Compound Kushen Injection suppresses multiple myeloma progression via TOP1-targeted coordination of DNA damage and endoplasmic reticulum stress.

Background: Multiple myeloma (MM) is a plasma cell malignancy that remains incurable due to inevitable relapse and poor treatment tolerance. Compound Kushen Injection (CKI), a traditional Chinese medicinal formulation, has been reported to exert anti-tumor effects in various cancers, but its efficacy and mechanisms in MM remain unclear.

Purpose: This study aimed to elucidate the anti-MM mechanisms of CKI, focusing on its induction of DNA damage response (DDR) and endoplasmic reticulum (ER) stress, and to assess synergy with proteasome inhibitors (PIs).

Integrating Transcriptome, Metabolome and Microbiome to Explore the Molecular Mechanism of Phenotypic Plasticity in P. rotata During Low-Altitude Domestication.

The endangered Tibetan herb Phlomoides rotata is threatened by overharvesting and slow natural regeneration. To support its sustainable utilisation, we investigated the mechanisms underlying its phenotypic plasticity during low-altitude adaptation using an integrated multi-omics approach. Specifically, rhizosphere soils and leaf tissues were collected from P.

Modulation of growth characteristics and endogenous hormone by cutting intensity in Eleutherococcus giraldii.

Eleutherococcus giraldii (E. giraldii) is a quintessential medicinal plant in traditional Chinese medicine. This study established control, heavy pruning, and light pruning groups to reveal growth indexes and endogenous phytohormones in cultivated E.

Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress.

Acute myeloid leukemia (AML) is the most common hematological malignancy. Leukemia stem cells exhibit high levels of oxidative stress, with reactive oxygen species (ROS) being the primary products of this stress, inducing the expression of Jab1. Previous studies have demonstrated that Jab1, as a transcriptional coactivator of c-JUN, promotes the malignant progression of AML under oxidative stress.

Integrated physiological, biochemical and transcriptomic analyses elucidate the response of alpine plant Lamiophlomis rotata (Benth.) Kudo to Low-Nitrogen stress.

Lamiophlomis rotata (Benth.) Kudo, an endangered medicinal plant endemic to the Qinghai-Tibet Plateau (altitude of 3100-5000 m), faces conservation challenges due to wild resource scarcity and cultivation difficulties. This investigation employed a gradient nitrogen stress system (N1-N4) with a nitrogen-free control (CK) to decipher its nitrogen adaptation mechanisms.

Dual-Bioinspired Janus Membranes with Asymmetric Superwettability for High-Efficiency Oil-Water Separation and Environmental Remediation.

The escalating discharge of petroleum-based contaminants and industrial organic pollutants poses significant threats to global ecosystems and human health, necessitating urgent advancements in sustainable water remediation technologies. To address this challenge, a rationally engineered Janus membrane with asymmetric superwettability was presented, synthesized through a dual-bioinspired fabrication strategy. The membrane was developed via selective surface etching of stainless steel mesh (SSM) substrates using laser etching power gradients, followed by hierarchical functionalization.

A Mitochondrion-Targeted NIR-II Modulator for Synergistic Ferroptosis-Immunotherapy.

Immune checkpoint inhibitors (ICIs) have limited clinical efficacy against gastric cancer (GC) due to the nonimmunogenic tumor microenvironment. Therefore, inducing immunogenic cell death (ICD) to reprogram the immunogenic landscape is essential. This study develops HD-FA nanoparticles by encapsulating a novel mitochondrion-targeted NIR-II modulator, HD, within DSPE-PEG-FA.

Effects of Bandwidth on Ear Differentiation and Grain Yield Formation of Maize in Strip Intercropping.

In strip intercropping, increasing bandwidth enhances light energy utilization and facilitates mechanized production, yet it constrains the realization of maize yield advantages. The impact of bandwidth on the ear differentiation and development and yield formation requires further investigation. In this study, different bandwidths (T1, 1.

MMP14 from BM-MSCs facilitates progression and Ara-C resistance in acute myeloid leukemia via the JAK/STAT pathway.

Growing evidence underscores the pivotal impact of crosstalk between leukemic stem cells (LSCs) and mesenchymal stromal cells (MSCs) within their niche on leukemia initiation, progression, and therapy response. Although MMP14 plays an important role in inflammation and cancer, the regulation and role of MSC-derived MMP14 in acute myeloid leukemia (AML) are largely unknown. Here, we found that AML patient-derived MSCs (AML-MSCs) were more supportive of AML cell growth compared to healthy donor-derived MSCs (HD-MSCs).

Association of cadmium and lead exposure with mortality in cancer survivors: A prospective cohort study.

Lead and cadmium are well-documented for their carcinogenic properties and their potential to induce cellular malignancy. Nevertheless, there is a paucity of research examining the correlation between blood cadmium and lead levels and the prognostic outcomes of cancer survivors. This study aims to investigate the relationship between blood concentrations of these heavy metals and both overall and site-specific cancer mortality risks among cancer survivors.

Effective integrated thermal management using hygroscopic hydrogel for photovoltaic-thermoelectric applications.

As the proportion of solar energy in the global energy mix increases, photovoltaic cells have emerged as one of the fastest-growing technologies in the renewable energy sector. However, photovoltaics utilize only a limited portion of the incident solar spectrum, resulting in significant amounts of light energy being wasted as heat. This excess heat raises the surface temperature of photovoltaic cells, which in turn reduces their overall efficiency.

Phlomoides rotata adapts to low-nitrogen environments by promoting root growth and increasing root organic acid exudate.

Nitrogen (N) is one of the three major elements required for plant growth and development. It is of great significance to study the effects of different nitrogen application levels on the growth and root exudates of Phlomoides rotata, and can provide a theoretical basis for its scientific application of fertilizer to increase production. In this study, Phlomoides rotata were grown under different nitrogen conditions for two months.

Multi-Omic Analysis Reveals the Impact of Bortezomib in Hyperleukocytic Acute Myeloid Leukemia.

Background: Hyperleukocytic acute myeloid leukemia (HL-AML) is associated with early complications and high mortality rates, highlighting the urgent need for more effective therapeutic strategies.

Methods: This study conducted label-free proteomic analysis on serum from HL-AML and non-HL AML (NHL-AML) patients, integrating the data with the OHSU transcriptomic database. Flow cytometry was used to evaluate the in vitro impact of bortezomib.

Clinical and immunological characteristics of high-risk double-hit multiple myeloma.

At present, the characteristics of double-hit multiple myeloma (DHMM) are unknown. We retrospectively analyzed the clinical data from 433 new diagnosed MM patients and found that DHMM have a higher β2-MG level and percentage of bone marrow plasma cell. Cox regression analysis showed that the prognosis of DHMM was not limited by clinical indicators.

Biomimetic Leaf-Shaped Wedge Structure with Mixed Wettability for Fog Harvesting.

Water scarcity is a pressing issue in arid and semi-arid regions, making fog harvesting a promising method for water collection. However, enhancing the rate of fog harvesting remains a challenge. Controlling the movement of droplets on functional surfaces is crucial for the development of effective water-harvesting devices.

Study on leukapheresis of hyperleukocytic acute myeloid leukemia through in vitro centrifugation.

Respiratory failure, intracranial hemorrhage and infection were more common in hyperleukocytic acute myeloid leukemia patients than in non-hyperleukocytic leukemia patients. Compared with non-apheresis treatment, the white blood cells decreased significantly and the infection rate decreased after apheresis treatment. However, the treatment time of leukapheresis in patients with hyperleukocytic leukemia is very long, while it is more damaging to cells.

Effects of Micro-Topography and Vegetation on Soil Moisture on Fixed Sand Dunes in Tengger Desert, China.

Soil moisture is a key factor in arid ecosystems, with local variations influenced by topography and vegetation. Understanding this relationship is crucial for combating desertification. Employing ANOVA, Mean Decrease Accuracy (MDA) analysis from random forest modeling and Structural Equation Modeling (SEM), this study investigates the distribution of soil moisture and its associations with topographic and vegetative factors across four micro-geomorphic units in the Tengger Desert, China.

FLT3-selective PROTAC: Enhanced safety and increased synergy with Venetoclax in FLT3-ITD mutated acute myeloid leukemia.

Acute myeloid leukemia (AML) patients carrying Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations often face a poor prognosis. While some FLT3 inhibitors have been used clinically, challenges such as short efficacy and poor specificity persist. Proteolytic targeting chimera (PROTAC), with its lower ligand affinity requirement for target proteins, offers higher and rapid targeting capability.

Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity.

Gestational stress can exacerbate postpartum depression (PPD), for which treatment options remain limited. Environmental enrichment (EE) may be a therapeutic intervention for neuropsychiatric disorders, including depression, but the specific mechanisms by which EE might impact PPD remain unknown. Here we examined the behavioral, molecular, and cellular impact of EE in a stable PPD model in rats developed through maternal separation (MS).

The Neuroprotective Effects of BMSC-Derived Exosomes against Glutamate-Induced HT22 Cell Cytotoxicity.

Many central nervous system diseases are closely related to nerve damage caused by dysregulation of the endogenous neurotransmitter glutamate. Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) play an important role in improving injury and regeneration functions. However, its mechanism remains unknown.

Development of a risk assessment model for cardiac injury in patients newly diagnosed with acute myeloid leukemia based on a multicenter, real-world analysis in China.

Background: Studies have revealed that acute myeloid leukemia (AML) patients are prone to combined cardiac injury. We aimed to identify hematological risk factors associated with cardiac injury in newly diagnosed AML patients before chemotherapy and develop a personalized predictive model.

Methods: The population baseline, blood test, electrocardiogram, echocardiograph, and genetic and cytogenetic data were collected from newly diagnosed AML patients.

Improved photosynthetic performance under unilateral weak light conditions in a wide-narrow-row intercropping system is associated with altered sugar transport.

Intercropping improves resource utilization. Under wide-narrow-row maize (Zea mays) intercropping, maize plants are subjected to weak unilateral illumination and exhibit high photosynthetic performance. However, the mechanism regulating photosynthesis under unilateral weak light remains unknown.