Economic evaluation of liraglutide vs dulaglutide or oral semaglutide in patients with type 2 diabetes mellitus: a systematic review.

Introduction: The management of type 2 diabetes not only requires effective medications to regulate blood glucose levels, but also needs to consider the economic implications. Liraglutide, dulaglutide, and semaglutide, three widely-used glucagon-like peptide-1 receptor agonists, have shown significant efficacy in diabetes treatment. This review aimed to systematically assess the cost-effectiveness of liraglutide in comparison to dulaglutide or oral semaglutide for treating type 2 diabetes.

Seroprevalence of Toxoplasma gondii in Equids: A Global Systematic Review and Meta-analysis.

Background: Toxoplasmosis is a zoonotic infectious disease caused by T. gondii, a widely distributed obligate intracellular parasite. It has received widespread attention because it can infect a large number of domestic and wild animals, thereby posing a threat to public health and the economy on a global scale.

Prevalence and Genetic Characterization of in Nine Species of Wild Rodents in China.

is a foodborne zoonotic parasite that can infect humans and a variety of warm-blooded animals. Wild rodents play an important role as intermediate hosts of , and the survey data of in wild rodents in China are limited. Therefore, from August 2023 to May 2024, a total of 510 brain tissue samples were collected from nine species of wild rodents, and was detected using a nested PCR targeting the gene.

Protein kinase B inhibitors enhance the sensitivity of translocated promoter region-fibroblast growth factor receptor 1 cells to fibroblast growth factor receptor 1 inhibitor-induced apoptosis.

ObjectiveFibroblast growth factor receptor 1 (FGFR1) inhibitors are considered effective for treating 8p11 myeloproliferative syndrome. However, targeting FGFR1 alone may be inadequate for patients with translocated promoter region (TPR)-FGFR1 rearrangement.MethodsIn this study, we established TPR-FGFR1-expressing BaF3 cells and performed RNA sequencing analysis.

Cost-utility analysis of empagliflozin compared with dapagliflozin in patients with type 2 diabetes in China.

Background: Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, performs a reduction in the all-cause mortality and cardiovascular mortality in type 2 diabetes mellitus (T2DM) patients compared to dapagliflozin, which has been included in the national volume-based procurement in China. The objective of this study is to evaluate the long-term cost-utility of the addition of empagliflozin (10 mg or 25 mg) versus dapagliflozin (10 mg) in T2DM patients with insufficient control by metformin monotherapy from the perspective of Chinese health care payers.

Methods: The IQVIA CORE diabetes model was used for cost-utility analysis to compare the long-term economics of empagliflozin (10 or 25 mg) versus dapagliflozin (10 mg) respectively.

Evaluation of pigment composition and antioxidant properties in the flesh of seven colored pummelo cultivars.

The color of pummelo fruit is an important trait, but specific pigments' contribution remains unclear. This study analyzed seven colored pummelo cultivars, including three red (Sanhongmiyou, Gusangyou, and Chuhongyou); three pale-red (Ruby pummelo, Guanximiyou, and Feihongyou) and one orange (Jinjumiyou). Carotenoid, flavonoid, and anthocyanin content and antioxidant capacity were analyzed for each cultivar.

Zhi-Zi-Chi decoction ameliorates depression-like behavior in chronic unpredictable mild stress-induced mice via the PI3K/AKT/mTOR signaling pathway.

Ethnopharmacological Relevance: Zhi-Zi-Chi decoction (ZZCD), a famous classical prescription of traditional Chinese medicine (TCM), has long been used for depression treatment, but its detailed molecular anti-depression mechanisms remain to be further elucidated.

Aim Of The Study: To explore the antidepressant properties and potential mechanisms of ZZCD in ameliorating depression-like behavior through network pharmacology and in vivo experimental validation.

Materials And Methods: A chronic unpredictable mild stress (CUMS)-induced mouse depressive model was established in this present study.

Monte carlo analysis of low-energy 125I brachytherapy: implications for clinical dosimetry.

One of the primary limitations of the recommendations of the American Association of Physicists in Medicine (AAPM) Task Group is that it does not consider attenuation effects from individual sources in multi-source brachytherapy implants. To address this issue, the inter-source effect (ISE) parameter has been introduced. In the present study the ISE is evaluated and compared for several I brachytherapy sources simulating three different I source models with the Geant4 code.

ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways.

Multiple myeloma (MM) pathogenesis is closely associated with aberrant epigenetic regulation and resulting modifications, such as dimethylation of lysine 36 in histone H3 (H3K36me2). However, the recognition signature of H3K36me2 and its functional role in MM remain largely unknown. Here, the zinc-finger MYND-type-containing 8 (ZMYND8) is identified as a potential reader of the H3K36me2 mark that suppresses MM progression.

Global Prevalence and Distribution of H9 Subtype of Avian Influenza Viruses in Wild Birds: Literature Review with Meta-Analysis.

As a natural accelerator of highly pathogenic avian influenza in wild birds, the H9 subtype of avian influenza poses a substantial threat to both humans and the poultry industry. A comprehensive meta-analysis is necessary to assess the current status of the global H9 outbreak. In this research, a literature review and meta-analysis are presented on the surveillance studies of the H9 subtype of avian influenza in wild birds worldwide up to 2024.

Prevalence of Pentatrichomonas hominis infection in wild rodents.

Background: Pentatrichomonas hominis is a zoonotic pathogen linked to gastrointestinal diseases in various animal species and humans. However, its prevalence of in wild rodents remains unexplored. Therefore, investigating the prevalence and molecular characteristics of P.

Cost-effectiveness of benmelstobart and anlotinib plus chemotherapy as first-line therapy for extensive-stage small cell lung cancer in China.

The results of the ETER701 trial showed that benmelstobart and anlotinib plus chemotherapy have potential advantages in the treatment of extensive small cell lung cancer (ES-SCLC). However, it must be noted that the high cost cannot be ignored. This study was designed to assess the cost-effectiveness of benmelstobart (B) and anlotinib (A) plus etoposide and carboplatin (EC) as first-line treatment options for patients with ES-SCLC in China.

Cost-utility analysis of add-on Qili Qiangxin capsules in chronic heart failure with reduced ejection fraction in China.

Aims: The study aimed to analyse the cost-utility of Chinese patent medicine Qili Qiangxin (QLQX) capsules in heart failure with a reduced ejection fraction from the healthcare payer's perspective.

Methods And Results: From the perspective of the healthcare payer, a Markov model was established to estimate the cost-utility of adding QLQX capsules to standard treatment versus standard treatment. A 19-year lifetime horizon was chosen with a 3-month cycle in the base case analysis.

NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis.

Background: Emerging evidence has revealed that PKM2 has oncogenic functions independent of its canonical pyruvate kinase activity, serving as a protein kinase that regulates gene expression. However, the mechanism by which PKM2, as a histone kinase, regulates the transcription of genes involved in triple-negative breast cancer (TNBC) metastasis remains poorly understood.

Methods: We integrated cellular analysis, including cell viability, proliferation, colony formation, and migration assays; biochemical assays, including protein interaction studies and ChIP; clinical sample analysis; RNA-Seq and CUT&Tag data; and xenograft or mammary-specific gene knockout mouse models, to investigate the epigenetic modulation of TNBC metastasis via NONO-dependent interactions with nuclear PKM2.

Prevalence of Clostridium perfringens in sheep (Ovis aries) and goat (Capra hircus) populations across Asia: A systematic review and meta-analysis.

South Asia, East Asia, and Southeast Asia have consistently been the regions with the highest prevalence of Clostridium perfringens in sheep and goats. Given the significant economic importance of sheep and goats in these regions and the potential threat posed by this pathogen, a thorough investigation of the prevalence of C. perfringens in sheep and goats throughout Asia is important to inform the development of robust and effective regulatory measures to prevent its spread among sheep and goats.

Prevalence and genotype analysis of Cryptosporidium spp. in nine species of wild rodents in China.

Cryptosporidium is a significant zoonotic parasite with broad distribution in both humans and rodents. In this study, 510 fecal samples were collected from nine species of wild rodents across Guangxi, Yunnan, and Hunan Provinces in China. Nested PCR analysis targeting the SSU rRNA gene revealed an overall Cryptosporidium infection rate of 1.

Sub-Minute Fabrication of Metal Organic Framework Membranes via Additive-Accelerated Electrodeposition.

Efficient fabrication of metal organic framework (MOF) membranes is important for their broad applications in molecular separations. However, current approaches for MOF membrane fabrication are usually time-consuming due to the slow, random nucleation and crystal growth, particularly the lack of in-situ defect healing ability. Here, we report an additive-accelerated electrodeposition method, which allows ultrafast fabrication of MOF membranes through the synergy of electric field and catecholamine additives.

Fengshi gutong capsules attenuates CIA-induced RA bone destruction in rats by targeting TNF-α inhibition: Integration and experimental validation of network pharmacology and proteomics.

Ethnopharmacological Relevance: Fengshi Gutong Capsule (FSGT) is a proprietary Chinese medicine with established clinical efficacy in Rheumatoid arthritis (RA); however, its underlying mechanisms remain unclear.

Aim: This study aims to elucidate the mechanisms by which FSGT alleviates RA.

Materials And Methods: A collagen-induced arthritis (CIA) rat model was employed to assess the therapeutic effects of FSGT in RA.

Prevalence of in Nine Species of Wild Rodents in Guangxi, Hunan, and Yunan Provinces, China.

, a flagellated protozoan, is widely distributed in wild rodents. To characterize the presence of in wild rodents in southern China, this study collected 344 fecal samples from wild rodents in Guangxi, Hunan, and Yunnan provinces. The β-giardin gene () was amplified to identify the presence of sp.

Identification of key genes controlling anthocyanin biosynthesis in the fruits of a bud variety of Tarocco blood-orange.

Tarocco is a prevalent blood-orange variety in China, has a bud variant identified in Wenzhou City. To characterize the quality traits and molecular mechanisms underlying inhibition of anthocyanin synthesis in this variety, we collected fruits of Tarocco (WT) and the bud variant Ouya (MT) at nine developmental stages. Their anthocyanin, soluble sugar, and organic acid profiles were examined, and transcriptomes and metabolites were analyzed at three developmental stages.

Lipid droplets deposition in perihematoma tissue is associated with neurological dysfunction after intracerebral hemorrhage.

Secondary brain injury following intracerebral hemorrhage (ICH) significantly reduces patients' quality of life due to impaired neurological function. Lipid droplets are implicated in secondary brain injury in various central nervous system diseases. Thus, the role and mechanisms of lipid droplets in secondary brain injury post-ICH require further investigation.

Dupilumab induced ocular surface diseases: an analysis of FAERS database, literature review and disease-gene interaction networks.

Background: Adverse events (AE) in dupilumab-induced ocular surface diseases (DIOSD) have raised concerns regarding its safety. The objective of this study was to evaluate DIOSD by employing database analysis and clinical case review, along with mechanism analysis.

Research Design And Methods: Database AE data were extracted from FAERS from 2017 Quarter 1 (Q1) to 2023 Q1.

Poly(thioctic acid) Hydrogels Integrated with Self-Healing, Bioadhesion, Antioxidation, and Antibiosis for Infected Wound Treatment.

Bacterial infections pose significant challenges in wound healing and are a serious threat to human health. Hydrogels have emerged as an ideal wound dressing due to their three-dimensional network, which facilitates exudate absorption and maintains a moist environment conducive to healing. Herein, we developed integrated hydrogels composed of poly(thioctic acid) (PTA), polydopamine (PDA), and curcumin (Cur).

Saikosaponin inhibits Eimeria tenella infection by modifying the NF-κB pathway and regulating cytokines and the intestinal microbial community.

Eimeria tenella (E. tenella) is an intestinal parasite that not only endangers the health of broiler chickens but may also cause death in severe cases. However, the growing critical problem of drug resistance in E.