Estrogen Alleviates Sevoflurane-Induced Neurotoxicity by Inhibiting ERα-Tau Binding.

Sevoflurane-induced neurotoxicity is age-dependent, but the role of sex differences is unclear. While testosterone has protective effects, the impact of estrogen remains unknown. This study investigates the effects of sevoflurane on neurotoxicity in adult, middle-aged, and aged male and female mice.

[Advances in molecular mechanisms and neuronal circuits underlying circadian rhythms in ].

Circadian rhythms are core regulatory mechanisms that evolved to align biological functions with the Earth's rotation. These rhythms are conserved across organisms from unicellular life to multicellular species and play essential roles in metabolism, immune responses, and sleep-wake cycle. Circadian disruptions are strongly associated with various diseases.

Neuroprotective effects of testosterone on sevoflurane-induced neurotoxicity in testosterone-deprived male mice.

This study aims to investigate whether androgen deprivation, simulating conditions of aging or disease-induced low testosterone levels, increases the susceptibility of male mice to sevoflurane neurotoxicity, and whether testosterone supplementation can reverse the toxic effects of sevoflurane. In here, young male mice were subjected to orchiectomy (ORC) to induce testosterone deprivation. Various techniques, including western blotting, immunofluorescence, Morris Water Maze, Golgi staining, and neuronal signal measurement, were used to evaluate the effects of sevoflurane on long-term (ORC 10 weeks) and short-term (ORC 2 weeks) testosterone deprivation, and assess whether testosterone (1 mg/kg 1 h before sevoflurane exposure) could mitigate sevoflurane-induced neurotoxicity.

The best indices of anaesthesia depth monitored by electroencephalogram in different age groups.

Current electroencephalogram (EEG) indices for monitoring the depth of anaesthesia have not been adjusted for age. This study aims to identify the most suitable EEG indices for monitoring anaesthesia depth across different age groups. In here, we conducted a prospective observational trial to observe whether different EEG features in different age groups can detect anaesthesia depth and compare their performance.

Preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing EEG delta-wave activity and LFP theta oscillation in hippocampal CA1.

Sleep fragmentation (SF) is a common sleep problem experienced during the perioperative period by older adults, and is associated with postoperative cognitive dysfunction (POCD). Increasing evidence indicates that delta-wave activity during non-rapid eye movement (NREM) sleep is involved in sleep-dependent memory consolidation and that hippocampal theta oscillations are related to spatial exploratory memory. Recovery sleep (RS), a self-regulated state of sleep homeostasis, enhances delta-wave power and memory performance in sleep-deprived older mice.

A novel prognostic model of breast cancer based on cuproptosis-related lncRNAs.

Objective: Breast cancer (BC) is a deadly form of malignancy responsible for the death of a large number of women every year. Cuproptosis is a newly discovered form of cell death that may have implications for the prognosis of BC. Long non-coding RNAs (lncRNAs) have been shown to be involved in the progression and development of BC.

HPFG: semi-supervised medical image segmentation framework based on hybrid pseudo-label and feature-guiding.

Semi-supervised learning methods have been attracting much attention in medical image segmentation due to the lack of high-quality annotation. To cope with the noise problem of pseudo-label in semi-supervised medical image segmentation and the limitations of contrastive learning applications, we propose a semi-supervised medical image segmentation framework, HPFG, based on hybrid pseudo-label and feature-guiding, which consists of a hybrid pseudo-label strategy and two different feature-guiding modules. The hybrid pseudo-label strategy uses the CutMix operation and an auxiliary network to enable the labeled images to guide the unlabeled images to generate high-quality pseudo-label and reduce the impact of pseudo-label noise.

Analysis of Magnetic Resonance Imaging Perfusion Parameters for the Identification of Spinal Metastatic Tumors with Rich Blood Supply.

Purpose: To determine the reliability of dynamic magnetic resonance imaging (MRI) perfusion parameters for the evaluation of blood supply to spinal metastatic tumors.

Methods: A total of 36 patients with spinal metastasis who underwent dynamic contrast-enhanced magnetic resonance spinal perfusion imaging at Tianjin Hospital from December 2018 to December 2020 were reviewed. Subsequently, the patients underwent corresponding preoperative examination using digital subtraction angiography of the spine at the hospital and were divided into 2 groups accordingly.

Coupling effect of reaction conditions on the catalytic activity of Cu-Mn composite oxide catalysts for toluene.

Volatile organic compounds (VOCs) are one of the major components of air pollution. Catalytic combustion is a promising technology for the treatment of VOCs and at its center is the preparation of efficient and cheap catalysts. In this study, by loading copper (Cu) and manganese (Mn) on Santa Barbara Amorphous-15 (SBA-15) molecular sieve, the Cu-Mn/SBA-15 ( = 1, 2; = 1, 2) composite metal oxide catalyst was prepared using the equal volume impregnation method.

The locus coeruleus-dorsal hippocampal CA1 pathway is involved in depression-induced perioperative neurocognitive disorders in adult mice.

Background: Patients undergoing surgical anesthesia increasingly suffer from preoperative depression. Clinical studies have shown that depression is a risk factor for perioperative neurocognitive disorders (PNDs) in elder patients. However, the underlying mechanism, especially at the neural circuit level, remains poorly understood.

ALKBH5 ALLEVIATES HYPOXIA POSTCONDITIONING INJURY IN d -GALACTOSE-INDUCED SENESCENT CARDIOMYOCYTES BY REGULATING STAT3.

Ischemic postconditioning (I/Post) reduces I/R injury by activating endogenous cardioprotection mechanisms, such as the JAK/signal transducer and activator of transcription 3 (STAT3) and PI3K/Akt pathways, which offer a traditional approach to myocardial protection. According to a previous study, cardioprotection by I/Post may be lost in aged mice, and in our previous research, hypoxic postconditioning (H/Post) lacked a protective effect in senescent cardiomyocytes, which was associated with low expression of long noncoding RNA H19. The N6-methyladenosine (m 6 A) modification is a dynamic and reversible process that has been confirmed to play a role in cardiovascular diseases.

Effect of Folic Acid Treatment for Patients with Traumatic Brain Injury (TBI)-Related Hospital Acquired Pneumonia (HAP): A Retrospective Cohort Study.

Hospital Acquired Pneumonia (HAP) is one of the most common complications and late causes of death in TBI patients. Targeted prevention and treatment of HAP are of great significance for improving the prognosis of TBI patients. In the previous clinical observation, we found that folic acid treatment for TBI patients has a good effect on preventing and treating HAP.

Age-dependent Electroencephalogram Characteristics During Different Levels of Anesthetic Depth.

The monitoring of anesthetic depth based on electroencephalogram derivation is not currently adjusted for age. Here we analyze the influence of age factors on electroencephalogram characteristics. Frontal electroencephalogram recordings were obtained from 80 adults during routine clinical anesthesia.

DPBET: A dual-path lung nodules segmentation model based on boundary enhancement and hybrid transformer.

Accurate segmentation of lung nodules is an important basis for the subsequent differentiation of benign and malignant pathological types, which is conducive to early detection of lung cancer. Due to the local feature extraction characteristics of convolution and the limited receptive field of continuous down-sampling, the existing deep convolutional neural networks (CNN) for lung nodules segmentation cause the loss of information of lesion boundaries and locations. To address this issue, a dual-path lung nodules segmentation model based on boundary enhancement and hybrid transformer (DPBET) is proposed in this paper.

Co-combustion of high alkali coal with municipal sludge: Thermal behaviour, kinetic analysis, and micro characteristic.

Blending sludge rich in protein and aliphatic hydrocarbons into the high alkali coal (HAC) has been demonstrated to reduce the ash melting temperature of the HAC/sludge mixture, thereby increasing the effectiveness and efficiency of liquid slagging. However, whether the incorporation of sludge can affect the combustion stability of the original coal-fired boiler is still debatable. As the combustion stability of the fuel can directly affect the operational safety of the boiler, it is of great practical value for exploring the effect of sludge incorporation on the combustion performance of HAC.

[Effects of Different Aeration Treatments on Bacterial Diversity, Metabolic Activity, and Function in Constructed Wetlands].

Bacteria play a key role in the removal of pollutants and nutrients in constructed wetlands. DNA and RNA high-throughput sequencing was used to investigate the diversity, metabolic activity, and function of bacteria in aquaculture wastewater and in constructed wetlands treated by different aeration levels. The results revealed that:① a total of 4042 operational taxonomic units (OTUs) were detected in aquaculture wastewater and constructed wetland treatment groups.

Development and validation of a novel risk assessment model to estimate the probability of pulmonary embolism in postoperative patients.

Pulmonary embolism (PE) is a leading cause of mortality in postoperative patients. Numerous PE prevention clinical practice guidelines are available but not consistently implemented. This study aimed to develop and validate a novel risk assessment model to assess the risk of PE in postoperative patients.

miR-346-3p promotes osteoclastogenesis via inhibiting TRAF3 gene.

MicroRNAs (miRNAs) modulate gene expression and regulate many physiological and pathological conditions. However, their modulation and effect in osteoclastogenesis remain unknown. In this study, we investigated the role of miR-346-3p in regulating the osteoclast differentiation from RAW264.

Coupled effects of urbanization level and dam on microplastics in surface waters in a coastal watershed of Southeast China.

Investigating the heterogeneous distribution pattern of plastic pollution in river systems is useful for better understanding the transport pathways of plastics from land to sea. Therefore, we analyzed samples from 17 sites to evaluate the distribution pattern of microplastics (MPs) in Minjiang River Watershed. The MP concentrations ranged between 0.

Characterization and role of PGK from Litopenaeus vannamei in WSSV infection.

Phosphoglycerate kinase (EC 2.7.2.

Glycogen phosphorylase of shrimp (Litopenaeus vannamei): Structure, expression and anti-WSSV function.

Glycogen phosphorylase (GP, EC 2.4.1.

Nematicidal amide alkaloids from the seeds of Clausena lansium.

Five new amide alkaloids (1-3, 5-6) were isolated from the seeds of Clausena lansium together with one new natural product (4) and four known analogues (7-10). The structures of the new amide alkaloids were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR as well as HRESIMS, and by comparison with the literature. The bioactivity results showed that compound 8 expressed potent nematicidal activity against Panagrellus redivevus, with IC value of 0.

A retrospective study of female reproductive parameters in the Kunming dog.

The Kunming dog is the first and only working dog breed from China to be recognized worldwide. As a domestic working dog, its excellent working performance has been well established; however, its normal reproductive parameters are not well understood. Therefore, this study was conducted to document the main reproductive parameters of this purebred working dog in field breeding conditions.