera was established by using two-fold dilutions of serum and 100 TCID of the virus. The 62 sera samples of giant pandas, which were gathered from zoos and reserve region of Sichuan Province, China were detected. The neutralization antibody titer of 1:4 was recognized as the positive criterion, 8 sera samples were detected to be positive, and the positive rate was 12.

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Synopsis of recent research by authors named "He-Ting Sun"

  • - He-Ting Sun's recent research focuses on the intersection of zoonotic diseases and parasite prevalence in wildlife, with significant studies on Plasmodium infection in wild birds and rodent-related diseases in China.
  • - The findings highlight the therapeutic potential of natural compounds like stachyose in mitigating cardiac injuries arising from ischemia-reperfusion, as well as underscoring the importance of understanding parasite transmission dynamics in avian and mammalian hosts.
  • - Sun also investigates the molecular detection and characterization of various pathogens in different wildlife species, contributing valuable insights into zoonotic transmission risks and potential public health implications.