Hi-Enhancer: a two-stage framework for prediction and localization of enhancers based on Blending-KAN and Stacking-Auto models.

Motivation: Gene expression plays a crucial role in cell function, and enhancers can regulate gene expression precisely. Therefore, accurate prediction of enhancers is particularly critical. However, existing prediction methods have low accuracy or rely on fixed multiple epigenetic signals, which may not always be available.

Retraction notice to "3D printing technique applied in vaginoplasty: A case report" [Heliyon 8 (2022) e11868].

[This retracts the article DOI: 10.1016/j.heliyon.

Detection of HO and redox potential of an acute wound of rabbits with different sugar intakes based on a SERS-active microneedle.

To detect HO and redox potential of an acute wound simultaneously, a SERS-active microneedle was fabricated by integrating HO and redox potential SERS probes into two grooves of an acupuncture needle, respectively. When the SERS-active microneedle was inserted into tissues, an acute wound was formed and the two SERS probes were introduced into the wound to sense HO and redox potential of the wound. The feasibility of the SERS-active microneedle was evaluated and .

Electrochemical stability of electrospun silicon/carbon nanofiber anode materials: a review.

Silicon (Si) is regarded as a promising anode material owing to its high specific capacity and low lithiation potential. The large volume change and the pulverization of silicon during the lithiation/delithiation process hinder its direct energy storage application. This review focuses on the electrospun silicon/carbon (Si/C) nanofiber anode materials for lithium-ion batteries for long-term stable energy storage.

EfficientNet-resDDSC: A Hybrid Deep Learning Model Integrating Residual Blocks and Dilated Convolutions for Inferring Gene Causality in Single-Cell Data.

Gene Regulatory Networks (GRNs) reveal complex interactions between genes in organisms, crucial for understanding the life system's operation. The rapid development of biotechnology, especially single-cell RNA sequencing (scRNA-seq), has generated a large amount of scRNA-seq data, which can be analyzed to explore the regulatory relationships between genes at the single-cell level. Previous models used to construct GRNs mainly aim at constructing associative relationships between genes, but usually fail to accurately reveal the causality between genes.

The anti-inflammatory effects of itaconate and its derivatives in neurological disorders.

Almost 16 % of the global population is affected by neurological disorders, including neurodegenerative and cerebral neuroimmune diseases, triggered by acute or chronic inflammation. Neuroinflammation is recognized as a common pathogenic mechanism in a wide array of neurological conditions including Alzheimer's disease, Parkinson's disease, postoperative cognitive dysfunction, stroke, traumatic brain injury, and multiple sclerosis. Inflammatory process in the central nervous system (CNS) can lead to neuronal damage and neuronal apoptosis, consequently exacerbating these diseases.

Dual-input robust diagnostics for railway point machines via audio signals.

Railway Point Machine (RPM) is a fundamental component of railway infrastructure and plays a crucial role in ensuring the safe operation of trains. Its primary function is to divert trains from one track to another, enabling connections between different lines and facilitating route selection. By judiciously deploying turnouts, railway systems can provide efficient transportation services while ensuring the safety of passengers and cargo.

Breakup-Free and Colorful Liquid Metal Thin Films via Electrochemical Oxidation.

Thin-film metal conductors featuring high conductivity and stretchability are basic building blocks for high-performance conformable electronics. Gallium-based liquid metals are attractive candidates for thin-film conductors due to their intrinsic stretchability and ease of processing. Moreover, the phase change nature of liquid metal provides an opportunity to create conformal electronics in a substrate-free manner.

Fabrication, Microstructures and Sensor Applications of Highly Ordered Electrospun Nanofibers: A Review.

The review summarizes the fabrication, microstructures, and sensor applications of highly ordered electrospun nanofibers. In the traditional electrospinning process, electrospun nanofibers usually have disordered or random microstructures due to the chaotic oscillation of the electrospinning jet. Different electrospinning methods can be formed by introducing external forces, such as magnetic, electric, or mechanical forces, and ordered nanofibers can be collected.

Nervonic acid and its sphingolipids: Biological functions and potential food applications.

Nervonic acid, a 24-carbon fatty acid with only one double bond at the 9th carbon (C24:1n-9), is abundant in the human brain, liver, and kidney. It not only functions in free form but also serves as a critical component of sphingolipids which participate in many biological processes such as cell membrane formation, apoptosis, and neurotransmission. Recent studies show that nervonic acid supplementation is not only beneficial to human health but also can improve the many medical conditions such as neurological diseases, cancers, diabetes, obesity, and their complications.

AngClust: Angle Feature-Based Clustering for Short Time Series Gene Expression Profiles.

When clustering gene expression, it is expected that correlation coefficients of genes in the same clusters are high, and that gene ontology (GO) enrichment analysis of most clusters will be significant. However, existing short-term gene expression clustering algorithms have limitations. To address this problem, we proposed a novel clustering process based on angular features for short-term gene expression.

miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN.

Glaucoma is an optic neuropathy that may lead to visual field loss and blindness. Human trabecular meshwork (HTM) cell dysfunction increases intraocular pressure, which leads to glaucoma. microRNAs (miRs) are single‑stranded non‑coding RNAs that regulate cellular processes in HTM cells.

Dexmedetomidine improves neurodevelopment and cognitive impairment in infants with congenital heart disease.

Explore if dexmedetomidine (DEX) improves neurodevelopment and cognitive impairment in infants with congenital heart disease. We retrospectively analyzed 256 pediatric patients aged less than 2 years with heart disease undergoing thoracic surgery. The intelligence quotient and neurodevelopment were tested.

Critical microRNAs and regulatory motifs in cleft palate identified by a conserved miRNA-TF-gene network approach in humans and mice.

Cleft palate (CP) is the second most common congenital birth defect. The etiology of CP is complicated, with involvement of various genetic and environmental factors. To investigate the gene regulatory mechanisms, we designed a powerful regulatory analytical approach to identify the conserved regulatory networks in humans and mice, from which we identified critical microRNAs (miRNAs), target genes and regulatory motifs (miRNA-TF-gene) related to CP.

Anesthetic management of tracheal laceration from traumatic dislocation of the first rib: a case report and literature of the review.

Background: Tracheobronchial lacerations from trauma can be life-threatening and present significant challenges for safe anesthetic management. Early recognition of tracheal injuries and prompt airway control can be lifesaving.

Case Presentation: A 56-year-old man with no significant medical history presented with difficulty breathing after a blunt trauma to his chest to the emergency room and was diagnosed with dislocation of the first rib and tracheal laceration after a chest tomography (CT) study.

Porous Polyvinylidene Fluoride Thin-Film Sensors from Colloidal Crystal Templates.

With the development of the materials science, biosensors tend to be thin, flexible, versatile, and are extensively employed in biotechnology, clinical diagnosis, biochips, etc. However, most existing biosensors are single-functionalized and destitute in contrivable microstructure, which result in some inherent limitations. In this work, a novel thin-film sensor that had dual response generated from one stimulus was designed based on the colloidal crystal templates and devisable circuit system.

A platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors.

Three molecular targeted tyrosine kinase inhibitors (TKI) were conjugated to classical platinum-based drugs with an aim to circumvent TKI resistance, predominately mediated by the emergence of secondary mutations on oncogenic kinases. The hybrids were found to maintain specificity towards the same oncogenic kinases as the original TKI. Importantly, they are remarkably less affected by TKI resistance, presumably due to their unique structure and the observed dual mechanism of anticancer activity (kinase inhibition and DNA damage).