The diverse roles of circular RNAs in cholangiocarcinoma.

Cholangiocarcinoma (CCA) is a malignant tumor that develops in the extrahepatic bile duct, that is, from the left and right hepatic ducts to the lower end of the common bile duct. Because of its indeterminate etiology, difficulties in the diagnosis of early lesions, easy invasion and metastasis and resistance to chemotherapeutic drugs, the trend of mortality rate deterioration of patients with CCA has not been fundamentally reversed. And the molecular mechanisms underlying the development of CCA are not well characterized.

A Multimodal Smart Window with Visible-NIR-LWIR Electro-Modulation for All Weather.

Intelligent modulation of solar and thermal radiation for a smart window, including visible, near-infrared (NIR), and long-wave infrared (LWIR) spectral tri-bands (0.38-25 µm), to achieve indoor comfort and energy efficiency is a critical frontier in sustainable building design. However, independent regulations of multi-functional radiation of visible lighting, NIR heating, and LWIR radiative cooling for dynamic operational requirements and weather conditions are not fully solved.

The functional roles of deoxyelephantopin potential target circTNPO3 in regulating pancreatic cancer malignant phenotype and gemcitabine chemoresistance via miR-188-5p/CDCA3/TRAF2-mediated remodeling of NF-κB signaling pathway.

Background: Pancreatic cancer (PC) has been one of the most severe digestive system malignant tumor with poor prognosis that threatens human health. Chemotherapy is essential for patients with advanced PC, but unfortunately the curative effect is limited by chemoresistance. CircTNPO3, a recently discovered circular RNA (circRNA), has been indicated to be associated with multi-types of tumors.

AI-Powered Innovations in Food Safety from Farm to Fork.

Artificial intelligence is comprehensively transforming the food safety governance system by integrating modern technologies and building intelligent control systems that provide rapid solutions for the entire food supply chain from farm to fork. This article systematically reviews the core applications of AI in the orbit of food safety. First, in the production and quality control of primary food sources, the integration of spectral data with AI efficiently identifies pest and disease, food spoilage, and pesticide and veterinary drug residues.

Dual-Mode Microfluidic Workstation for Rapid Detection of Multiple Mycotoxins on Chip.

The assurance of food safety requires sensitive monitoring of multiple mycotoxins due to their severe impacts on the food industry and high health risks posed to consumers. Herein, we proposed a chemiluminescent/colorimetric dual-signal readout microfluidic method, incorporating a streptavidin-biotin-alkaline phosphatase (SA-Biotin-ALP) signal amplification system for the highly sensitive detection of Deoxynivalenol (DON), Ochratoxin A (OTA), and Aflatoxin B1 (AFB1). The indirect competitive enzyme-linked immunoassay (ic-ELISA) was integrated into microfluidic chip, resulting in sensitive detection ranges of DON in the range of 4-128 ng/mL, 2-64 ng/mL for OTA, and 0.

Ferroelectric Polarization Electric Field Induced High Performance Graphene/LiNbO Dynamic Diode Generator.

Substantial endeavors have been dedicated to continuously harvesting mechanical energy from the environment, where dynamic semiconductor diode generators (DDGs) have recently been drawing significant attention as the miniature, portable in situ energy device. However, despite their unique advantages of direct-current output and high current density, the output voltage of DDG is usually less than 1 V, which needs to be further improved to satisfy the demands of practical applications. Therefore, this study proposes a vertical graphene/LiNbO DDG that is conducive to an ultra-high voltage output.

Surface Electromyography Combined with Artificial Intelligence in Predicting Neuromuscular Falls in the Elderly: A Narrative Review of Present Applications and Future Perspectives.

: Falls among the elderly are a major public health concern, leading to increased disability and mortality. Traditional protective measures are important, but early detection and prevention are equally critical. Surface electromyography (sEMG) signals, which assess muscle electrical activity, can indicate a fall risk by detecting muscle weakness or instability.

Nature-Inspired Macromolecular Biocomposites Based on Decellularized Extracellular Matrix.

Extracellular matrix (ECM) is a multifaceted network that encases cells, composed of various polysaccharides, proteins, and adhesion molecules, etc. It plays a critical role in providing structural support to cells and regulating essential cellular activities such as proliferation, migration, and differentiation. Due to these functions, decellularized extracellular matrix (dECM) has attracted considerable interest in biomedicine and holds promising application potential.

Utilization of 3D printing modeling techniques in the simulation instruction of ultrasound-guided puncture procedures on scoliotic spines of spinal muscular atrophy.

Background: Puncture training with simulation models has emerged as a critical method for transmitting puncture skills, improving success rates, and minimizing injuries. Yet, obstacles such as proper material for ultrasound guidance, restricted options of 3D printing resources, and available substances to simulate human skin and muscle still hinder the production of simulation models that closely replicate clinical practice. This study aimed to develop a selective laser melting (SLM), 3D-printed simulation model that replicated the spine and skin contours of patients with spinal scoliosis.

Piperidine polyketide alkaloids of bacterial origin: Occurrence, bioactivity, and biosynthesis.

Alkaloids are typically found in plants and certain animals, but are rare in actinomycetes. Recently, there have been significant advances in the discovery of bacterial alkaloids and the elucidation of their biosynthetic pathways. Based upon biosynthetic insights, a specialized class of secondary metabolites termed piperidine polyketide alkaloids (PPAs) has been identified from actinomycetes.

E2F1-mediated transcriptional activation predicts poor prognosis and promotes the proliferation of leiomyosarcoma.

Objective: Soft tissue and bone cancers, collectively known as sarcomas, constitute a diverse array of uncommon tumors originating from connective tissues. Among sarcomas, leiomyosarcoma (LMS) is one of the most frequently encountered subtypes. This study aims to investigate the expression, clinical significance, biological regulation, and dysregulation mechanisms of extra spindle pole bodies like 1 (), a gene critical for cell cycle regulation in LMS.

The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration.

Background: Wet age-related macular degeneration (wAMD) is a vision-threatening eye disease worldwide. The amplitude of low-frequency fluctuation (ALFF) method was used to observe changes in spontaneous brain activity, which may help to investigate the underlying pathological mechanism of AMD.

Methods: Eighteen patients with wAMD and 18 age- and gender-matched healthy controls (HCs) were recruited.

Super-strong hydrogel reinforced by an interconnected hollow microfiber network via regulating the water-cellulose-copolymer interplay.

The discontinuous fiber reinforced hydrogels are easy to fail due to the fracture of the fiber matrix during load-bearing. Here, we propose a novel strategy based on the synergistic reinforcement of interconnected natural fiber networks at multiple scales to fabricate hydrogels with extraordinary mechanical properties. Specifically, the P(AA-AM)/Cel (P(AA-AM), poly(acrylic acid-acrylamide); Cel, cellulose) hydrogel is synthesized by copolymerizing AA and AM on a substrate of paper with an interconnected hollow cellulose microfiber network.

Cardiovascular mortality risk among small bowel adenocarcinoma patients: a population-based study.

Background: The objective of this research is to statistically assess the risk of cardiovascular mortality (CVM) between patients with small bowel adenocarcinoma (SBA) and the general population. Additionally, it aims to identify CVM-associated risk factors among individuals with SBA.

Methods: Data obtained between 2000 and 2017 on SBA patients from the Surveillance, Epidemiology, and End Results (SEER) database were examined.

The Efficacy of Liposomal Bupivacaine in Thoracic Surgery: A Systematic Review and Meta-Analysis.

Purpose: Patients undergoing thoracic surgery suffer from severe postoperative pain, and a series of complications will occur if there is no effective analgesic treatment. Liposomal bupivacaine (LB) is a novel multivesicular formulation with up to 72 hours of analgesia, which can be used in thoracic surgery. This meta-analysis aimed to evaluate the efficacy of LB in improving recovery in patients undergoing thoracic surgery compared with non-liposomal local anesthetics.

Role of a route map in learning lumbar spinal ultrasonography: a study protocol for a randomised, controlled teaching study.

Introduction: Lumbar spinal ultrasonography is an important tool used by pain physicians and anaesthesiologists to perform pain-related scanning, interventional treatments and anaesthesia in clinical practice. However, ultrasound images of the lumbar spine are complex and numerous. Moreover, long learning curves are necessary for novice physicians to memorise, master and apply this modality in their clinical practice.

Bioinformatics analysis revealed underlying molecular mechanisms associated with asthma severity and identified GABAergic related pathway as a potential therapy for Th2-high endotype asthma.

Background: Asthma, a principally T helper 2 (Th2) cell mediated immunological disease, is categorized into Th2-high and Th2-low endotypes. The influence of these endotypes on clinical characteristics and treatment responsiveness in asthma is yet to be completely understood. This study delves into the underlying molecular mechanisms of Th2 endotypes on asthma.

Hyaluronan-decorated copper-doxorubicin-anlotinib nanoconjugate for targeted synergistic chemo/chemodynamic/antiangiogenic tritherapy against hepatocellular carcinoma.

Copper-based nanomaterials show considerable potential in the chemodynamic therapy of cancers. However, their clinical application is restricted by low catalytic activity in tumor microenvironment and copper-induced tumor angiogenesis. Herein, a novel copper-doxorubicin-anlotinib (CDA) nanoconjugate was constructed by the combination of copper-hydrazide coordination, hydrazone linkage and Schiff base bond.

Effects of Heated Infiltration Solutions and Forced-Air Heating Blankets on Intraoperative Hypothermia During Liposuction: A Factorial Randomized Controlled Trial.

Background: This study was conducted to compare the effects of heat preservation by two recommended methods, heated infiltration solutions and forced-air heating blankets, in patients undergoing liposuction under general anesthesia.

Methods: Forty patients were divided into four groups based on whether heated infiltration solutions or forced-air heating blankets were used. Group A received general anesthesia liposuction plastic surgery routine temperature care.

Prediction Model of Ocular Metastases in Gastric Adenocarcinoma: Machine Learning-Based Development and Interpretation Study.

Although gastric adenocarcinoma (GA) related ocular metastasis (OM) is rare, its occurrence indicates a more severe disease. We aimed to utilize machine learning (ML) to analyze the risk factors of GA-related OM and predict its risks. This is a retrospective cohort study.

KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway.

Colon adenocarcinoma (COAD) is the most common malignancy of the digestive tract, which is characterized by a dismal prognosis. No effective treatment has been established presently, thus there is an urgent need to understand the mechanisms driving COAD progression in order to develop effective therapeutic approaches and enhance clinical outcomes. In this study, we found that KLF7 is overexpressed in COAD tissues and correlated with clinicopathological features of COAD.

A comparison between transforaminal lumbar epidural injection performed under picture archiving and communication systems-based magnetic resonance imaging planning and injection under immediate X-ray guidance.

Objectives: The study aimed to compare the treatment cost, operation time, clinical effect, and complications between punctures done under magnetic resonance imaging (MRI) planning based on picture archiving and communication systems (PACS) and punctures done under immediate X-ray fluoroscopy guidance in the treatment of lumbar disc herniation by transforaminal lumbar epidural injection.

Patients And Methods: In this prospective study conducted between October 2016 and June 2021, 128 patients were randomly divided into Groups A and B by the random number table method. In Group A (n=66; 36 males, 30 females; mean age: 64.

Ozone exposure affects corneal epithelial fate by promoting mtDNA leakage and cGAS/STING activation.

Ozone is a common air pollutant associated with various human diseases. The human ocular surface is frequently exposed to ozone in the troposphere, but the mechanisms by which ozone affects the ocular surface health remain unclear. This study aimed to establish a mouse model to investigate the effects of ozone exposure on the ocular surface and the corneal epithelium.