Genetic diversity and expanded epidemic area of novel tick-borne pathogen wetland virus in ticks, wild and domestic animals, and patient in China.

Wetland virus (WELV) is a recently identified segmented orthonairovirus associated with human febrile illness in northeastern China. To elucidate its ecological drivers and transmission patterns, we conducted multi-host surveillance in seven eco-climate regions across China through an integrated approach combining molecular and serological profiling. Over 33,000 questing and feeding ticks representing 11 species were systematically screened WELV-RNA alongside 1,493 wild small mammals, while 2,578 domestic animals and 3,921 patients presenting with outdoor field or tick exposure history underwent both WELV specific molecular and serological evaluation.

The Treatment of Subtrochanteric Fracture with Reversed Contralateral Distal Femoral Locking Compression Plate (DF-LCP) Using a Progressive and Intermittent Drilling Procedure in Three Osteopetrosis Patients.

Objective: To describe the application of reversed contralateral distal femoral locking compression plate (DF-LCP) inserted through a progressive and intermittent drilling procedure in the treatment of osteopetrotic subtrochanteric fracture (OSF).

Methods: Three patients (one male and two females with an average age of 45.33 ± 11.

Identification of a new orthonairovirus associated with human febrile illness in China.

The genus Orthonairovirus, which is part of the family Nairoviridae, includes the important tick-transmitted pathogens Crimean-Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in Tamdy orthonairovirus of the Nairoviridae family.

First detection of Borrelia miyamotoi infections in ticks and humans from the northeast of Inner Mongolia, China.

Borrelia miyamotoi is a relapsing fever spirochete that can cause chills, fatigue, headache, myalgia, arthralgia, and even meningitis, damaging human health. B. miyamotoi has a wide distribution since its discovery in Ixodes persulcatus in 1994.

A New Segmented Virus Associated with Human Febrile Illness in China.

Background: In 2017, surveillance for tickborne diseases in China led to the identification of a patient who presented to a hospital in Inner Mongolia with a febrile illness that had an unknown cause. The clinical manifestation of the illness was similar to that of tickborne encephalitis virus (TBEV) infection, but neither TBEV RNA nor antibodies against the virus were detected.

Methods: We obtained a blood specimen from the index patient and attempted to isolate and identify a causative pathogen, using genome sequence analysis and electron microscopy.

Association of genotypes of rs671 within with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas.

Objective: : This study aimed to determine if gastric cardia adenocarcinoma (GCA) risk was associated with the lys (A or *2) allele at the rs671 (glu504lys) polymorphism within the aldehyde dehydrogenase 2 () gene in a Chinese Han population. We also aimed to investigate genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma (ESCC).

Methods: : We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and low-incidence areas for both GCA and ESCC in China.